Class information for:
Level 1: PROPAFENONE//FLECAINIDE//MEXILETINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3795 1906 26.3 56%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
11 3       ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION 130936
896 2             AMIODARONE//ANTIARRHYTHMIC DRUGS//PROPAFENONE 11339
3795 1                   PROPAFENONE//FLECAINIDE//MEXILETINE 1906

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROPAFENONE authKW 614193 5% 38% 101
2 FLECAINIDE authKW 369641 4% 27% 85
3 MEXILETINE authKW 211479 3% 23% 57
4 ORG 7797 authKW 112132 0% 100% 7
5 ENCAINIDE authKW 96904 1% 55% 11
6 5 HYDROXYPROPAFENONE authKW 82381 0% 86% 6
7 DIPRAFENONE authKW 64076 0% 100% 4
8 AJMALINE authKW 35877 1% 20% 11
9 5 HYDROXY PROPAFENONE authKW 32038 0% 100% 2
10 ANTIMYOTONIC AGENTS authKW 32038 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cardiac & Cardiovascular System 20963 41% 0% 787
2 Pharmacology & Pharmacy 7881 38% 0% 729
3 Peripheral Vascular Diseases 496 5% 0% 104
4 Chemistry, Analytical 489 8% 0% 158
5 Medicine, General & Internal 373 8% 0% 154
6 Chemistry, Medicinal 325 5% 0% 88
7 Toxicology 257 4% 0% 81
8 Medical Laboratory Technology 101 1% 0% 28
9 Emergency Medicine 101 1% 0% 22
10 Biochemical Research Methods 48 3% 0% 51

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN NEW DRUGS THER EUT 32038 0% 100% 2
2 48 BLVD SERURIER 16019 0% 100% 1
3 ABT ALLGMEINE PHARMAKOL 16019 0% 100% 1
4 AHMANSON PEDIAT PEDIAT CARDIOL 16019 0% 100% 1
5 BIO PROJECT 21 16019 0% 100% 1
6 CARDIAC PAGING SERV 16019 0% 100% 1
7 CHILDRENS MEM HOSP PEDIAT CARDIOL 16019 0% 100% 1
8 CLIN ELE OPHYSIOL ECHOCARDIOGR H 16019 0% 100% 1
9 CLIN SUPPLIES OPERAT DISPENSARY GGPDC 16019 0% 100% 1
10 EARLY ADME GGPSE 16019 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMERICAN JOURNAL OF CARDIOLOGY 20301 10% 1% 184
2 AMERICAN HEART JOURNAL 12008 5% 1% 104
3 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 9938 4% 1% 83
4 CLINICAL PHARMACOLOGY & THERAPEUTICS 8861 3% 1% 57
5 ZEITSCHRIFT FUR KARDIOLOGIE 6613 2% 1% 41
6 EUROPEAN HEART JOURNAL 6219 3% 1% 63
7 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 5822 3% 1% 51
8 HERZ KREISLAUF 4715 1% 2% 17
9 JOURNAL OF CLINICAL PHARMACOLOGY 3981 2% 1% 37
10 ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE 3537 1% 1% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROPAFENONE 614193 5% 38% 101 Search PROPAFENONE Search PROPAFENONE
2 FLECAINIDE 369641 4% 27% 85 Search FLECAINIDE Search FLECAINIDE
3 MEXILETINE 211479 3% 23% 57 Search MEXILETINE Search MEXILETINE
4 ORG 7797 112132 0% 100% 7 Search ORG+7797 Search ORG+7797
5 ENCAINIDE 96904 1% 55% 11 Search ENCAINIDE Search ENCAINIDE
6 5 HYDROXYPROPAFENONE 82381 0% 86% 6 Search 5+HYDROXYPROPAFENONE Search 5+HYDROXYPROPAFENONE
7 DIPRAFENONE 64076 0% 100% 4 Search DIPRAFENONE Search DIPRAFENONE
8 AJMALINE 35877 1% 20% 11 Search AJMALINE Search AJMALINE
9 5 HYDROXY PROPAFENONE 32038 0% 100% 2 Search 5+HYDROXY+PROPAFENONE Search 5+HYDROXY+PROPAFENONE
10 ANTIMYOTONIC AGENTS 32038 0% 100% 2 Search ANTIMYOTONIC+AGENTS Search ANTIMYOTONIC+AGENTS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BRYSON, HM , PALMER, KJ , LANGTRY, HD , FITTON, A , (1993) PROPAFENONE - A REAPPRAISAL OF ITS PHARMACOLOGY, PHARMACOKINETICS AND THERAPEUTIC USE IN CARDIAC-ARRHYTHMIAS.DRUGS. VOL. 45. ISSUE 1. P. 85 -130 141 71% 59
2 LABBE, L , TURGEON, J , (1999) CLINICAL PHARMACOKINETICS OF MEXILETINE.CLINICAL PHARMACOKINETICS. VOL. 37. ISSUE 5. P. 361 -384 84 78% 35
3 MONK, JP , BROGDEN, RN , (1990) MEXILETINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC USE IN THE TREATMENT OF ARRHYTHMIAS.DRUGS. VOL. 40. ISSUE 3. P. 374 -411 98 80% 42
4 FUNCKBRENTANO, C , KROEMER, HK , LEE, JT , RODEN, DM , (1990) DRUG-THERAPY - PROPAFENONE.NEW ENGLAND JOURNAL OF MEDICINE. VOL. 322. ISSUE 8. P. 518 -525 71 84% 102
5 HARRON, WG , BROGDEN, RN , (1987) PROPAFENONE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC USE IN THE TREATMENT OF ARRHYTHMIAS.DRUGS. VOL. 34. ISSUE 6. P. 617-647 75 91% 51
6 FABER, TS , CAMM, AJ , (1996) THE DIFFERENTIATION OF PROPAFENONE FROM OTHER CLASS IC AGENTS, FOCUSING ON THE EFFECT ON VENTRICULAR RESPONSE RATE ATTRIBUTABLE TO ITS BETA-BLOCKING ACTION.EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 51. ISSUE 3-4. P. 199-208 63 73% 3
7 TAMARGO, J , CAPUCCI, A , MABO, P , (2012) SAFETY OF FLECAINIDE.DRUG SAFETY. VOL. 35. ISSUE 4. P. 273-289 48 52% 9
8 CATALANO, A , CAROCCI, A , SINICROPI, MS , (2015) MEXILETINE METABOLITES: A REVIEW.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 11. P. 1400 -1413 42 56% 1
9 HII, JTY , DUFF, HJ , BURGESS, ED , (1991) CLINICAL PHARMACOKINETICS OF PROPAFENONE.CLINICAL PHARMACOKINETICS. VOL. 21. ISSUE 1. P. 1 -10 50 88% 31
10 BROGDEN, RN , TODD, PA , (1987) ENCAINIDE - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY.DRUGS. VOL. 34. ISSUE 5. P. 519-538 60 90% 6

Classes with closest relation at Level 1


Rank Class id link
1 15499 CIBENZOLINE//DISOPYRAMIDE//AH 1058
2 3840 CARDIAC & CARDIOVASCULAR SYSTEM//PROGRAMMED VENTRICULAR STIMULATION//ELECTROPHYSIOLOGICAL TESTING
3 27140 MORICIZINE//ETHMOZINE//TIRACIZINE
4 27637 N ACETYLPROCAINAMIDE//ABUNDANCE OF ECTOPARASITES//ANTIARRHYTHMIC PROCANBIDR
5 7162 SOTALOL//DOFETILIDE//CLASS III ANTIARRHYTHMIC AGENT
6 1563 SODIUM CHANNEL//USE DEPENDENT BLOCK//NA CHANNEL
7 30780 1 AZABICYCLO330OCTANE//PILSICAINIDE HYDROCHLORIDE//SUN 1165
8 3886 AMIODARONE//DESETHYLAMIODARONE//INTRAVENOUS AMIODARONE
9 36861 FISIOL CELLUARE//INDENOLOL//K COMPETITION
10 15182 ANIPAMIL//KINGS CARDIOVASC BIOL MED//ISCHEMIA AND RE PERFUSION

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