Class information for:
Level 1: CFTR//CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR//CYSTIC FIBROSIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2342 2275 46.0 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
597 3       CYSTIC FIBROSIS//CFTR//JOURNAL OF CYSTIC FIBROSIS 14714
542 2             CYSTIC FIBROSIS//CFTR//JOURNAL OF CYSTIC FIBROSIS 14714
2342 1                   CFTR//CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR//CYSTIC FIBROSIS 2275

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CFTR authKW 1614430 17% 31% 394
2 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR authKW 1087457 10% 35% 229
3 CYSTIC FIBROSIS authKW 510469 26% 6% 589
4 GREGORY FLEMING JAMES CYST FIBROSIS address 483706 4% 45% 81
5 IVACAFTOR authKW 358087 2% 68% 39
6 CHLORIDE CHANNEL authKW 268966 7% 12% 161
7 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR authKW 267848 2% 43% 46
8 POTENTIATOR authKW 224014 2% 45% 37
9 VX 770 authKW 204127 1% 89% 17
10 SC JOHNSON MED address 174676 1% 48% 27

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Physiology 11720 25% 0% 571
2 Cell Biology 5698 27% 0% 605
3 Biochemistry & Molecular Biology 5433 42% 0% 951
4 Respiratory System 3349 10% 0% 238
5 Biophysics 816 8% 0% 179
6 Pharmacology & Pharmacy 294 9% 0% 210
7 Medicine, Research & Experimental 162 4% 0% 99
8 Chemistry, Medicinal 84 3% 0% 59
9 Critical Care Medicine 60 1% 0% 31
10 Biochemical Research Methods 33 2% 0% 52

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GREGORY FLEMING JAMES CYST FIBROSIS 483706 4% 45% 81
2 SC JOHNSON MED 174676 1% 48% 27
3 PROGRAMME MOL STRUCT FUNCT 167227 1% 69% 18
4 CARDIAC MEMBRANE PHYSIOL 120765 1% 50% 18
5 CYST FIBROSIS 102330 4% 9% 84
6 PHYSIOL BIOL CELLULAI 87102 1% 19% 34
7 CYST FIBROSIS TRANSLAT 69017 0% 86% 6
8 MTA SE ION CHANNEL GRP 47927 0% 71% 5
9 BIOFIG BIO ERS FUNCT INTEGRAT GENOM 45092 0% 31% 11
10 CYST FIBROSIS TREATMENT 44925 1% 28% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CYSTIC FIBROSIS 25447 2% 4% 43
2 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 21705 5% 2% 108
3 JOURNAL OF GENERAL PHYSIOLOGY 16013 3% 2% 63
4 PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 7891 3% 1% 70
5 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 6777 2% 1% 54
6 JOURNAL OF BIOLOGICAL CHEMISTRY 6094 12% 0% 268
7 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 5429 2% 1% 37
8 JOURNAL OF MEMBRANE BIOLOGY 4331 2% 1% 39
9 LANCET RESPIRATORY MEDICINE 3263 0% 3% 8
10 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 1888 1% 1% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CFTR 1614430 17% 31% 394 Search CFTR Search CFTR
2 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 1087457 10% 35% 229 Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR
3 CYSTIC FIBROSIS 510469 26% 6% 589 Search CYSTIC+FIBROSIS Search CYSTIC+FIBROSIS
4 IVACAFTOR 358087 2% 68% 39 Search IVACAFTOR Search IVACAFTOR
5 CHLORIDE CHANNEL 268966 7% 12% 161 Search CHLORIDE+CHANNEL Search CHLORIDE+CHANNEL
6 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR 267848 2% 43% 46 Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR+CFTR Search CYSTIC+FIBROSIS+TRANSMEMBRANE+CONDUCTANCE+REGULATOR+CFTR
7 POTENTIATOR 224014 2% 45% 37 Search POTENTIATOR Search POTENTIATOR
8 VX 770 204127 1% 89% 17 Search VX+770 Search VX+770
9 DELTA F508 CFTR 171774 1% 80% 16 Search DELTA+F508+CFTR Search DELTA+F508+CFTR
10 CORRECTOR 156452 2% 27% 44 Search CORRECTOR Search CORRECTOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CALLEBAUT, I , HOFFMANN, B , LEHN, P , MORNON, JP , (2017) MOLECULAR MODELLING AND MOLECULAR DYNAMICS OF CFTR.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 74. ISSUE 1. P. 3 -22 162 82% 0
2 RIORDAN, JR , (2008) CFTR FUNCTION AND PROSPECTS FOR THERAPY.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 77. ISSUE . P. 701-726 110 64% 280
3 LUKACS, GL , VERKMAN, AS , (2012) CFTR: FOLDING, MISFOLDING AND CORRECTING THE DELTA F508 CONFORMATIONAL DEFECT.TRENDS IN MOLECULAR MEDICINE. VOL. 18. ISSUE 2. P. 81 -91 80 84% 107
4 CHIN, S , HUNG, M , BEAR, CE , (2017) CURRENT INSIGHTS INTO THE ROLE OF PKA PHOSPHORYLATION IN CFTR CHANNEL ACTIVITY AND THE PHARMACOLOGICAL RESCUE OF CYSTIC FIBROSIS DISEASE-CAUSING MUTANTS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 74. ISSUE 1. P. 57 -66 93 89% 0
5 PRANKE, IM , SERMET-GAUDELUS, I , (2014) BIOSYNTHESIS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 52. ISSUE . P. 26 -38 110 70% 12
6 ZEGARRA-MORAN, O , GALIETTA, LJV , (2017) CFTR PHARMACOLOGY.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 74. ISSUE 1. P. 117 -128 90 87% 0
7 WANG, YT , WRENNALL, JA , CAI, ZW , LI, HY , SHEPPARD, DN , (2014) UNDERSTANDING HOW CYSTIC FIBROSIS MUTATIONS DISRUPT CFTR FUNCTION: FROM SINGLE MOLECULES TO ANIMAL MODELS.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 52. ISSUE . P. 47 -57 83 77% 26
8 FARINHA, CM , CANATO, S , (2017) FROM THE ENDOPLASMIC RETICULUM TO THE PLASMA MEMBRANE: MECHANISMS OF CFTR FOLDING AND TRAFFICKING.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 74. ISSUE 1. P. 39 -55 95 75% 0
9 CANT, N , POLLOCK, N , FORD, RC , (2014) CFTR STRUCTURE AND CYSTIC FIBROSIS.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 52. ISSUE . P. 15 -25 103 65% 13
10 LOPES-PACHECO, M , (2016) CFTR MODULATORS: SHEDDING LIGHT ON PRECISION MEDICINE FOR CYSTIC FIBROSIS.FRONTIERS IN PHARMACOLOGY. VOL. 7. ISSUE . P. - 119 60% 0

Classes with closest relation at Level 1


Rank Class id link
1 36383 HUMAN MOL GENET PROGRAM//CFTR GENE EXPRESSION//CFTR PROMOTER
2 6126 AIRWAY SURFACE LIQUID//SUBMUCOSAL GLANDS//CYST FIBROSIS PULM TREATMENT
3 11241 CYSTIC FIBROSIS//INFECT CYST FIBROSIS UNIT//ANTI INFLAMMATORY AGENTS ADMINISTRATION DOSAGE ADVERSE EFFECTS
4 32766 EPITHELIAL CELL BIOL//JOINT HUMAN REPROD RELATED DIS//BAK FOONG PILLS
5 1681 CYSTIC FIBROSIS//CFTR GENE//SWEAT TEST
6 16206 GENE MED GRP//GENEMED GRP//EXPT TREATMENT CYST FIBROSIS
7 23621 PANCREATIC DUCT//PANCREATIC DUCT EPITHELIAL CELLS//PANCREATIC DUCT CELLS
8 9084 CL SECRETION//RAT DISTAL COLON//CHLORIDE SECRETION
9 15129 TMEM16A//CALCIUM ACTIVATED CHLORIDE CHANNEL//ANOCTAMIN 1
10 11107 DENTS DISEASE//CLCN5//CHLORIDE CHANNEL

Go to start page