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KD2400 Bioactive Molecules 6.0 credits

Bioaktiva molekyler

Course on bioactive molecules, including their chemical characterization and mechanisms of action. The aim of the course is to work with natural products and give students experience in practical use of preparative and analytical separation methods including GC-MS and LC andLC-MS. Bioactivity of fractions obtained will be tested on various organisms such as insects and microbes.  

  • Educational level

    Second cycle

  • Academic level (A-D)

  • Subject area

    Chemical Science and Engineering

  • Grade scale

    A, B, C, D, E, FX, F

Course offerings

Autumn 12 for programme students

Autumn 13 for programme students CANCELLED

  • Periods

    Autumn 13 P2 (6.0 credits)

  • Application code

    50014

  • Start date

    2013 week: 45

  • End date

    2014 week: 3

  • Language of instruction

    English

  • Campus

    KTH Campus

  • Number of lectures

  • Number of exercises

  • Tutoring time

    Daytime

  • Form of study

    Normal

  • Number of places *

    Min. 7

    *) The Course date may be cancelled if number of admitted are less than minimum of places.

  • Schedule

    Schedule (new window)

  • Course responsible

    Anna Karin M Borg Karlsson <akbk@kth.se>

  • Teacher

    Anna Karin M Borg Karlsson <akbk@kth.se>

  • Target group

    TMVTM åk 2, CKEMV (MVT2), CBIOT (MVT2)

Information for research students about course offerings

Ph d students are wellcome to attend the course and the content can then be adjusted to the pH d students own reserachproject

Learning outcomes

After the course the student should be able to:

  • Give examples of important areas where bioctive compounds are involved
  • give examples of the diversity in structure and bioactivity
  • follow the general route how to identify bioactive molecules
  • practically use the main instruments for identifying molecules
  • practically use main methods to test bioactivity
  • understand the evolutionary and molecular background for bioactivity (selected cases)
  • evaluate the importance of doses in relation to bioactivity

Course main content

  • Methods how to determine bioactivity
  • Chemical, farmacological, biological tools for determining bioactive molecules
  • The wide structural range of bioactive molecules
  • Natural products as an important area for new lead compounds in the development of new drugs
  • Selected mechanisms of bioactivity, e.g. electrophysiology, ion channels,
  • Applications in pharmacology, chemical ecology,environmental toxicology, atompheric chemistry

Disposition

Lectures and laboratory work.

Eligibility

Admission requirements for programme students at KTH:
At least 150 credits from grades 1, 2 and 3 of which at least 110 credits from years 1 and 2, and bachelor's work must be completed, within a programme that includes:
75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 6 university credits (hp) in computer science or corresponding.

Admission requirements for independent students:
75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 6 university credits (hp) in computer science or corresponding. Documented proficiency in English corresponding to English B.

Prerequisites

basic level organic chemistry, analytical chemistry

Literature

To be announced at the latest three weeks before the course starts.
Handouts

Examination

  • LAB1 - Laboratory Work, 1.5 credits, grade scale: P, F
  • PRO1 - Project Work, 1.0 credits, grade scale: P, F
  • TEN1 - Examination, 3.5 credits, grade scale: A, B, C, D, E, FX, F

All presentations within the project work and all laboratory work is mandatory.

Requirements for final grade

Project work (PRO1; 1 credits)
Examination (TEN1; 3.5 credits) 
Laboratory work (LAB1; 1.5 credits)

The final grade will be the same as for the examination

Offered by

CHE/Chemistry

Examiner

Anna Karin M Borg Karlsson <akbk@kth.se>

Supplementary information

The course is replaced by KD2401

Version

Course plan valid from: Autumn 11.
Examination information valid from: Autumn 11.