Class information for:
Level 3: CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
346 36072 32.2 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
346 3       CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN 36072
1488 2             CAMPTOTHECIN//TOPOISOMERASE I//SN 38 7627
1654 2             DISTAMYCIN//MINOR GROOVE BINDER//PYRROLE IMIDAZOLE POLYAMIDE 6885
1783 2             SHIKONIN//NAPHTHOQUINONE//PLUMBAGIN 6353
2227 2             CARDIOTOXICITY//ANTHRACYCLINES//DOXORUBICIN 4791
2252 2             ANGUCYCLINE//IDARUBICIN//ANGUCYCLINONE 4694
2496 2             IFOSFAMIDE//CHEMOSENSITIVITY TEST//MESNA 3914
3321 2             BLEOMYCIN//MIGRASTATIN//BLEOMYCIN HYDROLASE 1808

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CARDIOTOXICITY authKW 448536 3% 52% 1024
2 ANTHRACYCLINES authKW 263303 2% 42% 739
3 CAMPTOTHECIN authKW 224036 2% 45% 589
4 DOXORUBICIN authKW 154668 3% 17% 1074
5 SHIKONIN authKW 153755 1% 82% 223
6 TOPOISOMERASE I authKW 151402 1% 57% 316
7 TOPOISOMERASE II authKW 126778 1% 46% 326
8 TOPOISOMERASE authKW 119591 1% 44% 322
9 NAPHTHOQUINONE authKW 117557 1% 47% 297
10 PLUMBAGIN authKW 106028 0% 74% 170

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 58254 22% 1% 7998
2 Pharmacology & Pharmacy 32302 19% 1% 7000
3 Chemistry, Medicinal 31513 9% 1% 3389
4 Chemistry, Organic 25458 13% 1% 4818
5 Biochemistry & Molecular Biology 12116 19% 0% 6898
6 Chemistry, Multidisciplinary 5589 11% 0% 3968
7 Biophysics 3263 5% 0% 1646
8 Toxicology 2344 3% 0% 1158
9 Microbiology 652 3% 0% 1201
10 Hematology 505 2% 0% 723

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL PHARMACOL 11317 1% 4% 317
2 PHARMACEUT TECHNOL BIOCHEM 11138 0% 19% 72
3 MODIFIED ANTIBIOT 10883 0% 65% 20
4 CELL MED 9390 0% 70% 16
5 ROCKY MT CANC REHABIL 9063 0% 51% 21
6 QUIM SINTET HETEROCICL 8445 0% 100% 10
7 HRICHTUNG PHARMAZEUT CHEM 8389 0% 76% 13
8 PHARMACOL ANTITUMORALE 8128 0% 26% 38
9 DANIEL DEN HOED KLIN 8087 0% 28% 34
10 AUCKLAND CANC SOC 7501 0% 12% 76

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 83636 2% 12% 858
2 CANCER TREATMENT REPORTS 34033 1% 14% 300
3 JOURNAL OF ANTIBIOTICS 31589 1% 8% 505
4 ANTI-CANCER DRUG DESIGN 30483 0% 24% 151
5 INVESTIGATIONAL NEW DRUGS 23692 1% 11% 270
6 ANTI-CANCER DRUGS 12951 1% 7% 227
7 CANCER RESEARCH 12834 2% 2% 808
8 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 12078 0% 9% 166
9 BIOCHEMICAL PHARMACOLOGY 8772 1% 2% 457
10 BIOORGANIC & MEDICINAL CHEMISTRY 8079 1% 3% 366

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 CARDIOTOXICITY 448536 3% 52% 1024 Search CARDIOTOXICITY Search CARDIOTOXICITY
2 ANTHRACYCLINES 263303 2% 42% 739 Search ANTHRACYCLINES Search ANTHRACYCLINES
3 CAMPTOTHECIN 224036 2% 45% 589 Search CAMPTOTHECIN Search CAMPTOTHECIN
4 DOXORUBICIN 154668 3% 17% 1074 Search DOXORUBICIN Search DOXORUBICIN
5 SHIKONIN 153755 1% 82% 223 Search SHIKONIN Search SHIKONIN
6 TOPOISOMERASE I 151402 1% 57% 316 Search TOPOISOMERASE+I Search TOPOISOMERASE+I
7 TOPOISOMERASE II 126778 1% 46% 326 Search TOPOISOMERASE+II Search TOPOISOMERASE+II
8 TOPOISOMERASE 119591 1% 44% 322 Search TOPOISOMERASE Search TOPOISOMERASE
9 NAPHTHOQUINONE 117557 1% 47% 297 Search NAPHTHOQUINONE Search NAPHTHOQUINONE
10 PLUMBAGIN 106028 0% 74% 170 Search PLUMBAGIN Search PLUMBAGIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WANG, JC , (1996) DNA TOPOISOMERASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 65. ISSUE . P. 635-692 402 81% 1741
2 STERBA, M , POPELOVA, O , VAVROVA, A , JIRKOVSKY, E , KOVARIKOVA, P , GERSL, V , SIMUNEK, T , (2013) OXIDATIVE STRESS, REDOX SIGNALING, AND METAL CHELATION IN ANTHRACYCLINE CARDIOTOXICITY AND PHARMACOLOGICAL CARDIOPROTECTION.ANTIOXIDANTS & REDOX SIGNALING. VOL. 18. ISSUE 8. P. 899 -929 224 82% 67
3 SCHOEFFLER, AJ , BERGER, JM , (2008) DNA TOPOISOMERASES: HARNESSING AND CONSTRAINING ENERGY TO GOVERN CHROMOSOME TOPOLOGY.QUARTERLY REVIEWS OF BIOPHYSICS. VOL. 41. ISSUE 1. P. 41-101 214 78% 204
4 CHAMPOUX, JJ , (2001) DNA TOPOISOMERASES: STRUCTURE, FUNCTION, AND MECHANISM.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 70. ISSUE . P. 369-413 147 80% 1421
5 FORTUNE, JM , OSHEROFF, N , (2000) TOPOISOMERASE II AS A TARGET FOR ANTICANCER DRUGS: WHEN ENZYMES STOP BEING NICE.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 64. VOL. 64. ISSUE . P. 221 -253 215 90% 229
6 BAILLY, C , CHAIRES, JB , (1998) SEQUENCE-SPECIFIC DNA MINOR GROOVE BINDERS. DESIGN AND SYNTHESIS OF NETROPSIN AND DISTAMYCIN ANALOGUES.BIOCONJUGATE CHEMISTRY. VOL. 9. ISSUE 5. P. 513 -538 223 87% 231
7 CARVALHO, FS , BURGEIRO, A , GARCIA, R , MORENO, AJ , CARVALHO, RA , OLIVEIRA, PJ , (2014) DOXORUBICIN-INDUCED CARDIOTOXICITY: FROM BIOENERGETIC FAILURE AND CELL DEATH TO CARDIOMYOPATHY.MEDICINAL RESEARCH REVIEWS. VOL. 34. ISSUE 1. P. 106 -135 142 73% 76
8 POMMIER, Y , (2013) DRUGGING TOPOISOMERASES: LESSONS AND CHALLENGES.ACS CHEMICAL BIOLOGY. VOL. 8. ISSUE 1. P. 82 -95 109 80% 188
9 VENDITTO, VJ , SIMANEK, EE , (2010) CANCER THERAPIES UTILIZING THE CAMPTOTHECINS: A REVIEW OF THE IN VIVO LITERATURE.MOLECULAR PHARMACEUTICS. VOL. 7. ISSUE 2. P. 307-349 194 68% 108
10 POMMIER, Y , POURQUIER, P , FAN, Y , STRUMBERG, D , (1998) MECHANISM OF ACTION OF EUKARYOTIC DNA TOPOISOMERASE I AND DRUGS TARGETED TO THE ENZYME.BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION. VOL. 1400. ISSUE 1-3. P. 83 -106 191 78% 433

Classes with closest relation at Level 3


Rank Class id link
1 408 CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE
2 230 P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA
3 9 CHEMISTRY, ORGANIC//JOURNAL OF HETEROCYCLIC CHEMISTRY//KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII
4 651 GOSSYPOL//3 MCPD//VORONOI DIAGRAM
5 489 CISPLATIN//STABILITY CONSTANTS//JOURNAL OF INORGANIC BIOCHEMISTRY
6 183 APTAMER//G QUADRUPLEX//RIBOZYME
7 142 DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH
8 409 BERBERINE//ALKALOIDS//RUTACEAE
9 285 ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE
10 216 NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG

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