Class information for:
Level 1: HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HYPOXIA INDUCIBLE FACTOR 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
268 3769 50.6 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2150 2             HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1 5019
268 1                   HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HYPOXIA INDUCIBLE FACTOR 1 3769

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HIF 1 ALPHA authKW 829203 11% 26% 399
2 HYPOXIA INDUCIBLE FACTOR authKW 775288 8% 32% 304
3 HYPOXIA INDUCIBLE FACTOR 1 authKW 500436 5% 33% 190
4 HIF 1 authKW 476719 5% 31% 192
5 HIF authKW 456971 5% 33% 170
6 HYPOXIA INDUCIBLE FACTOR 1 ALPHA authKW 456711 6% 24% 236
7 PROLYL HYDROXYLASE authKW 439804 3% 52% 105
8 HYPOXIA authKW 342791 24% 5% 907
9 VASC PROGRAM address 298949 2% 56% 66
10 HYPOXIA INDUCIBLE FACTOR HIF authKW 180378 2% 38% 58

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 8366 26% 0% 964
2 Cell Biology 6904 23% 0% 870
3 Biochemistry & Molecular Biology 5176 33% 0% 1245
4 Medicine, Research & Experimental 913 7% 0% 261
5 Biophysics 471 5% 0% 194
6 Genetics & Heredity 406 6% 0% 217
7 Physiology 383 4% 0% 169
8 Hematology 378 4% 0% 146
9 Chemistry, Medicinal 220 3% 0% 115
10 Developmental Biology 196 2% 0% 69

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VASC PROGRAM 298949 2% 56% 66
2 TUMOR HYPOXIA 64791 0% 67% 12
3 MCKUSICK NATHANS GENET MED 46198 2% 6% 90
4 PROGRAM VASC CELL ENGN 41655 0% 86% 6
5 SIGNALING DEV BIOL CANC 39821 1% 20% 25
6 CELL ENGN 28136 2% 4% 85
7 CELL GROWTH REGULAT ANGIOGENESIS 25918 0% 80% 4
8 HENDRIX BURN 25918 0% 80% 4
9 CLRE 24300 0% 100% 3
10 ERYTHROPOIETIN GRP 24300 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MOLECULAR MEDICINE-JMM 2141 1% 1% 25
2 JOURNAL OF BIOLOGICAL CHEMISTRY 1803 5% 0% 198
3 CANCER RESEARCH 1645 2% 0% 93
4 CANCER BIOLOGY & THERAPY 1486 1% 1% 23
5 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1354 3% 0% 113
6 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 1329 1% 1% 29
7 CANCER CELL 1327 0% 1% 16
8 ANTIOXIDANTS & REDOX SIGNALING 1232 1% 1% 22
9 MOLECULAR AND CELLULAR BIOLOGY 1125 2% 0% 58
10 ONCOGENE 1035 1% 0% 50

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HIF 1 ALPHA 829203 11% 26% 399 Search HIF+1+ALPHA Search HIF+1+ALPHA
2 HYPOXIA INDUCIBLE FACTOR 775288 8% 32% 304 Search HYPOXIA+INDUCIBLE+FACTOR Search HYPOXIA+INDUCIBLE+FACTOR
3 HYPOXIA INDUCIBLE FACTOR 1 500436 5% 33% 190 Search HYPOXIA+INDUCIBLE+FACTOR+1 Search HYPOXIA+INDUCIBLE+FACTOR+1
4 HIF 1 476719 5% 31% 192 Search HIF+1 Search HIF+1
5 HIF 456971 5% 33% 170 Search HIF Search HIF
6 HYPOXIA INDUCIBLE FACTOR 1 ALPHA 456711 6% 24% 236 Search HYPOXIA+INDUCIBLE+FACTOR+1+ALPHA Search HYPOXIA+INDUCIBLE+FACTOR+1+ALPHA
7 PROLYL HYDROXYLASE 439804 3% 52% 105 Search PROLYL+HYDROXYLASE Search PROLYL+HYDROXYLASE
8 HYPOXIA 342791 24% 5% 907 Search HYPOXIA Search HYPOXIA
9 HYPOXIA INDUCIBLE FACTOR HIF 180378 2% 38% 58 Search HYPOXIA+INDUCIBLE+FACTOR+HIF Search HYPOXIA+INDUCIBLE+FACTOR+HIF
10 HIF PROLYL HYDROXYLASE 164795 1% 88% 23 Search HIF+PROLYL+HYDROXYLASE Search HIF+PROLYL+HYDROXYLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SEMENZA, GL , (2003) TARGETING HIF-1 FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 3. ISSUE 10. P. 721-732 78 76% 3268
2 KEITH, B , JOHNSON, RS , SIMON, MC , (2012) HIF1 ALPHA AND HIF2 ALPHA: SIBLING RIVALRY IN HYPOXIC TUMOUR GROWTH AND PROGRESSION.NATURE REVIEWS CANCER. VOL. 12. ISSUE 1. P. 9 -22 113 61% 378
3 WENGER, RH , (2002) CELLULAR ADAPTATION TO HYPOXIA: O-2-SENSING PROTEIN HYDROXYLASES, HYPOXIA-INDUCIBLE TRANSCRIPTION FACTORS, AND O-2-REGULATED GENE EXPRESSION.FASEB JOURNAL. VOL. 16. ISSUE 10. P. - 136 77% 742
4 KE, QD , COSTA, M , (2006) HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1).MOLECULAR PHARMACOLOGY. VOL. 70. ISSUE 5. P. 1469-1480 128 72% 578
5 MYLLYHARJU, J , (2013) PROLYL 4-HYDROXYLASES, MASTER REGULATORS OF THE HYPOXIA RESPONSE.ACTA PHYSIOLOGICA. VOL. 208. ISSUE 2. P. 148-165 146 73% 40
6 KAELIN, WG , RATCLIFFE, PJ , (2008) OXYGEN SENSING BY METAZOANS: THE CENTRAL ROLE OF THE HIF HYDROXYLASE PATHWAY.MOLECULAR CELL. VOL. 30. ISSUE 4. P. 393-402 81 74% 991
7 SEMENZA, GL , (2014) OXYGEN SENSING, HYPOXIA-INDUCIBLE FACTORS, AND DISEASE PATHOPHYSIOLOGY.ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9. VOL. 9. ISSUE . P. 47-71 103 56% 160
8 BRACKEN, CP , WHITELAW, ML , PEET, DJ , (2003) THE HYPOXIA-INDUCIBLE FACTORS: KEY TRANSCRIPTIONAL REGULATORS OF HYPOXIC RESPONSES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 60. ISSUE 7. P. 1376-1393 179 71% 139
9 BARDOS, JI , ASHCROFT, M , (2005) NEGATIVE AND POSITIVE REGULATION OF HIF-1: A COMPLEX NETWORK.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1755. ISSUE 2. P. 107 -120 147 78% 160
10 SEMENZA, GL , (2010) DEFINING THE ROLE OF HYPOXIA-INDUCIBLE FACTOR 1 IN CANCER BIOLOGY AND THERAPEUTICS.ONCOGENE. VOL. 29. ISSUE 5. P. 625 -634 81 64% 640

Classes with closest relation at Level 1


Rank Class id link
1 20081 MUCOSAL INFLAMMAT PROGRAM//INFLAMMATION AND INNATE IMMUNITY//HEPATIC OXYGEN CONSUMPTION
2 16572 BOLD MRI//RENAL OXYGENATION//KIDNEY CIRCULATION
3 28175 CANC UK MRC//REPLICON INITIATION//HYPOXIA REOXYGENATION H R
4 25856 BNIP3//BCH DOMAIN//HGTD P
5 16535 AQUITAINE LIMOUSIN BRANCH//CD34HEMATOPOIETIC STEM AND PROGENITOR CELLS HSPCS//HYPOXIA
6 3154 HEMANGIOBLASTOMA//VON HIPPEL LINDAU DISEASE//VON HIPPEL LINDAU
7 33061 CITED2//CITED//MELANOCYTE SPECIFIC GENE MSG1
8 2109 CARBOGEN//TUMOR HYPOXIA//TUMOR OXYGENATION
9 37411 ANOXIA TOLERANCE GENETIC APPROACHES//DEGENERAT DIS BRANCH//EUKARYOTIC TRANSLATION ELONGATION FACTORS
10 21570 MIR 210//MICRORNA 210//C19MC

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