Class information for:
Level 1: AURORA KINASE//AURORA A//AURORA KINASE INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6479 1478 44.8 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
540 2             KINETOCHORE//MITOSIS//CENTROSOME 14738
6479 1                   AURORA KINASE//AURORA A//AURORA KINASE INHIBITOR 1478

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AURORA KINASE authKW 2338775 12% 63% 179
2 AURORA A authKW 2071018 11% 63% 158
3 AURORA KINASE INHIBITOR authKW 1276925 5% 82% 75
4 AURORA B authKW 736533 5% 44% 81
5 MLN8237 authKW 640405 2% 100% 31
6 AURORA KINASE A authKW 631370 3% 75% 41
7 TPX2 authKW 620094 3% 73% 41
8 AURKA authKW 615160 3% 66% 45
9 AZD1152 authKW 579117 2% 97% 29
10 AURORA A KINASE authKW 552108 3% 64% 42

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 8447 40% 0% 585
2 Cell Biology 3358 25% 0% 376
3 Chemistry, Medicinal 1377 10% 0% 143
4 Biochemistry & Molecular Biology 669 21% 0% 315
5 Pharmacology & Pharmacy 177 9% 0% 133
6 Genetics & Heredity 164 6% 0% 86
7 Pathology 95 3% 0% 44
8 Medicine, Research & Experimental 95 4% 0% 62
9 Developmental Biology 69 2% 0% 26
10 Hematology 63 3% 0% 42

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GRP CYCLE CELLULAIRE 134266 1% 50% 13
2 REGULATORY RADIOBIOL 113609 1% 50% 11
3 MOL PATHOBIOCHEM 56109 1% 23% 12
4 CNRSUPR 41 41316 0% 100% 2
5 DRUG DEV MANAGEMENT 41316 0% 100% 2
6 GRP CYCLE CELLULAIRE MED 41316 0% 100% 2
7 HORMONAL CARCINOGENSIS 41316 0% 100% 2
8 MICROBIOL CELL BIOL MCB 41316 0% 100% 2
9 UP RADIOSENSIT TUMORS NORMAL TISSUES EA2 41316 0% 100% 2
10 GUIZHOU PROV REGENERAT MED 40490 1% 20% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 7672 3% 1% 39
2 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 6318 3% 1% 39
3 INVESTIGATIONAL NEW DRUGS 2310 1% 1% 17
4 CLINICAL CANCER RESEARCH 2168 3% 0% 40
5 MOLECULAR CANCER 1394 1% 1% 11
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1063 3% 0% 37
7 CHEMICAL BIOLOGY & DRUG DESIGN 997 1% 1% 9
8 ONCOGENE 915 2% 0% 29
9 MOLECULAR BIOLOGY OF THE CELL 863 1% 0% 19
10 JOURNAL OF CELL BIOLOGY 834 2% 0% 26

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 AURORA KINASE 2338775 12% 63% 179 Search AURORA+KINASE Search AURORA+KINASE
2 AURORA A 2071018 11% 63% 158 Search AURORA+A Search AURORA+A
3 AURORA KINASE INHIBITOR 1276925 5% 82% 75 Search AURORA+KINASE+INHIBITOR Search AURORA+KINASE+INHIBITOR
4 AURORA B 736533 5% 44% 81 Search AURORA+B Search AURORA+B
5 MLN8237 640405 2% 100% 31 Search MLN8237 Search MLN8237
6 AURORA KINASE A 631370 3% 75% 41 Search AURORA+KINASE+A Search AURORA+KINASE+A
7 TPX2 620094 3% 73% 41 Search TPX2 Search TPX2
8 AURKA 615160 3% 66% 45 Search AURKA Search AURKA
9 AZD1152 579117 2% 97% 29 Search AZD1152 Search AZD1152
10 AURORA A KINASE 552108 3% 64% 42 Search AURORA+A+KINASE Search AURORA+A+KINASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MALUMBRES, M , DE CASTRO, IP , (2014) AURORA KINASE A INHIBITORS: PROMISING AGENTS IN ANTITUMORAL THERAPY.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 18. ISSUE 12. P. 1377 -1393 157 84% 16
2 YAN, M , WANG, CL , HE, B , YANG, MY , TONG, MY , LONG, ZJ , LIU, B , PENG, F , XU, LZ , ZHANG, Y , ET AL (2016) AURORA-A KINASE: A POTENT ONCOGENE AND TARGET FOR CANCER THERAPY.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 6. P. 1036 -1079 180 76% 0
3 NIKONOVA, AS , ASTSATUROV, I , SEREBRIISKII, IG , DUNBRACK, RL , GOLEMIS, EA , (2013) AURORA A KINASE (AURKA) IN NORMAL AND PATHOLOGICAL CELL DIVISION.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 70. ISSUE 4. P. 661 -687 142 60% 80
4 CICENAS, J , (2016) THE AURORA KINASE INHIBITORS IN CANCER RESEARCH AND THERAPY.JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. VOL. 142. ISSUE 9. P. 1995 -2012 124 82% 0
5 DURLACHER, CT , LI, ZL , CHEN, XW , HE, ZX , ZHOU, SF , (2016) AN UPDATE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF ALISERTIB, A SELECTIVE AURORA KINASE A INHIBITOR.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. VOL. 43. ISSUE 6. P. 585 -601 100 84% 2
6 LIBERTINI, S , ABAGNALE, A , PASSARO, C , BOTTA, G , PORTELLA, G , (2010) AURORA A AND B KINASES - TARGETS OF NOVEL ANTICANCER DRUGS.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 5. ISSUE 3. P. 219-241 159 67% 9
7 GOLDENSON, B , CRISPINO, JD , (2015) THE AURORA KINASES IN CELL CYCLE AND LEUKEMIA.ONCOGENE. VOL. 34. ISSUE 5. P. 537 -545 94 66% 32
8 KATSHA, A , BELKHIRI, A , GOFF, L , EL-RIFAI, W , (2015) AURORA KINASE A IN GASTROINTESTINAL CANCERS: TIME TO TARGET.MOLECULAR CANCER. VOL. 14. ISSUE . P. - 91 86% 10
9 FALCHOOK, GS , BASTIDA, CC , KURZROCK, R , (2015) AURORA KINASE INHIBITORS IN ONCOLOGY CLINICAL TRIALS: CURRENT STATE OF THE PROGRESS.SEMINARS IN ONCOLOGY. VOL. 42. ISSUE 6. P. 832 -848 89 83% 6
10 GAUTSCHI, O , HEIGHWAY, J , MACK, PC , PURNELL, PR , LARA, PN , GANDARA, DR , (2008) AURORA KINASES AS ANTICANCER DRUG TARGETS.CLINICAL CANCER RESEARCH. VOL. 14. ISSUE 6. P. 1639 -1648 70 91% 255

Classes with closest relation at Level 1


Rank Class id link
1 1972 SPINDLE ASSEMBLY CHECKPOINT//MAD2//CDC20
2 11497 POLO LIKE KINASE 1//PLK1//POLO LIKE KINASE
3 35189 REVERSINE//TAK 778//PURMORPHAMINE
4 10900 CYTOKINESIS//CENTRAL SPINDLE//CENTRALSPINDLIN
5 24379 NEK2//NIMA//NEK6
6 23620 KINESIN SPINDLE PROTEIN//EG5//KSP
7 16660 COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3
8 3081 CENTROSOME//CENTRIOLE//GAMMA TUBULIN
9 1570 EB1//MICROTUBULES//CHROMOSOME MOVEMENT
10 3854 SURVIVIN//YM155//SURVIVIN EXPRESSION

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