Class information for:
Level 2: PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3291 1872 33.8 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
3291 2             PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE 1872
9868 1                   PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//NUCLEOSIDE HYDROLASE 1113
22214 1                   MTAP//METHYLTHIOADENOSINE PHOSPHORYLASE//METHIONINE SALVAGE PATHWAY 390
22761 1                   METHIONINE DEPENDENCE//METHIONINASE//METHIONINE GAMMA LYASE 369

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PURINE NUCLEOSIDE PHOSPHORYLASE authKW 1105184 7% 53% 127
2 CARBOHYDRATE CHEM TEAM address 350619 2% 50% 43
3 METHIONINE DEPENDENCE authKW 277268 1% 100% 17
4 NUCLEOSIDE HYDROLASE authKW 262491 1% 62% 26
5 NUCLEOSIDE PHOSPHORYLASE authKW 257496 2% 53% 30
6 METHIONINASE authKW 251633 1% 86% 18
7 BIOQUIM ESTRUTURAL address 220174 1% 75% 18
8 METHYLTHIOADENOSINE PHOSPHORYLASE authKW 177590 1% 78% 14
9 MTAP authKW 162522 1% 59% 17
10 INVEST BIOTECNOL SUSTENTABLE LIBIOS address 132108 0% 90% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5103 44% 0% 829
2 Biophysics 1362 11% 0% 200
3 Oncology 830 13% 0% 239
4 Chemistry, Medicinal 629 6% 0% 115
5 Biochemical Research Methods 532 7% 0% 122
6 Biotechnology & Applied Microbiology 479 8% 0% 153
7 Chemistry, Organic 327 8% 0% 142
8 Pharmacology & Pharmacy 150 8% 0% 148
9 Crystallography 98 3% 0% 49
10 Microbiology 85 4% 0% 81

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARBOHYDRATE CHEM TEAM 350619 2% 50% 43
2 BIOQUIM ESTRUTURAL 220174 1% 75% 18
3 INVEST BIOTECNOL SUSTENTABLE LIBIOS 132108 0% 90% 9
4 DIPARTIMENTO BIOCHIM BIOFIS F CEDRANGOLO 102074 1% 48% 13
5 PROGRAMA POS MED CIENCIAS SAUDE 83945 1% 23% 22
6 REDE BRASILEIRA PESQUISAS TB 73391 0% 75% 6
7 ITALIAN BIOCATALYSIS 52832 0% 36% 9
8 BIOCRYSTALLOG UNIT 49696 0% 38% 8
9 STRUCT BIOL ZOOCHEM CEIS 48930 0% 100% 3
10 PESQUISAS BIOL MOL FUNC 39788 1% 20% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 5535 2% 1% 40
2 AGRICULTURAL AND BIOLOGICAL CHEMISTRY 2973 2% 1% 36
3 BIOCHEMISTRY 2746 5% 0% 97
4 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 1756 1% 1% 22
5 CURRENT DRUG TARGETS 1726 1% 1% 14
6 NUCLEOSIDES & NUCLEOTIDES 1188 0% 1% 7
7 JOURNAL OF CARBOHYDRATES-NUCLEOSIDES-NUCLEOTIDES 1121 0% 3% 2
8 BIOCATALYSIS AND BIOTRANSFORMATION 859 0% 1% 7
9 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 854 1% 0% 13
10 CANCER RESEARCH 848 3% 0% 47

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PURINE NUCLEOSIDE PHOSPHORYLASE 1105184 7% 53% 127 Search PURINE+NUCLEOSIDE+PHOSPHORYLASE Search PURINE+NUCLEOSIDE+PHOSPHORYLASE
2 METHIONINE DEPENDENCE 277268 1% 100% 17 Search METHIONINE+DEPENDENCE Search METHIONINE+DEPENDENCE
3 NUCLEOSIDE HYDROLASE 262491 1% 62% 26 Search NUCLEOSIDE+HYDROLASE Search NUCLEOSIDE+HYDROLASE
4 NUCLEOSIDE PHOSPHORYLASE 257496 2% 53% 30 Search NUCLEOSIDE+PHOSPHORYLASE Search NUCLEOSIDE+PHOSPHORYLASE
5 METHIONINASE 251633 1% 86% 18 Search METHIONINASE Search METHIONINASE
6 METHYLTHIOADENOSINE PHOSPHORYLASE 177590 1% 78% 14 Search METHYLTHIOADENOSINE+PHOSPHORYLASE Search METHYLTHIOADENOSINE+PHOSPHORYLASE
7 MTAP 162522 1% 59% 17 Search MTAP Search MTAP
8 METHIONINE GAMMA LYASE 131246 1% 62% 13 Search METHIONINE+GAMMA+LYASE Search METHIONINE+GAMMA+LYASE
9 L METHIONINE GAMMA LYASE 120097 0% 82% 9 Search L+METHIONINE+GAMMA+LYASE Search L+METHIONINE+GAMMA+LYASE
10 METHIONINE SALVAGE PATHWAY 117421 1% 60% 12 Search METHIONINE+SALVAGE+PATHWAY Search METHIONINE+SALVAGE+PATHWAY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BZOWSKA, A , KULIKOWSKA, E , SHUGAR, D , (2000) PURINE NUCLEOSIDE PHOSPHORYLASES: PROPERTIES, FUNCTIONS, AND CLINICAL ASPECTS.PHARMACOLOGY & THERAPEUTICS. VOL. 88. ISSUE 3. P. 349 -425 145 49% 270
2 SILVA, RG , NUNES, JES , CANDURI, F , BORGES, JC , GAVA, LM , MORENO, FB , BASSO, LA , SANTOS, DS , (2007) PURINE NUCLEOSIDE PHOSPHORYLASE: A POTENTIAL TARGET FOR THE DEVELOPMENT OF DRUGS TO TREAT T-CELL- AND APICOMPLEXAN PARASITE-MEDIATED DISEASES.CURRENT DRUG TARGETS. VOL. 8. ISSUE 3. P. 413 -422 65 86% 12
3 EVANS, GB , SCHRAMM, VL , TYLER, PC , (2015) THE IMMUCILLINS: DESIGN, SYNTHESIS AND APPLICATION OF TRANSITION-STATE ANALOGUES.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 34. P. 3897 -3909 48 86% 0
4 HOFFMAN, RM , (2015) DEVELOPMENT OF RECOMBINANT METHIONINASE TO TARGET THE GENERAL CANCER-SPECIFIC METABOLIC DEFECT OF METHIONINE DEPENDENCE: A 40-YEAR ODYSSEY.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 15. ISSUE 1. P. 21 -31 39 91% 5
5 CAVUOTO, P , FENECH, MF , (2012) A REVIEW OF METHIONINE DEPENDENCY AND THE ROLE OF METHIONINE RESTRICTION IN CANCER GROWTH CONTROL AND LIFE-SPAN EXTENSION.CANCER TREATMENT REVIEWS. VOL. 38. ISSUE 6. P. 726-736 58 56% 50
6 DURANDO, X , THIVAT, E , GIMBERGUES, P , CELLARIER, E , ABRIAL, C , DIB, M , TACCA, O , CHOLLET, P , (2008) METHIONINE DEPENDENCY OF CANCER CELLS: A NEW THERAPEUTIC APPROACH?.BULLETIN DU CANCER. VOL. 95. ISSUE 1. P. 69-76 50 86% 6
7 CELLARIER, E , DURANDO, X , VASSON, MP , FARGES, MC , DEMIDEN, A , MAURIZIS, JC , MADELMONT, JC , CHOLLET, P , (2003) METHIONINE DEPENDENCY AND CANCER TREATMENT.CANCER TREATMENT REVIEWS. VOL. 29. ISSUE 6. P. 489-499 62 70% 74
8 TAN, YY , XU, MX , HOFFMAN, RM , (2010) BROAD SELECTIVE EFFICACY OF RECOMBINANT METHIONINASE AND POLYETHYLENE GLYCOL-MODIFIED RECOMBINANT METHIONINASE ON CANCER CELLS IN VITRO.ANTICANCER RESEARCH. VOL. 30. ISSUE 4. P. 1041-1046 41 87% 12
9 SCHRAMM, VL , (2013) TRANSITION STATES, ANALOGUES, AND DRUG DEVELOPMENT.ACS CHEMICAL BIOLOGY. VOL. 8. ISSUE 1. P. 71-81 45 61% 36
10 BERTINO, JR , WAUD, WR , PARKER, WB , LUBIN, M , (2011) TARGETING TUMORS THAT LACK METHYLTHIOADENOSINE PHOSPHORYLASE (MTAP) ACTIVITY CURRENT STRATEGIES.CANCER BIOLOGY & THERAPY. VOL. 11. ISSUE 7. P. 627-632 37 82% 31

Classes with closest relation at Level 2


Rank Class id link
1 3150 ADENOSINE DEAMINASE//PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY//CECR1
2 1752 LESCH NYHAN SYNDROME//AMP DEAMINASE//LESCH NYHAN DISEASE
3 793 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES//CARBOCYCLIC NUCLEOSIDES
4 2622 TRIOSEPHOSPHATE ISOMERASE//HISTIDINE BIOSYNTHESIS//KETOSTEROID ISOMERASE
5 2596 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION A//ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
6 3021 SHIKIMATE PATHWAY//CHORISMATE MUTASE//ANTHRANILATE SYNTHASE
7 1136 POLYAMINES//SPERMIDINE//PUTRESCINE
8 1176 THYMIDYLATE SYNTHASE//THYMIDINE PHOSPHORYLASE//5 FLUOROURACIL
9 2245 HAIRY CELL LEUKEMIA//CLADRIBINE//2 CHLORODEOXYADENOSINE
10 1584 D AMINO ACID OXIDASE//D SERINE//SERINE RACEMASE

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