Class information for:
Level 1: POLO LIKE KINASE 1//PLK1//POLO LIKE KINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11497 977 44.8 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
540 2             KINETOCHORE//MITOSIS//CENTROSOME 14738
11497 1                   POLO LIKE KINASE 1//PLK1//POLO LIKE KINASE 977

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 POLO LIKE KINASE 1 authKW 2261924 10% 75% 97
2 PLK1 authKW 2160774 14% 52% 132
3 POLO LIKE KINASE authKW 1715131 10% 58% 94
4 POLO BOX DOMAIN authKW 950732 3% 89% 34
5 BI 2536 authKW 542566 3% 69% 25
6 VOLASERTIB authKW 410539 2% 77% 17
7 PLK3 authKW 291682 1% 67% 14
8 BI 6727 authKW 281274 1% 100% 9
9 POLO authKW 235023 2% 40% 19
10 PLK2 authKW 234380 2% 50% 15

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 5466 39% 0% 377
2 Oncology 3235 31% 0% 300
3 Biochemistry & Molecular Biology 1541 35% 0% 342
4 Chemistry, Medicinal 394 7% 0% 65
5 Genetics & Heredity 189 7% 0% 70
6 Developmental Biology 95 2% 0% 23
7 Biophysics 48 4% 0% 36
8 Hematology 39 3% 0% 27
9 Pharmacology & Pharmacy 36 6% 0% 62
10 Reproductive Biology 19 1% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL CYCLE SIGNAL TRANSDUCT 86809 1% 56% 5
2 CANC CAMPAIGN CELL CYCLE GENET GRP 70317 0% 75% 3
3 BIOL MECHANISMS SECT 62505 0% 100% 2
4 GYNECOL MOL ONCOL GYNECOL 62505 0% 100% 2
5 DELAWARE CARDIOVASC 46876 0% 50% 3
6 IMMUNE VASC CELL NETWORK 41669 0% 67% 2
7 MOL DISCOVERY PROGRAM 34084 1% 18% 6
8 ALLGEMEINES KRANKENHAUS CELLE MED 31253 0% 100% 1
9 ALTANA PHARMA AG 31253 0% 100% 1
10 BIOL CELLULAIRE DEV UMR 7622 31253 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY SERIES 15804 5% 1% 50
2 CELL CYCLE 3835 1% 1% 9
3 MOLECULAR CANCER THERAPEUTICS 2461 2% 0% 18
4 ONCOGENE 2194 4% 0% 36
5 CELL DIVISION 1360 0% 1% 3
6 ONCOTARGET 1312 2% 0% 23
7 MOLECULAR AND CELLULAR BIOLOGY 1058 3% 0% 28
8 JOURNAL OF BIOLOGICAL CHEMISTRY 634 6% 0% 59
9 AMERICAN JOURNAL OF CANCER RESEARCH 627 0% 1% 4
10 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 619 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 POLO LIKE KINASE 1 2261924 10% 75% 97 Search POLO+LIKE+KINASE+1 Search POLO+LIKE+KINASE+1
2 PLK1 2160774 14% 52% 132 Search PLK1 Search PLK1
3 POLO LIKE KINASE 1715131 10% 58% 94 Search POLO+LIKE+KINASE Search POLO+LIKE+KINASE
4 POLO BOX DOMAIN 950732 3% 89% 34 Search POLO+BOX+DOMAIN Search POLO+BOX+DOMAIN
5 BI 2536 542566 3% 69% 25 Search BI+2536 Search BI+2536
6 VOLASERTIB 410539 2% 77% 17 Search VOLASERTIB Search VOLASERTIB
7 PLK3 291682 1% 67% 14 Search PLK3 Search PLK3
8 BI 6727 281274 1% 100% 9 Search BI+6727 Search BI+6727
9 POLO 235023 2% 40% 19 Search POLO Search POLO
10 PLK2 234380 2% 50% 15 Search PLK2 Search PLK2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 STREBHARDT, K , (2010) MULTIFACETED POLO-LIKE KINASES: DRUG TARGETS AND ANTITARGETS FOR CANCER THERAPY.NATURE REVIEWS DRUG DISCOVERY. VOL. 9. ISSUE 8. P. 643 -U24 159 65% 277
2 LEE, KS , BURKE, TR , PARK, JE , BANG, JK , LEE, E , (2015) RECENT ADVANCES AND NEW STRATEGIES IN TARGETING PLK1 FOR ANTICANCER THERAPY.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 36. ISSUE 12. P. 858 -877 101 81% 6
3 PEZUK, JA , VALERA, ET , BRASSESCO, MS , (2016) PLK1 INHIBITION: PROSPECTIVE ROLE FOR THE TREATMENT OF PEDIATRIC TUMORS.CURRENT DRUG TARGETS. VOL. 17. ISSUE 14. P. 1661 -1672 108 80% 0
4 VAN DEN BOSSCHE, J , LARDON, F , DESCHOOLMEESTER, V , DE PAUW, I , VERMORKEN, JB , SPECENIER, P , PAUWELS, P , PEETERS, M , WOUTERS, A , (2016) SPOTLIGHT ON VOLASERTIB: PRECLINICAL AND CLINICAL EVALUATION OF A PROMISING PLK1 INHIBITOR.MEDICINAL RESEARCH REVIEWS. VOL. 36. ISSUE 4. P. 749 -786 83 88% 2
5 STREBHARDT, K , ULLRICH, A , (2006) OPINION - TARGETING POLO-LIKE KINASE 1 FOR CANCER THERAPY.NATURE REVIEWS CANCER. VOL. 6. ISSUE 4. P. 321 -330 85 72% 448
6 ARCHAMBAULT, V , LEPINE, G , KACHANER, D , (2015) UNDERSTANDING THE POLO KINASE MACHINE.ONCOGENE. VOL. 34. ISSUE 37. P. 4799 -4807 84 72% 19
7 LIU, XQ , (2015) TARGETING POLO-LIKE KINASES: A PROMISING THERAPEUTIC APPROACH FOR CANCER TREATMENT.TRANSLATIONAL ONCOLOGY. VOL. 8. ISSUE 3. P. 185 -195 66 87% 23
8 LIU, ZX , SUN, QR , WANG, XS , (2017) PLK1, A POTENTIAL TARGET FOR CANCER THERAPY.TRANSLATIONAL ONCOLOGY. VOL. 10. ISSUE 1. P. 22 -32 96 77% 0
9 HELMKE, C , BECKER, S , STREBHARDT, K , (2016) THE ROLE OF PLK3 IN ONCOGENESIS.ONCOGENE. VOL. 35. ISSUE 2. P. 135 -147 84 62% 6
10 YIM, H , ERIKSON, RL , (2014) PLK1-TARGETED THERAPIES IN TP53-OR RAS-MUTATED CANCER.MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. VOL. 761. ISSUE . P. 31 -39 86 84% 4

Classes with closest relation at Level 1


Rank Class id link
1 6479 AURORA KINASE//AURORA A//AURORA KINASE INHIBITOR
2 3081 CENTROSOME//CENTRIOLE//GAMMA TUBULIN
3 1972 SPINDLE ASSEMBLY CHECKPOINT//MAD2//CDC20
4 10900 CYTOKINESIS//CENTRAL SPINDLE//CENTRALSPINDLIN
5 24379 NEK2//NIMA//NEK6
6 2551 MPF//CDC2//GREATWALL
7 8368 CDC14//CYTOKINESIS//FISSION YEAST
8 15937 CDC25B//CDC25 PHOSPHATASE//CDC25A
9 23620 KINESIN SPINDLE PROTEIN//EG5//KSP
10 28520 MAP4K4//TNIK//MST3

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