Class information for:
Level 1: CYTOCHROME P450 REDUCTASE//CYTOCHROME P4502B4//NADPH CYTOCHROME P450 REDUCTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10330 1073 38.2 55%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
415 2             CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR 16559
10330 1                   CYTOCHROME P450 REDUCTASE//CYTOCHROME P4502B4//NADPH CYTOCHROME P450 REDUCTASE 1073

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYTOCHROME P450 REDUCTASE authKW 250842 3% 28% 31
2 CYTOCHROME P4502B4 authKW 157592 1% 46% 12
3 NADPH CYTOCHROME P450 REDUCTASE authKW 154884 3% 19% 28
4 CYTOCHROME B5 authKW 105911 3% 10% 36
5 P450 P450 INTERACTIONS authKW 85369 0% 100% 3
6 AH RECEPTOR NUCLEAR TRANSLOCATION authKW 56913 0% 100% 2
7 BIOSPECIFIC FISHING authKW 56913 0% 100% 2
8 CYTOCHROME P 450LM4 authKW 56913 0% 100% 2
9 FORM 1A2 authKW 56913 0% 100% 2
10 HYDROPHOBIC DOMAIN OF MEMBRANE BINDING ENZYMES authKW 56913 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 9605 76% 0% 813
2 Biophysics 5480 26% 0% 282
3 Pharmacology & Pharmacy 218 11% 0% 116
4 Toxicology 200 5% 0% 52
5 Cell Biology 107 7% 0% 77
6 Biochemical Research Methods 50 3% 0% 35
7 Entomology 7 1% 0% 12
8 Endocrinology & Metabolism 2 2% 0% 21
9 Spectroscopy 2 1% 0% 12
10 Architecture 2 0% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CEA GRENOBLEDBMSCBCNRS 37940 0% 67% 2
2 ARTMENT CHEM BIOCHEM 28456 0% 100% 1
3 BIOCHEM 7760 28456 0% 100% 1
4 BIOL JOINT PROGRAM BIOCHEM 28456 0% 100% 1
5 BLUEGRASS COMMUNITY TECH 28456 0% 100% 1
6 CANC UK TRANSGEN SERV 28456 0% 100% 1
7 CBCRBDBMS 28456 0% 100% 1
8 CEA GRENOBLE REDOX BIOL CHIM BIOCHEM 28456 0% 100% 1
9 CEA GRENOBLEDBMSCBCRB 28456 0% 100% 1
10 CNRS 5047 28456 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 13511 8% 1% 90
2 BIOCHEMISTRY 5796 10% 0% 105
3 BIOCHEMISTRY-MOSCOW 5336 3% 1% 37
4 BIOLOGICHESKIE MEMBRANY 3823 2% 1% 19
5 BIOMEDICA BIOCHIMICA ACTA 2688 1% 1% 14
6 DRUG METABOLISM REVIEWS 2301 1% 1% 9
7 BIOCHIMICA ET BIOPHYSICA ACTA 2221 4% 0% 48
8 DRUG METABOLISM AND DISPOSITION 1970 2% 0% 23
9 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1923 6% 0% 69
10 JOURNAL OF BIOLOGICAL CHEMISTRY 1796 9% 0% 101

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYTOCHROME P450 REDUCTASE 250842 3% 28% 31 Search CYTOCHROME+P450+REDUCTASE Search CYTOCHROME+P450+REDUCTASE
2 CYTOCHROME P4502B4 157592 1% 46% 12 Search CYTOCHROME+P4502B4 Search CYTOCHROME+P4502B4
3 NADPH CYTOCHROME P450 REDUCTASE 154884 3% 19% 28 Search NADPH+CYTOCHROME+P450+REDUCTASE Search NADPH+CYTOCHROME+P450+REDUCTASE
4 CYTOCHROME B5 105911 3% 10% 36 Search CYTOCHROME+B5 Search CYTOCHROME+B5
5 P450 P450 INTERACTIONS 85369 0% 100% 3 Search P450+P450+INTERACTIONS Search P450+P450+INTERACTIONS
6 AH RECEPTOR NUCLEAR TRANSLOCATION 56913 0% 100% 2 Search AH+RECEPTOR+NUCLEAR+TRANSLOCATION Search AH+RECEPTOR+NUCLEAR+TRANSLOCATION
7 BIOSPECIFIC FISHING 56913 0% 100% 2 Search BIOSPECIFIC+FISHING Search BIOSPECIFIC+FISHING
8 CYTOCHROME P 450LM4 56913 0% 100% 2 Search CYTOCHROME+P+450LM4 Search CYTOCHROME+P+450LM4
9 FORM 1A2 56913 0% 100% 2 Search FORM+1A2 Search FORM+1A2
10 HYDROPHOBIC DOMAIN OF MEMBRANE BINDING ENZYMES 56913 0% 100% 2 Search HYDROPHOBIC+DOMAIN+OF+MEMBRANE+BINDING+ENZYMES Search HYDROPHOBIC+DOMAIN+OF+MEMBRANE+BINDING+ENZYMES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 REED, JR , BACKES, WL , (2012) FORMATION OF P450 . P450 COMPLEXES AND THEIR EFFECT ON P450 FUNCTION.PHARMACOLOGY & THERAPEUTICS. VOL. 133. ISSUE 3. P. 299-310 51 78% 18
2 BACKES, WL , KELLEY, RW , (2003) ORGANIZATION OF MULTIPLE CYTOCHROME P450S WITH NADPH-CYTOCHROME P450 REDUCTASE IN MEMBRANES.PHARMACOLOGY & THERAPEUTICS. VOL. 98. ISSUE 2. P. 221-233 53 90% 89
3 DAVYDOV, DR , (2011) MICROSOMAL MONOOXYGENASE AS A MULTIENZYME SYSTEM: THE ROLE OF P450-P450 INTERACTIONS.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 7. ISSUE 5. P. 543 -558 71 56% 21
4 HLAVICA, P , (2015) MECHANISTIC BASIS OF ELECTRON TRANSFER TO CYTOCHROMES P450 BY NATURAL REDOX PARTNERS AND ARTIFICIAL DONOR CONSTRUCTS.MONOOXYGENASE, PEROXIDASE AND PEROXYGENASE PROPERTIES AND MECHANISMS OF CYTOCHROME P450. VOL. 851. ISSUE . P. 247 -297 123 28% 0
5 REED, JR , BACKES, WL , (2017) PHYSICAL STUDIES OF P450-P450 INTERACTIONS: PREDICTING QUATERNARY STRUCTURES OF P450 COMPLEXES IN MEMBRANES FROM THEIR X-RAY CRYSTAL STRUCTURES.FRONTIERS IN PHARMACOLOGY. VOL. 8. ISSUE . P. - 54 55% 0
6 KANDEL, SE , LAMPE, JN , (2014) ROLE OF PROTEIN-PROTEIN INTERACTIONS IN CYTOCHROME P450-MEDIATED DRUG METABOLISM AND TOXICITY.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 27. ISSUE 9. P. 1474 -1486 63 42% 20
7 ZHANG, HM , HAMDANE, D , IM, SC , WASKELL, L , (2008) CYTOCHROME B(5) INHIBITS ELECTRON TRANSFER FROM NADPH-CYTOCHROME P450 REDUCTASE TO FERRIC CYTOCHROME P4502B4.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 283. ISSUE 9. P. 5217-5225 35 92% 19
8 REED, JR , CONNICK, JP , CHENG, DM , CAWLEY, GF , BACKES, WL , (2012) EFFECT OF HOMOMERIC P450-P450 COMPLEXES ON P450 FUNCTION.BIOCHEMICAL JOURNAL. VOL. 446. ISSUE . P. 489-497 36 80% 7
9 REED, JR , EYER, M , BACKES, WL , (2010) FUNCTIONAL INTERACTIONS BETWEEN CYTOCHROMES P450 1A2 AND 2B4 REQUIRE BOTH ENZYMES TO RESIDE IN THE SAME PHOSPHOLIPID VESICLE EVIDENCE FOR PHYSICAL COMPLEX FORMATION.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 285. ISSUE 12. P. 8942 -8952 35 83% 13
10 KELLEY, RW , CHENG, DM , BACKES, WL , (2006) HETEROMERIC COMPLEX FORMATION BETWEEN CYP2E1 AND CYP1A2: EVIDENCE FOR THE INVOLVEMENT OF ELECTROSTATIC INTERACTIONS.BIOCHEMISTRY. VOL. 45. ISSUE 51. P. 15807 -15816 36 88% 13

Classes with closest relation at Level 1


Rank Class id link
1 3305 P450BM 3//CYTOCHROME P450CAM//CYTOCHROME P450 BM3
2 14058 CYTOCHROME B5//NADH CYTOCHROME B5 REDUCTASE//CYTOCHROME B5 REDUCTASE
3 6572 SITE OF METABOLISM//CYTOCHROME P450//ATYPICAL KINETICS
4 16549 ADRENODOXIN//CYTOCHROME P450SCC//ADRENODOXIN REDUCTASE
5 10101 ANTLEY BIXLER SYNDROME//ADRENARCHE//17 ALPHA HYDROXYLASE DEFICIENCY
6 1927 CYTOCHROME P450//S BIOCHEM//ONE DAY TREATMENT
7 19686 CINNAMATE 4 HYDROXYLASE//ENZYMOL CELLULAIRE MOL//TULIPA FOSTERIANA
8 10357 CHLORZOXAZONE//CYP2E1//6 HYDROXYCHLORZOXAZONE
9 34996 ACTIVE CENTER ANALOGS OF SUPEROXIDE DISMUTASE//COFPLATON//COFPROPAMINE
10 8052 COMPOUND I//LISE MEITNER MINERVA COMPUTAT QUANTUM CHEM//MULTIPLE OXIDANTS

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