Class information for:
Level 1: MITHRAMYCIN//SP1//TOLFENAMIC ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15722 696 43.7 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
3037 2             KLF4//KRUPPEL LIKE FACTOR//GADD45 2468
15722 1                   MITHRAMYCIN//SP1//TOLFENAMIC ACID 696

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MITHRAMYCIN authKW 760212 5% 47% 37
2 SP1 authKW 494420 17% 9% 119
3 TOLFENAMIC ACID authKW 342710 4% 31% 25
4 AUREOLIC ACID authKW 296127 1% 75% 9
5 SPECIFICITY PROTEIN 1 authKW 274168 3% 31% 20
6 SP3 authKW 229152 5% 16% 32
7 SP TRANSCRIPTION FACTORS authKW 225610 2% 43% 12
8 SP PROTEINS authKW 175481 1% 67% 6
9 MITHRAMYCIN A authKW 136664 1% 35% 9
10 OLIVOMYCIN A authKW 131614 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2111 46% 0% 323
2 Oncology 917 20% 0% 141
3 Cell Biology 710 18% 0% 124
4 Biophysics 274 8% 0% 57
5 Genetics & Heredity 189 8% 0% 57
6 Pharmacology & Pharmacy 97 9% 0% 66
7 Chemistry, Medicinal 84 4% 0% 28
8 Developmental Biology 64 2% 0% 16
9 Biotechnology & Applied Microbiology 11 3% 0% 23
10 Neurosciences 11 5% 0% 36

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSLAT ANIM 131614 0% 100% 3
2 VET PHYSIOL TOXICOL 87743 0% 100% 2
3 VET PHYSIOL PHARMACOL 84683 6% 5% 42
4 BIOL FUNDAMENTAL CIENCIES SALUT 65804 0% 50% 3
5 BIOL FUNC 45160 3% 4% 24
6 4 BIOQUIM BIOL MOL 43871 0% 100% 1
7 4 PHARM 43871 0% 100% 1
8 BEREICH WIRKSTOFFE 43871 0% 100% 1
9 BIOCHEM MOL BIOLBK21 PROJECT MED SCI 43871 0% 100% 1
10 BIOCHEM MOL BIOLSEODAEMOON KU 43871 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 1287 2% 0% 11
2 JOURNAL OF BIOLOGICAL CHEMISTRY 805 8% 0% 55
3 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 662 1% 0% 4
4 JOURNAL OF ANTIBIOTICS 642 1% 0% 10
5 BIOCHEMISTRY 603 4% 0% 28
6 NUCLEIC ACIDS RESEARCH 503 3% 0% 22
7 GENE 485 2% 0% 15
8 JOURNAL OF INORGANIC BIOCHEMISTRY 370 1% 0% 7
9 FEBS OPEN BIO 369 0% 0% 2
10 PHARMACOLOGY & TOXICOLOGY 291 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MITHRAMYCIN 760212 5% 47% 37 Search MITHRAMYCIN Search MITHRAMYCIN
2 SP1 494420 17% 9% 119 Search SP1 Search SP1
3 TOLFENAMIC ACID 342710 4% 31% 25 Search TOLFENAMIC+ACID Search TOLFENAMIC+ACID
4 AUREOLIC ACID 296127 1% 75% 9 Search AUREOLIC+ACID Search AUREOLIC+ACID
5 SPECIFICITY PROTEIN 1 274168 3% 31% 20 Search SPECIFICITY+PROTEIN+1 Search SPECIFICITY+PROTEIN+1
6 SP3 229152 5% 16% 32 Search SP3 Search SP3
7 SP TRANSCRIPTION FACTORS 225610 2% 43% 12 Search SP+TRANSCRIPTION+FACTORS Search SP+TRANSCRIPTION+FACTORS
8 SP PROTEINS 175481 1% 67% 6 Search SP+PROTEINS Search SP+PROTEINS
9 MITHRAMYCIN A 136664 1% 35% 9 Search MITHRAMYCIN+A Search MITHRAMYCIN+A
10 OLIVOMYCIN A 131614 0% 100% 3 Search OLIVOMYCIN+A Search OLIVOMYCIN+A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VIZCAINO, C , MANSILLA, S , PORTUGAL, J , (2015) SP1 TRANSCRIPTION FACTOR: A LONG-STANDING TARGET IN CANCER CHEMOTHERAPY.PHARMACOLOGY & THERAPEUTICS. VOL. 152. ISSUE . P. 111 -124 105 61% 17
2 SAFE, S , IMANIRAD, P , SREEVALSAN, S , NAIR, V , JUTOORU, I , (2014) TRANSCRIPTION FACTOR SP1, ALSO KNOWN AS SPECIFICITY PROTEIN 1 AS A THERAPEUTIC TARGET.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 18. ISSUE 7. P. 759 -769 58 60% 19
3 BEISHLINE, K , AZIZKHAN-CLIFFORD, J , (2015) SP1 AND THE 'HALLMARKS OF CANCER'.FEBS JOURNAL. VOL. 282. ISSUE 2. P. 224 -258 72 20% 38
4 BOSSERMAN, MA , FLOREZ, AB , SHAABAN, KA , BRANA, AF , SALAS, JA , MENDEZ, C , ROHR, J , (2011) CHARACTERIZATION OF THE TERMINAL ACTIVATION STEP CATALYZED BY OXYGENASE CMMOIV OF THE CHROMOMYCIN BIOSYNTHETIC PATHWAY FROM STREPTOMYCES GRISEUS.BIOCHEMISTRY. VOL. 50. ISSUE 8. P. 1421-1428 26 84% 2
5 BARCELO, F , ORTIZ-LOMBARDIA, M , MARTORELL, M , OLIVER, M , MENDEZ, C , SALAS, JA , PORTUGAL, J , (2010) DNA BINDING CHARACTERISTICS OF MITHRAMYCIN AND CHROMOMYCIN ANALOGUES OBTAINED BY COMBINATORIAL BIOSYNTHESIS.BIOCHEMISTRY. VOL. 49. ISSUE 49. P. 10543-10552 31 67% 19
6 NUNEZ, LE , NYBO, SE , GONZALEZ-SABIN, J , PEREZ, M , MENENDEZ, N , BRANA, AF , SHAABAN, KA , HE, M , MORIS, F , SALAS, JA , ET AL (2012) A NOVEL MITHRAMYCIN ANALOGUE WITH HIGH ANTITUMOR ACTIVITY AND LESS TOXICITY GENERATED BY COMBINATORIAL BIOSYNTHESIS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 12. P. 5813 -5825 30 64% 14
7 FERNANDEZ-GUIZAN, A , MANSILLA, S , BARCELO, F , VIZCAINO, C , NUNEZ, LE , MORIS, F , GONZALEZ, S , PORTUGAL, J , (2014) THE ACTIVITY OF A NOVEL MITHRAMYCIN ANALOG IS RELATED TO ITS BINDING TO DNA, CELLULAR ACCUMULATION, AND INHIBITION OF SP1-DRIVEN GENE TRANSCRIPTION.CHEMICO-BIOLOGICAL INTERACTIONS. VOL. 219. ISSUE . P. 123 -132 25 74% 3
8 BOUWMAN, P , PHILIPSEN, S , (2002) REGULATION OF THE ACTIVITY OF SP1-RELATED TRANSCRIPTION FACTORS.MOLECULAR AND CELLULAR ENDOCRINOLOGY. VOL. 195. ISSUE 1-2. P. 27 -38 47 38% 331
9 MENDEZ, C , GONZALEZ-SABIN, J , MORIS, F , SALAS, JA , (2015) EXPANDING THE CHEMICAL DIVERSITY OF THE ANTITUMORAL COMPOUND MITHRAMYCIN BY COMBINATORIAL BIOSYNTHESIS AND BIOCATALYSIS: THE QUEST FOR MITHRALOGS WITH IMPROVED THERAPEUTIC WINDOW.PLANTA MEDICA. VOL. 81. ISSUE 15. P. 1326 -1338 32 55% 2
10 TEVYASHOVA, AN , DURANDIN, NA , VINOGRADOV, AM , ZBARSKY, VB , REZNIKOVA, MI , DEZHENKOVA, LG , BYKOV, EE , OLSUFYEVA, EN , KUZMIN, VA , SHTIL, AA , ET AL (2013) ROLE OF THE ACYL GROUPS IN CARBOHYDRATE CHAINS IN CYTOTOXIC PROPERTIES OF OLIVOMYCIN A.JOURNAL OF ANTIBIOTICS. VOL. 66. ISSUE 9. P. 523 -530 20 91% 2

Classes with closest relation at Level 1


Rank Class id link
1 8864 KLF4//KRUPPEL LIKE FACTOR//KLF5
2 36462 ZBP 89//ZNF148//BAK GENES
3 36295 MIR 335//MICRORNA 335//B CELL CLL LYMPHOMA 2 LIKE 2
4 32339 HIRANO BODIES//TMEM132A//INTRANEURONAL INCLUSIONS
5 34666 ZNF703//C8ORF4//THYROID CANCER 1
6 11917 2 DEOXYGLYCOSIDES//VANCOSAMINE//2 6 ANHYDRO 2 THIO SUGAR
7 26432 YY1//YIN YANG 1//YY2
8 11799 GLMU//BIOSYNTHET CHEM//DEOXYSUGARS
9 20943 NF Y//CCAAT BOX//NF YB
10 9157 SABARUBICIN//BARMINOMYCIN//ACTINOMYCIN

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