Class information for:
Level 1: TDP 43//C9ORF72//FUS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3819 1900 52.7 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
49 3       ALZHEIMERS DISEASE//AMYOTROPHIC LATERAL SCLEROSIS//DEMENTIA 92146
699 2             AMYOTROPHIC LATERAL SCLEROSIS//FRONTOTEMPORAL DEMENTIA//ALS 13006
3819 1                   TDP 43//C9ORF72//FUS 1900

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TDP 43 authKW 3709031 20% 61% 378
2 C9ORF72 authKW 2705032 11% 84% 201
3 FUS authKW 1103090 6% 61% 113
4 FRONTOTEMPORAL LOBAR DEGENERATION authKW 741748 9% 28% 167
5 FTLD authKW 698275 4% 61% 71
6 TARDBP authKW 582584 2% 84% 43
7 AMYOTROPHIC LATERAL SCLEROSIS authKW 554930 23% 8% 442
8 FUSED IN SARCOMA authKW 401727 2% 83% 30
9 ALS authKW 390679 11% 12% 209
10 FUS TLS authKW 386117 2% 83% 29

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 14787 51% 0% 972
2 Clinical Neurology 13734 37% 0% 709
3 Geriatrics & Gerontology 5255 9% 0% 174
4 Pathology 4466 14% 0% 269
5 Genetics & Heredity 1471 13% 0% 242
6 Biochemistry & Molecular Biology 1446 26% 0% 494
7 Cell Biology 570 11% 0% 204
8 Psychiatry 26 3% 0% 48
9 Multidisciplinary Sciences 18 1% 0% 15
10 Biophysics 10 2% 0% 39

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIAG CURE RARE DIS 114270 0% 89% 8
2 REFERENCE MALAD RA SLA 107123 1% 67% 10
3 NEUROMUSCULAR DIS GRP 106325 1% 44% 15
4 NEURODEGENERAT BRAIN DIS GRP 102469 2% 18% 35
5 NORTHCOTT NEUROSCI 96659 1% 32% 19
6 NEUROPATHOL CELL BIOL 88987 1% 46% 12
7 DEMENTIA PROJECT 76511 1% 48% 10
8 LONDON NEURODEGENERAT DIS BRAIN BANK 73454 0% 57% 8
9 UNITE FONCT NEUROGENET MOL CELLULAIRE 72304 0% 50% 9
10 TRANSLAT NEUROPATHOL 71577 0% 64% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROBIOLOGY OF AGING 68834 8% 3% 157
2 AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION 67636 2% 11% 39
3 ACTA NEUROPATHOLOGICA 56397 8% 2% 143
4 HUMAN MOLECULAR GENETICS 12665 5% 1% 88
5 NEUROPATHOLOGY 12182 2% 2% 33
6 MOLECULAR NEURODEGENERATION 10360 1% 3% 19
7 AMYOTROPHIC LATERAL SCLEROSIS 7932 1% 3% 19
8 ALZHEIMERS RESEARCH & THERAPY 4559 1% 3% 10
9 JAMA NEUROLOGY 4306 1% 2% 13
10 BRAIN 4014 2% 1% 40

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TDP 43 3709031 20% 61% 378 Search TDP+43 Search TDP+43
2 C9ORF72 2705032 11% 84% 201 Search C9ORF72 Search C9ORF72
3 FUS 1103090 6% 61% 113 Search FUS Search FUS
4 FRONTOTEMPORAL LOBAR DEGENERATION 741748 9% 28% 167 Search FRONTOTEMPORAL+LOBAR+DEGENERATION Search FRONTOTEMPORAL+LOBAR+DEGENERATION
5 FTLD 698275 4% 61% 71 Search FTLD Search FTLD
6 TARDBP 582584 2% 84% 43 Search TARDBP Search TARDBP
7 AMYOTROPHIC LATERAL SCLEROSIS 554930 23% 8% 442 Search AMYOTROPHIC+LATERAL+SCLEROSIS Search AMYOTROPHIC+LATERAL+SCLEROSIS
8 FUSED IN SARCOMA 401727 2% 83% 30 Search FUSED+IN+SARCOMA Search FUSED+IN+SARCOMA
9 ALS 390679 11% 12% 209 Search ALS Search ALS
10 FUS TLS 386117 2% 83% 29 Search FUS+TLS Search FUS+TLS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LAGIER-TOURENNE, C , POLYMENIDOU, M , CLEVELAND, DW , (2010) TDP-43 AND FUS/TLS: EMERGING ROLES IN RNA PROCESSING AND NEURODEGENERATION.HUMAN MOLECULAR GENETICS. VOL. 19. ISSUE . P. R46-R64 174 69% 334
2 BLOKHUIS, AM , GROEN, EJN , KOPPERS, M , VAN DEN BERG, LH , PASTERKAMP, RJ , (2013) PROTEIN AGGREGATION IN AMYOTROPHIC LATERAL SCLEROSIS.ACTA NEUROPATHOLOGICA. VOL. 125. ISSUE 6. P. 777 -794 167 80% 74
3 LING, SC , POLYMENIDOU, M , CLEVELAND, DW , (2013) CONVERGING MECHANISMS IN ALS AND FTD: DISRUPTED RNA AND PROTEIN HOMEOSTASIS.NEURON. VOL. 79. ISSUE 3. P. 416-438 143 59% 265
4 BOWDEN, HA , DORMANN, D , (2016) ALTERED MRNP GRANULE DYNAMICS IN FTLD PATHOGENESIS.JOURNAL OF NEUROCHEMISTRY. VOL. 138. ISSUE . P. 112 -133 163 85% 2
5 DENG, H , GAO, K , JANKOVIC, J , (2014) THE ROLE OF FUS GENE VARIANTS IN NEURODEGENERATIVE DISEASES.NATURE REVIEWS NEUROLOGY. VOL. 10. ISSUE 6. P. 337-348 152 82% 32
6 ROHRER, JD , ISAACS, AM , MIZLIENSKA, S , MEAD, S , LASHLEY, T , WRAY, S , SIDLE, K , FRATTA, P , ORRELL, RW , HARDY, J , ET AL (2015) C9ORF72 EXPANSIONS IN FRONTOTEMPORAL DEMENTIA AND AMYOTROPHIC LATERAL SCLEROSIS.LANCET NEUROLOGY. VOL. 14. ISSUE 3. P. 291 -301 104 89% 44
7 MACKENZIE, IRA , RADEMAKERS, R , NEUMANN, M , (2010) TDP-43 AND FUS IN AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEMENTIA.LANCET NEUROLOGY. VOL. 9. ISSUE 10. P. 995-1007 137 72% 304
8 BURATTI, E , (2015) FUNCTIONAL SIGNIFICANCE OF TDP-43 MUTATIONS IN DISEASE.ADVANCES IN GENETICS, VOL 91. VOL. 91. ISSUE . P. 1 -53 140 93% 8
9 GUERRERO, EN , WANG, HB , MITRA, J , HEGDE, PM , STOWELL, SE , LIACHKO, NF , KRAEMER, BC , GARRUTO, RM , RAO, KS , HEGDE, ML , (2016) TDP-43/FUS IN MOTOR NEURON DISEASE: COMPLEXITY AND CHALLENGES.PROGRESS IN NEUROBIOLOGY. VOL. 145. ISSUE . P. 78 -97 196 70% 0
10 SCOTTER, EL , CHEN, HJ , SHAW, CE , (2015) TDP-43 PROTEINOPATHY AND ALS: INSIGHTS INTO DISEASE MECHANISMS AND THERAPEUTIC TARGETS.NEUROTHERAPEUTICS. VOL. 12. ISSUE 2. P. 352 -363 127 81% 15

Classes with closest relation at Level 1


Rank Class id link
1 17353 PROGRANULIN//PGRN//GRANULIN
2 35314 UBIQUILIN//UBIQUILIN 1//UBQLN1
3 7068 AMYOTROPHIC LATERAL SCLEROSIS//PRIMARY LATERAL SCLEROSIS//MOTOR NEURON DISEASE
4 402 AMYOTROPHIC LATERAL SCLEROSIS//SOD1//ALS
5 2623 FRONTOTEMPORAL DEMENTIA//PRIMARY PROGRESSIVE APHASIA//SEMANTIC DEMENTIA
6 34141 NEURONAL INTRANUCLEAR INCLUSION DISEASE//INTRANUCLEAR INCLUSION BODY DISEASE//NEURONAL INTRANUCLEAR HYALINE INCLUSION DISEASE
7 2809 AMYOTROPHIC LATERAL SCLEROSIS//AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION//MOTOR NEURON DISEASE
8 6198 P BODIES//STRESS GRANULES//DECAPPING
9 5543 PROGRESSIVE SUPRANUCLEAR PALSY//CORTICOBASAL DEGENERATION//ARGYROPHILIC GRAIN DISEASE
10 20907 OXYSTEROL BINDING PROTEIN//MEMBRANE CONTACT SITES//OSBP

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