Class information for:
Level 2: PD L1//PD 1//FOXP3

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
919 11160 47.3 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
10 3       IMMUNOLOGY//JOURNAL OF IMMUNOLOGY//IMMUNOL 134299
919 2             PD L1//PD 1//FOXP3 11160
110 1                   FOXP3//REGULATORY T CELLS//TREG 4345
721 1                   PD L1//PD 1//IPILIMUMAB 3134
2395 1                   CD28//COSTIMULATION//B7 2259
16595 1                   TIM 3//GALECTIN 9//TIM 1 646
23216 1                   B7 H4//B7 H3//SOLUBLE B7 H4 354
24008 1                   ICOS//B7RP 1//INDUCIBLE COSTIMULATOR 326
35492 1                   LAG 3//LYMPHOCYTE ACTIVATION GENE 3//CD223 96

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 PD L1 authKW 762668 3% 73% 382
2 PD 1 authKW 710500 4% 62% 422
3 FOXP3 authKW 677638 6% 39% 634
4 REGULATORY T CELLS authKW 655190 9% 23% 1052
5 IPILIMUMAB authKW 459281 2% 61% 275
6 NIVOLUMAB authKW 377275 2% 76% 182
7 COSTIMULATION authKW 327149 4% 29% 413
8 CTLA 4 authKW 318115 3% 35% 336
9 TIM 3 authKW 291388 1% 81% 131
10 PEMBROLIZUMAB authKW 250413 1% 78% 118

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Immunology 150768 55% 1% 6170
2 Oncology 10086 17% 0% 1919
3 Transplantation 8805 6% 1% 691
4 Medicine, Research & Experimental 5301 9% 0% 1024
5 Hematology 1837 5% 0% 526
6 Cell Biology 1316 8% 0% 849
7 Allergy 1290 2% 0% 200
8 Rheumatology 1053 2% 0% 231
9 Surgery 307 5% 0% 582
10 Pathology 189 2% 0% 212

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 IMMUNOL 82701 14% 2% 1563
2 LUDWIG CANC IMMUNOTHER Y 82067 1% 52% 58
3 IMMUNOL IMMUNOPATHOL 65356 1% 36% 66
4 CELL SIGNALLING SECT 25911 0% 59% 16
5 UNIT IMMUNE HOMEOSTASIS 25510 0% 67% 14
6 NEUROL DIS 24788 1% 7% 122
7 TRANSPLANTAT IMMUNOL GRP 22853 0% 25% 34
8 IMMUNE TOLERANCE 21199 0% 52% 15
9 MED ONCOL IMMUNOTHER Y 20689 0% 32% 24
10 DONALD A ADAM COMPREHENS MELANOMA 15744 0% 52% 11

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 JOURNAL OF IMMUNOLOGY 82214 11% 2% 1274
2 CANCER IMMUNOLOGY RESEARCH 51395 1% 20% 92
3 EUROPEAN JOURNAL OF IMMUNOLOGY 31822 4% 3% 394
4 IMMUNITY 20686 1% 5% 162
5 ONCOIMMUNOLOGY 19572 1% 9% 83
6 JOURNAL OF EXPERIMENTAL MEDICINE 17340 3% 2% 282
7 INTERNATIONAL IMMUNOLOGY 14287 1% 4% 146
8 NATURE IMMUNOLOGY 11498 1% 4% 97
9 CLINICAL IMMUNOLOGY 9862 1% 4% 99
10 IMMUNOTHERAPY 9783 0% 7% 51

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 PD L1 762668 3% 73% 382 Search PD+L1 Search PD+L1
2 PD 1 710500 4% 62% 422 Search PD+1 Search PD+1
3 FOXP3 677638 6% 39% 634 Search FOXP3 Search FOXP3
4 REGULATORY T CELLS 655190 9% 23% 1052 Search REGULATORY+T+CELLS Search REGULATORY+T+CELLS
5 IPILIMUMAB 459281 2% 61% 275 Search IPILIMUMAB Search IPILIMUMAB
6 NIVOLUMAB 377275 2% 76% 182 Search NIVOLUMAB Search NIVOLUMAB
7 COSTIMULATION 327149 4% 29% 413 Search COSTIMULATION Search COSTIMULATION
8 CTLA 4 318115 3% 35% 336 Search CTLA+4 Search CTLA+4
9 TIM 3 291388 1% 81% 131 Search TIM+3 Search TIM+3
10 PEMBROLIZUMAB 250413 1% 78% 118 Search PEMBROLIZUMAB Search PEMBROLIZUMAB

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PARDOLL, DM , (2012) THE BLOCKADE OF IMMUNE CHECKPOINTS IN CANCER IMMUNOTHERAPY.NATURE REVIEWS CANCER. VOL. 12. ISSUE 4. P. 252 -264 95 80% 1583
2 JOSEFOWICZ, SZ , LU, LF , RUDENSKY, AY , (2012) REGULATORY T CELLS: MECHANISMS OF DIFFERENTIATION AND FUNCTION.ANNUAL REVIEW OF IMMUNOLOGY, VOL 30. VOL. 30. ISSUE . P. 531 -564 156 69% 697
3 TOPALIAN, SL , DRAKE, CG , PARDOLL, DM , (2015) IMMUNE CHECKPOINT BLOCKADE: A COMMON DENOMINATOR APPROACH TO CANCER THERAPY.CANCER CELL. VOL. 27. ISSUE 4. P. 450 -461 94 88% 250
4 FRANCISCO, LM , SAGE, PT , SHARPE, AH , (2010) THE PD-1 PATHWAY IN TOLERANCE AND AUTOIMMUNITY.IMMUNOLOGICAL REVIEWS. VOL. 236. ISSUE . P. 219-242 165 81% 414
5 KEIR, ME , BUTTE, MJ , FREEMAN, GJ , SHARPEL, AH , (2008) PD-1 AND ITS LIGANDS IN TOLERANCE AND IMMUNITY.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 26. ISSUE . P. 677 -704 119 80% 1242
6 POSTOW, MA , CALLAHAN, MK , WOLCHOK, JD , (2015) IMMUNE CHECKPOINT BLOCKADE IN CANCER THERAPY.JOURNAL OF CLINICAL ONCOLOGY. VOL. 33. ISSUE 17. P. 1974 -U161 73 89% 225
7 GREENWALD, RJ , FREEMAN, GJ , SHARPE, AH , (2005) THE B7 FAMILY REVISITED.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 23. ISSUE . P. 515 -548 129 87% 1237
8 BOUR-JORDAN, H , ESENSTEN, JH , MARTINEZ-LLORDELLA, M , PENARANDA, C , STUMPF, M , BLUESTONE, JA , (2011) INTRINSIC AND EXTRINSIC CONTROL OF PERIPHERAL T-CELL TOLERANCE BY COSTIMULATORY MOLECULES OF THE CD28/B7 FAMILY.IMMUNOLOGICAL REVIEWS. VOL. 241. ISSUE . P. 180 -205 195 73% 154
9 INTLEKOFER, AM , THOMPSON, CB , (2013) AT THE BENCH: PRECLINICAL RATIONALE FOR CTLA-4 AND PD-1 BLOCKADE AS CANCER IMMUNOTHERAPY.JOURNAL OF LEUKOCYTE BIOLOGY. VOL. 94. ISSUE 1. P. 25-39 155 90% 63
10 NGUYEN, LT , OHASHI, PS , (2015) CLINICAL BLOCKADE OF PD1 AND LAG3-POTENTIAL MECHANISMS OF ACTION.NATURE REVIEWS IMMUNOLOGY. VOL. 15. ISSUE 1. P. 45 -56 104 85% 72

Classes with closest relation at Level 2


Rank Class id link
1 140 IMMUNOTHERAPY//DENDRITIC CELLS//CANCER IMMUNOLOGY IMMUNOTHERAPY
2 854 CD40//BAFF//CD40 LIGAND
3 1133 INTERLEUKIN 18//IL 33//IL 18
4 1367 DENDRITIC CELLS//DC SIGN//LANGERHANS CELLS
5 1915 IMMUNOSENESCENCE//INTERLEUKIN 7//IL 7
6 277 TRANSPLANTATION//TRANSPLANTATION PROCEEDINGS//IMMUNOLOGY
7 741 ANTIGEN PRESENTATION//IMMUNOLOGY//ANTIGEN PROCESSING
8 1321 INTERLEUKIN 12//CD23//INTERLEUKIN 4
9 721 SUPERANTIGEN//IMMUNOLOGY//T CELL RECEPTOR
10 2906 SIGLEC//TREM2//TREM 1

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