Class information for:
Level 2: FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2141 5046 41.0 80%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
2141 2             FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR 5046
8938 1                   SREBP//SCAP//STEROL REGULATORY ELEMENT BINDING PROTEIN 1203
10090 1                   LIVER X RECEPTOR//LXR//T0901317 1093
10148 1                   FATTY ACID SYNTHASE//FASN//C75 1087
12692 1                   CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN 888
17998 1                   ACETYL COA CARBOXYLASE//SORAPHEN A//SORAPHEN 571
28565 1                   USF1//UPSTREAM TRANSCRIPTION FACTOR 1//USF 204

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FATTY ACID SYNTHASE authKW 895703 6% 46% 322
2 LIVER X RECEPTOR authKW 838201 5% 54% 259
3 LXR authKW 375066 3% 44% 140
4 SREBP authKW 327901 2% 44% 123
5 LIPOGENESIS authKW 135419 3% 14% 164
6 T0901317 authKW 135182 1% 72% 31
7 SCAP authKW 124275 1% 62% 33
8 CHREBP authKW 110972 1% 54% 34
9 ACETYL COA CARBOXYLASE authKW 103454 2% 20% 87
10 STEROL REGULATORY ELEMENT BINDING PROTEIN authKW 103026 1% 30% 56

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 17456 49% 0% 2482
2 Endocrinology & Metabolism 3623 11% 0% 574
3 Cell Biology 3346 15% 0% 748
4 Biophysics 2737 9% 0% 474
5 Nutrition & Dietetics 1829 6% 0% 283
6 Oncology 783 9% 0% 431
7 Chemistry, Medicinal 392 3% 0% 171
8 Medicine, Research & Experimental 329 4% 0% 213
9 Genetics & Heredity 236 4% 0% 219
10 Peripheral Vascular Diseases 197 3% 0% 132

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCL RECEPTORS CELL SIGNALING 58254 1% 20% 49
2 UMR 1103 43547 0% 60% 12
3 U465 27158 0% 22% 20
4 UMR 6293 22207 0% 28% 13
5 BIOCHEM PROGRAMMES 18148 0% 100% 3
6 BREAST CANC TRANSLAT PROGRAM 18148 0% 100% 3
7 PROGRAM IMMUNOL BIO IMMUNO GENE THER Y CANC 18148 0% 100% 3
8 UNIV HOSP NUTR SUPPORT INFECT CONTROL 18148 0% 100% 3
9 HLTH SERV CATALONIA 18142 0% 50% 6
10 LIPID METAB CANC 16734 0% 23% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF LIPID RESEARCH 12378 3% 2% 133
2 JOURNAL OF BIOLOGICAL CHEMISTRY 11713 11% 0% 555
3 CELL METABOLISM 6584 1% 3% 40
4 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 4094 1% 2% 43
5 BIOCHEMICAL JOURNAL 3623 3% 0% 136
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2507 3% 0% 176
7 MOLECULAR ENDOCRINOLOGY 1913 1% 1% 43
8 LIPIDS 1572 1% 1% 40
9 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1561 1% 1% 45
10 CURRENT OPINION IN LIPIDOLOGY 1287 0% 1% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FATTY ACID SYNTHASE 895703 6% 46% 322 Search FATTY+ACID+SYNTHASE Search FATTY+ACID+SYNTHASE
2 LIVER X RECEPTOR 838201 5% 54% 259 Search LIVER+X+RECEPTOR Search LIVER+X+RECEPTOR
3 LXR 375066 3% 44% 140 Search LXR Search LXR
4 SREBP 327901 2% 44% 123 Search SREBP Search SREBP
5 LIPOGENESIS 135419 3% 14% 164 Search LIPOGENESIS Search LIPOGENESIS
6 T0901317 135182 1% 72% 31 Search T0901317 Search T0901317
7 SCAP 124275 1% 62% 33 Search SCAP Search SCAP
8 CHREBP 110972 1% 54% 34 Search CHREBP Search CHREBP
9 ACETYL COA CARBOXYLASE 103454 2% 20% 87 Search ACETYL+COA+CARBOXYLASE Search ACETYL+COA+CARBOXYLASE
10 STEROL REGULATORY ELEMENT BINDING PROTEIN 103026 1% 30% 56 Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN Search STEROL+REGULATORY+ELEMENT+BINDING+PROTEIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MENENDEZ, JA , LUPU, R , (2007) FATTY ACID SYNTHASE AND THE LIPOGENIC PHENOTYPE IN CANCER PATHOGENESIS.NATURE REVIEWS CANCER. VOL. 7. ISSUE 10. P. 763-777 99 67% 832
2 TICE, CM , NOTO, PB , FAN, KY , ZHUANG, LH , LALA, DS , SINGH, SB , (2014) THE MEDICINAL CHEMISTRY OF LIVER X RECEPTOR (LXR) MODULATORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 17. P. 7182 -7205 118 77% 8
3 FLAVIN, R , PELUSO, S , NGUYEN, PL , LODA, M , (2010) FATTY ACID SYNTHASE AS A POTENTIAL THERAPEUTIC TARGET IN CANCER.FUTURE ONCOLOGY. VOL. 6. ISSUE 4. P. 551 -562 87 84% 146
4 JAKOBSSON, T , TREUTER, E , GUSTAFSSON, JA , STEFFENSEN, KR , (2012) LIVER X RECEPTOR BIOLOGY AND PHARMACOLOGY: NEW PATHWAYS, CHALLENGES AND OPPORTUNITIES.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 33. ISSUE 7. P. 394 -404 93 74% 92
5 ABRAMSON, HN , (2011) THE LIPOGENESIS PATHWAY AS A CANCER TARGET.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 16. P. 5615-5638 117 67% 46
6 EBERLE, D , HEGARTY, B , BOSSARD, P , FERRE, P , FOUFELLE, F , (2004) SREBP TRANSCRIPTION FACTORS: MASTER REGULATORS OF LIPID HOMEOSTASIS.BIOCHIMIE. VOL. 86. ISSUE 11. P. 839-848 81 81% 449
7 VIENNOIS, E , MOUZAT, K , DUFOUR, J , MOREL, L , LOBACCARO, JM , BARON, S , (2012) SELECTIVE LIVER X RECEPTOR MODULATORS (SLIMS): WHAT USE IN HUMAN HEALTH?.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 351. ISSUE 2. P. 129-141 92 75% 45
8 BARANOWSKI, M , (2008) BIOLOGICAL ROLE OF LIVER X RECEPTORS.JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. VOL. 59. ISSUE 4. P. 31-55 95 76% 119
9 VAN GILST, WH , DE BOER, RA , CANNON, MV , (2016) EMERGING ROLE OF LIVER X RECEPTORS IN CARDIAC PATHOPHYSIOLOGY AND HEART FAILURE.BASIC RESEARCH IN CARDIOLOGY. VOL. 111. ISSUE 1. P. - 102 71% 0
10 MAQDASY, S , TROUSSON, A , TAUVERON, I , VOLLE, DH , BARON, S , LOBACCARO, JMA , (2016) ONCE AND FOR ALL, LXR ALPHA AND LXR BETA ARE GATEKEEPERS OF THE ENDOCRINE SYSTEM.MOLECULAR ASPECTS OF MEDICINE. VOL. 49. ISSUE . P. 31 -46 110 55% 2

Classes with closest relation at Level 2


Rank Class id link
1 3581 PHOSPHOENOLPYRUVATE CARBOXYKINASE//GLYCERONEOGENESIS//BROWN ADIPOSE TISSUE HEMIDENERVATION
2 3076 PEPTIDE DEFORMYLASE//ENOYL ACP REDUCTASE//ACYL CARRIER PROTEIN
3 2612 WARBURG EFFECT//PKM2//PYRUVATE KINASE
4 3219 OLEOYL ESTRONE//JCR LA CP RAT//HERITAGE MED 275
5 2357 PEUTZ JEGHERS SYNDROME//AMPK//LKB1
6 2916 OXYSTEROLS//CHOLESTEROL OXIDES//CHOLESTEROL OXIDATION PRODUCTS
7 2370 FAT GRAFTING//ADIPOGENESIS//ADIPOCYTE DIFFERENTIATION
8 1628 LIPID DROPLETS//CARDIOLIPIN//PERILIPIN
9 2654 NURR1//NUR77//PGC 1 ALPHA
10 1696 NONALCOHOLIC FATTY LIVER DISEASE//NON ALCOHOLIC FATTY LIVER DISEASE//NONALCOHOLIC STEATOHEPATITIS

Go to start page