Class information for:
Level 1: 11 BETA HYDROXYSTEROID DEHYDROGENASE//11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1//11 BETA HSD1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1795 2482 39.8 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
284 3       POLYCYSTIC OVARY SYNDROME//ENDOCRINOLOGY & METABOLISM//CORTISOL 42633
2727 2             11 BETA HYDROXYSTEROID DEHYDROGENASE//11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1//11 BETA HSD1 3287
1795 1                   11 BETA HYDROXYSTEROID DEHYDROGENASE//11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1//11 BETA HSD1 2482

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 11 BETA HYDROXYSTEROID DEHYDROGENASE authKW 3074676 14% 70% 356
2 11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 authKW 1184029 4% 87% 111
3 11 BETA HSD1 authKW 1043164 4% 79% 107
4 11 BETA HSD2 authKW 358713 2% 61% 48
5 MOL HYPERTENS address 358281 1% 79% 37
6 CORTISONE authKW 344366 3% 34% 83
7 11 BETA HSD1 INHIBITOR authKW 323278 1% 91% 29
8 GLUCOCORTICOID METABOLISM authKW 279584 1% 78% 29
9 11 BETA HSD authKW 190847 1% 52% 30
10 HEXOSE 6 PHOSPHATE DEHYDROGENASE authKW 185018 1% 79% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Endocrinology & Metabolism 41183 49% 0% 1226
2 Chemistry, Medicinal 730 6% 0% 144
3 Biochemistry & Molecular Biology 698 18% 0% 446
4 Reproductive Biology 616 3% 0% 85
5 Peripheral Vascular Diseases 401 4% 0% 111
6 Physiology 281 5% 0% 116
7 Nutrition & Dietetics 225 3% 0% 78
8 Pharmacology & Pharmacy 133 7% 0% 174
9 Medicine, Research & Experimental 129 4% 0% 97
10 Urology & Nephrology 122 3% 0% 70

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL HYPERTENS 358281 1% 79% 37
2 MOL SYST TOXICOL 140689 1% 37% 31
3 ENDOCRINOL UNIT 96445 5% 6% 123
4 MED CHEM CLIN PHARM 88557 0% 60% 12
5 REG ENDOCRINE UNIT 64949 1% 41% 13
6 DEV ENDOCRINE SIGNALLING 41425 0% 42% 8
7 MOLEC HYPERTENS 36903 0% 100% 3
8 UFR MED SECTEUR NORD 36903 0% 100% 3
9 QUEEN ELIZABETH HOSP 36383 3% 4% 71
10 QUEEN ELIZABETH HOSP MED 34165 0% 56% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STEROIDS 27695 4% 2% 99
2 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 17934 5% 1% 115
3 JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 13301 6% 1% 161
4 ENDOCRINOLOGY 8114 5% 1% 129
5 ENDOCRINE RESEARCH 7556 1% 2% 29
6 MOLECULAR AND CELLULAR ENDOCRINOLOGY 7074 3% 1% 71
7 CLINICAL ENDOCRINOLOGY 6225 2% 1% 62
8 JOURNAL OF ENDOCRINOLOGY 5974 3% 1% 64
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2023 3% 0% 66
10 HORMONE AND METABOLIC RESEARCH 1701 1% 0% 30

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 11 BETA HYDROXYSTEROID DEHYDROGENASE 3074676 14% 70% 356 Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE
2 11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 1184029 4% 87% 111 Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE+TYPE+1 Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE+TYPE+1
3 11 BETA HSD1 1043164 4% 79% 107 Search 11+BETA+HSD1 Search 11+BETA+HSD1
4 11 BETA HSD2 358713 2% 61% 48 Search 11+BETA+HSD2 Search 11+BETA+HSD2
5 CORTISONE 344366 3% 34% 83 Search CORTISONE Search CORTISONE
6 11 BETA HSD1 INHIBITOR 323278 1% 91% 29 Search 11+BETA+HSD1+INHIBITOR Search 11+BETA+HSD1+INHIBITOR
7 GLUCOCORTICOID METABOLISM 279584 1% 78% 29 Search GLUCOCORTICOID+METABOLISM Search GLUCOCORTICOID+METABOLISM
8 11 BETA HSD 190847 1% 52% 30 Search 11+BETA+HSD Search 11+BETA+HSD
9 HEXOSE 6 PHOSPHATE DEHYDROGENASE 185018 1% 79% 19 Search HEXOSE+6+PHOSPHATE+DEHYDROGENASE Search HEXOSE+6+PHOSPHATE+DEHYDROGENASE
10 11 BETA HYDROXYSTEROID DEHYDROGENASE 1 177616 1% 76% 19 Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE+1 Search 11+BETA+HYDROXYSTEROID+DEHYDROGENASE+1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CHAPMAN, K , HOLMES, M , SECKL, J , (2013) 11 BETA-HYDROXYSTEROID DEHYDROGENASES: INTRACELLULAR GATE-KEEPERS OF TISSUE GLUCOCORTICOID ACTION.PHYSIOLOGICAL REVIEWS. VOL. 93. ISSUE 3. P. 1139 -1206 477 65% 130
2 TOMLINSON, JW , WALKER, EA , BUJALSKA, IJ , DRAPER, N , LAVERY, GG , COOPER, MS , HEWISON, M , STEWART, PM , (2004) 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1: A TISSUE-SPECIFIC REGULATOR OF GLUCOCORTICOID RESPONSE.ENDOCRINE REVIEWS. VOL. 25. ISSUE 5. P. 831-866 267 75% 566
3 STEWART, PM , KROZOWSKI, ZS , (1999) 11 BETA-HYDROXYSTEROID DEHYDROGENASE.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 57. VOL. 57. ISSUE . P. 249 -324 246 73% 336
4 GATHERCOLE, LL , LAVERY, GG , MORGAN, SA , COOPER, MS , SINCLAIR, AJ , TOMLINSON, JW , STEWART, PM , (2013) 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1: TRANSLATIONAL AND THERAPEUTIC ASPECTS.ENDOCRINE REVIEWS. VOL. 34. ISSUE 4. P. 525 -555 202 68% 34
5 SCOTT, JS , GOLDBERG, FW , TURNBULL, AV , (2014) MEDICINAL CHEMISTRY OF INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11 BETA-HSD1).JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 11. P. 4466 -4486 135 97% 22
6 WOODS, C , TOMLINSON, JW , (2015) THE DEHYDROGENASE HYPOTHESIS.GLUCOCORTICOID SIGNALING: FROM MOLECULES TO MICE TO MAN. VOL. 872. ISSUE . P. 353 -380 147 84% 0
7 DRAPER, N , STEWART, PM , (2005) 11 BETA-HYDROXYSTEROID DEHYDROGENASE AND THE PRE-RECEPTOR REGULATION OF CORTICOSTEROID HORMONE ACTION.JOURNAL OF ENDOCRINOLOGY. VOL. 186. ISSUE 2. P. 251-271 133 88% 228
8 PEREIRA, CD , AZEVEDO, I , MONTEIRO, R , MARTINS, MJ , (2012) 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1: RELEVANCE OF ITS MODULATION IN THE PATHOPHYSIOLOGY OF OBESITY, THE METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITUS.DIABETES OBESITY & METABOLISM. VOL. 14. ISSUE 10. P. 869 -881 128 79% 32
9 WHITE, PC , MUNE, T , AGARWAL, AK , (1997) 11 BETA-HYDROXYSTEROID DEHYDROGENASE AND THE SYNDROME OF APPARENT MINERALOCORTICOID EXCESS.ENDOCRINE REVIEWS. VOL. 18. ISSUE 1. P. 135 -156 143 78% 395
10 WAMIL, M , SECKL, JR , (2007) INHIBITION OF 11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 AS A PROMISING THERAPEUTIC TARGET.DRUG DISCOVERY TODAY. VOL. 12. ISSUE 13-14. P. 504-520 122 78% 98

Classes with closest relation at Level 1


Rank Class id link
1 23558 STEROID DIABETES//GLUCOCORTICOID INDUCED DIABETES//DRUG INDUCED DIABETES
2 17641 HIGH BLOOD P SURE UNIT//ST GEORGE HOSP RENAL MED//ASSOCIATED MEASURES
3 1897 ALDOSTERONE//EPLERENONE//SPIRONOLACTONE
4 35869 FOOD DRUG EVALUAT//GENOMELAB GENE EXPRESSION PROFILER GEXP//GLUCOCORTICOID INSULIN LIKE GROWTH FACTOR 1 AXIS
5 11254 GLOBAL QUAL SERV ANALYT SCI//PARTIAL COMPONENT REGRESSION//FLUMETHASONE
6 4272 GLYCYRRHIZIN//LICORICE//GLYCYRRHIZIC ACID
7 3011 GLUCOCORTICOID RECEPTOR//TRANSREPRESSION//GLUCOCORTICOID RESISTANCE
8 26213 HAIR CORTISOL//OBES CGG//IVEY CHAIR MOL TOXICOL
9 14044 19 NORDEOXYCORTICOSTERONE//ALDOSTERONE BIOSYNTHESIS//ALDOSTERONE SYNTHASE DEFICIENCY
10 25953 PSEUDOHYPOALDOSTERONISM//TRANSIENT PSEUDOHYPOALDOSTERONISM//SALT LOSS

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