Class information for:
Level 1: KINESIN SPINDLE PROTEIN//EG5//KSP

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23620 340 38.8 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
365 3       MICROTUBULES//MITOSIS//KINETOCHORE 34118
540 2             KINETOCHORE//MITOSIS//CENTROSOME 14738
23620 1                   KINESIN SPINDLE PROTEIN//EG5//KSP 340

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KINESIN SPINDLE PROTEIN authKW 3176734 11% 91% 39
2 EG5 authKW 2414181 15% 54% 50
3 KSP authKW 1642199 9% 57% 32
4 KSP INHIBITORS authKW 1277284 5% 89% 16
5 MITOTIC KINESIN authKW 926446 4% 74% 14
6 ISPINESIB authKW 905575 3% 92% 11
7 EG5 INHIBITOR authKW 638642 2% 89% 8
8 KIF14 authKW 559575 3% 69% 9
9 KINESIN SPINDLE PROTEIN INHIBITOR authKW 538856 2% 100% 6
10 SB743921 authKW 538856 2% 100% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2143 24% 0% 81
2 Oncology 1261 32% 0% 110
3 Biochemistry & Molecular Biology 213 24% 0% 82
4 Pharmacology & Pharmacy 171 15% 0% 52
5 Chemistry, Organic 168 11% 0% 39
6 Cell Biology 106 11% 0% 37
7 Crystallography 57 4% 0% 14
8 Biophysics 11 3% 0% 11
9 Urology & Nephrology 6 2% 0% 7
10 Biochemical Research Methods 5 2% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR SAFETY 179619 1% 100% 2
2 MOL MOTOR 179619 1% 100% 2
3 ORGAN MED SYNTH LASOM 179619 1% 100% 2
4 MOL MOTORS 101032 1% 38% 3
5 ANIM CELL SYST 89809 0% 100% 1
6 BIOANALIT MEDICAMENTOS CBIM 89809 0% 100% 1
7 BIOCHEMMINIST EDUC 89809 0% 100% 1
8 BIOL STRUCT JEAN PIERRE EBEL MOTEURS MOL 89809 0% 100% 1
9 BIOL STRUCTJPEBEL PROT CYTOSQUELETTE 89809 0% 100% 1
10 BIOL STRUCTLMM 89809 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INVESTIGATIONAL NEW DRUGS 4245 3% 0% 11
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1403 6% 0% 20
3 EXPERT OPINION ON THERAPEUTIC PATENTS 1001 1% 0% 5
4 CURRENT TOPICS IN MEDICINAL CHEMISTRY 983 1% 0% 5
5 JOURNAL OF MEDICINAL CHEMISTRY 801 4% 0% 14
6 MOLECULAR CANCER THERAPEUTICS 785 2% 0% 6
7 BIOORGANIC & MEDICINAL CHEMISTRY 677 3% 0% 10
8 CHEMMEDCHEM 620 1% 0% 4
9 ACS MEDICINAL CHEMISTRY LETTERS 583 1% 0% 3
10 CLINICAL GENITOURINARY CANCER 521 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 KINESIN SPINDLE PROTEIN 3176734 11% 91% 39 Search KINESIN+SPINDLE+PROTEIN Search KINESIN+SPINDLE+PROTEIN
2 EG5 2414181 15% 54% 50 Search EG5 Search EG5
3 KSP 1642199 9% 57% 32 Search KSP Search KSP
4 KSP INHIBITORS 1277284 5% 89% 16 Search KSP+INHIBITORS Search KSP+INHIBITORS
5 MITOTIC KINESIN 926446 4% 74% 14 Search MITOTIC+KINESIN Search MITOTIC+KINESIN
6 ISPINESIB 905575 3% 92% 11 Search ISPINESIB Search ISPINESIB
7 EG5 INHIBITOR 638642 2% 89% 8 Search EG5+INHIBITOR Search EG5+INHIBITOR
8 KIF14 559575 3% 69% 9 Search KIF14 Search KIF14
9 KINESIN SPINDLE PROTEIN INHIBITOR 538856 2% 100% 6 Search KINESIN+SPINDLE+PROTEIN+INHIBITOR Search KINESIN+SPINDLE+PROTEIN+INHIBITOR
10 SB743921 538856 2% 100% 6 Search SB743921 Search SB743921

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PEREZ-MELERO, C , (2014) KSP INHIBITORS AS ANTIMITOTIC AGENTS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 20. P. 2286 -2311 122 71% 5
2 EL-NASSAN, HB , (2013) ADVANCES IN THE DISCOVERY OF KINESIN SPINDLE PROTEIN (EG5) INHIBITORS AS ANTITUMOR AGENTS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 62. ISSUE . P. 614 -631 103 67% 34
3 JIANG, C , YOU, QD , (2013) KINESIN SPINDLE PROTEIN INHIBITORS IN CANCER: A PATENT REVIEW (2008-PRESENT).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 23. ISSUE 12. P. 1547-1560 53 85% 5
4 MYERS, SM , COLLINS, I , (2016) RECENT FINDINGS AND FUTURE DIRECTIONS FOR INTERPOLAR MITOTIC KINESIN INHIBITORS IN CANCER THERAPY.FUTURE MEDICINAL CHEMISTRY. VOL. 8. ISSUE 4. P. 463 -489 62 63% 0
5 KNIGHT, SD , PARRISH, CA , (2008) RECENT PROGRESS IN THE IDENTIFICATION AND CLINICAL EVALUATION OF INHIBITORS OF THE MITOTIC KINESIN KSP.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 8. ISSUE 10. P. 888 -904 36 82% 34
6 JIANG, C , ZHANG, XJ , SHEN, Z , YOU, QD , (2010) KINESIN SPINDLE PROTEIN INHIBITORS.PROGRESS IN CHEMISTRY. VOL. 22. ISSUE 1. P. 153-162 33 85% 1
7 ZHAO, GD , WAN, RZ , LIU, ZP , (2014) DEVELOPMENTS OF KINESIN SPINDLE PROTEIN INHIBITORS AS ANTITUMOR AGENTS BASED ON THE FIVE-MEMBERED HETEROCYCLE SCAFFOLDS.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 23. P. 2691 -2701 30 77% 3
8 HUSZAR, D , THEOCLITOU, ME , SKOLNIK, J , HERBST, R , (2009) KINESIN MOTOR PROTEINS AS TARGETS FOR CANCER THERAPY.CANCER AND METASTASIS REVIEWS. VOL. 28. ISSUE 1-2. P. 197 -208 37 51% 103
9 YOU, QD , LIU, F , WU, WT , GUO, QL , CHERN, J , YANG, L , CHEN, ML , JIANG, C , (2009) DESIGN, SYNTHESIS AND EVALUATION OF TETRAHYDROISOQUINOLINES AS NEW KINESIN SPINDLE PROTEIN INHIBITORS.CHEMICAL & PHARMACEUTICAL BULLETIN. VOL. 57. ISSUE 6. P. 567 -571 26 84% 5
10 INFANTE, JR , PATNAIK, A , VERSCHRAEGEN, CF , OLSZANSKI, AJ , SHAHEEN, M , BURRIS, HA , TOLCHER, AW , PAPADOPOULOS, KP , BEERAM, M , HYNES, SM , ET AL (2017) TWO PHASE 1 DOSE-ESCALATION STUDIES EXPLORING MULTIPLE REGIMENS OF LITRONESIB (LY2523355), AN EG5 INHIBITOR, IN PATIENTS WITH ADVANCED CANCER.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 79. ISSUE 2. P. 315 -326 23 79% 0

Classes with closest relation at Level 1


Rank Class id link
1 3255 KINESIN//MOLECULAR MOTORS//AXONS AND DENDRITES
2 1570 EB1//MICROTUBULES//CHROMOSOME MOVEMENT
3 4975 BIGINELLI REACTION//DIHYDROPYRIMIDINONES//3 4 DIHYDROPYRIMIDIN 21H ONES
4 1972 SPINDLE ASSEMBLY CHECKPOINT//MAD2//CDC20
5 6479 AURORA KINASE//AURORA A//AURORA KINASE INHIBITOR
6 10900 CYTOKINESIS//CENTRAL SPINDLE//CENTRALSPINDLIN
7 24888 CANC VACCINE DEV//INNOVAT CANC THER Y//PERSONALIZED PEPTIDE VACCINE
8 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION
9 11497 POLO LIKE KINASE 1//PLK1//POLO LIKE KINASE
10 5476 COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS

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