Class information for:
Level 1: SITE OF METABOLISM//CYTOCHROME P450//ATYPICAL KINETICS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6572 1468 48.3 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
6572 1                   SITE OF METABOLISM//CYTOCHROME P450//ATYPICAL KINETICS 1468

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SITE OF METABOLISM authKW 153153 1% 82% 9
2 CYTOCHROME P450 authKW 108306 14% 3% 209
3 ATYPICAL KINETICS authKW 84923 0% 58% 7
4 MOLEC EXPTL MED BIOCHEM NX4 address 83196 0% 100% 4
5 HAZARDEXPERT authKW 74279 0% 71% 5
6 COMPUTAT CHEM MOL STRUCT address 66555 0% 80% 4
7 SPECTRAL BINDING authKW 66555 0% 80% 4
8 ACTIVE SITE TOPOLOGY authKW 64993 0% 63% 5
9 HUMAN DRUG METABOLISM authKW 64993 0% 63% 5
10 TYPE II BINDING authKW 64993 0% 63% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 5781 19% 0% 279
2 Pharmacology & Pharmacy 4408 33% 0% 485
3 Biochemistry & Molecular Biology 3657 43% 0% 625
4 Biophysics 2194 15% 0% 217
5 Toxicology 1758 11% 0% 161
6 Computer Science, Interdisciplinary Applications 1614 9% 0% 139
7 Chemistry, Multidisciplinary 457 14% 0% 207
8 Mathematical & Computational Biology 317 3% 0% 44
9 Computer Science, Information Systems 256 4% 0% 59
10 Biochemical Research Methods 112 4% 0% 57

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLEC EXPTL MED BIOCHEM NX4 83196 0% 100% 4
2 COMPUTAT CHEM MOL STRUCT 66555 0% 80% 4
3 DRUG METAB PHARMACOKINET BIOANALYT CHEM 62391 0% 50% 6
4 CHEM PHARMACOCHEM 49910 0% 40% 6
5 LHASA LTD 43325 0% 42% 5
6 CELL MOL BIOL CORE 41598 0% 100% 2
7 DDS DMPK 41598 0% 100% 2
8 LEAD MOL DESIGN 41598 0% 100% 2
9 LOCAL DISCOVERY DMPK 41598 0% 100% 2
10 PHRD GLOBAL BIOL 41598 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 47525 9% 2% 131
2 JOURNAL OF CHEMICAL INFORMATION AND MODELING 20181 4% 2% 55
3 DRUG METABOLISM REVIEWS 16350 2% 3% 28
4 CURRENT DRUG METABOLISM 14851 2% 3% 28
5 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 11669 7% 1% 98
6 CHEMICAL RESEARCH IN TOXICOLOGY 9939 3% 1% 50
7 XENOBIOTICA 9878 3% 1% 43
8 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 6737 2% 1% 24
9 MOLECULAR INFORMATICS 6077 1% 2% 12
10 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 5377 1% 1% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SITE OF METABOLISM 153153 1% 82% 9 Search SITE+OF+METABOLISM Search SITE+OF+METABOLISM
2 CYTOCHROME P450 108306 14% 3% 209 Search CYTOCHROME+P450 Search CYTOCHROME+P450
3 ATYPICAL KINETICS 84923 0% 58% 7 Search ATYPICAL+KINETICS Search ATYPICAL+KINETICS
4 HAZARDEXPERT 74279 0% 71% 5 Search HAZARDEXPERT Search HAZARDEXPERT
5 SPECTRAL BINDING 66555 0% 80% 4 Search SPECTRAL+BINDING Search SPECTRAL+BINDING
6 ACTIVE SITE TOPOLOGY 64993 0% 63% 5 Search ACTIVE+SITE+TOPOLOGY Search ACTIVE+SITE+TOPOLOGY
7 HUMAN DRUG METABOLISM 64993 0% 63% 5 Search HUMAN+DRUG+METABOLISM Search HUMAN+DRUG+METABOLISM
8 TYPE II BINDING 64993 0% 63% 5 Search TYPE+II+BINDING Search TYPE+II+BINDING
9 BURIED ACTIVE SITE 62397 0% 100% 3 Search BURIED+ACTIVE+SITE Search BURIED+ACTIVE+SITE
10 CYP2B4 62391 0% 50% 6 Search CYP2B4 Search CYP2B4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SEVRIOUKOVA, IF , POULOS, TL , (2015) CURRENT APPROACHES FOR INVESTIGATING AND PREDICTING CYTOCHROME P450 3A4-LIGAND INTERACTIONS.MONOOXYGENASE, PEROXIDASE AND PEROXYGENASE PROPERTIES AND MECHANISMS OF CYTOCHROME P450. VOL. 851. ISSUE . P. 83 -105 90 75% 3
2 OLSEN, L , OOSTENBRINK, C , JORGENSEN, FS , (2015) PREDICTION OF CYTOCHROME P450 MEDIATED METABOLISM.ADVANCED DRUG DELIVERY REVIEWS. VOL. 86. ISSUE . P. 61 -71 80 70% 12
3 NAIR, PC , MCKINNON, RA , MINERS, JO , (2016) CYTOCHROME P450 STRUCTURE-FUNCTION: INSIGHTS FROM MOLECULAR DYNAMICS SIMULATIONS.DRUG METABOLISM REVIEWS. VOL. 48. ISSUE 3. P. 434 -452 80 66% 1
4 HLAVICA, P , (2017) CHALLENGES IN ASSIGNMENT OF ALLOSTERIC EFFECTS IN CYTOCHROME P450-CATALYZED SUBSTRATE OXIDATIONS TO STRUCTURAL DYNAMICS IN THE HEMOPROTEIN ARCHITECTURE.JOURNAL OF INORGANIC BIOCHEMISTRY. VOL. 167. ISSUE . P. 100 -115 90 56% 0
5 KIRCHMAIR, J , WILLIAMSON, MJ , TYZACK, JD , TAN, L , BOND, PJ , BENDER, A , GLEN, RC , (2012) COMPUTATIONAL PREDICTION OF METABOLISM: SITES, PRODUCTS, SAR, P450 ENZYME DYNAMICS, AND MECHANISMS.JOURNAL OF CHEMICAL INFORMATION AND MODELING. VOL. 52. ISSUE 3. P. 617 -648 97 42% 87
6 DE GRAAF, C , VERMEULEN, NPE , FEENSTRA, KA , (2005) CYTOCHROME P450 IN SILICO: AN INTEGRATIVE MODELING APPROACH.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 48. ISSUE 8. P. 2725-2755 100 52% 144
7 DELISLE, RK , OTTEN, J , RHODES, S , (2011) IN SILICO MODELING OF P450 SUBSTRATES, INHIBITORS, ACTIVATORS, AND INDUCERS.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. VOL. 14. ISSUE 5. P. 396-416 89 59% 8
8 DENISOV, IG , FRANK, DJ , SLIGAR, SG , (2009) COOPERATIVE PROPERTIES OF CYTOCHROMES P450.PHARMACOLOGY & THERAPEUTICS. VOL. 124. ISSUE 2. P. 151 -167 98 52% 38
9 STJERNSCHANTZ, E , VERMEULEN, NPE , OOSTENBRINK, C , (2008) COMPUTATIONAL PREDICTION OF DRUG BINDING AND RATIONALISATION OF SELECTIVITY TOWARDS CYTOCHROMES P450.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 4. ISSUE 5. P. 513 -527 77 66% 37
10 DONG, D , WU, BJ , CHOW, D , HU, M , (2012) SUBSTRATE SELECTIVITY OF DRUG-METABOLIZING CYTOCHROME P450S PREDICTED FROM CRYSTAL STRUCTURES AND IN SILICO MODELING.DRUG METABOLISM REVIEWS. VOL. 44. ISSUE 2. P. 192 -208 60 74% 15

Classes with closest relation at Level 1


Rank Class id link
1 3305 P450BM 3//CYTOCHROME P450CAM//CYTOCHROME P450 BM3
2 10330 CYTOCHROME P450 REDUCTASE//CYTOCHROME P4502B4//NADPH CYTOCHROME P450 REDUCTASE
3 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A
4 8052 COMPOUND I//LISE MEITNER MINERVA COMPUTAT QUANTUM CHEM//MULTIPLE OXIDANTS
5 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
6 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
7 12542 REACTIVE METABOLITES//METABOLITE IDENTIFICATION//PHARMACOKINET DYNAM METAB
8 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM
9 17456 N ALKYLPROTOPORPHYRIN//N ALKYLPROTOPORPHYRIN IX//TAPE PORPHYRIN
10 6598 CYP2A6//COTININE//CYP2A5

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