Class information for:
Level 2: CYCLOOXYGENASE 2//COX 2//CELECOXIB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2305 4519 44.4 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
2305 2             CYCLOOXYGENASE 2//COX 2//CELECOXIB 4519
180 1                   CYCLOOXYGENASE 2//COX 2//CELECOXIB 4006
23913 1                   PTGS2//CYCLOOXYGENASE 2 GENE//COX 2 POLYMORPHISM 330
34596 1                   CYCLOOXYGENASE 1 INHIBITOR//ANTIOXIDANT DEFENSE MECHANISM//BIOMED NETWORK HEPAT DIGEST DIS 109
36785 1                   GRAPTOPETALUM PARAGUAYENSE E WALTHER//GRAPTOPETALUM PARAGUAYENSE//3 HYDROXYL 3 METHYLGLUTAROYL HMG 74

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYCLOOXYGENASE 2 authKW 813575 14% 19% 648
2 COX 2 authKW 669173 12% 18% 562
3 CELECOXIB authKW 478252 7% 22% 316
4 SULINDAC authKW 198767 2% 35% 83
5 NSAIDS authKW 133628 6% 8% 263
6 CYCLOOXYGENASE authKW 125162 6% 7% 254
7 ASPIRIN authKW 119541 7% 6% 311
8 COX 2 INHIBITORS authKW 90599 2% 15% 92
9 CHEMOPREVENTION authKW 85036 5% 6% 221
10 NS 398 authKW 79197 1% 27% 44

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 41886 50% 0% 2248
2 Gastroenterology & Hepatology 4201 10% 0% 447
3 Pathology 955 5% 0% 216
4 Cell Biology 566 8% 0% 351
5 Medicine, Research & Experimental 532 5% 0% 236
6 Pharmacology & Pharmacy 522 9% 0% 402
7 Biochemistry & Molecular Biology 131 10% 0% 430
8 Medicine, General & Internal 105 4% 0% 183
9 Public, Environmental & Occupational Health 101 3% 0% 154
10 Urology & Nephrology 74 2% 0% 89

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADV MICROSCOP DIS 20266 0% 100% 3
2 GASTROINTESTINAL OTHER CANC GRP 19641 0% 36% 8
3 HANGZHOU HOSP 15119 0% 20% 11
4 CANC PREVENT 14850 2% 2% 93
5 INTEGRATED CANC PREVENT 14078 0% 17% 12
6 CLIN CANC PREVENT 236 13510 0% 100% 2
7 DEFINED TUMOR MARKER EVALUAT 13510 0% 100% 2
8 EICOSANOIDS TUMOR DEV SECT 13510 0% 100% 2
9 GASTROINTESTINAL OTHER CANCERS GRP 13510 0% 100% 2
10 PROGRAMA DOCTORADO MORFOL 13510 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER PREVENTION RESEARCH 13179 1% 4% 49
2 CANCER RESEARCH 6313 4% 1% 195
3 PROGRESS IN EXPERIMENTAL TUMOR RESEARCH 5386 0% 6% 13
4 CARCINOGENESIS 5217 2% 1% 96
5 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 5147 2% 1% 70
6 CLINICAL CANCER RESEARCH 4396 2% 1% 100
7 ONCOLOGY REPORTS 3915 2% 1% 77
8 ANTICANCER RESEARCH 3173 2% 1% 97
9 INTERNATIONAL JOURNAL OF CANCER 2934 2% 0% 96
10 BRITISH JOURNAL OF CANCER 2911 2% 1% 90

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYCLOOXYGENASE 2 813575 14% 19% 648 Search CYCLOOXYGENASE+2 Search CYCLOOXYGENASE+2
2 COX 2 669173 12% 18% 562 Search COX+2 Search COX+2
3 CELECOXIB 478252 7% 22% 316 Search CELECOXIB Search CELECOXIB
4 SULINDAC 198767 2% 35% 83 Search SULINDAC Search SULINDAC
5 NSAIDS 133628 6% 8% 263 Search NSAIDS Search NSAIDS
6 CYCLOOXYGENASE 125162 6% 7% 254 Search CYCLOOXYGENASE Search CYCLOOXYGENASE
7 ASPIRIN 119541 7% 6% 311 Search ASPIRIN Search ASPIRIN
8 COX 2 INHIBITORS 90599 2% 15% 92 Search COX+2+INHIBITORS Search COX+2+INHIBITORS
9 CHEMOPREVENTION 85036 5% 6% 221 Search CHEMOPREVENTION Search CHEMOPREVENTION
10 NS 398 79197 1% 27% 44 Search NS+398 Search NS+398

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 THUN, MJ , HENLEY, SJ , PATRONO, C , (2002) NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AS ANTICANCER AGENTS: MECHANISTIC, PHARMACOLOGIC, AND CLINICAL ISSUES.JOURNAL OF THE NATIONAL CANCER INSTITUTE. VOL. 94. ISSUE 4. P. 252 -266 132 71% 850
2 BENAMOUZIG, R , UZZAN, B , LITTLE, J , CHAUSSADE, S , (2005) LOW DOSE ASPIRIN, COX-INHIBITION AND CHEMOPREVENTION OF COLORECTAL CANCER.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 5. ISSUE 5. P. 493-503 154 80% 10
3 LIAO, ZX , MASON, KA , MILAS, L , (2007) CYCLO-OXYGENASE-2 AND ITS INHIBITION IN CANCER - IS THERE A ROLE?.DRUGS. VOL. 67. ISSUE 6. P. 821 -845 149 72% 47
4 UMAR, A , VINER, JL , ANDERSON, WF , HAWK, ET , (2003) DEVELOPMENT OF COX INHIBITORS IN CANCER PREVENTION AND THERAPY.AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS. VOL. 26. ISSUE 4. P. S48-S57 152 84% 18
5 ANDERSON, WF , UMAR, A , VINER, JL , HAWK, ET , (2002) THE ROLE OF CYCLOOXYGENASE INHIBITORS IN CANCER PREVENTION.CURRENT PHARMACEUTICAL DESIGN. VOL. 8. ISSUE 12. P. 1035 -1062 193 65% 48
6 BOSETTI, C , ROSATO, V , GALLUS, S , CUZICK, J , LA VECCHIA, C , (2012) ASPIRIN AND CANCER RISK: A QUANTITATIVE REVIEW TO 2011.ANNALS OF ONCOLOGY. VOL. 23. ISSUE 6. P. 1403-1415 82 79% 111
7 BROWN, JR , DUBOIS, RN , (2005) COX-2: A MOLECULAR TARGET FOR COLORECTAL CANCER PREVENTION.JOURNAL OF CLINICAL ONCOLOGY. VOL. 23. ISSUE 12. P. 2840-2855 115 61% 289
8 HARRIS, RE , BEEBE-DONK, J , DOSS, H , DOSS, DB , (2005) ASPIRIN, IBUPROFEN, AND OTHER NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN CANCER PREVENTION: A CRITICAL REVIEW OF NON-SELECTIVE COX-2 BLOCKADE (REVIEW).ONCOLOGY REPORTS. VOL. 13. ISSUE 4. P. 559-583 125 58% 213
9 SUBONGKOT, S , FRAME, D , LESLIE, W , DRAJEEER, D , (2003) SELECTIVE CYCLOOXYGENASE-2 INHIBITION: A TARGET IN CANCER PREVENTION AND TREATMENT.PHARMACOTHERAPY. VOL. 23. ISSUE 1. P. 9-28 131 72% 26
10 ONGURU, O , CASEY, MB , KAJITA, S , NAKAMURA, N , LLOYD, RV , (2005) CYCLOOXYGENASE-2 AND THROMBOXANE SYNTHASE IN NON-ENDOCRINE AND ENDOCRINE TUMORS: A REVIEW.ENDOCRINE PATHOLOGY. VOL. 16. ISSUE 4. P. 253-277 114 78% 15

Classes with closest relation at Level 2


Rank Class id link
1 466 NSAIDS//NON STEROIDAL ANTI INFLAMMATORY DRUGS//COX 2 INHIBITORS
2 1311 PROSTAGLANDIN D 2//CRTH2//MOL BEHAV BIOL
3 2474 ABERRANT CRYPT FOCI//ANTINEOPLASTIC DRUGS//COLON CARCINOGENESIS
4 2447 DYSFIBRINOGENEMIA//AFIBRINOGENEMIA//FIBRINOGEN
5 1071 LYNCH SYNDROME//MICROSATELLITE INSTABILITY//HNPCC
6 1300 THIAZOLIDINEDIONES//PPAR GAMMA//ROSIGLITAZONE
7 3384 CIGARETTE SMOKE//ENVIRONMENTAL CIGARETTE SMOKE//LUNG TUMOR
8 2158 NF KAPPA B//I KAPPA B//IKK
9 1045 BARRETTS ESOPHAGUS//ESOPHAGEAL CANCER//BARRETTS OESOPHAGUS
10 2107 LYMPHANGIOGENESIS//VEGF C//PODOPLANIN

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