Class information for:
Level 2: IVABRADINE//SINOATRIAL NODE//HCN CHANNELS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2637 3514 37.1 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
11 3       ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION 130936
2637 2             IVABRADINE//SINOATRIAL NODE//HCN CHANNELS 3514
3300 1                   SINOATRIAL NODE//HCN CHANNELS//PACEMAKER CURRENT 2016
10195 1                   IVABRADINE//RESTING HEART RATE//HOWARD GILMAN HEART VALVE DIS 1083
26073 1                   ZATEBRADINE//ALINIDINE//YM758 263
31516 1                   SALVICINE//DIPFLUZINE//DIPFLUZINE HYDROCHLORIDE 152

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IVABRADINE authKW 1824416 8% 78% 268
2 SINOATRIAL NODE authKW 1079242 7% 50% 250
3 HCN CHANNELS authKW 729882 4% 68% 124
4 PACEMAKER CURRENT authKW 368146 2% 76% 56
5 I H authKW 284913 2% 52% 63
6 I F CURRENT authKW 270296 1% 84% 37
7 HYPERPOLARIZATION ACTIVATED CURRENT authKW 270268 1% 66% 47
8 RESTING HEART RATE authKW 262755 2% 55% 55
9 ZD7288 authKW 241849 1% 61% 46
10 HCN4 authKW 209210 1% 71% 34

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cardiac & Cardiovascular System 29016 36% 0% 1264
2 Physiology 10828 20% 0% 691
3 Peripheral Vascular Diseases 4729 11% 0% 399
4 Pharmacology & Pharmacy 2363 17% 0% 605
5 Neurosciences 1379 14% 0% 485
6 Cell Biology 156 6% 0% 196
7 Hematology 126 3% 0% 94
8 Biophysics 116 3% 0% 114
9 Medicine, Research & Experimental 107 3% 0% 116
10 Medicine, General & Internal 66 4% 0% 135

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PHYSIOL NEUROBIOL 174148 1% 95% 21
2 HOWARD GILMAN HEART VALVE DIS 146805 1% 65% 26
3 ETTORE SANSAVINI HLTH SCI FDN 59218 0% 45% 15
4 CIMMBA 47347 0% 42% 13
5 IAVONE CARDIOVASC TRANSLAT 34743 0% 50% 8
6 DAVEE NEUROL CLIN NEUROSCI 33109 0% 25% 15
7 FISIOL MOL NEUROBIOL 27799 0% 80% 4
8 STATE DRUG PHYTOCHEM 26063 0% 100% 3
9 LA PITIE SALPETRIERE HOSP 25538 0% 18% 16
10 GVM CARE 24305 1% 11% 25

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EUROPEAN HEART JOURNAL SUPPLEMENTS 21074 1% 5% 50
2 JOURNAL OF PHYSIOLOGY-LONDON 10202 4% 1% 148
3 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 8992 3% 1% 93
4 ACTA PHARMACOLOGICA SINICA 8103 2% 1% 73
5 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 6831 2% 1% 72
6 ADVANCES IN CARDIOLOGY 6370 0% 7% 10
7 KARDIOLOGIYA 5347 2% 1% 64
8 CIRCULATION RESEARCH 4727 2% 1% 75
9 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 4580 2% 1% 82
10 CLINICAL RESEARCH IN CARDIOLOGY 4478 1% 2% 24

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 IVABRADINE 1824416 8% 78% 268 Search IVABRADINE Search IVABRADINE
2 SINOATRIAL NODE 1079242 7% 50% 250 Search SINOATRIAL+NODE Search SINOATRIAL+NODE
3 HCN CHANNELS 729882 4% 68% 124 Search HCN+CHANNELS Search HCN+CHANNELS
4 PACEMAKER CURRENT 368146 2% 76% 56 Search PACEMAKER+CURRENT Search PACEMAKER+CURRENT
5 I H 284913 2% 52% 63 Search I+H Search I+H
6 I F CURRENT 270296 1% 84% 37 Search I+F+CURRENT Search I+F+CURRENT
7 HYPERPOLARIZATION ACTIVATED CURRENT 270268 1% 66% 47 Search HYPERPOLARIZATION+ACTIVATED+CURRENT Search HYPERPOLARIZATION+ACTIVATED+CURRENT
8 RESTING HEART RATE 262755 2% 55% 55 Search RESTING+HEART+RATE Search RESTING+HEART+RATE
9 ZD7288 241849 1% 61% 46 Search ZD7288 Search ZD7288
10 HCN4 209210 1% 71% 34 Search HCN4 Search HCN4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BIEL, M , WAHL-SCHOTT, C , MICHALAKIS, S , ZONG, XG , (2009) HYPERPOLARIZATION-ACTIVATED CATION CHANNELS: FROM GENES TO FUNCTION.PHYSIOLOGICAL REVIEWS. VOL. 89. ISSUE 3. P. 847 -885 258 61% 324
2 MANGONI, ME , NARGEOT, J , (2008) GENESIS AND REGULATION OF THE HEART AUTOMATICITY.PHYSIOLOGICAL REVIEWS. VOL. 88. ISSUE 3. P. 919-982 256 53% 201
3 ROMANELLI, MN , SARTIANI, L , MASI, A , MANNAIONI, G , MANETTI, D , MUGELLI, A , CERBAI, E , (2016) HCN CHANNELS MODULATORS: THE NEED FOR SELECTIVITY.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 16. P. 1764 -1791 205 77% 0
4 POSTEA, O , BIEL, M , (2011) EXPLORING HCN CHANNELS AS NOVEL DRUG TARGETS.NATURE REVIEWS DRUG DISCOVERY. VOL. 10. ISSUE 12. P. 903 -914 124 91% 70
5 WICKENDEN, AD , MAHER, MP , CHAPLAN, SR , (2009) HCN PACEMAKER CHANNELS AND PAIN: A DRUG DISCOVERY PERSPECTIVE.CURRENT PHARMACEUTICAL DESIGN. VOL. 15. ISSUE 18. P. 2149-2168 150 81% 24
6 VERKERK, AO , VAN GINNEKEN, ACG , WILDERS, R , (2009) PACEMAKER ACTIVITY OF THE HUMAN SINOATRIAL NODE: ROLE OF THE HYPERPOLARIZATION-ACTIVATED CURRENT, I-F.INTERNATIONAL JOURNAL OF CARDIOLOGY. VOL. 132. ISSUE 3. P. 318 -336 135 89% 20
7 BARUSCOTTI, M , BUCCHI, A , DIFRANCESCO, D , (2005) PHYSIOLOGY AND PHARMACOLOGY OF THE CARDIAC PACEMAKER ("FUNNY") CURRENT.PHARMACOLOGY & THERAPEUTICS. VOL. 107. ISSUE 1. P. 59-79 122 89% 159
8 HE, C , CHEN, F , LI, B , HU, Z , (2014) NEUROPHYSIOLOGY OF HCN CHANNELS: FROM CELLULAR FUNCTIONS TO MULTIPLE REGULATIONS.PROGRESS IN NEUROBIOLOGY. VOL. 112. ISSUE . P. 1-23 132 55% 62
9 DIFRANCESCO, D , (2010) THE ROLE OF THE FUNNY CURRENT IN PACEMAKER ACTIVITY.CIRCULATION RESEARCH. VOL. 106. ISSUE 3. P. 434-446 91 87% 169
10 KONCZ, I , SZEL, T , JAEGER, K , BACZKO, I , CERBAI, E , ROMANELLI, MN , PAPP, JG , VARRO, A , (2011) SELECTIVE PHARMACOLOGICAL INHIBITION OF THE PACEMAKER CHANNEL ISOFORMS (HCN1-4) AS NEW POSSIBLE THERAPEUTICAL TARGETS.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 24. P. 3662 -3674 115 91% 11

Classes with closest relation at Level 2


Rank Class id link
1 1489 SPIRAL WAVE//T WAVE ALTERNANS//OPTICAL MAPPING
2 3016 MITRAL VALVE PROLAPSE//TOYOOKA JR//HUMAN RIB BONE
3 691 POTASSIUM CHANNELS//BK CHANNEL//RETIGABINE
4 2204 MIBEFRADIL//T TYPE CALCIUM CHANNEL//CALCIUM CHANNELS
5 1369 HEART RATE VARIABILITY//AUTONOMIC NERVOUS SYSTEM//DIABETIC CARDIOMYOPATHY
6 1064 LONG QT SYNDROME//BRUGADA SYNDROME//QT INTERVAL
7 377 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY//PHOSPHOLAMBAN//CARDIAC & CARDIOVASCULAR SYSTEM
8 1393 RYANODINE RECEPTOR//EXCITATION CONTRACTION COUPLING//SARCOPLASMIC RETICULUM
9 942 HEART FAILURE//ACUTE HEART FAILURE//EUROPEAN JOURNAL OF HEART FAILURE
10 896 AMIODARONE//ANTIARRHYTHMIC DRUGS//PROPAFENONE

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