Class information for:
Level 1: PROLYL OLIGOPEPTIDASE//PROLYL ENDOPEPTIDASE//PROLYL ENDOPEPTIDASE INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14313 777 35.1 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1415 2             DIPEPTIDYL PEPTIDASE IV//CD26//AMINOPEPTIDASE 7997
14313 1                   PROLYL OLIGOPEPTIDASE//PROLYL ENDOPEPTIDASE//PROLYL ENDOPEPTIDASE INHIBITOR 777

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROLYL OLIGOPEPTIDASE authKW 2702685 12% 72% 96
2 PROLYL ENDOPEPTIDASE authKW 2066879 12% 58% 90
3 PROLYL ENDOPEPTIDASE INHIBITOR authKW 808402 3% 86% 24
4 OLIGOPEPTIDASE B authKW 742437 3% 82% 23
5 ACYLAMINOACYL PEPTIDASE authKW 396249 1% 92% 11
6 JTP 4819 authKW 353679 1% 100% 9
7 ACYLPEPTIDE HYDROLASE authKW 353667 2% 60% 15
8 ACYLAMINO ACID RELEASING ENZYME authKW 235786 1% 100% 6
9 OLIGOPEPTIDASE authKW 202088 2% 43% 12
10 OXIDIZED PROTEIN HYDROLASE authKW 175048 1% 64% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2653 49% 0% 380
2 Chemistry, Medicinal 875 11% 0% 82
3 Biophysics 612 11% 0% 86
4 Pharmacology & Pharmacy 497 17% 0% 131
5 Neurosciences 261 13% 0% 101
6 Cell Biology 91 8% 0% 59
7 Biotechnology & Applied Microbiology 80 6% 0% 45
8 Biochemical Research Methods 43 3% 0% 27
9 Medicine, Research & Experimental 35 4% 0% 29
10 Parasitiology 31 2% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HASELTE 78595 0% 100% 2
2 GEN PATHOPHYSIOL NERVOUS SYST 69858 1% 44% 4
3 GEN PATHOL NERVOUS SYST 65489 1% 33% 5
4 PATHOGEN HOST INTER E 58943 0% 50% 3
5 BIOL CHAIR MICROBIOL 39298 0% 100% 1
6 BIOL LILLE PASTEUR LILLEURA 1309 39298 0% 100% 1
7 BIOL LILLE PHARM 39298 0% 100% 1
8 BIOL LILLEUMR CNRS 8525 39298 0% 100% 1
9 BIOL PARASITAIRE CHIMOTHER IE 39298 0% 100% 1
10 BIOQUIM PROT PEPTIDE 39298 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOCHEMISTRY 4448 5% 0% 35
2 CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 3587 1% 1% 9
3 JOURNAL OF ANTIBIOTICS 1487 2% 0% 16
4 ACTA BIOCHIMICA ET BIOPHYSICA SINICA 1151 1% 0% 9
5 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 787 1% 0% 8
6 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 576 1% 0% 7
7 BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 564 2% 0% 14
8 BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 541 1% 0% 5
9 JOURNAL OF NEUROCHEMISTRY 518 2% 0% 17
10 CHEMBIOCHEM 421 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROLYL OLIGOPEPTIDASE 2702685 12% 72% 96 Search PROLYL+OLIGOPEPTIDASE Search PROLYL+OLIGOPEPTIDASE
2 PROLYL ENDOPEPTIDASE 2066879 12% 58% 90 Search PROLYL+ENDOPEPTIDASE Search PROLYL+ENDOPEPTIDASE
3 PROLYL ENDOPEPTIDASE INHIBITOR 808402 3% 86% 24 Search PROLYL+ENDOPEPTIDASE+INHIBITOR Search PROLYL+ENDOPEPTIDASE+INHIBITOR
4 OLIGOPEPTIDASE B 742437 3% 82% 23 Search OLIGOPEPTIDASE+B Search OLIGOPEPTIDASE+B
5 ACYLAMINOACYL PEPTIDASE 396249 1% 92% 11 Search ACYLAMINOACYL+PEPTIDASE Search ACYLAMINOACYL+PEPTIDASE
6 JTP 4819 353679 1% 100% 9 Search JTP+4819 Search JTP+4819
7 ACYLPEPTIDE HYDROLASE 353667 2% 60% 15 Search ACYLPEPTIDE+HYDROLASE Search ACYLPEPTIDE+HYDROLASE
8 ACYLAMINO ACID RELEASING ENZYME 235786 1% 100% 6 Search ACYLAMINO+ACID+RELEASING+ENZYME Search ACYLAMINO+ACID+RELEASING+ENZYME
9 OLIGOPEPTIDASE 202088 2% 43% 12 Search OLIGOPEPTIDASE Search OLIGOPEPTIDASE
10 OXIDIZED PROTEIN HYDROLASE 175048 1% 64% 7 Search OXIDIZED+PROTEIN+HYDROLASE Search OXIDIZED+PROTEIN+HYDROLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MANNISTO, PT , GARCIA-HORSMAN, JA , (2017) MECHANISM OF ACTION OF PROLYL OLIGOPEPTIDASE (PREP) IN DEGENERATIVE BRAIN DISEASES: HAS PEPTIDASE ACTIVITY ONLY A MODULATORY ROLE ON THE INTERACTIONS OF PREP WITH PROTEINS?.FRONTIERS IN AGING NEUROSCIENCE. VOL. 9. ISSUE . P. - 85 90% 0
2 LAWANDI, J , GERBER-LEMAIRE, S , JUILLERAT-JEANNERET, L , MOITESSIER, N , (2010) INHIBITORS OF PROLYL OLIGOPEPTIDASES FOR THE THERAPY OF HUMAN DISEASES: DEFINING DISEASES AND INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 53. ISSUE 9. P. 3423 -3438 96 75% 32
3 GARCIA-HORSMAN, JA , MANNISTO, PT , VENALAINEN, JI , (2007) ON THE ROLE OF PROLYL OLIGOPEPTIDASE IN HEALTH AND DISEASE.NEUROPEPTIDES. VOL. 41. ISSUE 1. P. 1 -24 119 55% 126
4 SZELTNER, Z , POLGAR, L , (2008) STRUCTURE, FUNCTION AND BIOLOGICAL RELEVANCE OF PROLYL OLIGOPEPTIDASE.CURRENT PROTEIN & PEPTIDE SCIENCE. VOL. 9. ISSUE 1. P. 96 -107 94 75% 43
5 LOPEZ, A , TARRAGO, T , GIRALT, E , (2011) LOW MOLECULAR WEIGHT INHIBITORS OF PROLYL OLIGOPEPTIDASE: A REVIEW OF COMPOUNDS PATENTED FROM 2003 TO 2010.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 21. ISSUE 7. P. 1023 -1044 79 84% 12
6 MANNISTO, PT , VANALAINEN, J , JALKANEN, A , GARCIA-HORSMAN, JA , (2007) PROLYL OLIGOPEPTIDASE: A POTENTIAL TARGET FOR THE TREATMENT OF COGNITIVE DISORDERS.DRUG NEWS & PERSPECTIVES. VOL. 20. ISSUE 5. P. 293 -305 80 80% 57
7 MYOHANEN, TT , GARCIA-HORSMAN, JA , TENORIO-LARANGA, J , MANNISTO, PT , (2009) ISSUES ABOUT THE PHYSIOLOGICAL FUNCTIONS OF PROLYL OLIGOPEPTIDASE BASED ON ITS DISCORDANT SPATIAL ASSOCIATION WITH SUBSTRATES AND INCONSISTENCIES AMONG MRNA, PROTEIN LEVELS, AND ENZYMATIC ACTIVITY.JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. VOL. 57. ISSUE 9. P. 831-848 78 57% 27
8 LOPEZ, A , MENDIETA, L , PRADES, R , ROYO, S , TARRAGO, T , GIRALT, E , (2013) PEPTIDE POP INHIBITORS FOR THE TREATMENT OF THE COGNITIVE SYMPTOMS OF SCHIZOPHRENIA.FUTURE MEDICINAL CHEMISTRY. VOL. 5. ISSUE 13. P. 1509-1523 56 74% 0
9 VAN ELZEN, R , LAMBEIR, AM , (2011) STRUCTURE AND FUNCTION RELATIONSHIP IN PROLYL OLIGOPEPTIDASE.CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. VOL. 10. ISSUE 3. P. 297-305 45 94% 6
10 BRANDT, I , SCHARPE, S , LAMBEIR, AM , (2007) SUGGESTED FUNCTIONS FOR PROLYL OLIGOPEPTIDASE: A PUZZLING PARADOX.CLINICA CHIMICA ACTA. VOL. 377. ISSUE 1-2. P. 50-61 66 65% 47

Classes with closest relation at Level 1


Rank Class id link
1 22358 THIMET OLIGOPEPTIDASE//NEUROLYSIN//ENDOPEPTIDASE 2415
2 36613 PROLYLCARBOXYPEPTIDASE//PRCP//ANGIOTENSINASE C
3 3369 DIPEPTIDYL PEPTIDASE IV//CD26//DIPEPTIDYL PEPTIDASE
4 18393 PROLIDASE//PROLIDASE DEFICIENCY//PROLIDASE ACTIVITY
5 17545 AMINOPEPTIDASE//LEUCINE AMINOPEPTIDASE//PROLYL AMINOPEPTIDASE
6 22614 AMINOACYLASE//L AMINOACYLASE//D AMINOACYLASE
7 22611 DIPEPTIDYL PEPTIDASE III//GOAT BRAIN//PEPTIDASE FAMILY M49
8 25189 GRIFOLIN//CURTISIAN//THELEPHORA AURANTIOTINCTA
9 22028 ACSDKP//N ACETYL SERYL ASPARTYL LYSYL PROLINE//HEMOREGULATORY PEPTIDE
10 2161 THYROTROPIN RELEASING HORMONE//TRH//TRH RECEPTOR

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