Class information for:
Level 2: THIAZOLIDINEDIONES//PPAR GAMMA//ROSIGLITAZONE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1300 8578 45.3 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
66 3       LEPTIN//ADIPONECTIN//ENDOCRINOLOGY & METABOLISM 84415
1300 2             THIAZOLIDINEDIONES//PPAR GAMMA//ROSIGLITAZONE 8578
3093 1                   PIOGLITAZONE//THIAZOLIDINEDIONES//ROSIGLITAZONE 2068
3123 1                   PPAR DELTA//PPAR BETA DELTA//PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 2060
5985 1                   15D PGJ2//15 DEOXY DELTA12 14 PROSTAGLANDIN J2//CYCLOPENTENONE PROSTAGLANDINS 1547
9168 1                   PPAR GAMMA//PPAR RESEARCH//TROGLITAZONE 1182
13971 1                   PRO12ALA POLYMORPHISM//PRO12ALA//PPAR GAMMA 2 801
15078 1                   TROGLITAZONE//JTT 501//CS 045 732
29356 1                   REPROD METAB//ADIPQ//AIB3 188

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THIAZOLIDINEDIONES authKW 1168075 8% 50% 657
2 PPAR GAMMA authKW 876419 9% 32% 774
3 ROSIGLITAZONE authKW 790211 6% 43% 513
4 PIOGLITAZONE authKW 780932 6% 43% 505
5 TROGLITAZONE authKW 554490 3% 57% 273
6 PPAR RESEARCH journal 511736 3% 54% 265
7 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA authKW 447294 4% 34% 368
8 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR authKW 437116 4% 33% 369
9 PPAR authKW 371961 4% 32% 332
10 PPAR DELTA authKW 197638 1% 59% 94

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Endocrinology & Metabolism 16992 18% 0% 1542
2 Pharmacology & Pharmacy 5415 17% 0% 1439
3 Chemistry, Medicinal 4827 8% 0% 661
4 Medicine, Research & Experimental 3338 8% 0% 723
5 Peripheral Vascular Diseases 2347 6% 0% 478
6 Biochemistry & Molecular Biology 1961 17% 0% 1436
7 Cell Biology 1436 9% 0% 739
8 Oncology 945 8% 0% 650
9 Cardiac & Cardiovascular System 802 5% 0% 439
10 Biophysics 363 4% 0% 301

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ATHEROSCLEROSE 85787 1% 31% 78
2 MOL TOXICOL CARCINOGENESIS 50681 1% 22% 65
3 FRONTIERS GENET 38376 0% 35% 31
4 U545 36184 1% 23% 44
5 U325 21044 0% 22% 27
6 REPROD METAB 20719 0% 45% 13
7 NUCL RECEPTOR DISCOVERY 18015 0% 30% 17
8 INTEGRAT GENOM 16544 1% 7% 69
9 LBRE 16007 0% 75% 6
10 VASC DIS PREVENT PROGRAM 14227 0% 67% 6

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PPAR RESEARCH 511736 3% 54% 265
2 DIABETES OBESITY & METABOLISM 12366 1% 4% 88
3 METABOLISM-CLINICAL AND EXPERIMENTAL 5308 1% 1% 117
4 DIABETES 5024 2% 1% 133
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3941 2% 1% 173
6 DIABETES CARE 3521 1% 1% 109
7 DIABETES & VASCULAR DISEASE RESEARCH 2519 0% 4% 17
8 DIABETIC MEDICINE 2294 1% 1% 62
9 DIABETOLOGIA 2156 1% 1% 73
10 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2145 1% 1% 69

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THIAZOLIDINEDIONES 1168075 8% 50% 657 Search THIAZOLIDINEDIONES Search THIAZOLIDINEDIONES
2 PPAR GAMMA 876419 9% 32% 774 Search PPAR+GAMMA Search PPAR+GAMMA
3 ROSIGLITAZONE 790211 6% 43% 513 Search ROSIGLITAZONE Search ROSIGLITAZONE
4 PIOGLITAZONE 780932 6% 43% 505 Search PIOGLITAZONE Search PIOGLITAZONE
5 TROGLITAZONE 554490 3% 57% 273 Search TROGLITAZONE Search TROGLITAZONE
6 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 447294 4% 34% 368 Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+GAMMA Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR+GAMMA
7 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 437116 4% 33% 369 Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR Search PEROXISOME+PROLIFERATOR+ACTIVATED+RECEPTOR
8 PPAR 371961 4% 32% 332 Search PPAR Search PPAR
9 PPAR DELTA 197638 1% 59% 94 Search PPAR+DELTA Search PPAR+DELTA
10 15D PGJ2 172469 1% 65% 75 Search 15D+PGJ2 Search 15D+PGJ2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PETERS, JM , SHAH, YM , GONZALEZ, FJ , (2012) THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN CARCINOGENESIS AND CHEMOPREVENTION.NATURE REVIEWS CANCER. VOL. 12. ISSUE 3. P. 181 -195 170 77% 115
2 PIRAT, C , FARCE, A , LEBEGUE, N , RENAULT, N , FURMAN, C , MILLET, R , YOUS, S , SPECA, S , BERTHELOT, P , DESREUMAUX, P , ET AL (2012) TARGETING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARS): DEVELOPMENT OF MODULATORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 9. P. 4027 -4061 156 92% 55
3 CHO, N , MOMOSE, Y , (2008) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONISTS AS INSULIN SENSITIZERS: FROM THE DISCOVERY TO RECENT PROGRESS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 8. ISSUE 17. P. 1483 -1507 191 82% 47
4 MENENDEZ-GUTIERREZ, MP , ROSZER, T , RICOTE, M , (2012) BIOLOGY AND THERAPEUTIC APPLICATIONS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 12. ISSUE 6. P. 548 -584 242 59% 16
5 MICHALIK, L , AUWERX, J , BERGER, JP , CHATTERJEE, VK , GLASS, CK , GONZALEZ, FJ , GRIMALDI, PA , KADOWAKI, T , LAZAR, MA , O'RAHILLY, S , ET AL (2006) INTERNATIONAL UNION OF PHARMACOLOGY. LXI. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 58. ISSUE 4. P. 726-741 174 62% 418
6 HAMBLIN, M , CHANG, L , FAN, YB , ZHANG, JF , CHEN, YE , (2009) PPARS AND THE CARDIOVASCULAR SYSTEM.ANTIOXIDANTS & REDOX SIGNALING. VOL. 11. ISSUE 6. P. 1415 -1452 232 58% 72
7 WILLSON, TM , BROWN, PJ , STERNBACH, DD , HENKE, BR , (2000) THE PPARS: FROM ORPHAN RECEPTORS TO DRUG DISCOVERY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 43. ISSUE 4. P. 527 -550 168 56% 1213
8 NEELS, JG , GRIMALDI, PA , (2014) PHYSIOLOGICAL FUNCTIONS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA.PHYSIOLOGICAL REVIEWS. VOL. 94. ISSUE 3. P. 795 -858 251 39% 33
9 HE, WM , (2009) PPAR GAMMA 2(PRO12ALA) POLYMORPHISM AND HUMAN HEALTH.PPAR RESEARCH. VOL. . ISSUE . P. - 163 77% 26
10 KOSTAPANOS, MS , ELISAF, MS , MIKHAILIDIS, DP , (2013) PIOGLITAZONE AND CANCER: ANGEL OR DEMON?.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 27. P. 4913-4929 156 73% 11

Classes with closest relation at Level 2


Rank Class id link
1 2370 FAT GRAFTING//ADIPOGENESIS//ADIPOCYTE DIFFERENTIATION
2 1896 METFORMIN//ACARBOSE//REPAGLINIDE
3 4149 BETATROPHIN//ANGPTL4//ANGIOPOIETIN LIKE PROTEIN 2
4 1356 PEROXISOME//ADRENOLEUKODYSTROPHY//ZELLWEGER SYNDROME
5 2654 NURR1//NUR77//PGC 1 ALPHA
6 2692 FATTY ACID BINDING PROTEIN//CD36//FABP
7 3080 CONJUGATED LINOLEIC ACID//CLA//CONJUGATED LINOLEIC ACID CLA
8 2141 FATTY ACID SYNTHASE//LIVER X RECEPTOR//LXR
9 2305 CYCLOOXYGENASE 2//COX 2//CELECOXIB
10 1167 GLUCAGON LIKE PEPTIDE 1//GLP 1//INCRETIN

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