Class information for:
Level 2: MATRIX METALLOPROTEINASE//METALLOPROTEINASES//MT1 MMP

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
707 12920 44.0 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
707 2             MATRIX METALLOPROTEINASE//METALLOPROTEINASES//MT1 MMP 12920
239 1                   TIMP 1//MATRIX METALLOPROTEINASE//TIMP 2 3844
4006 1                   MATRIX METALLOPROTEINASE//METALLOPROTEINASES//MORPHOL ESTOMATOL PHYSIOL 1864
6635 1                   TACE INHIBITORS//MMP INHIBITORS//MATRIX METALLOPROTEINASE INHIBITOR 1461
6862 1                   ADAM17//ADAM12//ADAM 1434
9024 1                   MT1 MMP//CANC CELL//MEMBRANE TYPE 1 MATRIX METALLOPROTEINASE 1195
9057 1                   MATRIX METALLOPROTEINASE//MMP 9//MATRIX METALLOPROTEINASE 9 1191
17517 1                   MODIFIED TETRACYCLINE//PAEDIAT PNEUMONOL ALLERGOL//DBMR 595
21571 1                   HUMAN MACROPHAGE METALLOELASTASE//MMP 1 GENE//MMP1 414
23378 1                   CTRP3//SORSBY FUNDUS DYSTROPHY//SORSBYS FUNDUS DYSTROPHY 348
27423 1                   AP 1 C FOS//ASCORBATE INDUCED OSTEOBLASTIC DIFFERENTIATION//BIOL CHIM PROT BIOL INGN CARTILAGE 230
29346 1                   RECK//REVERSION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIFS//RECK GENE 188
31248 1                   ANESTHET//CHANG GUNG MEM HOSP LIN KOU//APOPTOSIS INHIBITOR 5 156

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 MATRIX METALLOPROTEINASE authKW 1227088 15% 27% 1942
2 METALLOPROTEINASES authKW 447220 5% 27% 704
3 MT1 MMP authKW 262781 2% 57% 194
4 TIMP 1 authKW 255932 2% 42% 260
5 MMP 9 authKW 250164 3% 24% 447
6 GELATINASE authKW 243965 2% 37% 278
7 MMP 2 authKW 227953 3% 29% 338
8 TISSUE INHIBITOR OF METALLOPROTEINASE authKW 218593 2% 44% 212
9 TIMP 2 authKW 172280 1% 47% 155
10 MATRIX METALLOPROTEINASE 9 authKW 169562 2% 24% 296

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 14801 19% 0% 2462
2 Biochemistry & Molecular Biology 9428 26% 0% 3304
3 Cell Biology 7318 14% 0% 1793
4 Peripheral Vascular Diseases 2826 5% 0% 655
5 Chemistry, Medicinal 2390 5% 0% 617
6 Pathology 2234 4% 0% 568
7 Cardiac & Cardiovascular System 2084 6% 0% 810
8 Medicine, Research & Experimental 1785 6% 0% 717
9 Biophysics 906 4% 0% 538
10 Neurosciences 688 7% 0% 900

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC CELL 106770 1% 50% 90
2 ANESTHET 50631 0% 35% 62
3 ARTHRIT TISSUE DEGENERAT PROGRAM 31820 0% 36% 38
4 MORPHOL ESTOMATOL PHYSIOL 27928 0% 39% 30
5 HERITAGE MED 4 62 23134 0% 70% 14
6 MOL ONCOL VIROL 19750 0% 31% 27
7 TUMOR DEV BIOL 16023 0% 18% 37
8 PROTEASES CANC PROGRAM 15736 0% 67% 10
9 ABT BIOCHEM 1 13883 0% 59% 10
10 MATRIX METALLOPROTEINASE UNIT 13883 0% 59% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLINICAL & EXPERIMENTAL METASTASIS 8205 1% 4% 84
2 MATRIX BIOLOGY 7086 0% 5% 64
3 JOURNAL OF BIOLOGICAL CHEMISTRY 5618 5% 0% 650
4 COLLAGEN AND RELATED RESEARCH 3588 0% 7% 22
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3481 2% 1% 202
6 INTERNATIONAL JOURNAL OF CANCER 3408 1% 1% 178
7 MATRIX 3003 0% 7% 18
8 CANCER RESEARCH 2608 2% 1% 222
9 INVASION & METASTASIS 1910 0% 4% 19
10 CLINICAL CANCER RESEARCH 1632 1% 1% 107

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 MATRIX METALLOPROTEINASE 1227088 15% 27% 1942 Search MATRIX+METALLOPROTEINASE Search MATRIX+METALLOPROTEINASE
2 METALLOPROTEINASES 447220 5% 27% 704 Search METALLOPROTEINASES Search METALLOPROTEINASES
3 MT1 MMP 262781 2% 57% 194 Search MT1+MMP Search MT1+MMP
4 TIMP 1 255932 2% 42% 260 Search TIMP+1 Search TIMP+1
5 MMP 9 250164 3% 24% 447 Search MMP+9 Search MMP+9
6 GELATINASE 243965 2% 37% 278 Search GELATINASE Search GELATINASE
7 MMP 2 227953 3% 29% 338 Search MMP+2 Search MMP+2
8 TISSUE INHIBITOR OF METALLOPROTEINASE 218593 2% 44% 212 Search TISSUE+INHIBITOR+OF+METALLOPROTEINASE Search TISSUE+INHIBITOR+OF+METALLOPROTEINASE
9 TIMP 2 172280 1% 47% 155 Search TIMP+2 Search TIMP+2
10 MATRIX METALLOPROTEINASE 9 169562 2% 24% 296 Search MATRIX+METALLOPROTEINASE+9 Search MATRIX+METALLOPROTEINASE+9

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SBARDELLA, D , FASCIGLIONE, GF , GIOIA, M , CIACCIO, C , TUNDO, GR , MARINI, S , COLETTA, M , (2012) HUMAN MATRIX METALLOPROTEINASES: AN UBIQUITARIAN CLASS OF ENZYMES INVOLVED IN SEVERAL PATHOLOGICAL PROCESSES.MOLECULAR ASPECTS OF MEDICINE. VOL. 33. ISSUE 2. P. 119 -208 583 52% 58
2 VAN DEN STEEN, PE , DUBOIS, B , NELISSEN, I , RUDD, PM , DWEK, RA , OPDENAKKER, G , (2002) BIOCHEMISTRY AND MOLECULAR BIOLOGY OF GELATINASE B OR MATRIX METALLOPROTEINASE-9 (MMP-9).CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 37. ISSUE 6. P. 375 -536 404 52% 489
3 VANDENBROUCKE, RE , LIBERT, C , (2014) IS THERE NEW HOPE FOR THERAPEUTIC MATRIX METALLOPROTEINASE INHIBITION?.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 12. P. 904 -927 183 66% 95
4 WHITTAKER, M , FLOYD, CD , BROWN, P , GEARING, AJH , (1999) DESIGN AND THERAPEUTIC APPLICATION OF MATRIX METALLOPROTEINASE INHIBITORS.CHEMICAL REVIEWS. VOL. 99. ISSUE 9. P. 2735 -2776 216 76% 707
5 EDWARDS, DR , HANDSLEY, MM , PENNINGTON, CJ , (2008) THE ADAM METALLOPROTEINASES.MOLECULAR ASPECTS OF MEDICINE. VOL. 29. ISSUE 5. P. 258-289 192 65% 464
6 VISSE, R , NAGASE, H , (2003) MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF METALLOPROTEINASES - STRUCTURE, FUNCTION, AND BIOCHEMISTRY.CIRCULATION RESEARCH. VOL. 92. ISSUE 8. P. 827-839 113 73% 2256
7 ITOH, Y , (2015) MEMBRANE-TYPE MATRIX METALLOPROTEINASES: THEIR FUNCTIONS AND REGULATIONS.MATRIX BIOLOGY. VOL. 44-46. ISSUE . P. 207 -223 155 82% 25
8 ZUCKER, S , PEI, DQ , CAO, J , LOPEZ-OTIN, C , (2003) MEMBRANE TYPE-MATRIX METALLOPROTEINASES (MT-MMP).CELL SURFACE PROTEASES. VOL. 54. ISSUE . P. 1 -74 255 76% 122
9 SPINALE, FG , (2007) MYOCARDIAL MATRIX REMODELING AND THE MATRIX METALLOPROTEINASES: INFLUENCE ON CARDIAC FORM AND FUNCTION.PHYSIOLOGICAL REVIEWS. VOL. 87. ISSUE 4. P. 1285-1342 236 48% 508
10 VAFADARI, B , SALAMIAN, A , KACZMAREK, L , (2016) MMP-9 IN TRANSLATION: FROM MOLECULE TO BRAIN PHYSIOLOGY, PATHOLOGY, AND THERAPY.JOURNAL OF NEUROCHEMISTRY. VOL. 139. ISSUE . P. 91 -114 171 60% 9

Classes with closest relation at Level 2


Rank Class id link
1 2572 UROKINASE RECEPTOR//UPAR//UPA
2 3766 MINOCYCLINE//BLACK THYROID//COL 3
3 2517 PROTEASE ACTIVATED RECEPTOR//THROMBIN//THROMBIN RECEPTOR
4 2619 CARNOSINE//CD147//EMMPRIN
5 3688 LIPOCALIN 2//APOLIPOPROTEIN D//ZINC ALPHA 2 GLYCOPROTEIN
6 1878 ALPORT SYNDROME//LAMININ//BASEMENT MEMBRANE
7 938 CARDIAC HYPERTROPHY//HYPERTROPHY//CARDIOTROPHIN 1
8 3692 SPARC//OSTEONECTIN//JWA
9 1744 CATHEPSIN//CATHEPSIN K//CATHEPSIN B
10 2107 LYMPHANGIOGENESIS//VEGF C//PODOPLANIN

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