Class information for:
Level 1: EXPLORATORY DISCOVERY//LHRH ANTAGONIST//AZALINE B

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
21073 434 25.6 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
17 4 REPRODUCTIVE BIOLOGY//OBSTETRICS & GYNECOLOGY//VETERINARY SCIENCES 563730
132 3       REPRODUCTIVE BIOLOGY//FERTILITY AND STERILITY//OBSTETRICS & GYNECOLOGY 66807
3005 2             ENDOCRINE POLYPEPTIDE CANC//GHRH ANTAGONISTS//LHRH RECEPTOR 2547
21073 1                   EXPLORATORY DISCOVERY//LHRH ANTAGONIST//AZALINE B 434

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPLORATORY DISCOVERY address 438373 2% 69% 9
2 LHRH ANTAGONIST authKW 298992 4% 25% 17
3 AZALINE B authKW 225141 1% 80% 4
4 ANTIOVULATORY ACTIVITY authKW 195432 1% 56% 5
5 ABBOTT 43818 authKW 140714 0% 100% 2
6 BETIDAMINO ACIDS authKW 140714 0% 100% 2
7 NON PEPTIDE LHRH ANTAGONISTS authKW 140714 0% 100% 2
8 12 4 5 6 7 TETRAHYDRO 1H PYRROLO3 2 CPYRIDIN 3 YL ETHYLAMINE authKW 70357 0% 100% 1
9 2 4 HYDROXYBIPHENYL 3 YL 1H INDOLES authKW 70357 0% 100% 1
10 2 PHENYL 4 PIPERAZINYL BENZIMIDAZOLE authKW 70357 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 4530 30% 0% 132
2 Chemistry, Organic 748 20% 0% 86
3 Pharmacology & Pharmacy 515 22% 0% 95
4 Endocrinology & Metabolism 180 9% 0% 39
5 Biochemistry & Molecular Biology 109 17% 0% 75
6 Chemistry, Multidisciplinary 106 13% 0% 56
7 Biochemical Research Methods 101 6% 0% 26
8 Obstetrics & Gynecology 78 5% 0% 21
9 Reproductive Biology 54 3% 0% 11
10 Chemistry, Analytical 52 6% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPLORATORY DISCOVERY 438373 2% 69% 9
2 AMER CLIN SCI 70357 0% 100% 1
3 BOX 0132 70357 0% 100% 1
4 CHIM BIOMELECOLARE 70357 0% 100% 1
5 MED CHEM PHARMACOL PHARMACOKINET DYNAM 70357 0% 100% 1
6 MED GEN CLIN REPROD MED 70357 0% 100% 1
7 MED HAMPTON RD 70357 0% 100% 1
8 MED T002 REPROD PEPTIDE BIOL 70357 0% 100% 1
9 OBSTET GYNECOL PATHOL MED BIOCHEM GENE 70357 0% 100% 1
10 PHARM PHARMACEUT CHEM MED 70357 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 8857 12% 0% 52
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 6689 11% 0% 49
3 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 3383 3% 0% 11
4 CONTRACEPTION 2426 3% 0% 13
5 JOURNAL OF PEPTIDE RESEARCH 1910 1% 1% 5
6 JOURNAL OF THE INSTITUTION OF BRITISH TELECOMMUNICATIONS ENGINEERS 975 0% 1% 1
7 PHARMACEUTICAL RESEARCH 865 2% 0% 10
8 ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 754 2% 0% 10
9 INTERNATIONAL JOURNAL OF PHARMACEUTICS 731 3% 0% 13
10 JOURNAL OF IMMUNOASSAY 671 0% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LHRH ANTAGONIST 298992 4% 25% 17 Search LHRH+ANTAGONIST Search LHRH+ANTAGONIST
2 AZALINE B 225141 1% 80% 4 Search AZALINE+B Search AZALINE+B
3 ANTIOVULATORY ACTIVITY 195432 1% 56% 5 Search ANTIOVULATORY+ACTIVITY Search ANTIOVULATORY+ACTIVITY
4 ABBOTT 43818 140714 0% 100% 2 Search ABBOTT+43818 Search ABBOTT+43818
5 BETIDAMINO ACIDS 140714 0% 100% 2 Search BETIDAMINO+ACIDS Search BETIDAMINO+ACIDS
6 NON PEPTIDE LHRH ANTAGONISTS 140714 0% 100% 2 Search NON+PEPTIDE+LHRH+ANTAGONISTS Search NON+PEPTIDE+LHRH+ANTAGONISTS
7 12 4 5 6 7 TETRAHYDRO 1H PYRROLO3 2 CPYRIDIN 3 YL ETHYLAMINE 70357 0% 100% 1 Search 12+4+5+6+7+TETRAHYDRO+1H+PYRROLO3+2+CPYRIDIN+3+YL+ETHYLAMINE Search 12+4+5+6+7+TETRAHYDRO+1H+PYRROLO3+2+CPYRIDIN+3+YL+ETHYLAMINE
8 2 4 HYDROXYBIPHENYL 3 YL 1H INDOLES 70357 0% 100% 1 Search 2+4+HYDROXYBIPHENYL+3+YL+1H+INDOLES Search 2+4+HYDROXYBIPHENYL+3+YL+1H+INDOLES
9 2 PHENYL 4 PIPERAZINYL BENZIMIDAZOLE 70357 0% 100% 1 Search 2+PHENYL+4+PIPERAZINYL+BENZIMIDAZOLE Search 2+PHENYL+4+PIPERAZINYL+BENZIMIDAZOLE
10 3 2 DIBENZOFURANYLALANINE 70357 0% 100% 1 Search 3+2+DIBENZOFURANYLALANINE Search 3+2+DIBENZOFURANYLALANINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MIWA, K , HITAKA, T , IMADA, T , SASAKI, S , YOSHIMATSU, M , KUSAKA, M , TANAKA, A , NAKATA, D , FURUYA, S , ENDO, S , ET AL (2011) DISCOVERY OF 1-{4[1-(2,6-DIFLUOROBENZYL)-5-[(DIMETHYLAMINO)METHYL]-3-(6-METHOXYPYRIDAZIN-3-YL)-2,4-DIOXO-1,2,3,4-TETRAHYDROTHIENO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-3-METHOXYUREA (TAK-385) AS A POTENT, ORALLY ACTIVE, NON-PEPTIDE ANTAGONIST OF THE HUMAN GONADOTROPIN-RELEASING HORMONE RECEPTOR.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 14. P. 4998 -5012 68 84% 8
2 BETZ, SF , ZHU, YF , CHEN, C , STRUTHERS, RS , (2008) NON-PEPTIDE GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 51. ISSUE 12. P. 3331-3348 59 55% 26
3 SARMA, P , TIWARI, A , KONDASKAR, A , CLIFFE, IA , (2006) PEPTIDOMIMETIC GNRH RECEPTOR ANTAGONISTS FOR THE TREATMENT OF REPRODUCTIVE AND PROLIFERATIVE DISEASES.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 16. ISSUE 6. P. 733 -751 51 70% 3
4 HEITMAN, LH , IJZERMAN, AP , (2008) G PROTEIN-COUPLED RECEPTORS OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS: A CASE FOR GNRH, LH, FSH, AND GPR54 RECEPTOR LIGANDS.MEDICINAL RESEARCH REVIEWS. VOL. 28. ISSUE 6. P. 975-1011 53 52% 20
5 ZHU, YF , CHEN, C , STRUTHERS, RS , (2004) NONPEPTIDE GONADOTROPIN RELEASING HORMONE ANTAGONISTS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 39. VOL. 39. ISSUE . P. 99 -110 36 88% 11
6 TUCCI, FC , CHEN, C , (2004) SYNTHESIS OF ORALLY ACTIVE SMALL-MOLECULE GONADOTROPIN-RELEASING HORMONE ANTAGONISTS.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 7. ISSUE 6. P. 832-847 31 91% 1
7 GUO, ZQ , ZHU, YF , GROSS, TD , TUCCI, FC , GAO, YH , MOORJANI, M , CONNORS, PJ , ROWBOTTOM, MW , CHEN, YS , STRUTHERS, RS , ET AL (2004) SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1-ARYLMETHYL-5-ARYL-6-METHYLURACILS AS POTENT GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 47. ISSUE 5. P. 1259 -1271 23 96% 26
8 ARNOULD, JC , DELOUVRIE, B , BOUTRON, P , DOSSETTER, AG , FOOTE, KM , HAMON, A , HANCOX, U , HARRIS, CS , HUTTON, M , LAMORLETTE, M , ET AL (2007) SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF THIENO[2,3-B] PYRROLES AS ANTAGONISTS OF THE GNRH RECEPTOR.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 17. ISSUE 23. P. 6448-6454 23 88% 5
9 ARMER, RE , SMELT, KH , (2004) NON-PEPTIDIC GNRH RECEPTOR ANTAGONISTS.CURRENT MEDICINAL CHEMISTRY. VOL. 11. ISSUE 22. P. 3017-3028 31 69% 19
10 IMADA, T , CHO, N , IMAEDA, T , HAYASE, Y , SASAKI, S , KASAI, S , HARADA, M , MATSUMOTO, H , ENDO, S , SUZUKI, N , ET AL (2006) DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS OF THIENO[2,3-B]PYRIDIN-4-ONE DERIVATIVES AS A NOVEL CLASS OF POTENT, ORALLY ACTIVE, NON-PEPTIDE LUTEINIZING HORMONE-RELEASING HORMONE RECEPTOR ANTAGONISTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 13. P. 3809 -3825 27 73% 12

Classes with closest relation at Level 1


Rank Class id link
1 10053 WOMENS HOSP MAX PLANCK CLIN UNIT REPROD MED//ANIM SCI PROD GRP//1000 CARSON ST
2 13740 LHRH RECEPTOR//ENDOCRINE POLYPEPTIDE CANC//CYTOTOXIC LHRH ANALOG
3 30920 PHARMACOPERONE//ER EXPORT MOTIF//EXPORT TRAFFICKING
4 22358 THIMET OLIGOPEPTIDASE//NEUROLYSIN//ENDOPEPTIDASE 2415
5 2801 GNRH RECEPTOR//GONADOTROPES//ALPHA T3 1 CELLS
6 17701 MALE CONTRACEPTION//REPROD CONTRACEPT//RISUG
7 2172 GNRH ANTAGONIST//OVARIAN STIMULATION//RECOMBINANT FSH
8 7304 TERMINAL NERVE//NERVUS TERMINALIS//GNRH
9 1816 ANDROGEN DEPRIVATION THERAPY//BICALUTAMIDE//COMBINED ANDROGEN BLOCKADE
10 34914 LIVING HLTH SCI//REHABIL BIOMED SCI//ZINC DEFICIENCY AND ITS RECOVERY

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