Class information for:
Level 3: CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
408 29468 39.3 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
1363 2             TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS 8244
1816 2             INTERNATIONAL JOURNAL OF HYPERTHERMIA//HYPERTHERMIA//ISOLATED LIMB PERFUSION 6226
2150 2             HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1 5019
2256 2             CARBONIC ANHYDRASE//CHIM BIOINORGAN//POLO SCI 4686
2612 2             WARBURG EFFECT//PKM2//PYRUVATE KINASE 3575
3350 2             VDAC//VOLTAGE DEPENDENT ANION CHANNEL//HEXOKINASE 1718

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CHIM BIOINORGAN address 3017117 12% 85% 547
2 POLO SCI address 699429 3% 70% 153
3 CARBONIC ANHYDRASE authKW 647871 5% 47% 1122
4 NEUROFARBA address 567747 4% 43% 205
5 INTERNATIONAL JOURNAL OF HYPERTHERMIA journal 536857 4% 48% 920
6 SEZ SCI FARMACEUT address 491264 2% 93% 81
7 SEZ SCI FARMACEUT NUTRACEUT address 421001 2% 91% 71
8 DIPARTIMENTO NEUROFARBA address 348373 1% 82% 65
9 SECT PHARMACEUT NUTRICEUT SCI address 321027 1% 93% 53
10 HYPOXIA authKW 303963 9% 11% 2200

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 122348 37% 1% 9159
2 Radiology, Nuclear Medicine & Medical Imaging 43572 17% 1% 4240
3 Biochemistry & Molecular Biology 17183 25% 0% 6212
4 Chemistry, Medicinal 12008 7% 1% 1787
5 Cell Biology 10170 12% 0% 3014
6 Biophysics 8633 8% 1% 1926
7 Biology 3707 4% 0% 1029
8 Medicine, Research & Experimental 2151 5% 0% 1157
9 Pharmacology & Pharmacy 1586 7% 0% 1831
10 Physiology 923 3% 0% 782

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIM BIOINORGAN 3017117 12% 85% 547
2 POLO SCI 699429 3% 70% 153
3 NEUROFARBA 567747 4% 43% 205
4 SEZ SCI FARMACEUT 491264 2% 93% 81
5 SEZ SCI FARMACEUT NUTRACEUT 421001 2% 91% 71
6 DIPARTIMENTO NEUROFARBA 348373 1% 82% 65
7 SECT PHARMACEUT NUTRICEUT SCI 321027 1% 93% 53
8 CHIM INORGAN BIOINORGAN 185638 1% 41% 69
9 CHIM BIOORGAN 153584 3% 18% 128
10 IST BIOSCI BIORISORSE 125976 1% 54% 36

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 INTERNATIONAL JOURNAL OF HYPERTHERMIA 536857 4% 48% 920
2 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 72333 4% 6% 1016
3 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 35785 1% 12% 239
4 RADIATION RESEARCH 29499 2% 6% 401
5 BRITISH JOURNAL OF CANCER 22164 2% 3% 579
6 CANCER RESEARCH 18397 3% 2% 788
7 INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 13855 1% 5% 242
8 RADIOTHERAPY AND ONCOLOGY 12923 1% 4% 254
9 CANCER CLINICAL TRIALS 6456 0% 20% 26
10 ANTI-CANCER DRUG DESIGN 6051 0% 9% 56

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 CARBONIC ANHYDRASE 647871 5% 47% 1122 Search CARBONIC+ANHYDRASE Search CARBONIC+ANHYDRASE
2 HYPOXIA 303963 9% 11% 2200 Search HYPOXIA Search HYPOXIA
3 HYPERTHERMIA 218273 4% 19% 941 Search HYPERTHERMIA Search HYPERTHERMIA
4 CARBONIC ANHYDRASE INHIBITORS 178214 2% 35% 79 Search CARBONIC+ANHYDRASE+INHIBITORS Search CARBONIC+ANHYDRASE+INHIBITORS
5 HIF 1 ALPHA 174959 2% 30% 471 Search HIF+1+ALPHA Search HIF+1+ALPHA
6 HYDRATASE ACTIVITY 163099 1% 96% 26 Search HYDRATASE+ACTIVITY Search HYDRATASE+ACTIVITY
7 BETA CLASS ENZYME 162860 1% 100% 25 Search BETA+CLASS+ENZYME Search BETA+CLASS+ENZYME
8 HYPOXIA INDUCIBLE FACTOR 157506 1% 36% 352 Search HYPOXIA+INDUCIBLE+FACTOR Search HYPOXIA+INDUCIBLE+FACTOR
9 VDAC 135590 1% 69% 161 Search VDAC Search VDAC
10 TUMOR HYPOXIA 131397 1% 60% 177 Search TUMOR+HYPOXIA Search TUMOR+HYPOXIA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SUPURAN, CT , DE SIMONE, G , ALTERIO, V , DI FIORE, A , D'AMBROSIO, K , (2012) MULTIPLE BINDING MODES OF INHIBITORS TO CARBONIC ANHYDRASES: HOW TO DESIGN SPECIFIC DRUGS TARGETING 15 DIFFERENT ISOFORMS?.CHEMICAL REVIEWS. VOL. 112. ISSUE 8. P. 4421 -4468 220 75% 103
2 SUPURAN, CT , (2016) HOW MANY CARBONIC ANHYDRASE INHIBITION MECHANISMS EXIST?.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 31. ISSUE 3. P. 345 -360 157 96% 6
3 KRISHNAMURTHY, VM , KAUFMAN, GK , URBACH, AR , GITLIN, I , GUDIKSEN, KL , WEIBEL, DB , WHITESIDES, GM , (2008) CARBONIC ANHYDRASE AS A MODEL FOR BIOPHYSICAL AND PHYSICAL-ORGANIC STUDIES OF PROTEINS AND PROTEIN-LIGAND BINDING.CHEMICAL REVIEWS. VOL. 108. ISSUE 3. P. 946 -1051 315 48% 260
4 SUPURAN, CT , (2017) ADVANCES IN STRUCTURE-BASED DRUG DISCOVERY OF CARBONIC ANHYDRASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 12. ISSUE 1. P. 61 -88 178 96% 0
5 PASTOREK, J , PASTOREKOVA, S , (2015) HYPOXIA-INDUCED CARBONIC ANHYDRASE IX AS A TARGET FOR CANCER THERAPY: FROM BIOLOGY TO CLINICAL USE.SEMINARS IN CANCER BIOLOGY. VOL. 31. ISSUE . P. 52 -64 141 83% 27
6 KEITH, B , JOHNSON, RS , SIMON, MC , (2012) HIF1 ALPHA AND HIF2 ALPHA: SIBLING RIVALRY IN HYPOXIC TUMOUR GROWTH AND PROGRESSION.NATURE REVIEWS CANCER. VOL. 12. ISSUE 1. P. 9 -22 123 67% 378
7 WALSH, JC , LEBEDEV, A , ATEN, E , MADSEN, K , MARCIANO, L , KOLB, HC , (2014) THE CLINICAL IMPORTANCE OF ASSESSING TUMOR HYPOXIA: RELATIONSHIP OF TUMOR HYPOXIA TO PROGNOSIS AND THERAPEUTIC OPPORTUNITIES.ANTIOXIDANTS & REDOX SIGNALING. VOL. 21. ISSUE 10. P. 1516 -1554 199 71% 20
8 SEMENZA, GL , (2003) TARGETING HIF-1 FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 3. ISSUE 10. P. 721-732 81 79% 3268
9 EBBESEN, P , PETTERSEN, EO , GORR, TA , JOBST, G , WILLIAMS, K , KIENINGER, J , WENGER, RH , PASTOREKOVA, S , DUBOIS, L , LAMBIN, P , ET AL (2009) TAKING ADVANTAGE OF TUMOR CELL ADAPTATIONS TO HYPOXIA FOR DEVELOPING NEW TUMOR MARKERS AND TREATMENT STRATEGIES.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 24. ISSUE . P. 1 -39 234 70% 39
10 BASS, PD , GUBLER, DA , JUDD, TC , WILLIAMS, RM , (2013) MITOMYCINOID ALKALOIDS: MECHANISM OF ACTION, BIOSYNTHESIS, TOTAL SYNTHESES, AND SYNTHETIC APPROACHES.CHEMICAL REVIEWS. VOL. 113. ISSUE 8. P. 6816-6863 184 72% 33

Classes with closest relation at Level 3


Rank Class id link
1 518 ANGIOGENESIS//RETINOPATHY OF PREMATURITY//ENDOSTATIN
2 465 RENAL CELL CARCINOMA//ANGIOMYOLIPOMA//TUBEROUS SCLEROSIS
3 222 MYOTONIC DYSTROPHY//ALDOSTERONE//PHYSIOLOGY
4 278 CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY
5 103 O GLCNACYLATION//O GLCNAC TRANSFERASE//O GLCNACASE
6 346 CARDIOTOXICITY//ANTHRACYCLINES//CAMPTOTHECIN
7 262 AUTOPHAGY//RESVERATROL//HISTONE DEACETYLASE INHIBITOR
8 285 ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE
9 651 GOSSYPOL//3 MCPD//VORONOI DIAGRAM
10 260 NUCL MED//RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING//JOURNAL OF NUCLEAR MEDICINE

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