Class information for:
Level 1: MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3501 1970 43.1 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
502 3       HOMOCYSTEINE//FOLATE//FOLIC ACID 22046
254 2             HOMOCYSTEINE//FOLATE//FOLIC ACID 19695
3501 1                   MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE 1970

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MTHFR authKW 1479511 15% 32% 298
2 FOLATE authKW 676306 20% 11% 390
3 METHYLENETETRAHYDROFOLATE REDUCTASE authKW 485068 8% 21% 149
4 MTHFR POLYMORPHISM authKW 180305 2% 36% 32
5 VITAMINS CARCINOGENESIS address 170461 1% 50% 22
6 METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR authKW 149779 1% 33% 29
7 ONE CARBON METABOLISM authKW 136735 2% 18% 48
8 MTRR authKW 128933 1% 40% 21
9 FOLATE METABOLISM authKW 121373 2% 24% 33
10 C677T authKW 116670 1% 30% 25

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 11359 40% 0% 783
2 Nutrition & Dietetics 6605 16% 0% 309
3 Genetics & Heredity 2217 15% 0% 296
4 Public, Environmental & Occupational Health 1201 11% 0% 222
5 Hematology 723 7% 0% 130
6 Gastroenterology & Hepatology 291 4% 0% 88
7 Medicine, Research & Experimental 192 5% 0% 96
8 Medical Laboratory Technology 134 2% 0% 32
9 Toxicology 106 3% 0% 59
10 Biochemistry & Molecular Biology 82 10% 0% 203

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VITAMINS CARCINOGENESIS 170461 1% 50% 22
2 VITAMIN METAB 65625 1% 35% 12
3 UNIDADE PESQUISA GENET BIOL MOL UPGEM 55349 0% 71% 5
4 VITAMIN CARCINOGENESIS 46495 0% 100% 3
5 UPGEM 43047 0% 56% 5
6 JEAN MAYER US AGR 35705 1% 9% 27
7 ONCOHEMATOL PEDIAT CEONHPE 34870 0% 75% 3
8 NUTR EPIGENET GRP 34510 0% 32% 7
9 BIOBANK PUBL HLTH CLIN MED 30997 0% 100% 2
10 CHILDRENS ONCOL HEMATOL 30997 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 33640 6% 2% 117
2 CANCER CAUSES & CONTROL 7554 2% 1% 40
3 JOURNAL OF NUTRITION 6006 4% 1% 72
4 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 5781 2% 1% 46
5 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 5474 2% 1% 31
6 GENETIC TESTING AND MOLECULAR BIOMARKERS 4184 1% 2% 18
7 TUMOR BIOLOGY 3395 2% 1% 37
8 MOLECULAR BIOLOGY REPORTS 3001 2% 1% 34
9 CARCINOGENESIS 2636 2% 0% 45
10 CANCER EPIDEMIOLOGY 2448 1% 1% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MTHFR 1479511 15% 32% 298 Search MTHFR Search MTHFR
2 FOLATE 676306 20% 11% 390 Search FOLATE Search FOLATE
3 METHYLENETETRAHYDROFOLATE REDUCTASE 485068 8% 21% 149 Search METHYLENETETRAHYDROFOLATE+REDUCTASE Search METHYLENETETRAHYDROFOLATE+REDUCTASE
4 MTHFR POLYMORPHISM 180305 2% 36% 32 Search MTHFR+POLYMORPHISM Search MTHFR+POLYMORPHISM
5 METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR 149779 1% 33% 29 Search METHYLENETETRAHYDROFOLATE+REDUCTASE+MTHFR Search METHYLENETETRAHYDROFOLATE+REDUCTASE+MTHFR
6 ONE CARBON METABOLISM 136735 2% 18% 48 Search ONE+CARBON+METABOLISM Search ONE+CARBON+METABOLISM
7 MTRR 128933 1% 40% 21 Search MTRR Search MTRR
8 FOLATE METABOLISM 121373 2% 24% 33 Search FOLATE+METABOLISM Search FOLATE+METABOLISM
9 C677T 116670 1% 30% 25 Search C677T Search C677T
10 METHIONINE SYNTHASE REDUCTASE 105122 1% 32% 21 Search METHIONINE+SYNTHASE+REDUCTASE Search METHIONINE+SYNTHASE+REDUCTASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 IZMIRLI, M , (2013) A LITERATURE REVIEW OF MTHFR (C677T AND A1298C POLYMORPHISMS) AND CANCER RISK.MOLECULAR BIOLOGY REPORTS. VOL. 40. ISSUE 1. P. 625-637 145 88% 18
2 TANG, M , WANG, SQ , LIU, BJ , CAO, Q , LI, BJ , LI, PC , LI, YF , QIN, C , ZHANG, W , (2014) THE METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM AND TUMOR RISK: EVIDENCE FROM 134 CASE-CONTROL STUDIES.MOLECULAR BIOLOGY REPORTS. VOL. 41. ISSUE 7. P. 4659 -4673 123 95% 2
3 NAZKI, FH , SAMEER, AS , GANAIE, BA , (2014) FOLATE: METABOLISM, GENES, POLYMORPHISMS AND THE ASSOCIATED DISEASES.GENE. VOL. 533. ISSUE 1. P. 11-20 91 71% 57
4 DUTHIE, SJ , (2011) FOLATE AND CANCER: HOW DNA DAMAGE, REPAIR AND METHYLATION IMPACT ON COLON CARCINOGENESIS.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 34. ISSUE 1. P. 101 -109 63 83% 83
5 LIEW, SC , DAS GUPTA, E , (2015) METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM: EPIDEMIOLOGY, METABOLISM AND THE ASSOCIATED DISEASES.EUROPEAN JOURNAL OF MEDICAL GENETICS. VOL. 58. ISSUE 1. P. 1 -10 85 54% 20
6 FIGUEIREDO, JC , LEVINE, AJ , CROTT, JW , BAURLEY, J , HAILE, RW , (2013) FOLATE-GENETICS AND COLORECTAL NEOPLASIA: WHAT WE KNOW AND NEED TO KNOW NEXT.MOLECULAR NUTRITION & FOOD RESEARCH. VOL. 57. ISSUE 4. P. 607-627 72 73% 12
7 POOJA, S , CARLUS, J , SEKHAR, D , FRANCIS, A , GUPTA, N , KONWAR, R , KUMAR, S , KUMAR, S , THANGARAJ, K , RAJENDER, S , (2015) MTHFR 677C > T POLYMORPHISM AND THE RISK OF BREAST CANCER: EVIDENCE FROM AN ORIGINAL STUDY AND POOLED DATA FOR 28031 CASES AND 31880 CONTROLS.PLOS ONE. VOL. 10. ISSUE 3. P. - 58 88% 3
8 KIM, YI , (2007) FOLATE AND COLORECTAL CANCER: AN EVIDENCE-BASED CRITICAL REVIEW.MOLECULAR NUTRITION & FOOD RESEARCH. VOL. 51. ISSUE 3. P. 267-292 97 49% 179
9 SHENG, XW , ZHANG, YX , ZHAO, EJ , LU, S , ZHENG, XL , GE, H , LU, WQ , (2012) MTHFR C677T POLYMORPHISM CONTRIBUTES TO COLORECTAL CANCER SUSCEPTIBILITY: EVIDENCE FROM 61 CASE-CONTROL STUDIES.MOLECULAR BIOLOGY REPORTS. VOL. 39. ISSUE 10. P. 9669-9679 59 89% 6
10 TENG, Z , WANG, L , CAI, S , YU, P , WANG, J , GONG, J , LIU, YP , (2013) THE 677C > T (RS1801133) POLYMORPHISM IN THE MTHFR GENE CONTRIBUTES TO COLORECTAL CANCER RISK: A META-ANALYSIS BASED ON 71 RESEARCH STUDIES.PLOS ONE. VOL. 8. ISSUE 2. P. - 60 79% 14

Classes with closest relation at Level 1


Rank Class id link
1 31131 BELOW SEA LEVEL//RAMAS FERTIL//HUMAN GENOME GENET DISORDERS
2 1292 NEURAL TUBE DEFECTS//FOLIC ACID//ANENCEPHALY
3 8151 FOLATE//FOLIC ACID//FOOD FOLATE
4 26698 S ADENOSYLHOMOCYSTEINE//W CHINA PRECLIN FORENS MED SCI//BASIC CARDIOCEREBRAL VASC DIS
5 8721 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYLTRANSFERASE
6 63 HOMOCYSTEINE//HYPERHOMOCYSTEINEMIA//FOLATE
7 24196 OXIDATIVE BALANCE SCORE//ADENOMA CASES//ALCOHOL COLORECTAL ADENOMATOUS POLYPS
8 31935 DIETARY COMPOUNDS//MIR 1260B//3 UTR LUCIFERASE ASSAY
9 22078 ICF SYNDROME//EXCELLENCE MOL GENET CANC HUMAN DIS//COBRALINE 1
10 8011 BETAINE//CHOLINE//CHOLINE DEFICIENCY

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