Class information for:
Level 2: CARBONIC ANHYDRASE//CHIM BIOINORGAN//POLO SCI

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2256 4686 38.6 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2256 2             CARBONIC ANHYDRASE//CHIM BIOINORGAN//POLO SCI 4686
2987 1                   CHIM BIOINORGAN//CARBONIC ANHYDRASE//POLO SCI 2093
10538 1                   CARBONIC ANHYDRASE III//CARBONIC ANHYDRASE//CARBONIC ANHYDRASE VI 1055
11541 1                   CARBONIC ANHYDRASE//HUMAN CARBONIC ANHYDRASE II//IMIDAZOLIDINE RING HYDROLYSIS 974
19617 1                   SULFATHIAZOLE COMPLEXES//N SUBSTITUTED SULFONAMIDES//SULFONAMIDE LIGANDS 497
37057 1                   PRE ANALYTICAL PROCESS//OCCUPAT HLTH PREVENT REINTEGRAT//SCI QUAL HLTH CARE 67

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 CARBONIC ANHYDRASE authKW 3393137 24% 47% 1115
2 CHIM BIOINORGAN address 3017117 12% 85% 547
3 POLO SCI address 699429 3% 70% 153
4 NEUROFARBA address 567747 4% 43% 205
5 CARBONIC ANHYDRASE IX authKW 506468 3% 60% 129
6 SEZ SCI FARMACEUT address 491264 2% 93% 81
7 SEZ SCI FARMACEUT NUTRACEUT address 421001 2% 91% 71
8 DIPARTIMENTO NEUROFARBA address 348373 1% 82% 65
9 SECT PHARMACEUT NUTRICEUT SCI address 321027 1% 93% 53
10 SULFONAMIDES authKW 295980 7% 14% 327

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Chemistry, Medicinal 22341 21% 0% 976
2 Biochemistry & Molecular Biology 5413 31% 0% 1441
3 Chemistry, Organic 2085 11% 0% 515
4 Chemistry, Inorganic & Nuclear 1627 8% 0% 356
5 Crystallography 1501 5% 0% 255
6 Biophysics 630 5% 0% 248
7 Physiology 512 5% 0% 216
8 Chemistry, Multidisciplinary 489 10% 0% 453
9 Oncology 254 6% 0% 283
10 Cell Biology 189 5% 0% 254

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIM BIOINORGAN 3017117 12% 85% 547
2 POLO SCI 699429 3% 70% 153
3 NEUROFARBA 567747 4% 43% 205
4 SEZ SCI FARMACEUT 491264 2% 93% 81
5 SEZ SCI FARMACEUT NUTRACEUT 421001 2% 91% 71
6 DIPARTIMENTO NEUROFARBA 348373 1% 82% 65
7 SECT PHARMACEUT NUTRICEUT SCI 321027 1% 93% 53
8 CHIM INORGAN BIOINORGAN 185638 1% 41% 69
9 CHIM BIOORGAN 153584 3% 18% 128
10 IST BIOSCI BIORISORSE 125976 1% 54% 36

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 184934 5% 12% 235
2 BIOORGANIC & MEDICINAL CHEMISTRY 18832 4% 2% 195
3 JOURNAL OF ENZYME INHIBITION 14295 1% 8% 28
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12691 5% 1% 224
5 JOURNAL OF MEDICINAL CHEMISTRY 3563 2% 1% 111
6 EXPERT OPINION ON THERAPEUTIC PATENTS 3324 1% 2% 34
7 REVUE ROUMAINE DE CHIMIE 3019 1% 1% 48
8 JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 2831 1% 1% 51
9 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1873 1% 1% 53
10 BIOCHEMISTRY 1620 3% 0% 122

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 CARBONIC ANHYDRASE 3393137 24% 47% 1115 Search CARBONIC+ANHYDRASE Search CARBONIC+ANHYDRASE
2 CARBONIC ANHYDRASE IX 506468 3% 60% 129 Search CARBONIC+ANHYDRASE+IX Search CARBONIC+ANHYDRASE+IX
3 SULFONAMIDES 295980 7% 14% 327 Search SULFONAMIDES Search SULFONAMIDES
4 CARBONIC ANHYDRASE INHIBITORS 178214 2% 35% 79 Search CARBONIC+ANHYDRASE+INHIBITORS Search CARBONIC+ANHYDRASE+INHIBITORS
5 HYDRATASE ACTIVITY 163099 1% 96% 26 Search HYDRATASE+ACTIVITY Search HYDRATASE+ACTIVITY
6 BETA CLASS ENZYME 162860 1% 100% 25 Search BETA+CLASS+ENZYME Search BETA+CLASS+ENZYME
7 CA IX 140367 1% 57% 38 Search CA+IX Search CA+IX
8 SULFAMIDE 116268 1% 54% 33 Search SULFAMIDE Search SULFAMIDE
9 CARBONIC ANHYDRASE III 110075 1% 65% 26 Search CARBONIC+ANHYDRASE+III Search CARBONIC+ANHYDRASE+III
10 BETA CARBONIC ANHYDRASE 104222 0% 80% 20 Search BETA+CARBONIC+ANHYDRASE Search BETA+CARBONIC+ANHYDRASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SUPURAN, CT , (2016) HOW MANY CARBONIC ANHYDRASE INHIBITION MECHANISMS EXIST?.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 31. ISSUE 3. P. 345 -360 157 96% 6
2 SUPURAN, CT , DE SIMONE, G , ALTERIO, V , DI FIORE, A , D'AMBROSIO, K , (2012) MULTIPLE BINDING MODES OF INHIBITORS TO CARBONIC ANHYDRASES: HOW TO DESIGN SPECIFIC DRUGS TARGETING 15 DIFFERENT ISOFORMS?.CHEMICAL REVIEWS. VOL. 112. ISSUE 8. P. 4421 -4468 216 73% 103
3 KRISHNAMURTHY, VM , KAUFMAN, GK , URBACH, AR , GITLIN, I , GUDIKSEN, KL , WEIBEL, DB , WHITESIDES, GM , (2008) CARBONIC ANHYDRASE AS A MODEL FOR BIOPHYSICAL AND PHYSICAL-ORGANIC STUDIES OF PROTEINS AND PROTEIN-LIGAND BINDING.CHEMICAL REVIEWS. VOL. 108. ISSUE 3. P. 946 -1051 314 48% 260
4 SUPURAN, CT , (2017) ADVANCES IN STRUCTURE-BASED DRUG DISCOVERY OF CARBONIC ANHYDRASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 12. ISSUE 1. P. 61 -88 178 96% 0
5 SUPURAN, CT , (2008) CARBONIC ANHYDRASES: NOVEL THERAPEUTIC APPLICATIONS FOR INHIBITORS AND ACTIVATORS.NATURE REVIEWS DRUG DISCOVERY. VOL. 7. ISSUE 2. P. 168 -181 87 85% 607
6 PASTOREK, J , PASTOREKOVA, S , (2015) HYPOXIA-INDUCED CARBONIC ANHYDRASE IX AS A TARGET FOR CANCER THERAPY: FROM BIOLOGY TO CLINICAL USE.SEMINARS IN CANCER BIOLOGY. VOL. 31. ISSUE . P. 52 -64 122 72% 27
7 PASTOREKOVA, S , PARKKILA, S , PASTOREK, J , SUPURAN, CT , (2004) CARBONIC ANHYDRASES: CURRENT STATE OF THE ART, THERAPEUTIC APPLICATIONS AND FUTURE PROSPECTS.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 19. ISSUE 3. P. 199-229 124 84% 424
8 LINDSKOG, S , (1997) STRUCTURE AND MECHANISM OF CARBONIC ANHYDRASE.PHARMACOLOGY & THERAPEUTICS. VOL. 74. ISSUE 1. P. 1-20 138 83% 450
9 MCDONALD, PC , WINUM, JY , SUPURAN, CT , DEDHAR, S , (2012) RECENT DEVELOPMENTS IN TARGETING CARBONIC ANHYDRASE IX FOR CANCER THERAPEUTICS.ONCOTARGET. VOL. 3. ISSUE 1. P. 84-97 94 88% 85
10 CAPASSO, C , SUPURAN, CT , (2015) BACTERIAL, FUNGAL AND PROTOZOAN CARBONIC ANHYDRASES AS DRUG TARGETS.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 19. ISSUE 12. P. 1689 -1704 123 82% 0

Classes with closest relation at Level 2


Rank Class id link
1 3060 SULTAMS//BETA SULTAMS//SULTONES
2 1141 INTRACELLULAR PH//NA H EXCHANGER//AMERICAN JOURNAL OF PHYSIOLOGY
3 2150 HIF 1 ALPHA//HYPOXIA INDUCIBLE FACTOR//HIF 1
4 1898 SCORPIONATES//CHEMISTRY, INORGANIC & NUCLEAR//SCORPIONATE LIGANDS
5 489 CHEMISTRY, INORGANIC & NUCLEAR//MACROCYCLIC LIGANDS//INORGANIC CHEMISTRY
6 3647 PYRAZOLO1 5 A1 3 5TRIAZINE//N ALKYLSULFAMATES//1 2 5 THIADIAZOLE 1 1 DIOXIDE DERIVATIVES
7 2596 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION A//ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
8 981 C 4 PHOTOSYNTHESIS//ALTERNATIVE OXIDASE//CO2 CONCENTRATING MECHANISM
9 1363 TIRAPAZAMINE//DT DIAPHORASE//BIOREDUCTIVE DRUGS
10 2619 CARNOSINE//CD147//EMMPRIN

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