Class information for:
Level 1: PROLYLCARBOXYPEPTIDASE//PRCP//ANGIOTENSINASE C

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
36613 77 33.1 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1415 2             DIPEPTIDYL PEPTIDASE IV//CD26//AMINOPEPTIDASE 7997
36613 1                   PROLYLCARBOXYPEPTIDASE//PRCP//ANGIOTENSINASE C 77

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROLYLCARBOXYPEPTIDASE authKW 4665480 26% 59% 20
2 PRCP authKW 3965672 13% 100% 10
3 ANGIOTENSINASE C authKW 2039487 8% 86% 6
4 AMINOCYCLOPENTANE authKW 793134 3% 100% 2
5 BENZIMIDAZOLE PYRROLIDINYL AMIDES authKW 396567 1% 100% 1
6 BRADYKININ 1 8 authKW 396567 1% 100% 1
7 DIPEPTIDYL PEPTIDASE 7 authKW 396567 1% 100% 1
8 ENDOTHELIN B RECEPTOR LIKE PROTEIN authKW 396567 1% 100% 1
9 KALLIKRIEN KININ SYSTEM authKW 396567 1% 100% 1
10 NEW DRUG RESEARCH AND DEVELOPMENT authKW 396567 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 200 16% 0% 12
2 Medicine, Research & Experimental 120 16% 0% 12
3 Biochemistry & Molecular Biology 92 31% 0% 24
4 Biophysics 53 10% 0% 8
5 Chemistry, Organic 40 12% 0% 9
6 Endocrinology & Metabolism 33 9% 0% 7
7 Hematology 16 5% 0% 4
8 Biochemical Research Methods 13 5% 0% 4
9 Physiology 11 5% 0% 4
10 Pharmacology & Pharmacy 9 9% 0% 7

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OB GYN REPROD SCI NEUROBIOL 396567 1% 100% 1
2 IN VITRO SCI 253796 5% 16% 4
3 PROGRAM INTEGRAT CELL SIGNALING NEUROBIOL METAB 169946 8% 7% 6
4 PROGRAM CELL SIGNALING NEUROBIOL METAB 99140 1% 25% 1
5 OB GYN REPROD SCI 58504 4% 5% 3
6 UNIV HOSP HARRINGTON MCLAUGHLIN HEART VASC 56651 1% 14% 1
7 METAB DISORDERS 36982 10% 1% 8
8 GLOBAL STRUCT BIOL 33045 1% 8% 1
9 VIVO PHARMACOL 27346 3% 3% 2
10 MOL PATHOL ECOL BIOCHEM 26436 1% 7% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MEDICAL HYPOTHESES 2731 10% 0% 8
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1273 12% 0% 9
3 MOLECULAR METABOLISM 1189 1% 0% 1
4 IRCS MEDICAL SCIENCE-BIOCHEMISTRY 1089 4% 0% 3
5 MEDICAL SCIENCE RESEARCH-BIOCHEMISTRY 1053 1% 0% 1
6 JOURNAL OF INFLAMMATION-LONDON 1025 1% 0% 1
7 BMC STRUCTURAL BIOLOGY 790 1% 0% 1
8 FRONTIERS IN NEUROENDOCRINOLOGY 732 1% 0% 1
9 JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 450 1% 0% 1
10 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 444 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROLYLCARBOXYPEPTIDASE 4665480 26% 59% 20 Search PROLYLCARBOXYPEPTIDASE Search PROLYLCARBOXYPEPTIDASE
2 PRCP 3965672 13% 100% 10 Search PRCP Search PRCP
3 ANGIOTENSINASE C 2039487 8% 86% 6 Search ANGIOTENSINASE+C Search ANGIOTENSINASE+C
4 AMINOCYCLOPENTANE 793134 3% 100% 2 Search AMINOCYCLOPENTANE Search AMINOCYCLOPENTANE
5 BENZIMIDAZOLE PYRROLIDINYL AMIDES 396567 1% 100% 1 Search BENZIMIDAZOLE+PYRROLIDINYL+AMIDES Search BENZIMIDAZOLE+PYRROLIDINYL+AMIDES
6 BRADYKININ 1 8 396567 1% 100% 1 Search BRADYKININ+1+8 Search BRADYKININ+1+8
7 DIPEPTIDYL PEPTIDASE 7 396567 1% 100% 1 Search DIPEPTIDYL+PEPTIDASE+7 Search DIPEPTIDYL+PEPTIDASE+7
8 ENDOTHELIN B RECEPTOR LIKE PROTEIN 396567 1% 100% 1 Search ENDOTHELIN+B+RECEPTOR+LIKE+PROTEIN Search ENDOTHELIN+B+RECEPTOR+LIKE+PROTEIN
9 KALLIKRIEN KININ SYSTEM 396567 1% 100% 1 Search KALLIKRIEN+KININ+SYSTEM Search KALLIKRIEN+KININ+SYSTEM
10 NEW DRUG RESEARCH AND DEVELOPMENT 396567 1% 100% 1 Search NEW+DRUG+RESEARCH+AND+DEVELOPMENT Search NEW+DRUG+RESEARCH+AND+DEVELOPMENT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SCARRY, SC , RIMOLDI, JM , (2013) DISCOVERY AND DEVELOPMENT OF PROLYLCARBOXYPEPTIDASE INHIBITORS FOR CARDIOMETABOLIC DISORDERS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 48. VOL. 48. ISSUE . P. 91-103 29 76% 2
2 GRAHAM, TH , SHU, M , VERRAS, A , CHEN, Q , GARCIA-CALVO, M , LI, XH , LISNOCK, J , TONG, XC , TUNG, EC , WILTSIE, J , ET AL (2014) PYRAZOLES AS NON-CLASSICAL BIOISOSTERES IN PROLYLCARBOXYPEPTIDASE (PRCP) INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 24. ISSUE 7. P. 1657 -1660 28 72% 2
3 KEHOE, K , VERKERK, R , SIM, Y , WAUMANS, Y , VAN DER VEKEN, P , LAMBEIR, AM , DE MEESTER, I , (2013) VALIDATION OF A SPECIFIC PROLYLCARBOXYPEPTIDASE ACTIVITY ASSAY AND ITS SUITABILITY FOR PLASMA AND SERUM MEASUREMENTS.ANALYTICAL BIOCHEMISTRY. VOL. 443. ISSUE 2. P. 232 -239 31 60% 1
4 GRAHAM, TH , LIU, WS , VERRAS, A , REIBARKH, M , BLEASBY, K , BHATT, UR , CHEN, Q , GARCIA-CALVO, M , GEISSLER, WM , GORSKI, JN , ET AL (2012) A NEW CLASS OF PROLYLCARBOXYPEPTIDASE INHIBITORS, PART 2: THE AMINOCYCLOPENTANES.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 22. ISSUE 8. P. 2818-2822 17 77% 4
5 GRAHAM, TH , LIU, WS , VERRAS, A , SEBHAT, IK , XIONG, YS , BLEASBY, K , BHATT, UR , CHEN, Q , GARCIA-CALVO, M , GEISSLER, WM , ET AL (2012) A NEW CLASS OF PROLYLCARBOXYPEPTIDASE INHIBITORS, PART 1: DISCOVERY AND EVALUATION.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 22. ISSUE 8. P. 2811-2817 18 69% 4
6 DEBENHAM, JS , GRAHAM, TH , VERRAS, A , ZHANG, Y , CLEMENTS, MJ , KUETHE, JT , MADSEN-DUGGAN, C , LIU, WS , BHATT, UR , CHEN, DL , ET AL (2013) DISCOVERY AND OPTIMIZATION OF ORALLY ACTIVE CYCLOHEXANE-BASED PROLYLCARBOXYPEPTIDASE (PRCP) INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 23. ISSUE 23. P. 6228 -6233 18 64% 2
7 JEONG, JK , DIANO, S , (2013) PROLYL CARBOXYPEPTIDASE AND ITS INHIBITORS IN METABOLISM.TRENDS IN ENDOCRINOLOGY AND METABOLISM. VOL. 24. ISSUE 2. P. 61-67 24 46% 8
8 GRAHAM, TH , SHEN, HC , LIU, WS , XIONG, YS , VERRAS, A , BLEASBY, K , BHATT, UR , CHABIN, RM , CHEN, DL , CHEN, Q , ET AL (2012) THE DISCOVERY OF NON-BENZIMIDAZOLE AND BRAIN-PENETRANT PROLYLCARBOXYPEPTIDASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 22. ISSUE 1. P. 658 -665 18 56% 6
9 SHEN, HC , DING, FX , JIANG, JL , VERRAS, A , CHABIN, RM , XU, SY , TONG, XC , CHEN, Q , XIE, D , LASSMAN, ME , ET AL (2012) DISCOVERY OF BENZODIHYDROISOFURANS AS NOVEL, POTENT, BIOAVAILABLE AND BRAIN-PENETRANT PROLYLCARBOXYPEPTIDASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 22. ISSUE 4. P. 1550-1556 9 82% 5
10 JEONG, JK , DIANO, S , (2014) PROLYL CARBOXYPEPTIDASE MRNA EXPRESSION IN THE MOUSE BRAIN.BRAIN RESEARCH. VOL. 1542. ISSUE . P. 85-92 11 58% 1

Classes with closest relation at Level 1


Rank Class id link
1 3705 FACTOR XII//FACTOR XI//FACTOR XI DEFICIENCY
2 14313 PROLYL OLIGOPEPTIDASE//PROLYL ENDOPEPTIDASE//PROLYL ENDOPEPTIDASE INHIBITOR
3 25142 TOFUYO//CARLSBERG RESEARCH COMMUNICATIONS//SERINE CARBOXYPEPTIDASE
4 36272 BULGARIAN PEDIATRIC EMERGENCY CARE//CIRCASEMIANNUAL RHYTHM//CROHNS ADULT ONSET
5 6313 ANGIOTENSIN 1 7//ANGIOTENSIN CONVERTING ENZYME 2//MAS RECEPTOR
6 2515 MELANOCORTIN//MELANOCORTIN RECEPTOR//MELANOCORTIN 4 RECEPTOR
7 31199 HLTH SCI SW MED BIOCHEM//HLTH SCI SW MED OBSTET GYNECOL//20A DIHYDROPROGESTERONE
8 30378 ARTMENT MED CELL BIOL//C57BL 6J AGT//CENT HUMAN MORPHOL
9 13030 TAFI//THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR//CARBOXYPEPTIDASE U
10 18393 PROLIDASE//PROLIDASE DEFICIENCY//PROLIDASE ACTIVITY

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