Class information for:
Level 1: BIOCHEM TECHNOL SCI TECHNOL//GPR35//RESONANT WAVEGUIDE GRATING BIOSENSOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
26108 263 46.6 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
405 3       BACTERIORHODOPSIN//G PROTEIN COUPLED RECEPTOR//G PROTEIN 29641
705 2             G PROTEIN COUPLED RECEPTOR//GPCR//RHODOPSIN 12950
26108 1                   BIOCHEM TECHNOL SCI TECHNOL//GPR35//RESONANT WAVEGUIDE GRATING BIOSENSOR 263

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM TECHNOL SCI TECHNOL address 2730305 10% 87% 27
2 GPR35 authKW 1458861 6% 74% 17
3 RESONANT WAVEGUIDE GRATING BIOSENSOR authKW 1044934 3% 100% 9
4 REBINDING authKW 784849 5% 52% 13
5 LIGAND DIRECTED FUNCTIONAL SELECTIVITY authKW 580519 2% 100% 5
6 DYNAMIC MASS REDISTRIBUTION authKW 522458 3% 50% 9
7 MOL BIOCHEM PHARMACOL address 386586 10% 13% 26
8 DRUG TARGET RESIDENCE TIME authKW 348311 1% 100% 3
9 CROMOLYN DISODIUM authKW 232208 1% 100% 2
10 ELECTRIC BIOSENSOR authKW 232208 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 1619 46% 0% 121
2 Chemistry, Medicinal 518 14% 0% 36
3 Biochemical Research Methods 268 11% 0% 30
4 Biochemistry & Molecular Biology 130 22% 0% 58
5 Biophysics 121 9% 0% 23
6 Chemistry, Analytical 86 9% 0% 24
7 Biotechnology & Applied Microbiology 63 8% 0% 21
8 Cell Biology 23 7% 0% 18
9 Electrochemistry 6 2% 0% 5
10 Toxicology 3 2% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM TECHNOL SCI TECHNOL 2730305 10% 87% 27
2 MOL BIOCHEM PHARMACOL 386586 10% 13% 26
3 MED COUNCIL TECHNOL 232208 1% 100% 2
4 BIOCHEM TECHNOL 184349 10% 6% 27
5 BIOL CAXIAS DO SUL 116104 0% 100% 1
6 CERTARA QUANTITAT SYST PHARMACOL 116104 0% 100% 1
7 CHEST DISCOVERY 116104 0% 100% 1
8 COMPUTAT SCI CRYSTALLOG GRP 116104 0% 100% 1
9 EFAR 116104 0% 100% 1
10 ELTE IMMUNOL GRP 116104 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPERT OPINION ON DRUG DISCOVERY 16779 5% 1% 12
2 JOURNAL OF BIOMOLECULAR SCREENING 6762 4% 1% 10
3 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 4702 2% 1% 5
4 ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 4240 2% 1% 5
5 DRUG DISCOVERY TODAY 2308 3% 0% 7
6 MEDCHEMCOMM 2143 2% 0% 5
7 NATURE REVIEWS DRUG DISCOVERY 1977 2% 0% 4
8 FUNDAMENTAL & CLINICAL PHARMACOLOGY 1421 2% 0% 5
9 BRITISH JOURNAL OF PHARMACOLOGY 1268 5% 0% 14
10 CURRENT OPINION IN PHARMACOLOGY 1230 2% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GPR35 1458861 6% 74% 17 Search GPR35 Search GPR35
2 RESONANT WAVEGUIDE GRATING BIOSENSOR 1044934 3% 100% 9 Search RESONANT+WAVEGUIDE+GRATING+BIOSENSOR Search RESONANT+WAVEGUIDE+GRATING+BIOSENSOR
3 REBINDING 784849 5% 52% 13 Search REBINDING Search REBINDING
4 LIGAND DIRECTED FUNCTIONAL SELECTIVITY 580519 2% 100% 5 Search LIGAND+DIRECTED+FUNCTIONAL+SELECTIVITY Search LIGAND+DIRECTED+FUNCTIONAL+SELECTIVITY
5 DYNAMIC MASS REDISTRIBUTION 522458 3% 50% 9 Search DYNAMIC+MASS+REDISTRIBUTION Search DYNAMIC+MASS+REDISTRIBUTION
6 DRUG TARGET RESIDENCE TIME 348311 1% 100% 3 Search DRUG+TARGET+RESIDENCE+TIME Search DRUG+TARGET+RESIDENCE+TIME
7 CROMOLYN DISODIUM 232208 1% 100% 2 Search CROMOLYN+DISODIUM Search CROMOLYN+DISODIUM
8 ELECTRIC BIOSENSOR 232208 1% 100% 2 Search ELECTRIC+BIOSENSOR Search ELECTRIC+BIOSENSOR
9 G PROTEIN COUPLED RECEPTOR 35 232208 1% 100% 2 Search G+PROTEIN+COUPLED+RECEPTOR+35 Search G+PROTEIN+COUPLED+RECEPTOR+35
10 LABEL FREE CELL PHENOTYPIC ASSAY 232208 1% 100% 2 Search LABEL+FREE+CELL+PHENOTYPIC+ASSAY Search LABEL+FREE+CELL+PHENOTYPIC+ASSAY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DENG, HY , FANG, Y , (2012) DISCOVERY OF NITROPHENOLS AS GPR35 AGONISTS.MEDCHEMCOMM. VOL. 3. ISSUE 10. P. 1270 -1274 22 81% 0
2 VAUQUELIN, G , (2016) EFFECTS OF TARGET BINDING KINETICS ON IN VIVO DRUG EFFICACY: K(OFF), K(ON) AND REBINDING.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 173. ISSUE 15. P. 2319 -2334 24 48% 4
3 VAUQUELIN, G , (2015) ON THE 'MICRO'-PHARMACODYNAMIC AND PHARMACOKINETIC MECHANISMS THAT CONTRIBUTE TO LONG-LASTING DRUG ACTION.EXPERT OPINION ON DRUG DISCOVERY. VOL. 10. ISSUE 10. P. 1085 -1098 35 39% 4
4 WANG, JX , ZHANG, XL , FANG, Y , LIANG, XM , (2016) LABEL-FREE CELL PHENOTYPIC ASSAYS FOR ASSESSING DRUG POLYPHARMACOLOGY.CURRENT PHARMACEUTICAL DESIGN. VOL. 22. ISSUE 21. P. 3190 -3200 36 36% 1
5 MACKENZIE, AE , MILLIGAN, G , (2017) THE EMERGING PHARMACOLOGY AND FUNCTION OF GPR35 IN THE NERVOUS SYSTEM.NEUROPHARMACOLOGY. VOL. 113. ISSUE . P. 661 -671 30 28% 1
6 DENG, HY , HU, HB , HE, MQ , HU, JY , NIU, WJ , FERRIE, AM , FANG, Y , (2011) DISCOVERY OF 2-(4-METHYLFURAN-2(5H)-YLIDENE)MALONONITRILE AND THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID DERIVATIVES AS G PROTEIN-COUPLED RECEPTOR 35 (GPR35) AGONISTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 20. P. 7385 -7396 18 82% 12
7 DENG, HY , WANG, CM , SU, M , FANG, Y , (2012) PROBING BIOCHEMICAL MECHANISMS OF ACTION OF MUSCARINIC M3 RECEPTOR ANTAGONISTS WITH LABEL-FREE WHOLE CELL ASSAYS.ANALYTICAL CHEMISTRY. VOL. 84. ISSUE 19. P. 8232-8239 22 67% 5
8 COPELAND, RA , (2016) THE DRUG-TARGET RESIDENCE TIME MODEL: A 10-YEAR RETROSPECTIVE.NATURE REVIEWS DRUG DISCOVERY. VOL. 15. ISSUE 2. P. 87 -95 16 34% 23
9 VAUQUELIN, G , (2012) DETERMINATION OF DRUG-RECEPTOR RESIDENCE TIMES BY RADIOLIGAND BINDING AND FUNCTIONAL ASSAYS: EXPERIMENTAL STRATEGIES AND PHYSIOLOGICAL RELEVANCE.MEDCHEMCOMM. VOL. 3. ISSUE 6. P. 645-651 26 47% 8
10 FANG, Y , (2014) LABEL-FREE DRUG DISCOVERY.FRONTIERS IN PHARMACOLOGY. VOL. 5. ISSUE . P. - 30 38% 5

Classes with closest relation at Level 1


Rank Class id link
1 26532 AGONIST AFFINITY//ANTAGONIST DISSOCIATION CONSTANTS//IRREVERSIBLE RECEPTOR INACTIVATION METHOD
2 15308 ECIS//ELECTRIC CELL SUBSTRATE IMPEDANCE SENSING//MOL BIOL BIOCHEM PROC TECHNOL
3 10380 XANOMELINE//M 1//ALCURONIUM
4 4196 G PROTEIN COUPLED RECEPTOR//GPCR//MEMBRANE PROT STRUCT FUNCT UNIT
5 10761 INTEGRATED OPTICAL SENSORS//REFLECTOMETRIC INTERFERENCE SPECTROSCOPY RIFS//REFLECTOMETRIC INTERFERENCE SPECTROSCOPY
6 12757 BIACORE//BIOMOL INTERACT ANAL//IASYS
7 4516 CANDESARTAN CILEXETIL//ANGIOTENSIN II RECEPTOR ANTAGONIST//LOSARTAN
8 32378 FLUORESCENT LIGANDS//1012 S//ALEXA FLUOR R 647
9 5001 KYNURENIC ACID//KYNURENINE//QUINOLINIC ACID
10 2285 G PROTEIN COUPLED RECEPTOR KINASE//ARRESTIN//BETA ARRESTIN

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