Class information for:
Level 2: RIBONUCLEOTIDE REDUCTASE//POLG//HYDROXYUREA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2341 4410 35.5 70%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
2341 2             RIBONUCLEOTIDE REDUCTASE//POLG//HYDROXYUREA 4410
5027 1                   RIBONUCLEOTIDE REDUCTASE//P53R2//TRIMIDOX 1685
8598 1                   POLG//MNGIE//DEOXYRIBONUCLEOSIDE KINASE 1237
17768 1                   THYMIDINE KINASE 1//DNA SYNTHESIZING ENZYMES//SERUM THYMIDINE KINASE 1 583
22052 1                   DCMP HYDROXYMETHYLASE//ACTIVE OXYGEN QUENCHING//ADENINE PHOSPHORIBOSYLTRANFERASE 395
22559 1                   HYDROXYUREA//GENET HUMAN THER Y//AV HALTS 377
32822 1                   AGING LESIONS//BIOCERANNICS//BIOCHEM CHOCIMSKA 5 133

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RIBONUCLEOTIDE REDUCTASE authKW 842542 6% 50% 243
2 POLG authKW 286147 1% 66% 63
3 HYDROXYUREA authKW 194017 4% 16% 175
4 MNGIE authKW 184325 1% 76% 35
5 DEOXYRIBONUCLEOSIDE KINASE authKW 159486 1% 96% 24
6 MITOCHONDRIAL DNA DEPLETION authKW 157027 1% 69% 33
7 THYMIDINE KINASE 1 authKW 156152 1% 59% 38
8 P53R2 authKW 142802 1% 74% 28
9 MITOCHONDRIAL DNA DEPLETION SYNDROME authKW 135617 1% 85% 23
10 ALPERS SYNDROME authKW 131091 1% 76% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 8326 38% 0% 1666
2 Genetics & Heredity 1911 10% 0% 438
3 Oncology 1763 12% 0% 540
4 Cell Biology 1333 11% 0% 475
5 Biophysics 992 6% 0% 286
6 Virology 752 4% 0% 161
7 Clinical Neurology 497 6% 0% 273
8 Toxicology 365 4% 0% 155
9 Dermatology 224 2% 0% 99
10 Pharmacology & Pharmacy 219 7% 0% 303

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SECT VET MED BIOCHEM 77038 0% 70% 16
2 VET MED CHEM 54182 1% 24% 33
3 EXPT TECHNOL MED 40270 0% 73% 8
4 GENET HUMAN THER Y 32974 0% 53% 9
5 SECT MED RADIOBIOL 28841 0% 83% 5
6 ANAT PHYSIOL BIOCHEM 26810 1% 10% 40
7 UNIT MOL NEUROGENET 23434 1% 15% 23
8 SCI GENET MICROBIOL 22649 0% 55% 6
9 GRP CLIN VIROL 22150 0% 80% 4
10 LUND PROT PROD PLATFORM 20767 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN ENZYME REGULATION 9052 1% 5% 28
2 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 6955 2% 1% 69
3 MITOCHONDRION 4356 1% 2% 26
4 JOURNAL OF BIOLOGICAL CHEMISTRY 4335 7% 0% 323
5 MUTATION RESEARCH 3605 1% 1% 66
6 BIOCHEMISTRY 2503 3% 0% 145
7 JOURNAL OF CLINICAL HEMATOLOGY AND ONCOLOGY 2487 0% 12% 3
8 NEUROMUSCULAR DISORDERS 2256 1% 1% 28
9 ZEITSCHRIFT FUR VERSUCHSTIERKUNDE 1783 0% 3% 10
10 MOLECULAR GENETICS AND METABOLISM 1341 1% 1% 25

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RIBONUCLEOTIDE REDUCTASE 842542 6% 50% 243 Search RIBONUCLEOTIDE+REDUCTASE Search RIBONUCLEOTIDE+REDUCTASE
2 POLG 286147 1% 66% 63 Search POLG Search POLG
3 HYDROXYUREA 194017 4% 16% 175 Search HYDROXYUREA Search HYDROXYUREA
4 MNGIE 184325 1% 76% 35 Search MNGIE Search MNGIE
5 DEOXYRIBONUCLEOSIDE KINASE 159486 1% 96% 24 Search DEOXYRIBONUCLEOSIDE+KINASE Search DEOXYRIBONUCLEOSIDE+KINASE
6 MITOCHONDRIAL DNA DEPLETION 157027 1% 69% 33 Search MITOCHONDRIAL+DNA+DEPLETION Search MITOCHONDRIAL+DNA+DEPLETION
7 THYMIDINE KINASE 1 156152 1% 59% 38 Search THYMIDINE+KINASE+1 Search THYMIDINE+KINASE+1
8 P53R2 142802 1% 74% 28 Search P53R2 Search P53R2
9 MITOCHONDRIAL DNA DEPLETION SYNDROME 135617 1% 85% 23 Search MITOCHONDRIAL+DNA+DEPLETION+SYNDROME Search MITOCHONDRIAL+DNA+DEPLETION+SYNDROME
10 ALPERS SYNDROME 131091 1% 76% 25 Search ALPERS+SYNDROME Search ALPERS+SYNDROME

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 EKLUND, H , UHLIN, U , FARNEGARDH, M , LOGAN, DT , NORDLUND, P , (2001) STRUCTURE AND FUNCTION OF THE RADICAL ENZYME RIBONUCLEOTIDE REDUCTASE.PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. VOL. 77. ISSUE 3. P. 177 -268 172 79% 200
2 EL-HATTAB, A , SCAGLIA, F , (2013) MITOCHONDRIAL DNA DEPLETION SYNDROMES: REVIEW AND UPDATES OF GENETIC BASIS, MANIFESTATIONS, AND THERAPEUTIC OPTIONS.NEUROTHERAPEUTICS. VOL. 10. ISSUE 2. P. 186-198 103 84% 46
3 COPELAND, WC , (2012) DEFECTS IN MITOCHONDRIAL DNA REPLICATION AND HUMAN DISEASE.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 47. ISSUE 1. P. 64 -74 92 90% 69
4 TOMTER, AB , ZOPPELLARO, G , ANDERSEN, NH , HERSLETH, HP , HAMMERSTAD, M , ROHR, AK , SANDVIK, GK , STRAND, KR , NILSSON, GE , BELL, CB , ET AL (2013) RIBONUCLEOTIDE REDUCTASE CLASS I WITH DIFFERENT RADICAL GENERATING CLUSTERS.COORDINATION CHEMISTRY REVIEWS. VOL. 257. ISSUE 1. P. 3-26 111 75% 27
5 KOLBERG, M , STRAND, KR , GRAFF, P , ANDERSSON, KK , (2004) STRUCTURE, FUNCTION, AND MECHANISM OF RIBONUCLEOTIDE REDUCTASES.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1699. ISSUE 1-2. P. 1-34 141 62% 213
6 SHAO, J , ZHOU, B , CHU, B , YEN, Y , (2006) RIBONUCLEOTIDE REDUCTASE INHIBITORS AND FUTURE DRUG DESIGN.CURRENT CANCER DRUG TARGETS. VOL. 6. ISSUE 5. P. 409-431 151 52% 165
7 AYE, Y , LI, M , LONG, MJC , WEISS, RS , (2015) RIBONUCLEOTIDE REDUCTASE AND CANCER: BIOLOGICAL MECHANISMS AND TARGETED THERAPIES.ONCOGENE. VOL. 34. ISSUE 16. P. 2011 -2021 95 55% 28
8 NORDLUND, N , REICHARD, P , (2006) RIBONUCLEOTIDE REDUCTASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 75. ISSUE . P. 681 -706 108 78% 61
9 SUOMALAINEN, A , ISOHANNI, P , (2010) MITOCHONDRIAL DNA DEPLETION SYNDROMES - MANY GENES, COMMON MECHANISMS.NEUROMUSCULAR DISORDERS. VOL. 20. ISSUE 7. P. 429 -437 74 93% 71
10 FINSTERER, J , AHTING, U , (2013) MITOCHONDRIAL DEPLETION SYNDROMES IN CHILDREN AND ADULTS.CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. VOL. 40. ISSUE 5. P. 635-644 80 90% 6

Classes with closest relation at Level 2


Rank Class id link
1 3150 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
2 381 MITOCHONDRIA//MELAS//MITOCHONDRIAL DISEASE
3 3408 ADENYLATE KINASE//PHOSPHOGLYCERATE KINASE//CHIM STRUCT MACROMOL
4 1422 XRCC1//GEMCITABINE//ERCC1
5 3633 GENE POINT MUTATIONS//HETEROKARYON 12//AD 3A LOCUS
6 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
7 2798 LEFLUNOMIDE//MIZORIBINE//DIHYDROOROTATE DEHYDROGENASE
8 2245 HAIRY CELL LEUKEMIA//CLADRIBINE//2 CHLORODEOXYADENOSINE
9 3519 NM23//NUCLEOSIDE DIPHOSPHATE KINASE//NM23 H1
10 513 EPOXIDATION//MET BIOCATALYSIS//TS 1

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