Class information for:
Level 1: G PROTEIN COUPLED RECEPTOR KINASE//ARRESTIN//BETA ARRESTIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2285 2296 49.8 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
405 3       BACTERIORHODOPSIN//G PROTEIN COUPLED RECEPTOR//G PROTEIN 29641
705 2             G PROTEIN COUPLED RECEPTOR//GPCR//RHODOPSIN 12950
2285 1                   G PROTEIN COUPLED RECEPTOR KINASE//ARRESTIN//BETA ARRESTIN 2296

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 G PROTEIN COUPLED RECEPTOR KINASE authKW 875147 5% 58% 113
2 ARRESTIN authKW 666400 6% 36% 140
3 BETA ARRESTIN authKW 595994 5% 37% 122
4 GRK2 authKW 369087 2% 58% 48
5 G PROTEIN COUPLED RECEPTOR KINASE 2 authKW 265006 1% 59% 34
6 GEORGE ZALLIE FAMILY CARDIOVASC GENE THER address 156956 1% 54% 22
7 BETA ADRENERGIC RECEPTOR KINASE authKW 156298 1% 51% 23
8 BETA ARRESTIN 1 authKW 156290 1% 49% 24
9 GRK authKW 134018 1% 40% 25
10 BETA ARRESTIN 2 authKW 120210 1% 31% 29

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 8815 52% 0% 1183
2 Cell Biology 2010 17% 0% 383
3 Pharmacology & Pharmacy 1279 16% 0% 366
4 Cardiac & Cardiovascular System 485 7% 0% 160
5 Peripheral Vascular Diseases 339 4% 0% 99
6 Physiology 228 4% 0% 102
7 Endocrinology & Metabolism 168 5% 0% 105
8 Biophysics 149 4% 0% 93
9 Neurosciences 107 7% 0% 154
10 Biochemical Research Methods 80 3% 0% 68

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GEORGE ZALLIE FAMILY CARDIOVASC GENE THER 156956 1% 54% 22
2 STUDY NEUROHORMONAL CONTROL CIRCULAT 110810 0% 83% 10
3 RALPH MURIEL ROBERTS VIS SCI 107261 0% 73% 11
4 EUGENE FEINER VASC BIOL THROMBOSIS 84675 0% 58% 11
5 GPCR EXP S SIGNAL TRANSDUCT L GEST 53190 0% 100% 4
6 HOWARD HUGHES MED S 44145 1% 20% 17
7 ALZHEIMERS DIS AGING 32721 0% 31% 8
8 PSYCHONEUROIMMUNOL 27241 1% 11% 19
9 CONTRAINTES TEAM 26595 0% 100% 2
10 DANISH FDN CARDIAC ARRHYTHMIAHEART 26595 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 22019 22% 0% 502
2 MOLECULAR PHARMACOLOGY 14629 5% 1% 104
3 PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE 7960 1% 3% 20
4 CELLULAR SIGNALLING 5580 2% 1% 43
5 TRENDS IN PHARMACOLOGICAL SCIENCES 2602 1% 1% 26
6 MOLECULAR ENDOCRINOLOGY 2521 1% 1% 33
7 CIRCULATION RESEARCH 1295 1% 0% 32
8 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1255 4% 0% 100
9 JOURNAL OF BIOMOLECULAR SCREENING 1095 1% 1% 12
10 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION 1044 0% 1% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 G PROTEIN COUPLED RECEPTOR KINASE 875147 5% 58% 113 Search G+PROTEIN+COUPLED+RECEPTOR+KINASE Search G+PROTEIN+COUPLED+RECEPTOR+KINASE
2 ARRESTIN 666400 6% 36% 140 Search ARRESTIN Search ARRESTIN
3 BETA ARRESTIN 595994 5% 37% 122 Search BETA+ARRESTIN Search BETA+ARRESTIN
4 GRK2 369087 2% 58% 48 Search GRK2 Search GRK2
5 G PROTEIN COUPLED RECEPTOR KINASE 2 265006 1% 59% 34 Search G+PROTEIN+COUPLED+RECEPTOR+KINASE+2 Search G+PROTEIN+COUPLED+RECEPTOR+KINASE+2
6 BETA ADRENERGIC RECEPTOR KINASE 156298 1% 51% 23 Search BETA+ADRENERGIC+RECEPTOR+KINASE Search BETA+ADRENERGIC+RECEPTOR+KINASE
7 BETA ARRESTIN 1 156290 1% 49% 24 Search BETA+ARRESTIN+1 Search BETA+ARRESTIN+1
8 GRK 134018 1% 40% 25 Search GRK Search GRK
9 BETA ARRESTIN 2 120210 1% 31% 29 Search BETA+ARRESTIN+2 Search BETA+ARRESTIN+2
10 BETA ARKCT 94559 0% 89% 8 Search BETA+ARKCT Search BETA+ARKCT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SATO, PY , CHUPRUN, JK , SCHWARTZ, M , KOCH, WJ , (2015) THE EVOLVING IMPACT OF G PROTEIN-COUPLED RECEPTOR KINASES IN CARDIAC HEALTH AND DISEASE.PHYSIOLOGICAL REVIEWS. VOL. 95. ISSUE 2. P. 377 -404 197 73% 12
2 GUREVICH, EV , TESMER, JJG , MUSHEGIAN, A , GUREVICH, VV , (2012) G PROTEIN-COUPLED RECEPTOR KINASES: MORE THAN JUST KINASES AND NOT ONLY FOR GPCRS.PHARMACOLOGY & THERAPEUTICS. VOL. 133. ISSUE 1. P. 40 -69 230 55% 92
3 FERGUSON, SSG , (2001) EVOLVING CONCEPTS IN G PROTEIN-COUPLED RECEPTOR ENDOCYTOSIS: THE ROLE IN RECEPTOR DESENSITIZATION AND SIGNALING.PHARMACOLOGICAL REVIEWS. VOL. 53. ISSUE 1. P. 1 -24 143 57% 1165
4 SMITH, JS , RAJAGOPAL, S , (2016) THE BETA-ARRESTINS: MULTIFUNCTIONAL REGULATORS OF G PROTEIN-COUPLED RECEPTORS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 291. ISSUE 17. P. 8969 -8977 83 85% 5
5 LUTTRELL, LM , GESTY-PALMER, D , (2010) BEYOND DESENSITIZATION: PHYSIOLOGICAL RELEVANCE OF ARRESTIN-DEPENDENT SIGNALING.PHARMACOLOGICAL REVIEWS. VOL. 62. ISSUE 2. P. 305-330 126 58% 162
6 GUREVICH, VV , GUREVICH, EV , (2006) THE STRUCTURAL BASIS OF ARRESTIN-MEDIATED REGULATION OF G-PROTEIN-COUPLED RECEPTORS.PHARMACOLOGY & THERAPEUTICS. VOL. 110. ISSUE 3. P. 465-502 152 59% 164
7 DEWIRE, SM , AHN, S , LEFKOWITZ, RJ , SHENOY, SK , (2007) BETA-ARRESTINS AND CELL SIGNALING.ANNUAL REVIEW OF PHYSIOLOGY. VOL. 69. ISSUE . P. 483-510 82 67% 632
8 SHENOY, SK , LEFKOWITZ, RJ , (2011) BETA-ARRESTIN-MEDIATED RECEPTOR TRAFFICKING AND SIGNAL TRANSDUCTION.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 32. ISSUE 9. P. 521-533 85 66% 234
9 PITCHER, JA , FREEDMAN, NJ , LEFKOWITZ, RJ , (1998) G PROTEIN-COUPLED RECEPTOR KINASES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 67. ISSUE . P. 653 -692 127 53% 776
10 MOORE, CAC , MILANO, SK , BENOVIC, JL , (2007) REGULATION OF RECEPTOR TRAFFICKING BY GRKS AND ARRESTINS.ANNUAL REVIEW OF PHYSIOLOGY. VOL. 69. ISSUE . P. 451-482 112 57% 305

Classes with closest relation at Level 1


Rank Class id link
1 30920 PHARMACOPERONE//ER EXPORT MOTIF//EXPORT TRAFFICKING
2 5552 MU OPIOID RECEPTOR//OPIOID RECEPTORS//OPIOID TOLERANCE
3 9142 RECEPTOR MOSAICS//HETEROMER//RECEPTOR RECEPTOR INTERACTIONS
4 31877 PHOSDUCIN//PHOSDUCIN LIKE PROTEIN//AMPHI PHLP
5 4196 G PROTEIN COUPLED RECEPTOR//GPCR//MEMBRANE PROT STRUCT FUNCT UNIT
6 6581 BETA ADRENOCEPTOR//BETA ADRENERGIC RECEPTOR SUBTYPES//BETA ADRENERGIC RECEPTOR
7 7382 JOURNAL OF CYCLIC NUCLEOTIDE RESEARCH//JOURNAL OF CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH//JOURNAL OF RECEPTOR RESEARCH
8 26108 BIOCHEM TECHNOL SCI TECHNOL//GPR35//RESONANT WAVEGUIDE GRATING BIOSENSOR
9 26532 AGONIST AFFINITY//ANTAGONIST DISSOCIATION CONSTANTS//IRREVERSIBLE RECEPTOR INACTIVATION METHOD
10 2682 PHOTOTRANSDUCTION//CYCLIC NUCLEOTIDE GATED CHANNEL//RETINAL RODS

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