Class information for:
Level 1: NEUTRAL ENDOPEPTIDASE//VASOPEPTIDASE INHIBITOR//OMAPATRILAT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5205 1657 35.1 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1415 2             DIPEPTIDYL PEPTIDASE IV//CD26//AMINOPEPTIDASE 7997
5205 1                   NEUTRAL ENDOPEPTIDASE//VASOPEPTIDASE INHIBITOR//OMAPATRILAT 1657

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUTRAL ENDOPEPTIDASE authKW 890415 9% 33% 145
2 VASOPEPTIDASE INHIBITOR authKW 475935 2% 70% 37
3 OMAPATRILAT authKW 443749 2% 71% 34
4 LCZ696 authKW 418814 2% 78% 29
5 NEUTRAL ENDOPEPTIDASE INHIBITOR authKW 311240 2% 68% 25
6 RACECADOTRIL authKW 290205 1% 75% 21
7 ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR authKW 257969 1% 100% 14
8 NEPRILYSIN INHIBITION authKW 240770 1% 93% 14
9 CANDOXATRIL authKW 212440 1% 82% 14
10 NEUTRAL ENDOPEPTIDASE 2411 authKW 207574 2% 43% 26

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 4887 33% 0% 543
2 Peripheral Vascular Diseases 1463 9% 0% 155
3 Biochemistry & Molecular Biology 996 24% 0% 393
4 Cardiac & Cardiovascular System 967 11% 0% 176
5 Chemistry, Medicinal 534 6% 0% 100
6 Neurosciences 378 11% 0% 186
7 Medicine, Research & Experimental 306 6% 0% 103
8 Endocrinology & Metabolism 278 6% 0% 103
9 Biophysics 259 6% 0% 93
10 Physiology 98 4% 0% 61

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VET AFFAIRS IOWA CITY HLTH CARE SYST 65806 0% 71% 5
2 PHARMACOCHIM MOL STRUCT 61996 1% 16% 21
3 CARDIOL HEART FAILURE HEART TRANSPLANT UNIT 36853 0% 100% 2
4 TRANSLAT MED DRUG METAB PHARMACOKINET 36853 0% 100% 2
5 UROGENITAL RENAL BIOL 36853 0% 100% 2
6 UNITE BIOCHIM STRUCT CELLULAIRE 35429 0% 38% 5
7 INSERM U266 31021 0% 21% 8
8 CNRS UMR 8600 30144 0% 27% 6
9 DAMIC 24567 0% 67% 2
10 TRANSLAT MED CLIN PHARMACOL PROFILING 24567 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROPEPTIDES 3803 1% 1% 23
2 CARDIOVASCULAR DRUG REVIEWS 3536 1% 2% 9
3 EUROPEAN JOURNAL OF PHARMACOLOGY 3494 4% 0% 74
4 PEPTIDES 3308 2% 0% 40
5 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2754 2% 0% 41
6 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2567 3% 0% 55
7 HYPERTENSION 2382 2% 0% 39
8 LIFE SCIENCES 1622 3% 0% 43
9 AMERICAN JOURNAL OF HYPERTENSION 1614 1% 0% 23
10 JACC-HEART FAILURE 1541 0% 2% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NEUTRAL ENDOPEPTIDASE 890415 9% 33% 145 Search NEUTRAL+ENDOPEPTIDASE Search NEUTRAL+ENDOPEPTIDASE
2 VASOPEPTIDASE INHIBITOR 475935 2% 70% 37 Search VASOPEPTIDASE+INHIBITOR Search VASOPEPTIDASE+INHIBITOR
3 OMAPATRILAT 443749 2% 71% 34 Search OMAPATRILAT Search OMAPATRILAT
4 LCZ696 418814 2% 78% 29 Search LCZ696 Search LCZ696
5 NEUTRAL ENDOPEPTIDASE INHIBITOR 311240 2% 68% 25 Search NEUTRAL+ENDOPEPTIDASE+INHIBITOR Search NEUTRAL+ENDOPEPTIDASE+INHIBITOR
6 RACECADOTRIL 290205 1% 75% 21 Search RACECADOTRIL Search RACECADOTRIL
7 ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR 257969 1% 100% 14 Search ANGIOTENSIN+RECEPTOR+NEPRILYSIN+INHIBITOR Search ANGIOTENSIN+RECEPTOR+NEPRILYSIN+INHIBITOR
8 NEPRILYSIN INHIBITION 240770 1% 93% 14 Search NEPRILYSIN+INHIBITION Search NEPRILYSIN+INHIBITION
9 CANDOXATRIL 212440 1% 82% 14 Search CANDOXATRIL Search CANDOXATRIL
10 NEUTRAL ENDOPEPTIDASE 2411 207574 2% 43% 26 Search NEUTRAL+ENDOPEPTIDASE+2411 Search NEUTRAL+ENDOPEPTIDASE+2411

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ROQUES, BP , NOBLE, F , DAUGE, V , FOURNIEZALUSKI, MC , BEAUMONT, A , (1993) NEUTRAL ENDOPEPTIDASE-24.11 - STRUCTURE, INHIBITION, AND EXPERIMENTAL AND CLINICAL-PHARMACOLOGY.PHARMACOLOGICAL REVIEWS. VOL. 45. ISSUE 1. P. 87-146 250 49% 501
2 EBERLIN, M , MUCK, T , MICHEL, MC , (2012) A COMPREHENSIVE REVIEW OF THE PHARMACODYNAMICS, PHARMACOKINETICS, AND CLINICAL EFFECTS OF THE NEUTRAL ENDOPEPTIDASE INHIBITOR RACECADOTRIL.FRONTIERS IN PHARMACOLOGY. VOL. 3. ISSUE . P. - 82 70% 12
3 BAYES-GENIS, A , BARALLAT, J , RICHARDS, AM , (2016) A TEST IN CONTEXT: NEPRILYSIN FUNCTION, INHIBITION, AND BIOMARKER.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. VOL. 68. ISSUE 6. P. 639 -653 52 60% 2
4 LIN, LM , WU, Y , WU, MF , LIN, JX , (2016) FOCUS ON THE NOVEL CARDIOVASCULAR DRUG LZC696: FROM EVIDENCE TO CLINICAL CONSIDERATION.CARDIOVASCULAR DRUGS AND THERAPY. VOL. 30. ISSUE 6. P. 623 -633 45 68% 0
5 CAMPBELL, DJ , (2003) VASOPEPTIDASE INHIBITION - A DOUBLE-EDGED SWORD?.HYPERTENSION. VOL. 41. ISSUE 3. P. 383-389 51 72% 82
6 ROQUES, BP , NOBLE, F , CRINE, P , FOURNIEZALUSKI, MC , (1995) INHIBITORS OF NEPRILYSIN - DESIGN, PHARMACOLOGICAL AND CLINICAL-APPLICATIONS.PROTEOLYTIC ENZYMES: ASPARTIC AND METALLO PEPTIDASES. VOL. 248. ISSUE . P. 263-283 70 71% 24
7 DELOMBAERT, S , CHATELAIN, RE , FINK, CA , TRAPANI, AJ , (1996) DESIGN AND PHARMACOLOGY OF DUAL ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS.CURRENT PHARMACEUTICAL DESIGN. VOL. 2. ISSUE 5. P. 443-462 65 68% 8
8 WORTHLEY, MI , CORTI, R , WORTHLEY, SG , (2004) VASOPEPTIDASE INHIBITORS: WILL THEY HAVE A ROLE IN CLINICAL PRACTICE?.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 57. ISSUE 1. P. 27-36 56 59% 22
9 SAGNELLA, GA , (2002) VASOPEPTIDASE INHIBITORS.JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. VOL. 3. ISSUE 2. P. 90 -95 36 92% 16
10 BRAUNWALD, E , (2015) THE PATH TO AN ANGIOTENSIN RECEPTOR ANTAGONIST-NEPRILYSIN INHIBITOR IN THE TREATMENT OF HEART FAILURE.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. VOL. 65. ISSUE 10. P. 1029 -1041 38 45% 23

Classes with closest relation at Level 1


Rank Class id link
1 32051 CD10//CD10 EXPRESSION//BIOPATHOLUMR 599
2 14477 ENDOTHELIN CONVERTING ENZYME//NEPRILYSIN//PHOSPHORAMIDON
3 22358 THIMET OLIGOPEPTIDASE//NEUROLYSIN//ENDOPEPTIDASE 2415
4 22611 DIPEPTIDYL PEPTIDASE III//GOAT BRAIN//PEPTIDASE FAMILY M49
5 14592 AMINOPEPTIDASE N//CD13//BESTATIN
6 15311 AMINOPEPTIDASE A//OXYTOCINASE//PLACENTAL LEUCINE AMINOPEPTIDASE
7 80 ATRIAL NATRIURETIC PEPTIDE//ATRIAL NATRIURETIC FACTOR//URODILATIN
8 12128 PROENKEPHALIN//MET ENKEPHALIN ARG6 PHE7//ENKEPHALIN PRECURSORS
9 2353 C TYPE NATRIURETIC PEPTIDE//NATRIURETIC PEPTIDE RECEPTOR//NATRIURETIC PEPTIDES
10 8798 ANGIOTENSIN CONVERTING ENZYME//ANGIOTENSIN I CONVERTING ENZYME//CD143

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