Class information for:
Level 2: PYRAZINAMIDE//ISONIAZID//RIFAMPICIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2486 3933 32.8 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
141 3       TUBERCULOSIS//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE//MYCOBACTERIUM TUBERCULOSIS 64640
2486 2             PYRAZINAMIDE//ISONIAZID//RIFAMPICIN 3933
5434 1                   BEDAQUILINE//INFECT DIS PHARMACOKINET//DELAMANID 1624
16318 1                   ISONIAZID//RIFAMPICIN//PYRAZINAMIDE 660
16470 1                   ISONIAZID//ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY//DRUG REASSESSMENT 651
20105 1                   PYRAZINAMIDE//PNCA//PYRAZINAMIDASE 476
29195 1                   ACUTE TOXIC MYOPATHY//ANTI TUBERCULOSIS CHEMOPROPHYLAXIS//ANTIBIOTIC RELATED TOXICITY 191
31726 1                   ETHAMBUTOL//TOXIC OPTIC NEUROPATHY//ETHAMBUTOL OPTIC NEUROPATHY 149
33978 1                   AGROCHEMICAL INTERACTIONS//ATENOLOL METABOLIC ACTIONS//METOPROLOL METABOLIC ACTIONS 118
37204 1                   17 BETA ESTRADIOLUM//26S PROTEASOME NON ATPASE REGULATORY SUBUNIT 13//BIOMED SEVILLE IBISSERV INFECT DIS 64

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PYRAZINAMIDE authKW 755771 5% 54% 179
2 ISONIAZID authKW 751920 9% 28% 346
3 RIFAMPICIN authKW 501407 7% 23% 282
4 ETHAMBUTOL authKW 309562 2% 42% 96
5 ANTITUBERCULOSIS DRUGS authKW 217695 2% 42% 67
6 BEDAQUILINE authKW 186468 1% 78% 31
7 TUBERCULOSIS authKW 181988 16% 4% 613
8 RIFAPENTINE authKW 163911 1% 60% 35
9 INFECT DIS PHARMACOKINET address 159462 1% 62% 33
10 DELAMANID authKW 157922 1% 88% 23

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Respiratory System 12654 15% 0% 596
2 Pharmacology & Pharmacy 10501 31% 0% 1232
3 Microbiology 9541 21% 0% 843
4 Infectious Diseases 7331 13% 0% 528
5 Chemistry, Medicinal 3205 9% 0% 358
6 Chemistry, Analytical 932 8% 0% 316
7 Medicine, General & Internal 822 8% 0% 326
8 Toxicology 468 4% 0% 159
9 Critical Care Medicine 462 2% 0% 97
10 Immunology 345 6% 0% 251

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INFECT DIS PHARMACOKINET 159462 1% 62% 33
2 INFECT DIS EXPT THER EUT 148824 1% 91% 21
3 TB 136951 5% 10% 186
4 TIBOTEC BVBA 59703 0% 77% 10
5 DRUG REASSESSMENT 54334 0% 100% 7
6 TB SECT 49719 1% 15% 42
7 IMED INFECT 38030 0% 70% 7
8 DST NRF EXCELLENCE BIOMED TB 26702 1% 12% 29
9 INFECT INFLAMMAT IMAGING 25137 0% 36% 9
10 CRIT PATH TB DRUG REGIMENS 23286 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 63017 5% 4% 187
2 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 39054 9% 1% 346
3 TUBERCULOSIS 28341 2% 5% 67
4 TUBERCLE 26048 1% 9% 39
5 TUBERCLE AND LUNG DISEASE 5008 0% 4% 17
6 ACS INFECTIOUS DISEASES 4629 0% 6% 10
7 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 4151 2% 1% 83
8 AMERICAN REVIEW OF RESPIRATORY DISEASE 3450 1% 1% 53
9 REVUE FRANCAISE DES MALADIES RESPIRATOIRES 3411 0% 6% 8
10 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2888 2% 1% 61

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRAZINAMIDE 755771 5% 54% 179 Search PYRAZINAMIDE Search PYRAZINAMIDE
2 ISONIAZID 751920 9% 28% 346 Search ISONIAZID Search ISONIAZID
3 RIFAMPICIN 501407 7% 23% 282 Search RIFAMPICIN Search RIFAMPICIN
4 ETHAMBUTOL 309562 2% 42% 96 Search ETHAMBUTOL Search ETHAMBUTOL
5 ANTITUBERCULOSIS DRUGS 217695 2% 42% 67 Search ANTITUBERCULOSIS+DRUGS Search ANTITUBERCULOSIS+DRUGS
6 BEDAQUILINE 186468 1% 78% 31 Search BEDAQUILINE Search BEDAQUILINE
7 TUBERCULOSIS 181988 16% 4% 613 Search TUBERCULOSIS Search TUBERCULOSIS
8 RIFAPENTINE 163911 1% 60% 35 Search RIFAPENTINE Search RIFAPENTINE
9 DELAMANID 157922 1% 88% 23 Search DELAMANID Search DELAMANID
10 PA 824 144486 1% 85% 22 Search PA+824 Search PA+824

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GOUTELLE, S , BOURGUIGNON, L , MAIRE, P , JELLIFFE, RW , NEELY, MN , (2014) THE CASE FOR USING HIGHER DOSES OF FIRST LINE ANTI-TUBERCULOSIS DRUGS TO OPTIMIZE EFFICACY.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 39. P. 6191 -6206 107 87% 1
2 ALSULTAN, A , PELOQUIN, CA , (2014) THERAPEUTIC DRUG MONITORING IN THE TREATMENT OF TUBERCULOSIS: AN UPDATE.DRUGS. VOL. 74. ISSUE 8. P. 839 -854 93 66% 39
3 VERBEECK, RK , GUNTHER, G , KIBUULE, D , HUNTER, C , RENNIE, TW , (2016) OPTIMIZING TREATMENT OUTCOME OF FIRST-LINE ANTI-TUBERCULOSIS DRUGS: THE ROLE OF THERAPEUTIC DRUG MONITORING.EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 72. ISSUE 8. P. 905 -916 94 81% 0
4 VAN DEN BOOGAARD, J , KIBIKI, GS , KISANGA, ER , BOEREE, MJ , AARNOUTSE, RE , (2009) NEW DRUGS AGAINST TUBERCULOSIS: PROBLEMS, PROGRESS, AND EVALUATION OF AGENTS IN CLINICAL DEVELOPMENT.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 53. ISSUE 3. P. 849 -862 95 65% 81
5 GROSSET, JH , SINGER, TG , BISHAI, WR , (2012) NEW DRUGS FOR THE TREATMENT OF TUBERCULOSIS: HOPE AND REALITY.INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. VOL. 16. ISSUE 8. P. 1005 -1014 68 77% 54
6 RAMIREZ-BUSBY, SM , VALAFAR, F , (2015) SYSTEMATIC REVIEW OF MUTATIONS IN PYRAZINAMIDASE ASSOCIATED WITH PYRAZINAMIDE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS CLINICAL ISOLATES.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 59. ISSUE 9. P. 5267 -5277 72 75% 6
7 WHITFIELD, MG , SOETERS, HM , WARREN, RM , YORK, T , SAMPSON, SL , STREICHER, EM , VAN HELDEN, PD , VAN RIE, A , (2015) A GLOBAL PERSPECTIVE ON PYRAZINAMIDE RESISTANCE: SYSTEMATIC REVIEW AND META-ANALYSIS.PLOS ONE. VOL. 10. ISSUE 7. P. - 77 71% 5
8 VILLEMAGNE, B , CRAUSTE, C , FLIPO, M , BAULARD, AR , DEPREZ, B , WILLAND, N , (2012) TUBERCULOSIS: THE DRUG DEVELOPMENT PIPELINE AT A GLANCE.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 51. ISSUE . P. 1 -16 71 64% 80
9 ZUMLA, A , NAHID, P , COLE, ST , (2013) ADVANCES IN THE DEVELOPMENT OF NEW TUBERCULOSIS DRUGS AND TREATMENT REGIMENS.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 5. P. 388 -404 53 54% 255
10 POCE, G , COCOZZA, M , CONSALVI, S , BIAVA, M , (2014) SAR ANALYSIS OF NEW ANTI-TB DRUGS CURRENTLY IN PRE-CLINICAL AND CLINICAL DEVELOPMENT.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 86. ISSUE . P. 335 -351 80 67% 9

Classes with closest relation at Level 2


Rank Class id link
1 70 TUBERCULOSIS//INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE//MYCOBACTERIUM TUBERCULOSIS
2 3967 PSEUDOPTEROSINS//PSEUDOPTEROGORGIA ELISABETHAE//AZORELLA COMPACTA
3 373 MYCOBACTERIUM TUBERCULOSIS//TUBERCULOSIS//INTERNATIONAL JOURNAL OF LEPROSY AND OTHER MYCOBACTERIAL DISEASES
4 3812 STOBADINE//IN VITRO ANTIMYCOBACTERIAL ACTIVITY//SPINACH CHLOROPLASTS
5 4008 DIHYDRALAZINE SULFATE//DRUG INDUCED LUPUS//HYDRALAZINE HYDROCHLORIDE
6 2794 ERGOTHIONEINE//CATALASE PEROXIDASE//MYCOTHIOL
7 1613 ACETAMINOPHEN//DRUG INDUCED LIVER INJURY//HEPATOTOXICITY
8 3076 PEPTIDE DEFORMYLASE//ENOYL ACP REDUCTASE//ACYL CARRIER PROTEIN
9 2444 DRY POWDER INHALER//PULMONARY DELIVERY//PULMONARY DRUG DELIVERY
10 1239 HETEROCYCLIC AMINES//HETEROCYCLIC AROMATIC AMINES//PHIP

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