Class information for:
Level 1: THIMET OLIGOPEPTIDASE//NEUROLYSIN//ENDOPEPTIDASE 2415

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22358 384 34.6 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1415 2             DIPEPTIDYL PEPTIDASE IV//CD26//AMINOPEPTIDASE 7997
22358 1                   THIMET OLIGOPEPTIDASE//NEUROLYSIN//ENDOPEPTIDASE 2415 384

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THIMET OLIGOPEPTIDASE authKW 2061784 9% 79% 33
2 NEUROLYSIN authKW 707287 3% 68% 13
3 ENDOPEPTIDASE 2415 authKW 639924 3% 62% 13
4 EP2415 authKW 565462 2% 89% 8
5 MIDWEST PROTEOME address 534532 3% 61% 11
6 ENDOPEPTIDASE 342415 authKW 397592 1% 100% 5
7 ENDOPEPTIDASE 2416 authKW 331325 1% 83% 5
8 INTRACELLULAR PEPTIDES authKW 331325 1% 83% 5
9 ENDOPEPTIDASE 342416 authKW 238555 1% 100% 3
10 EP2416 authKW 238555 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1631 54% 0% 207
2 Biophysics 311 11% 0% 43
3 Endocrinology & Metabolism 266 11% 0% 43
4 Pharmacology & Pharmacy 195 15% 0% 59
5 Neurosciences 166 14% 0% 55
6 Biochemical Research Methods 71 5% 0% 21
7 Biology 49 4% 0% 15
8 Medicine, Research & Experimental 39 5% 0% 19
9 Cell Biology 22 6% 0% 23
10 Physiology 14 3% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MIDWEST PROTEOME 534532 3% 61% 11
2 PROGRAM BIOL CELULAR 159037 1% 100% 2
3 SUPPORT PROTEOLYSIS CELL SIGNALING 159037 1% 100% 2
4 SUPPORT PROTEOLYSIS CELL SIGNALING N P 159037 1% 100% 2
5 SPECIAL PL TOXINOL LETA 119275 1% 50% 3
6 PROGRAMA BIOL CELULAR 115658 1% 36% 4
7 CELL BIOL DEV 90751 3% 10% 11
8 BIOL CELULARE DESENVOLVIMENTO 79518 0% 100% 1
9 CANC UNIT QCF CANC UNIT 79518 0% 100% 1
10 CELL BIOL PROGRAM BIOMED SCI 79518 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LETTERS IN PEPTIDE SCIENCE 2562 1% 1% 4
2 BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 1347 3% 0% 10
3 BIOCHEMICAL JOURNAL 1294 6% 0% 22
4 NEUROPEPTIDES 1118 2% 0% 6
5 JOURNAL OF NEUROCHEMISTRY 1082 4% 0% 17
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 649 6% 0% 24
7 JOURNAL OF NEUROENDOCRINOLOGY 618 1% 0% 5
8 ALZHEIMERS REPORTS 587 0% 1% 1
9 PEPTIDES 569 2% 0% 8
10 IMMUNOPHARMACOLOGY 533 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THIMET OLIGOPEPTIDASE 2061784 9% 79% 33 Search THIMET+OLIGOPEPTIDASE Search THIMET+OLIGOPEPTIDASE
2 NEUROLYSIN 707287 3% 68% 13 Search NEUROLYSIN Search NEUROLYSIN
3 ENDOPEPTIDASE 2415 639924 3% 62% 13 Search ENDOPEPTIDASE+2415 Search ENDOPEPTIDASE+2415
4 EP2415 565462 2% 89% 8 Search EP2415 Search EP2415
5 ENDOPEPTIDASE 342415 397592 1% 100% 5 Search ENDOPEPTIDASE+342415 Search ENDOPEPTIDASE+342415
6 ENDOPEPTIDASE 2416 331325 1% 83% 5 Search ENDOPEPTIDASE+2416 Search ENDOPEPTIDASE+2416
7 INTRACELLULAR PEPTIDES 331325 1% 83% 5 Search INTRACELLULAR+PEPTIDES Search INTRACELLULAR+PEPTIDES
8 ENDOPEPTIDASE 342416 238555 1% 100% 3 Search ENDOPEPTIDASE+342416 Search ENDOPEPTIDASE+342416
9 EP2416 238555 1% 100% 3 Search EP2416 Search EP2416
10 EC 342415 212046 1% 67% 4 Search EC+342415 Search EC+342415

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SHRIMPTON, CN , SMITH, AI , LEW, RA , (2002) SOLUBLE METALLOENDOPEPTIDASES AND NEUROENDOCRINE SIGNALING.ENDOCRINE REVIEWS. VOL. 23. ISSUE 5. P. 647-664 97 65% 63
2 RAY, K , HINES, CS , COLL-RODRIGUEZ, J , RODGERS, DW , (2004) CRYSTAL STRUCTURE OF HUMAN THIMET OLIGOPEPTIDASE PROVIDES INSIGHT INTO SUBSTRATE RECOGNITION, REGULATION, AND LOCALIZATION.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 279. ISSUE 19. P. 20480-20489 47 71% 46
3 OLIVEIRA, V , CAMPOS, M , MELO, RL , FERRO, ES , CAMARGO, ACM , JULIANO, MA , JULIANO, L , (2001) SUBSTRATE SPECIFICITY CHARACTERIZATION OF RECOMBINANT METALLO OLIGO-PEPTIDASES THIMET OLIGOPEPTIDASE AND NEUROLYSIN.BIOCHEMISTRY. VOL. 40. ISSUE 14. P. 4417 -4425 38 79% 36
4 BARRETT, AJ , BROWN, MA , DANDO, PM , KNIGHT, CG , MCKIE, N , RAWLINGS, ND , SERIZAWA, A , (1995) THIMET OLIGOPEPTIDASE AND OLIGOPEPTIDASE-M OR NEUROLYSIN.PROTEOLYTIC ENZYMES: ASPARTIC AND METALLO PEPTIDASES. VOL. 248. ISSUE . P. 529-556 42 79% 75
5 LIM, EJ , SAMPATH, S , COLL-RODRIGUEZ, J , SCHMIDT, J , RAY, K , RODGERS, DW , (2007) SWAPPING THE SUBSTRATE SPECIFICITIES OF THE NEUROPEPTIDASES NEUROLYSIN AND THIMET OLIGOPEPTIDASE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 282. ISSUE 13. P. 9722-9732 41 59% 10
6 FONTENELE-NETO, JD , MASSARELLI, EE , GARRIDO, PAG , BEAUDET, A , FERRO, ES , (2001) COMPARATIVE FINE STRUCTURAL DISTRIBUTION OF ENDOPEPTIDASE 24.15 (EC3.4.24.15) AND 24.16 (EC3.4.24.16) IN RAT BRAIN.JOURNAL OF COMPARATIVE NEUROLOGY. VOL. 438. ISSUE 4. P. 399-410 34 77% 35
7 FERRO, ES , CARRENO, FR , GONI, C , GARRIDO, PAG , GUIMARAES, AO , CASTRO, LM , OLIVEIRA, V , ARAUJO, MC , RIOLI, V , GOMES, MD , ET AL (2004) THE INTRACELLULAR DISTRIBUTION AND SECRETION OF ENDOPEPTIDASES 24.15 (EC 3.4.24.15) AND 24.16 (EC 3.4.24.16).PROTEIN AND PEPTIDE LETTERS. VOL. 11. ISSUE 5. P. 415-421 27 87% 15
8 CASTRO, LM , CAVALCANTI, DMLP , ARAUJO, CB , RIOLI, V , ICIMOTO, MY , GOZZO, FC , JULIANO, M , JULIANO, L , OLIVEIRA, V , FERRO, ES , (2014) PEPTIDOMIC ANALYSIS OF THE NEUROLYSIN-KNOCKOUT MOUSE BRAIN.JOURNAL OF PROTEOMICS. VOL. 111. ISSUE . P. 238 -248 29 59% 6
9 STEER, D , LEW, R , PERLMUTTER, P , SMITH, AI , AGUILAR, MI , (2002) INHIBITORS OF METALLOENDOPEPTIDASE EC 3.4.24.15 AND EC 3.4.24.16 STABILIZED AGAINST PROTEOLYSIS BY THE INCORPORATION OF BETA-AMINO ACIDS.BIOCHEMISTRY. VOL. 41. ISSUE 35. P. 10819-10826 30 81% 13
10 MACHADO, MFM , RIOLI, V , DALIO, FM , CASTRO, LM , JULIANO, MA , TERSARIOL, IL , FERRO, ES , JULIANO, L , OLIVEIRA, V , (2007) THE ROLE OF TYR(605) AND ALA(607) OF THIMET OLIGOPEPTIDASE AND TYR(606) AND GLY(608) OF NEUROLYSIN IN SUBSTRATE HYDROLYSIS AND INHIBITOR BINDING.BIOCHEMICAL JOURNAL. VOL. 404. ISSUE . P. 279-288 26 81% 6

Classes with closest relation at Level 1


Rank Class id link
1 14313 PROLYL OLIGOPEPTIDASE//PROLYL ENDOPEPTIDASE//PROLYL ENDOPEPTIDASE INHIBITOR
2 35160 TRIPEPTIDYL PEPTIDASE II//TPPII//TRIPEPTIDYL PEPTIDASE
3 24459 CLOSTRIDIUM HISTOLYTICUM//BACILLUS LICHENIFORMIS F114//FISHERIES PROD TECHNOL
4 5205 NEUTRAL ENDOPEPTIDASE//VASOPEPTIDASE INHIBITOR//OMAPATRILAT
5 21073 EXPLORATORY DISCOVERY//LHRH ANTAGONIST//AZALINE B
6 2394 NEUROTENSIN//NEUROTENSIN RECEPTOR//SR 48692
7 13740 LHRH RECEPTOR//ENDOCRINE POLYPEPTIDE CANC//CYTOTOXIC LHRH ANALOG
8 22611 DIPEPTIDYL PEPTIDASE III//GOAT BRAIN//PEPTIDASE FAMILY M49
9 8798 ANGIOTENSIN CONVERTING ENZYME//ANGIOTENSIN I CONVERTING ENZYME//CD143
10 18021 HEMORPHIN//KYOTORPHIN//NEOKYOTORPHIN

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