Class information for:
Level 1: MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1097 2856 40.2 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
142 3       DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH 64602
2147 2             MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 5031
1097 1                   MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 2856

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MGMT authKW 935835 8% 37% 236
2 O 6 METHYLGUANINE DNA METHYLTRANSFERASE authKW 829241 5% 58% 133
3 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE authKW 646701 3% 79% 77
4 ALKYLTRANSFERASE authKW 519514 2% 90% 54
5 O 6 BENZYLGUANINE authKW 493348 2% 77% 60
6 O 6 METHYLGUANINE authKW 452654 2% 63% 67
7 CANC UK CARCINOGENESIS GRP address 224655 1% 62% 34
8 O 6 ALKYLGUANINE authKW 160974 1% 94% 16
9 LOMEGUATRIB authKW 139678 0% 93% 14
10 CHLOROETHYLNITROSOUREAS authKW 120858 1% 54% 21

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 20967 45% 0% 1272
2 Toxicology 7251 16% 0% 445
3 Genetics & Heredity 3734 16% 0% 459
4 Biochemistry & Molecular Biology 1754 24% 0% 683
5 Chemistry, Medicinal 171 3% 0% 88
6 Pharmacology & Pharmacy 144 7% 0% 197
7 Biotechnology & Applied Microbiology 94 4% 0% 114
8 Cell Biology 84 5% 0% 142
9 Pathology 78 2% 0% 63
10 Biophysics 60 3% 0% 81

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC UK CARCINOGENESIS GRP 224655 1% 62% 34
2 PL TOXICOL 49453 1% 18% 26
3 BEIJING ENVIRONM VIRAL ONCOL 46466 0% 43% 10
4 MED BIOREGULAT BIOCHEM 42759 0% 100% 4
5 SECT GENOME DAMAGE REPAIR 41587 0% 32% 12
6 PATERSON CANC 34731 2% 6% 59
7 MOL CELL BIOL CHEM CARCINOGENESIS 32069 0% 100% 3
8 PATERSON CANC CARCINOGENESIS 32069 0% 100% 3
9 TOXICOL PL TOXICOL 32069 0% 100% 3
10 CARCINOGENESIS GRP 28877 0% 27% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARCINOGENESIS 86883 11% 3% 307
2 MUTATION RESEARCH 40210 6% 2% 175
3 CANCER RESEARCH 13051 8% 1% 220
4 MUTATION RESEARCH-DNA REPAIR 7888 1% 4% 19
5 DNA REPAIR 7133 1% 2% 37
6 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 3693 1% 1% 37
7 CLINICAL CANCER RESEARCH 2942 2% 0% 65
8 MUTAGENESIS 2465 1% 1% 23
9 CHEMICAL RESEARCH IN TOXICOLOGY 2459 1% 1% 35
10 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 1842 1% 1% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MGMT 935835 8% 37% 236 Search MGMT Search MGMT
2 O 6 METHYLGUANINE DNA METHYLTRANSFERASE 829241 5% 58% 133 Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE Search O+6+METHYLGUANINE+DNA+METHYLTRANSFERASE
3 O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 646701 3% 79% 77 Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE Search O+6+ALKYLGUANINE+DNA+ALKYLTRANSFERASE
4 ALKYLTRANSFERASE 519514 2% 90% 54 Search ALKYLTRANSFERASE Search ALKYLTRANSFERASE
5 O 6 BENZYLGUANINE 493348 2% 77% 60 Search O+6+BENZYLGUANINE Search O+6+BENZYLGUANINE
6 O 6 METHYLGUANINE 452654 2% 63% 67 Search O+6+METHYLGUANINE Search O+6+METHYLGUANINE
7 O 6 ALKYLGUANINE 160974 1% 94% 16 Search O+6+ALKYLGUANINE Search O+6+ALKYLGUANINE
8 LOMEGUATRIB 139678 0% 93% 14 Search LOMEGUATRIB Search LOMEGUATRIB
9 CHLOROETHYLNITROSOUREAS 120858 1% 54% 21 Search CHLOROETHYLNITROSOUREAS Search CHLOROETHYLNITROSOUREAS
10 TEMOZOLOMIDE 120469 5% 8% 137 Search TEMOZOLOMIDE Search TEMOZOLOMIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PEGG, AE , DOLAN, ME , MOSCHEL, RC , (1995) STRUCTURE, FUNCTION, AND INHIBITION OF O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 51. VOL. 51. ISSUE . P. 167 -223 218 88% 355
2 PEGG, AE , (2011) MULTIFACETED ROLES OF ALKYLTRANSFERASE AND RELATED PROTEINS IN DNA REPAIR, DNA DAMAGE, RESISTANCE TO CHEMOTHERAPY, AND RESEARCH TOOLS.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 24. ISSUE 5. P. 618-639 181 73% 66
3 PEGG, AE , (1990) MAMMALIAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE - REGULATION AND IMPORTANCE IN RESPONSE TO ALKYLATING CARCINOGENIC AND THERAPEUTIC AGENTS.CANCER RESEARCH. VOL. 50. ISSUE 19. P. 6119-6129 150 93% 754
4 KAINA, B , MARGISON, GP , CHRISTMANN, M , (2010) TARGETING O (6)-METHYLGUANINE-DNA METHYLTRANSFERASE WITH SPECIFIC INHIBITORS AS A STRATEGY IN CANCER THERAPY.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 67. ISSUE 21. P. 3663 -3681 115 86% 47
5 CHRISTMANN, M , VERBEEK, B , ROOS, WP , KAINA, B , (2011) O-6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) IN NORMAL TISSUES AND TUMORS: ENZYME ACTIVITY, PROMOTER METHYLATION AND IMMUNOHISTOCHEMISTRY.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1816. ISSUE 2. P. 179-190 122 73% 59
6 PEGG, AE , (2000) REPAIR OF O-6-ALKYLGUANINE BY ALKYLTRANSFERASES.MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. VOL. 462. ISSUE 2-3. P. 83 -100 115 85% 374
7 GERSON, SL , (2004) MGMT: ITS ROLE IN CANCER AETIOLOGY AND CANCER THERAPEUTICS.NATURE REVIEWS CANCER. VOL. 4. ISSUE 4. P. 296-307 99 84% 397
8 RABIK, CA , NJOKU, MC , DOLAN, ME , (2006) INACTIVATION OF O-6-ALKYLGUANINE DNA ALKYLTRANSFERASE AS A MEANS TO ENHANCE CHEMOTHERAPY.CANCER TREATMENT REVIEWS. VOL. 32. ISSUE 4. P. 261-276 124 83% 56
9 KAINA, B , CHRISTMANN, M , NAUMANN, S , ROOS, WP , (2007) MGMT: KEY NODE IN THE BATTLE AGAINST GENOTOXICITY, CARCINOGENICITY AND APOPTOSIS INDUCED BY ALKYLATING AGENTS.DNA REPAIR. VOL. 6. ISSUE 8. P. 1079 -1099 115 58% 243
10 TUBBS, JL , PEGG, AE , TAINER, JA , (2007) DNA BINDING, NUCLEOTIDE FLIPPING, AND THE HELIX-TURN-HELIX MOTIF IN BASE REPAIR BY O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND ITS IMPLICATIONS FOR CANCER CHEMOTHERAPY.DNA REPAIR. VOL. 6. ISSUE 8. P. 1100 -1115 98 73% 67

Classes with closest relation at Level 1


Rank Class id link
1 21701 DIPARTIMENTO FARMACOCHIM TOSSICOL BIOL//MTIC//SEZ CHIM FARMACEUT BIOL
2 16078 S 2250 KAWAGISHI//TAUROMUSTINE//SARCNU
3 26128 CLORETAZINE//VNP40101M//NEW ANTICANCER AGENT
4 1424 TEMOZOLOMIDE//GLIOBLASTOMA//GLIOBLASTOMA MULTIFORME
5 10981 N NITROSODIALKYLAMINE//N NITROSO N METHYLANILINE//IARC SCIENTIFIC PUBLICATIONS
6 16988 DNMT2//ALKB//N 6 METHYLADENOSINE
7 4599 MISMATCH REPAIR//MUTS//DNA MISMATCH REPAIR
8 5782 DNA ADDUCTS//I COMPOUNDS//P 32 POSTLABELING
9 1886 DNA GLYCOSYLASE//BASE EXCISION REPAIR//8 OXOGUANINE
10 17226 MUTA TM MOUSE//LACI//LACL

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