Class information for:
Level 2: HOMOCYSTEINE//FOLATE//FOLIC ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
254 19695 37.9 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
502 3       HOMOCYSTEINE//FOLATE//FOLIC ACID 22046
254 2             HOMOCYSTEINE//FOLATE//FOLIC ACID 19695
63 1                   HOMOCYSTEINE//HYPERHOMOCYSTEINEMIA//FOLATE 4660
1292 1                   NEURAL TUBE DEFECTS//FOLIC ACID//ANENCEPHALY 2736
1766 1                   VITAMIN B 12 DEFICIENCY//COBALAMIN//METHYLMALONIC ACID 2496
3501 1                   MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE 1970
6805 1                   HOMOCYSTEINE//FOLATE//CELLULAR NEUROBIOL NEURODEGENERAT 1441
7647 1                   METHIONINE ADENOSYLTRANSFERASE//S ADENOSYLMETHIONINE//GLYCINE N METHYLTRANSFERASE 1343
8011 1                   BETAINE//CHOLINE//CHOLINE DEFICIENCY 1303
8151 1                   FOLATE//FOLIC ACID//FOOD FOLATE 1286
11426 1                   S ADENOSYLHOMOCYSTEINE HYDROLASE//S ADENOSYL L HOMOCYSTEINE HYDROLASE//3 DEAZAADENOSINE 982
17681 1                   FOLATE//L METHYLFOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE GENE MTHFR 587
21832 1                   HOMOCYSTINURIA//CYSTATHIONINE BETA SYNTHASE//CYSTATHIONINE BETA SYNTHASE DEFICIENCY 403
26698 1                   S ADENOSYLHOMOCYSTEINE//W CHINA PRECLIN FORENS MED SCI//BASIC CARDIOCEREBRAL VASC DIS 248
27004 1                   HOMOCYSTEINE//ABT KLIN CHEM MED ZENT OR//AFFILIATED JIANGSU SHENZE HOSP 240

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 HOMOCYSTEINE authKW 3590703 19% 61% 3804
2 FOLATE authKW 1734647 10% 57% 1976
3 FOLIC ACID authKW 1125068 8% 47% 1562
4 VITAMIN B 12 authKW 534415 4% 45% 765
5 MTHFR authKW 527305 3% 61% 563
6 NEURAL TUBE DEFECTS authKW 518738 4% 46% 732
7 HYPERHOMOCYSTEINEMIA authKW 470876 3% 61% 502
8 METHYLENETETRAHYDROFOLATE REDUCTASE authKW 407244 2% 61% 432
9 VITAMIN B12 authKW 398754 3% 51% 506
10 COBALAMIN authKW 318228 2% 51% 407

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Nutrition & Dietetics 57812 15% 1% 2899
2 Medical Laboratory Technology 9851 4% 1% 777
3 Peripheral Vascular Diseases 3308 5% 0% 895
4 Medicine, General & Internal 2986 7% 0% 1447
5 Geriatrics & Gerontology 2494 2% 0% 430
6 Medicine, Research & Experimental 2249 5% 0% 1017
7 Hematology 2218 4% 0% 798
8 Genetics & Heredity 2166 6% 0% 1142
9 Biochemistry & Molecular Biology 1899 13% 0% 2522
10 Endocrinology & Metabolism 1300 4% 0% 870

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LOCUS HOMOCYSTEINE RELATED VITAMINS 70952 0% 83% 55
2 VITAMIN METAB 26218 0% 71% 24
3 VITAMINS CARCINOGENESIS 25634 0% 61% 27
4 VITAMIN BIOAVAI IL 22370 0% 85% 17
5 HUMAN NUTR AGING 20891 1% 11% 129
6 BIRTH DEFECTS DEV DISABIL 20603 1% 11% 122
7 CHILD HLTH EPIDEMIOL 20490 0% 88% 15
8 VITAMIN METAB AGING 18009 0% 73% 16
9 CELLULAR NEUROBIOL NEURODEGENERAT 16303 0% 30% 35
10 NUTR 16048 3% 2% 555

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY 59771 1% 17% 222
2 AMERICAN JOURNAL OF CLINICAL NUTRITION 25468 2% 4% 469
3 JOURNAL OF NUTRITION 21288 2% 3% 432
4 CLINICAL CHEMISTRY AND LABORATORY MEDICINE 15972 1% 5% 210
5 NUTRITION REVIEWS 6187 1% 4% 116
6 INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 5026 0% 4% 80
7 EUROPEAN JOURNAL OF CLINICAL NUTRITION 4470 1% 2% 128
8 EUROPEAN JOURNAL OF NUTRITION 4141 0% 4% 66
9 CLINICAL CHEMISTRY 3852 1% 2% 178
10 ATHEROSCLEROSIS 3634 1% 2% 164

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 HOMOCYSTEINE 3590703 19% 61% 3804 Search HOMOCYSTEINE Search HOMOCYSTEINE
2 FOLATE 1734647 10% 57% 1976 Search FOLATE Search FOLATE
3 FOLIC ACID 1125068 8% 47% 1562 Search FOLIC+ACID Search FOLIC+ACID
4 VITAMIN B 12 534415 4% 45% 765 Search VITAMIN+B+12 Search VITAMIN+B+12
5 MTHFR 527305 3% 61% 563 Search MTHFR Search MTHFR
6 NEURAL TUBE DEFECTS 518738 4% 46% 732 Search NEURAL+TUBE+DEFECTS Search NEURAL+TUBE+DEFECTS
7 HYPERHOMOCYSTEINEMIA 470876 3% 61% 502 Search HYPERHOMOCYSTEINEMIA Search HYPERHOMOCYSTEINEMIA
8 METHYLENETETRAHYDROFOLATE REDUCTASE 407244 2% 61% 432 Search METHYLENETETRAHYDROFOLATE+REDUCTASE Search METHYLENETETRAHYDROFOLATE+REDUCTASE
9 VITAMIN B12 398754 3% 51% 506 Search VITAMIN+B12 Search VITAMIN+B12
10 COBALAMIN 318228 2% 51% 407 Search COBALAMIN Search COBALAMIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 REFSUM, H , SMITH, AD , UELAND, PM , NEXO, E , CLARKE, R , MCPARTLIN, J , JOHNSTON, C , ENGBAEK, F , SCHNEEDE, J , MCPARTLIN, C , ET AL (2004) FACTS AND RECOMMENDATIONS ABOUT TOTAL HOMOCYSTEINE DETERMINATIONS: AN EXPERT OPINION.CLINICAL CHEMISTRY. VOL. 50. ISSUE 1. P. 3 -32 225 91% 547
2 REFSUM, H , UELAND, PM , NYGARD, O , VOLLSET, SE , (1998) HOMOCYSTEINE AND CARDIOVASCULAR DISEASE.ANNUAL REVIEW OF MEDICINE. VOL. 49. ISSUE . P. 31 -62 190 88% 1325
3 IMBARD, A , BENOIST, JF , BLOM, HJ , (2013) NEURAL TUBE DEFECTS, FOLIC ACID AND METHYLATION.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. VOL. 10. ISSUE 9. P. 4352-4389 214 93% 19
4 WERDER, SF , (2010) COBALAMIN DEFICIENCY, HYPERHOMOCYSTEINEMIA, AND DEMENTIA.NEUROPSYCHIATRIC DISEASE AND TREATMENT. VOL. 6. ISSUE . P. 159 -195 301 68% 20
5 NYGARD, O , VOLLSET, SE , REFSUM, H , BRATTSTROM, L , UELAND, PM , (1999) TOTAL HOMOCYSTEINE AND CARDIOVASCULAR DISEASE.JOURNAL OF INTERNAL MEDICINE. VOL. 246. ISSUE 5. P. 425 -454 264 87% 172
6 DURAND, P , PROST, M , LOREAU, N , LUSSIER-CACAN, S , BLACHE, D , (2001) IMPAIRED HOMOCYSTEINE METABOLISM AND ATHEROTHROMBOTIC DISEASE.LABORATORY INVESTIGATION. VOL. 81. ISSUE 5. P. 645 -672 206 89% 140
7 CASTRO, R , RIVERA, I , BLOM, HJ , JAKOBS, C , DE ALMEIDA, IT , (2006) HOMOCYSTEINE METABOLISM, HYPERHOMOCYSTEINAEMIA AND VASCULAR DISEASE: AN OVERVIEW.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 29. ISSUE 1. P. 3-20 169 86% 136
8 IZMIRLI, M , (2013) A LITERATURE REVIEW OF MTHFR (C677T AND A1298C POLYMORPHISMS) AND CANCER RISK.MOLECULAR BIOLOGY REPORTS. VOL. 40. ISSUE 1. P. 625-637 149 91% 18
9 PORTER, K , HOEY, L , HUGHES, CF , WARD, M , MCNULTY, H , (2016) CAUSES, CONSEQUENCES AND PUBLIC HEALTH IMPLICATIONS OF LOW B-VITAMIN STATUS IN AGEING.NUTRIENTS. VOL. 8. ISSUE 11. P. - 170 82% 0
10 NAZKI, FH , SAMEER, AS , GANAIE, BA , (2014) FOLATE: METABOLISM, GENES, POLYMORPHISMS AND THE ASSOCIATED DISEASES.GENE. VOL. 533. ISSUE 1. P. 11-20 113 88% 57

Classes with closest relation at Level 2


Rank Class id link
1 3095 PNEUMOMEDIASTINUM//SUBCUTANEOUS EMPHYSEMA//SPONTANEOUS PNEUMOMEDIASTINUM
2 1684 METHOTREXATE//FOLATE RECEPTOR//REDUCED FOLATE CARRIER
3 1475 THIAMINE//THIAMINE DEFICIENCY//WERNICKES ENCEPHALOPATHY
4 2144 JOURNAL OF INHERITED METABOLIC DISEASE//NEWBORN SCREENING//METHYLMALONIC ACIDEMIA
5 2958 HYDROGEN SULFIDE//CYSTATHIONINE GAMMA LYASE//GASOTRANSMITTER
6 3291 PURINE NUCLEOSIDE PHOSPHORYLASE//CARBOHYDRATE CHEM TEAM//METHIONINE DEPENDENCE
7 382 DNA METHYLATION//EPIGENETICS//METHYLATION
8 1350 ASCORBIC ACID//URIC ACID//HYDRAZINE
9 3247 PARAOXONASE//PARAOXONASE 1//PON1
10 2078 ASYMMETRIC DIMETHYLARGININE//ARGINASE//ADMA

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