Class information for:
Level 1: ONCOCIN//APIDAECIN//PROLINE RICH ANTIMICROBIAL PEPTIDES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
32729 135 39.1 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
388 3       TOXICON//ANTIMICROBIAL PEPTIDE//SNAKE VENOM 30875
1162 2             ANTIMICROBIAL PEPTIDE//CATHELICIDIN//DEFENSIN 9437
32729 1                   ONCOCIN//APIDAECIN//PROLINE RICH ANTIMICROBIAL PEPTIDES 135

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOCIN authKW 1809514 6% 100% 8
2 APIDAECIN authKW 1773312 10% 56% 14
3 PROLINE RICH ANTIMICROBIAL PEPTIDES authKW 904757 3% 100% 4
4 PYRRHOCORICIN authKW 706838 4% 63% 5
5 A3 APO authKW 678568 2% 100% 3
6 PROLINE RICH PEPTIDES authKW 651949 5% 41% 7
7 CHEM MINERAL address 530076 22% 8% 30
8 DROSOCIN authKW 517001 3% 57% 4
9 API88 authKW 452379 1% 100% 2
10 BAC7 authKW 452379 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 631 56% 0% 76
2 Chemistry, Medicinal 251 13% 0% 18
3 Microbiology 180 16% 0% 22
4 Pharmacology & Pharmacy 98 18% 0% 24
5 Biophysics 53 8% 0% 11
6 Biochemical Research Methods 40 7% 0% 9
7 Infectious Diseases 30 5% 0% 7
8 Chemistry, Multidisciplinary 14 10% 0% 13
9 Chemistry, Organic 12 6% 0% 8
10 Chemistry, Analytical 10 5% 0% 7

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEM MINERAL 530076 22% 8% 30
2 BIOANALYT CHEM 382217 27% 5% 37
3 BIOTECHNOL BIOMED 288994 19% 5% 26
4 CHEM MOL RECONGNIT 226189 1% 100% 1
5 CHIM BIOL MEMBRANES NANO OBJETS CBMN 226189 1% 100% 1
6 DIPARTMENTO SCI VITA 226189 1% 100% 1
7 MED IMAGING MED CLIN BIOL SMALL ANIM COM 226189 1% 100% 1
8 MICROBIOL STD DIAGNOST 226189 1% 100% 1
9 PHYS STUDENT TRAINING PROGRAM 226189 1% 100% 1
10 UNITE PROPER CNRS 9022 226189 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 15067 4% 1% 6
2 PROTEIN AND PEPTIDE LETTERS 7221 7% 0% 9
3 JOURNAL OF PEPTIDE SCIENCE 2006 3% 0% 4
4 LETTERS IN PEPTIDE SCIENCE 1824 1% 0% 2
5 NATURE MICROBIOLOGY 1751 1% 1% 1
6 AMINO ACIDS 1009 3% 0% 4
7 FUTURE MEDICINAL CHEMISTRY 988 1% 0% 2
8 INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 941 3% 0% 4
9 FRONTIERS IN CHEMISTRY 906 1% 0% 1
10 BIOCONJUGATE CHEMISTRY 721 3% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ONCOCIN 1809514 6% 100% 8 Search ONCOCIN Search ONCOCIN
2 APIDAECIN 1773312 10% 56% 14 Search APIDAECIN Search APIDAECIN
3 PROLINE RICH ANTIMICROBIAL PEPTIDES 904757 3% 100% 4 Search PROLINE+RICH+ANTIMICROBIAL+PEPTIDES Search PROLINE+RICH+ANTIMICROBIAL+PEPTIDES
4 PYRRHOCORICIN 706838 4% 63% 5 Search PYRRHOCORICIN Search PYRRHOCORICIN
5 A3 APO 678568 2% 100% 3 Search A3+APO Search A3+APO
6 PROLINE RICH PEPTIDES 651949 5% 41% 7 Search PROLINE+RICH+PEPTIDES Search PROLINE+RICH+PEPTIDES
7 DROSOCIN 517001 3% 57% 4 Search DROSOCIN Search DROSOCIN
8 API88 452379 1% 100% 2 Search API88 Search API88
9 BAC7 452379 1% 100% 2 Search BAC7 Search BAC7
10 DELIVERY MODULE 452379 1% 100% 2 Search DELIVERY+MODULE Search DELIVERY+MODULE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KNAPPE, D , RUDEN, S , LANGANKE, S , TIKKOO, T , RITZER, J , MIKUT, R , MARTIN, LL , HOFFMANN, R , HILPERT, K , (2016) OPTIMIZATION OF ONCOCIN FOR ANTIBACTERIAL ACTIVITY USING A SPOT SYNTHESIS APPROACH: EXTENDING THE PATHOGEN SPECTRUM TO STAPHYLOCOCCUS AUREUS.AMINO ACIDS. VOL. 48. ISSUE 1. P. 269 -280 22 67% 1
2 GOLDBACH, T , KNAPPE, D , REINSDORF, C , BERG, T , HOFFMANN, R , (2016) RIBOSOMAL BINDING AND ANTIBACTERIAL ACTIVITY OF ETHYLENE GLYCOL-BRIDGED APIDAECIN API137 AND ONCOCIN ONC112 CONJUGATES.JOURNAL OF PEPTIDE SCIENCE. VOL. 22. ISSUE 9. P. 592 -599 21 68% 1
3 LI, WY , SUN, Z , O'BRIEN-SIMPSON, NM , OTVOS, L , REYNOLDS, EC , HOSSAIN, MA , SEPAROVIC, F , WALDE, JD , (2017) THE EFFECT OF SELECTIVE D- OR N-ALPHA-METHYL ARGININE SUBSTITUTION ON THE ACTIVITY OF THE PROLINE-RICH ANTIMICROBIAL PEPTIDE, CHEX1-ARG20.FRONTIERS IN CHEMISTRY. VOL. 5. ISSUE . P. - 20 74% 0
4 KRIZSAN, A , VOLKE, D , WEINERT, S , STRATER, N , KNAPPE, D , HOFFMANN, R , (2014) INSECT-DERIVED PROLINE-RICH ANTIMICROBIAL PEPTIDES KILL BACTERIA BY INHIBITING BACTERIAL PROTEIN TRANSLATION AT THE 70S RIBOSOME.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 53. ISSUE 45. P. 12236 -12239 16 73% 30
5 KNAPPE, D , ADERMANN, K , HOFFMANN, R , (2015) ONCOCIN ONC72 IS EFFICACIOUS AGAINST ANTIBIOTIC-SUSCEPTIBLE KLEBSIELLA PNEUMONIAE ATCC 43816 IN A MURINE THIGH INFECTION MODEL.BIOPOLYMERS. VOL. 104. ISSUE 6. P. 707 -711 18 69% 1
6 KNAPPE, D , CASSONE, M , NOLLMANN, FI , OTVOS, L , HOFFMANN, R , (2014) HYDROXYPROLINE SUBSTITUTIONS STABILIZE NON-GLYCOSYLATED DROSOCIN AGAINST SERUM PROTEASES WITHOUT CHALLENGING ITS ANTIBACTERIAL ACTIVITY.PROTEIN AND PEPTIDE LETTERS. VOL. 21. ISSUE 4. P. 321-329 20 56% 1
7 HANSEN, A , SCHAFER, I , KNAPPE, D , SEIBEL, P , HOFFMANN, R , (2012) INTRACELLULAR TOXICITY OF PROLINE-RICH ANTIMICROBIAL PEPTIDES SHUTTLED INTO MAMMALIAN CELLS BY THE CELL-PENETRATING PEPTIDE PENETRATIN.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 56. ISSUE 10. P. 5194 -5201 18 53% 19
8 LI, WY , O'BRIEN-SIMPSON, NM , TAILHADES, J , PANTARAT, N , DAWSON, RM , OTVOS, L , REYNOLDS, EC , SEPAROVIC, F , HOSSAIN, MA , WADE, JD , (2015) MULTIMERIZATION OF A PROLINE-RICH ANTIMICROBIAL PEPTIDE, CHEX-ARG20, ALTERS ITS MECHANISM OF INTERACTION WITH THE ESCHERICHIA COLI MEMBRANE.CHEMISTRY & BIOLOGY. VOL. 22. ISSUE 9. P. 1250 -1258 20 45% 3
9 GUIDA, F , BENINCASA, M , ZAHARIEV, S , SCOCCHI, M , BERTI, F , GENNARO, R , TOSSI, A , (2015) EFFECT OF SIZE AND N-TERMINAL RESIDUE CHARACTERISTICS ON BACTERIAL CELL PENETRATION AND ANTIBACTERIAL ACTIVITY OF THE PRO LINE-RICH PEPTIDE BAC7.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 3. P. 1195 -1204 16 48% 11
10 BERTHOLD, N , HOFFMANN, R , (2014) CELLULAR UPTAKE OF APIDAECIN 1B AND RELATED ANALOGS IN GRAM-NEGATIVE BACTERIA REVEALS NOVEL ANTIBACTERIAL MECHANISM FOR PROLINE-RICH ANTIMICROBIAL PEPTIDES.PROTEIN AND PEPTIDE LETTERS. VOL. 21. ISSUE 4. P. 391-398 14 61% 8

Classes with closest relation at Level 1


Rank Class id link
1 210 ANTIMICROBIAL PEPTIDE//FROG SKIN//TEMPORIN
2 3503 INSECT IMMUNITY//PEPTIDOGLYCAN RECOGNITION PROTEIN//TOLL
3 544 CATHELICIDIN//ANTIMICROBIAL PEPTIDE//DEFENSINS
4 31239 COLOSTRININ//PROLINE RICH POLYPEPTIDE COMPLEX PRP//H BUNIATIAN BIOCHEM
5 6152 DNAJ//DNAK//GRPE
6 20232 MICROCIN//LASSO PEPTIDES//MICROCIN J25
7 10684 GLYCOPEPTIDES//TUMOR VACCINOL//ANTITUMOR VACCINES
8 36677 CAPILLARY ASSEMBLED MICROCHIP//CAPILLARY ASSEMBLED MICROCHIP CAS CHIP//LAMINAR FLOW ASSISTED DENDRITIC AMPLIFICATION
9 26233 PLECTASIN//JIANGSU SUPERMOL MED MAT PLICAT//FUSION EXPRESSION
10 36904 UNITE PROTEOMIE FONCTIONNELLE BIOP ERVAT ALIM//ANTI S AUREUS EOS//ANTI S AUREUS PEPTIDES

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