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DD2435 Mathematical Modelling of Biological Systems 9.0 credits

Neuronnäts- och biomodellering

The course focuses on mathematical modelling and computer simulation of nerve cells, neuronal networks and other physiological and biochemical structures and processes.

  • Educational level

    Second cycle

  • Academic level (A-D)

    D

  • Subject area

    Information Technology

  • Grade scale

    A, B, C, D, E, FX, F

Course offerings

Autumn 12 TBSBM, TSYBM for programme students

Autumn 13 biomod13 for programme students

Learning outcomes

After the course, the student should be able to

  • explain the useage of, and the assumptions behind biophysical and biochemical models and methods
  • compute basic biophysical and biochemical entities in stochiometry, ion statics and ion dynamics, diffusion and cell compartments
  • exemplify the usage of continous, stochastic or boolean models
  • explain models for synapes and their plasticity and of networks of neurons
  • use and develop simulation programs for genetic, biochemical, and neural networks

so that the student

  • is able to explain the useage of, and the assumptions behind biological models
  • in the working life can perform biological modeling and simulation work

Course main content

Methods for mathematical modelling and computer simulation of biological processes and functions. Of primary concern is the nervous system (nerve cells and neuronal networks) but other systems are also treated. Intracellular processes like biochemical networks, enzyme kinetics, cell signalling, genetic networks and switches are treated, as well as biological morphogenesis and some current theories of biological perception, learning and memory.

Eligibility

Single course students: 90 university credits including 45 university credits in Mathematics or Information Technology. English B, or equivalent.

Prerequisites

The mandatory courses for D, E, and F in mathematics, numerical analysis and computer science or the equivalent. Recommended the courses: DD2400 Cellular and Molecular Biology and DD2401 Neuroscience or the equivalent.

Literature

To be announced at least 4 weeks before course start at course web page. Previous year: D. Johnston & S. Miao-Sin Wu: Fundamentals of cellular neurophysiology, MIT Press.

Examination

  • LAB1 - Laboratory Work, 1.5 credits, grade scale: P, F
  • PRO2 - Project, 3.0 credits, grade scale: P, F
  • TEN2 - Examination, 4.5 credits, grade scale: A, B, C, D, E, FX, F

In this course all the regulations of the code of honor at the School of Computer science and Communication apply, see: http://www.kth.se/csc/student/hederskodex/1.17237?l=en_UK.

Requirements for final grade

Examination (TEN2; 4,5 university credits).
Laboratory assignments (LAB1; 1,5 university credits). Project assignment (PRO2; 3 university credits.).

Offered by

CSC/Computer Science

Contact

Erik Fransén, e-post: erikf@kth.se

Examiner

Erik Fransén <erikf@kth.se>

Supplementary information

This course can not be combined with DD2436 Modellling of Processes in Cell Biology.

The biggest part of the teaching in this course takes place at Campus Valhallavägen, but some teaching take place at Alba Nova.

Add-on studies

Please discuss with the instructor.

Version

Course plan valid from: Autumn 09.
Examination information valid from: Autumn 07.