Class information for:
Level 1: NIACIN//LAROPIPRANT//GPR109A

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12751 883 40.2 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
171 3       MONASCUS//CITRININ//MONASCUS PURPUREUS 58457
419 2             STATINS//EZETIMIBE//SIMVASTATIN 16502
12751 1                   NIACIN//LAROPIPRANT//GPR109A 883

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NIACIN authKW 2457317 25% 32% 224
2 LAROPIPRANT authKW 1429060 5% 92% 45
3 GPR109A authKW 868990 4% 74% 34
4 NICOTINIC ACID authKW 739424 13% 18% 118
5 EXTENDED RELEASE NIACIN authKW 731707 3% 92% 23
6 HM74A authKW 658663 2% 95% 20
7 NICOTINIC ACID RECEPTOR authKW 314361 1% 91% 10
8 NICOTINURIC ACID authKW 254631 1% 82% 9
9 PUMA G authKW 245900 1% 89% 8
10 HCA2 authKW 201188 1% 73% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cardiac & Cardiovascular System 2065 20% 0% 175
2 Pharmacology & Pharmacy 1440 25% 0% 222
3 Medicine, General & Internal 787 15% 0% 133
4 Peripheral Vascular Diseases 747 9% 0% 81
5 Endocrinology & Metabolism 262 8% 0% 69
6 Chemistry, Medicinal 245 6% 0% 50
7 Medicine, Research & Experimental 109 5% 0% 47
8 Primary Health Care 96 1% 0% 10
9 Nutrition & Dietetics 61 3% 0% 25
10 Biochemistry & Molecular Biology 35 10% 0% 90

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VIS SCI DISCOVERY 69160 0% 100% 2
2 VET AFFAIRS HEALTHCARE SYST 40332 1% 17% 7
3 ACCREDITAT COUNCIL CLIN LIPIDOL CERTIFIED CLIN 34580 0% 100% 1
4 ADIPOSE TISSUE SIGNALING 34580 0% 100% 1
5 ALGEMEEN ZIEKENHUIS STUIVENBERG 34580 0% 100% 1
6 ALLLIED HLTH SCI 34580 0% 100% 1
7 ARBEITSBEREICH LIPISTOFFWECHSEL 34580 0% 100% 1
8 ATORVASTAT CARDIOVASC GRP 34580 0% 100% 1
9 CARDIAC REHABILAT CHOLESTEROL CLIN 34580 0% 100% 1
10 CARDIOVASC DIABETS OBESITY METAB 34580 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CLINICAL LIPIDOLOGY 33202 3% 4% 25
2 EUROPEAN HEART JOURNAL SUPPLEMENTS 5670 1% 1% 13
3 AMERICAN JOURNAL OF CARDIOLOGY 4317 7% 0% 58
4 CURRENT ATHEROSCLEROSIS REPORTS 3332 1% 1% 8
5 INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 2674 2% 0% 18
6 CURRENT OPINION IN LIPIDOLOGY 2592 1% 1% 10
7 CLINICAL LIPIDOLOGY 2253 1% 1% 5
8 ATHEROSCLEROSIS 1689 3% 0% 23
9 AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS 1306 0% 1% 4
10 ARTERY 1036 0% 1% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NIACIN 2457317 25% 32% 224 Search NIACIN Search NIACIN
2 LAROPIPRANT 1429060 5% 92% 45 Search LAROPIPRANT Search LAROPIPRANT
3 GPR109A 868990 4% 74% 34 Search GPR109A Search GPR109A
4 NICOTINIC ACID 739424 13% 18% 118 Search NICOTINIC+ACID Search NICOTINIC+ACID
5 EXTENDED RELEASE NIACIN 731707 3% 92% 23 Search EXTENDED+RELEASE+NIACIN Search EXTENDED+RELEASE+NIACIN
6 HM74A 658663 2% 95% 20 Search HM74A Search HM74A
7 NICOTINIC ACID RECEPTOR 314361 1% 91% 10 Search NICOTINIC+ACID+RECEPTOR Search NICOTINIC+ACID+RECEPTOR
8 NICOTINURIC ACID 254631 1% 82% 9 Search NICOTINURIC+ACID Search NICOTINURIC+ACID
9 PUMA G 245900 1% 89% 8 Search PUMA+G Search PUMA+G
10 HCA2 201188 1% 73% 8 Search HCA2 Search HCA2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 JACOBSON, TA , (2010) A "HOT" TOPIC IN DYSLIPIDEMIA MANAGEMENT-"HOW TO BEAT A FLUSH": OPTIMIZING NIACIN TOLERABILITY TO PROMOTE LONG-TERM TREATMENT ADHERENCE AND CORONARY DISEASE PREVENTION.MAYO CLINIC PROCEEDINGS. VOL. 85. ISSUE 4. P. 365 -379 94 76% 27
2 GOUNI-BERTHOLD, I , BERTHOLD, HK , (2013) THE ROLE OF NIACIN IN LIPID-LOWERING TREATMENT: ARE WE AIMING TOO HIGH?.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 17. P. 3094-3106 87 79% 5
3 OFFERMANNS, S , COLLETTI, SL , LOVENBERG, TW , SEMPLE, G , WISE, A , IJZERMAN, AP , (2011) INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY. LXXXII: NOMENCLATURE AND CLASSIFICATION OF HYDROXY-CARBOXYLIC ACID RECEPTORS (GPR81, GPR109A, AND GPR109B).PHARMACOLOGICAL REVIEWS. VOL. 63. ISSUE 2. P. 269-290 78 71% 46
4 KEI, A , ELISAF, MS , (2012) NICOTINIC ACID: CLINICAL CONSIDERATIONS.EXPERT OPINION ON DRUG SAFETY. VOL. 11. ISSUE 4. P. 551-564 68 81% 7
5 SHEN, HC , COLLETTI, SL , (2010) HIGH-AFFINITY NIACIN RECEPTOR GPR109A AGONISTS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45. VOL. 45. ISSUE . P. 73-+ 54 89% 7
6 KEI, A , LIBEROPOULOS, EN , ELISAF, MS , (2011) WHAT RESTRICTS THE CLINICAL USE OF NICOTINIC ACID?.CURRENT VASCULAR PHARMACOLOGY. VOL. 9. ISSUE 4. P. 521-530 65 67% 1
7 VILLINES, TC , KIM, AS , GORE, RS , TAYLOR, AJ , (2012) NIACIN: THE EVIDENCE, CLINICAL USE, AND FUTURE DIRECTIONS.CURRENT ATHEROSCLEROSIS REPORTS. VOL. 14. ISSUE 1. P. 49-59 51 76% 21
8 TANG, C , OFFERMANNS, S , BLAD, CC , (2012) G PROTEIN-COUPLED RECEPTORS FOR ENERGY METABOLITES AS NEW THERAPEUTIC TARGETS.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 8. P. 603 -619 86 38% 58
9 SONG, WL , FITZGERALD, GA , (2013) THEMATIC REVIEW SERIES: NEW LIPID AND LIPOPROTEIN TARGETS FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES NIACIN, AN OLD DRUG WITH A NEW TWIST.JOURNAL OF LIPID RESEARCH. VOL. 54. ISSUE 10. P. 2586 -2594 59 61% 10
10 LUKASOVA, M , HANSON, J , TUNARU, S , OFFERMANNS, S , (2011) NICOTINIC ACID (NIACIN): NEW LIPID-INDEPENDENT MECHANISMS OF ACTION AND THERAPEUTIC POTENTIALS.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 32. ISSUE 12. P. 700-707 48 74% 32

Classes with closest relation at Level 1


Rank Class id link
1 2661 HIGH DENSITY LIPOPROTEIN//HDL//REVERSE CHOLESTEROL TRANSPORT
2 10374 FENOFIBRATE//FENOFIBRIC ACID//FIBRATES
3 413 STATINS//LOW DENSITY LIPOPROTEIN CHOLESTEROL//ATORVASTATIN
4 22797 ACIPIMOX//BETA PYRIDYLCARBINOL//4 BROMOCROTONIC ACID
5 23440 NICOTINAMIDE N METHYLTRANSFERASE//1 METHYLNICOTINAMIDE//NNMT
6 13608 EZETIMIBE//NPC1L1//CHOLESTEROL ABSORPTION INHIBITOR
7 23438 BILE ACID SEQUESTRANT//COLESEVELAM HCL//COLESEVELAM
8 9257 PRAVASTATIN//HMG COA REDUCTASE INHIBITORS//MEVALONIC ACID
9 22994 DIMETHYL FUMARATE//FUMARIC ACID ESTERS//MONOMETHYL FUMARATE
10 19224 HIGHLAND PSYCHIAT FDN//NIACIN SKIN TEST//NUTR HYG EPIDEMIOL

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