Class information for:
Level 2: WARBURG EFFECT//PKM2//PYRUVATE KINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2612 3575 45.3 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2612 2             WARBURG EFFECT//PKM2//PYRUVATE KINASE 3575
4289 1                   3 BROMOPYRUVATE//WARBURG EFFECT//CANCER METABOLISM 1811
8765 1                   PKM2//PYRUVATE KINASE//PYRUVATE KINASE DEFICIENCY 1219
25763 1                   FERMENTED WHEAT GERM EXTRACT//TKTL1//AVEMAR 273
25798 1                   2 DEOXY D GLUCOSE//CELL BIOL R 124//METABOLIC OXIDATIVE STRESS 272

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 WARBURG EFFECT authKW 587998 5% 35% 195
2 PKM2 authKW 579589 3% 75% 91
3 PYRUVATE KINASE authKW 427771 4% 33% 152
4 3 BROMOPYRUVATE authKW 365199 2% 70% 61
5 PYRUVATE KINASE DEFICIENCY authKW 325219 1% 81% 47
6 CANCER METABOLISM authKW 260963 3% 33% 94
7 GLYCOLYSIS authKW 209925 8% 9% 289
8 PYRUVATE KINASE M2 authKW 208792 1% 68% 36
9 GLUTAMINOLYSIS authKW 186156 1% 42% 52
10 AEROBIC GLYCOLYSIS authKW 162335 2% 28% 67

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 14613 34% 0% 1210
2 Cell Biology 5975 22% 0% 792
3 Biochemistry & Molecular Biology 4548 32% 0% 1144
4 Biophysics 902 7% 0% 243
5 Hematology 849 5% 0% 196
6 Medicine, Research & Experimental 393 5% 0% 182
7 Genetics & Heredity 199 5% 0% 164
8 Chemistry, Medicinal 90 2% 0% 82
9 Pathology 64 2% 0% 69
10 Biochemical Research Methods 55 2% 0% 83

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 WINSHIP CANC EMORY 36428 0% 53% 8
2 SYST BIOL HUMAN DIS 34154 0% 67% 6
3 BIOCHEM ENDOCRINOL 29707 0% 20% 17
4 REGULATORY ENVIRONM ANALYT METABOL 28452 0% 33% 10
5 CELL BIOL R 124 25618 0% 100% 3
6 HARBOR UCLA EDUC 24586 0% 26% 11
7 PL HUMAN GENET 23993 0% 19% 15
8 GASTROINTESTINAL GLAND SURG 23716 0% 56% 5
9 GEN SURG S 19212 0% 75% 3
10 INTERNAL NUCL MED 19212 0% 75% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOTARGET 9863 3% 1% 120
2 CELL METABOLISM 6336 1% 2% 33
3 JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 3717 1% 2% 29
4 METABOLOMICS 2782 1% 2% 18
5 CANCER CELL 2427 1% 1% 21
6 TUMOR BIOLOGY 1941 1% 1% 38
7 MOLECULAR CELL 1749 1% 1% 34
8 ANTICANCER RESEARCH 1725 2% 0% 64
9 NATURE REVIEWS CANCER 1540 0% 1% 14
10 MOLECULAR CANCER 1532 1% 1% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 WARBURG EFFECT 587998 5% 35% 195 Search WARBURG+EFFECT Search WARBURG+EFFECT
2 PKM2 579589 3% 75% 91 Search PKM2 Search PKM2
3 PYRUVATE KINASE 427771 4% 33% 152 Search PYRUVATE+KINASE Search PYRUVATE+KINASE
4 3 BROMOPYRUVATE 365199 2% 70% 61 Search 3+BROMOPYRUVATE Search 3+BROMOPYRUVATE
5 PYRUVATE KINASE DEFICIENCY 325219 1% 81% 47 Search PYRUVATE+KINASE+DEFICIENCY Search PYRUVATE+KINASE+DEFICIENCY
6 CANCER METABOLISM 260963 3% 33% 94 Search CANCER+METABOLISM Search CANCER+METABOLISM
7 GLYCOLYSIS 209925 8% 9% 289 Search GLYCOLYSIS Search GLYCOLYSIS
8 PYRUVATE KINASE M2 208792 1% 68% 36 Search PYRUVATE+KINASE+M2 Search PYRUVATE+KINASE+M2
9 GLUTAMINOLYSIS 186156 1% 42% 52 Search GLUTAMINOLYSIS Search GLUTAMINOLYSIS
10 AEROBIC GLYCOLYSIS 162335 2% 28% 67 Search AEROBIC+GLYCOLYSIS Search AEROBIC+GLYCOLYSIS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LI, ZW , YANG, P , LI, ZY , (2014) THE MULTIFACETED REGULATION AND FUNCTIONS OF PKM2 IN TUMOR PROGRESSION.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1846. ISSUE 2. P. 285 -296 104 76% 17
2 IQBAL, MA , GUPTA, V , GOPINATH, P , MAZUREK, S , BAMEZAI, RNK , (2014) PYRUVATE KINASE M2 AND CANCER: AN UPDATED ASSESSMENT.FEBS LETTERS. VOL. 588. ISSUE 16. P. 2685 -2692 73 87% 36
3 WONG, N , OJO, D , YAN, J , TANG, D , (2015) PKM2 CONTRIBUTES TO CANCER METABOLISM.CANCER LETTERS. VOL. 356. ISSUE 2. P. 184 -191 67 79% 32
4 ISRAELSEN, WJ , VANDER HEIDEN, MG , (2015) PYRUVATE KINASE: FUNCTION, REGULATION AND ROLE IN CANCER.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 43. ISSUE . P. 43 -51 66 85% 17
5 MAZUREK, S , (2011) PYRUVATE KINASE TYPE M2: A KEY REGULATOR OF THE METABOLIC BUDGET SYSTEM IN TUMOR CELLS.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 43. ISSUE 7. P. 969-980 74 63% 225
6 PAVLOVA, NN , THOMPSON, CB , (2016) THE EMERGING HALLMARKS OF CANCER METABOLISM.CELL METABOLISM. VOL. 23. ISSUE 1. P. 27 -47 64 29% 76
7 ALTMAN, BJ , STINE, ZE , DANG, CV , (2016) FROM KREBS TO CLINIC: GLUTAMINE METABOLISM TO CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 16. ISSUE 10. P. 619 -634 107 47% 5
8 GUPTA, V , WELLEN, KE , MAZUREK, S , BAMEZAI, RNK , (2014) PYRUVATE KINASE M2: REGULATORY CIRCUITS AND POTENTIAL FOR THERAPEUTIC INTERVENTION.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 15. P. 2595-2606 78 86% 5
9 CHANETON, B , GOTTLIEB, E , (2012) ROCKING CELL METABOLISM: REVISED FUNCTIONS OF THE KEY GLYCOLYTIC REGULATOR PKM2 IN CANCER.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 37. ISSUE 8. P. 309-316 57 95% 79
10 CANU, G , DE BONIS, M , MINUCCI, A , CAPOLUONGO, E , (2016) RED BLOOD CELL PK DEFICIENCY: AN UPDATE OF PK-LR GENE MUTATION DATABASE.BLOOD CELLS MOLECULES AND DISEASES. VOL. 57. ISSUE . P. 100 -109 62 97% 1

Classes with closest relation at Level 2


Rank Class id link
1 3350 VDAC//VOLTAGE DEPENDENT ANION CHANNEL//HEXOKINASE
2 2150 HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1
3 2061 GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE//PHOSPHOFRUCTOKINASE//PHOSPHOGLYCERATE MUTASE
4 2619 CARNOSINE//CD147//EMMPRIN
5 2141 FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR
6 2870 G6PD DEFICIENCY//GLUCOSE 6 PHOSPHATE DEHYDROGENASE//GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY
7 3297 GOODEIDAE//LDH C 4//LAKE CHAPALA
8 1485 METABOLOMICS//METABONOMICS//METABOLIC PROFILING
9 3408 ADENYLATE KINASE//PHOSPHOGLYCERATE KINASE//CHIM STRUCT MACROMOL
10 2649 SIRT1//SIRTUINS//SIRT3

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