Class information for:
Level 2: HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2150 5019 51.2 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2150 2             HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1 5019
268 1                   HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HYPOXIA INDUCIBLE FACTOR 1 3769
16746 1                   T CELL METABOLISM//IMMUNOMETABOLISM//VANDERBILT IMMUNOBIOL 638
20081 1                   MUCOSAL INFLAMMAT PROGRAM//INFLAMMATION AND INNATE IMMUNITY//HEPATIC OXYGEN CONSUMPTION 477
32705 1                   LEUKOCYTE ENDOTHELIAL ADHESIVE INTERACTIONS//ALVEOLAR HYPOXIA//LEUKOCYTE ENDOTHELIAL ADHERENCE 135

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 HIF 1 ALPHA authKW 696371 8% 27% 422
2 HYPOXIA INDUCIBLE FACTOR authKW 677630 7% 34% 328
3 HIF 1 authKW 412020 4% 33% 206
4 HYPOXIA INDUCIBLE FACTOR 1 authKW 403914 4% 34% 197
5 HYPOXIA INDUCIBLE FACTOR 1 ALPHA authKW 397180 5% 26% 254
6 HIF authKW 388934 4% 35% 181
7 HYPOXIA authKW 345373 21% 5% 1051
8 PROLYL HYDROXYLASE authKW 336538 2% 52% 106
9 VASC PROGRAM address 252503 1% 59% 70
10 HYPOXIA INDUCIBLE FACTOR HIF authKW 149803 1% 40% 61

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 8679 22% 0% 1129
2 Oncology 6898 21% 0% 1036
3 Biochemistry & Molecular Biology 5059 29% 0% 1460
4 Immunology 2274 12% 0% 594
5 Medicine, Research & Experimental 1316 7% 0% 359
6 Physiology 809 5% 0% 269
7 Hematology 722 4% 0% 224
8 Biophysics 352 4% 0% 209
9 Genetics & Heredity 301 5% 0% 236
10 Pathology 170 2% 0% 119

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VASC PROGRAM 252503 1% 59% 70
2 TUMOR HYPOXIA 66221 0% 78% 14
3 MCKUSICK NATHANS GENET MED 37002 2% 7% 93
4 MUCOSAL INFLAMMAT PROGRAM 31723 1% 18% 29
5 PROGRAM VASC CELL ENGN 31277 0% 86% 6
6 SIGNALING DEV BIOL CANC 29891 0% 20% 25
7 VANDERBILT IMMUNOBIOL 27366 0% 75% 6
8 ABRAMSON FAMILY CANC 26119 2% 6% 77
9 CELL ENGN 24181 2% 4% 91
10 CELL ENGN PEDIAT 21719 0% 71% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NATURE IMMUNOLOGY 2943 1% 1% 33
2 JOURNAL OF MOLECULAR MEDICINE-JMM 2632 1% 1% 32
3 IMMUNITY 2111 1% 1% 35
4 FRONTIERS IN IMMUNOLOGY 1709 1% 1% 29
5 JOURNAL OF BIOLOGICAL CHEMISTRY 1672 4% 0% 224
6 CANCER RESEARCH 1545 2% 0% 105
7 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1534 1% 1% 36
8 CELL METABOLISM 1474 0% 1% 19
9 CANCER BIOLOGY & THERAPY 1418 1% 1% 26
10 SEMINARS IN IMMUNOLOGY 1324 0% 2% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 HIF 1 ALPHA 696371 8% 27% 422 Search HIF+1+ALPHA Search HIF+1+ALPHA
2 HYPOXIA INDUCIBLE FACTOR 677630 7% 34% 328 Search HYPOXIA+INDUCIBLE+FACTOR Search HYPOXIA+INDUCIBLE+FACTOR
3 HIF 1 412020 4% 33% 206 Search HIF+1 Search HIF+1
4 HYPOXIA INDUCIBLE FACTOR 1 403914 4% 34% 197 Search HYPOXIA+INDUCIBLE+FACTOR+1 Search HYPOXIA+INDUCIBLE+FACTOR+1
5 HYPOXIA INDUCIBLE FACTOR 1 ALPHA 397180 5% 26% 254 Search HYPOXIA+INDUCIBLE+FACTOR+1+ALPHA Search HYPOXIA+INDUCIBLE+FACTOR+1+ALPHA
6 HIF 388934 4% 35% 181 Search HIF Search HIF
7 HYPOXIA 345373 21% 5% 1051 Search HYPOXIA Search HYPOXIA
8 PROLYL HYDROXYLASE 336538 2% 52% 106 Search PROLYL+HYDROXYLASE Search PROLYL+HYDROXYLASE
9 HYPOXIA INDUCIBLE FACTOR HIF 149803 1% 40% 61 Search HYPOXIA+INDUCIBLE+FACTOR+HIF Search HYPOXIA+INDUCIBLE+FACTOR+HIF
10 HIF PROLYL HYDROXYLASE 134737 0% 92% 24 Search HIF+PROLYL+HYDROXYLASE Search HIF+PROLYL+HYDROXYLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KEITH, B , JOHNSON, RS , SIMON, MC , (2012) HIF1 ALPHA AND HIF2 ALPHA: SIBLING RIVALRY IN HYPOXIC TUMOUR GROWTH AND PROGRESSION.NATURE REVIEWS CANCER. VOL. 12. ISSUE 1. P. 9 -22 119 65% 378
2 SEMENZA, GL , (2003) TARGETING HIF-1 FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 3. ISSUE 10. P. 721-732 78 76% 3268
3 MYLLYHARJU, J , (2013) PROLYL 4-HYDROXYLASES, MASTER REGULATORS OF THE HYPOXIA RESPONSE.ACTA PHYSIOLOGICA. VOL. 208. ISSUE 2. P. 148-165 156 78% 40
4 WENGER, RH , (2002) CELLULAR ADAPTATION TO HYPOXIA: O-2-SENSING PROTEIN HYDROXYLASES, HYPOXIA-INDUCIBLE TRANSCRIPTION FACTORS, AND O-2-REGULATED GENE EXPRESSION.FASEB JOURNAL. VOL. 16. ISSUE 10. P. - 138 78% 742
5 KE, QD , COSTA, M , (2006) HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1).MOLECULAR PHARMACOLOGY. VOL. 70. ISSUE 5. P. 1469-1480 129 72% 578
6 KAELIN, WG , RATCLIFFE, PJ , (2008) OXYGEN SENSING BY METAZOANS: THE CENTRAL ROLE OF THE HIF HYDROXYLASE PATHWAY.MOLECULAR CELL. VOL. 30. ISSUE 4. P. 393-402 81 74% 991
7 CHAN, MC , HOLT-MARTYN, JP , SCHOFIELD, CJ , RATCLIFFE, PJ , (2016) PHARMACOLOGICAL TARGETING OF THE HIF HYDROXYLASES - A NEW FIELD IN MEDICINE DEVELOPMENT.MOLECULAR ASPECTS OF MEDICINE. VOL. 47. ISSUE . P. 54 -75 120 64% 9
8 SEMENZA, GL , (2014) OXYGEN SENSING, HYPOXIA-INDUCIBLE FACTORS, AND DISEASE PATHOPHYSIOLOGY.ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9. VOL. 9. ISSUE . P. 47-71 106 58% 160
9 BRACKEN, CP , WHITELAW, ML , PEET, DJ , (2003) THE HYPOXIA-INDUCIBLE FACTORS: KEY TRANSCRIPTIONAL REGULATORS OF HYPOXIC RESPONSES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 60. ISSUE 7. P. 1376-1393 181 72% 139
10 BARDOS, JI , ASHCROFT, M , (2005) NEGATIVE AND POSITIVE REGULATION OF HIF-1: A COMPLEX NETWORK.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1755. ISSUE 2. P. 107 -120 147 78% 160

Classes with closest relation at Level 2


Rank Class id link
1 2612 WARBURG EFFECT//PKM2//PYRUVATE KINASE
2 1363 TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS
3 2098 ACUTE MOUNTAIN SICKNESS//HIGH ALTITUDE MEDICINE & BIOLOGY//HIGH ALTITUDE
4 1220 PTEN//MTOR//COWDEN SYNDROME
5 361 ANGIOGENESIS//ENDOSTATIN//VEGF
6 3833 CITED2//BRANCHIO OCULO FACIAL SYNDROME//AP 2 ALPHA
7 4149 BETATROPHIN//ANGPTL4//ANGIOPOIETIN LIKE PROTEIN 2
8 318 RENAL CELL CARCINOMA//PARTIAL NEPHRECTOMY//KIDNEY NEOPLASMS
9 2256 CARBONIC ANHYDRASE//CHIM BIOINORGAN//POLO SCI
10 2641 EPITHELIAL MESENCHYMAL TRANSITION//EMT//SNAIL

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