Class information for:
Level 1: G PROTEIN COUPLED RECEPTOR//GPCR//MEMBRANE PROT STRUCT FUNCT UNIT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4196 1830 52.7 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
405 3       BACTERIORHODOPSIN//G PROTEIN COUPLED RECEPTOR//G PROTEIN 29641
705 2             G PROTEIN COUPLED RECEPTOR//GPCR//RHODOPSIN 12950
4196 1                   G PROTEIN COUPLED RECEPTOR//GPCR//MEMBRANE PROT STRUCT FUNCT UNIT 1830

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 G PROTEIN COUPLED RECEPTOR authKW 230198 14% 5% 257
2 GPCR authKW 164598 8% 7% 141
3 MEMBRANE PROT STRUCT FUNCT UNIT address 150152 1% 75% 12
4 CONSTITUTIVE ACTIVITY authKW 129015 2% 18% 42
5 MED COMPUTAC address 124053 2% 25% 30
6 IONIC LOCK authKW 90833 0% 78% 7
7 GPCRS authKW 90730 2% 14% 40
8 UNITAT BIOESTADIST address 78980 2% 16% 30
9 RECEPTOR ACTIVATION authKW 78935 1% 18% 27
10 GPCR ACTIVATION authKW 71179 0% 53% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 7061 52% 0% 945
2 Chemistry, Medicinal 3714 14% 0% 254
3 Pharmacology & Pharmacy 2896 25% 0% 454
4 Biophysics 2123 13% 0% 241
5 Computer Science, Interdisciplinary Applications 1386 8% 0% 146
6 Biochemical Research Methods 517 7% 0% 119
7 Cell Biology 463 10% 0% 184
8 Mathematical & Computational Biology 320 3% 0% 50
9 Computer Science, Information Systems 163 3% 0% 56
10 Chemistry, Multidisciplinary 149 9% 0% 164

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MEMBRANE PROT STRUCT FUNCT UNIT 150152 1% 75% 12
2 MED COMPUTAC 124053 2% 25% 30
3 UNITAT BIOESTADIST 78980 2% 16% 30
4 OULU BIO 38132 0% 57% 4
5 MED CHEM NEUROENGN 35581 0% 27% 8
6 PHARMACEUT INTELLIGENCE PLATFORM 33368 0% 100% 2
7 PSYCHIAT MOLEC NEUROPHARMACOL SECT 33368 0% 100% 2
8 SECT THEORET RECEPTOR PHARMACOL 33368 0% 100% 2
9 SYNTH CHEM TECHNOL PHARMACEUT SUBST COMP M 33368 0% 100% 2
10 VAN ANDEL CAS RECEPTOR 33368 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR PHARMACOLOGY 24955 7% 1% 121
2 JOURNAL OF CHEMICAL INFORMATION AND MODELING 16167 3% 2% 55
3 RECEPTORS & CHANNELS 13572 1% 5% 16
4 TRENDS IN PHARMACOLOGICAL SCIENCES 11727 3% 1% 49
5 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 8444 2% 2% 30
6 JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH 3999 0% 3% 8
7 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 3520 2% 1% 37
8 JOURNAL OF MOLECULAR MODELING 2208 1% 1% 22
9 MOLECULAR INFORMATICS 2159 0% 2% 8
10 JOURNAL OF BIOLOGICAL CHEMISTRY 2066 8% 0% 143

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 G PROTEIN COUPLED RECEPTOR 230198 14% 5% 257 Search G+PROTEIN+COUPLED+RECEPTOR Search G+PROTEIN+COUPLED+RECEPTOR
2 GPCR 164598 8% 7% 141 Search GPCR Search GPCR
3 CONSTITUTIVE ACTIVITY 129015 2% 18% 42 Search CONSTITUTIVE+ACTIVITY Search CONSTITUTIVE+ACTIVITY
4 IONIC LOCK 90833 0% 78% 7 Search IONIC+LOCK Search IONIC+LOCK
5 GPCRS 90730 2% 14% 40 Search GPCRS Search GPCRS
6 RECEPTOR ACTIVATION 78935 1% 18% 27 Search RECEPTOR+ACTIVATION Search RECEPTOR+ACTIVATION
7 GPCR ACTIVATION 71179 0% 53% 8 Search GPCR+ACTIVATION Search GPCR+ACTIVATION
8 CONFORMATIONAL THERMOSTABILIZATION 69516 0% 83% 5 Search CONFORMATIONAL+THERMOSTABILIZATION Search CONFORMATIONAL+THERMOSTABILIZATION
9 GPCR STRUCTURE 66729 0% 50% 8 Search GPCR+STRUCTURE Search GPCR+STRUCTURE
10 ROTAMER TOGGLE SWITCH 53388 0% 80% 4 Search ROTAMER+TOGGLE+SWITCH Search ROTAMER+TOGGLE+SWITCH

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VENKATAKRISHNAN, AJ , DEUPI, X , LEBON, G , TATE, CG , SCHERTLER, GF , BABU, MM , (2013) MOLECULAR SIGNATURES OF G-PROTEIN-COUPLED RECEPTORS.NATURE. VOL. 494. ISSUE 7436. P. 185-194 62 65% 412
2 KATRITCH, V , CHEREZOV, V , STEVENS, RC , (2013) STRUCTURE-FUNCTION OF THE G PROTEIN-COUPLED RECEPTOR SUPERFAMILY.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013. VOL. 53. ISSUE . P. 531-556 71 62% 289
3 FANELLI, F , DE BENEDETTI, PG , (2011) UPDATE 1 OF: COMPUTATIONAL MODELING APPROACHES TO STRUCTURE-FUNCTION ANALYSIS OF G PROTEIN-COUPLED RECEPTORS.CHEMICAL REVIEWS. VOL. 111. ISSUE . P. PR438 -PR535 320 27% 38
4 CAVASOTTO, CN , PALOMBA, D , (2015) EXPANDING THE HORIZONS OF G PROTEIN-COUPLED RECEPTOR STRUCTURE-BASED LIGAND DISCOVERY AND OPTIMIZATION USING HOMOLOGY MODELS.CHEMICAL COMMUNICATIONS. VOL. 51. ISSUE 71. P. 13576 -13594 137 53% 9
5 KONTOYIANNI, M , (2016) G PROTEIN COUPLED RECEPTORS AND STRUCTURE-BASED ADVANCES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 13. P. 1489 -1505 111 55% 1
6 RODRIGUEZ, D , RANGANATHAN, A , CARLSSON, J , (2015) DISCOVERY OF GPCR LIGANDS BY MOLECULAR DOCKING SCREENING: NOVEL OPPORTUNITIES PROVIDED BY CRYSTAL STRUCTURES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 24. P. 2484 -2503 95 62% 8
7 ANDREWS, SP , BROWN, GA , CHRISTOPHER, JA , (2014) STRUCTURE-BASED AND FRAGMENT-BASED GPCR DRUG DISCOVERY.CHEMMEDCHEM. VOL. 9. ISSUE 2. P. 256-275 87 61% 27
8 RODRIGUEZ, D , GUTIERREZ-DE-TERAN, H , (2013) COMPUTATIONAL APPROACHES FOR LIGAND DISCOVERY AND DESIGN IN CLASS-A G PROTEIN-COUPLED RECEPTORS.CURRENT PHARMACEUTICAL DESIGN. VOL. 19. ISSUE 12. P. 2216 -2236 111 54% 7
9 LATORRACA, NR , VENKATAKRISHNAN, AJ , DROR, RO , (2017) GPCR DYNAMICS: STRUCTURES IN MOTION.CHEMICAL REVIEWS. VOL. 117. ISSUE 1. P. 139 -155 72 47% 1
10 STEVENS, RC , CHEREZOV, V , KATRITCH, V , ABAGYAN, R , KUHN, P , ROSEN, H , WUTHRICH, K , (2013) THE GPCR NETWORK: A LARGE-SCALE COLLABORATION TO DETERMINE HUMAN GPCR STRUCTURE AND FUNCTION.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 1. P. 25 -34 49 83% 88

Classes with closest relation at Level 1


Rank Class id link
1 3579 RHODOPSIN//RETINAL//BATHORHODOPSIN
2 15795 AMPHIPOLS//UMR 7099//MEMBRANE PROTEIN
3 30621 SEROTONIN1A RECEPTOR//BOVINE HIPPOCAMPUS//P MPPF
4 9142 RECEPTOR MOSAICS//HETEROMER//RECEPTOR RECEPTOR INTERACTIONS
5 26532 AGONIST AFFINITY//ANTAGONIST DISSOCIATION CONSTANTS//IRREVERSIBLE RECEPTOR INACTIVATION METHOD
6 26108 BIOCHEM TECHNOL SCI TECHNOL//GPR35//RESONANT WAVEGUIDE GRATING BIOSENSOR
7 10380 XANOMELINE//M 1//ALCURONIUM
8 30920 PHARMACOPERONE//ER EXPORT MOTIF//EXPORT TRAFFICKING
9 28909 GPRC5A//GPR12//GPR139
10 35909 MEGAKARYOCYTE RAT//PRESYNAPTIC GABAA RECEPTORS//SYNAPTIC BOUTON PREPARATION

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