Class information for:
Level 1: MU OPIOID RECEPTOR//OPIOID RECEPTORS//OPIOID TOLERANCE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5552 1607 41.5 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
440 3       NOCICEPTIN//OPIOID RECEPTORS//MORPHINE 26600
121 2             OPIOID RECEPTORS//MORPHINE//DELTA OPIOID RECEPTOR 24293
5552 1                   MU OPIOID RECEPTOR//OPIOID RECEPTORS//OPIOID TOLERANCE 1607

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MU OPIOID RECEPTOR authKW 299072 9% 11% 143
2 OPIOID RECEPTORS authKW 230526 10% 8% 153
3 OPIOID TOLERANCE authKW 154363 2% 25% 32
4 DELTA OPIOID RECEPTOR authKW 134549 4% 11% 63
5 MORPHINE authKW 109111 13% 3% 203
6 ULTRA LOW DOSE NALTREXONE authKW 97711 0% 86% 6
7 ETORPHINE authKW 84649 1% 23% 19
8 ACTION POTENTIAL SHORTENING VS PROLONGATION authKW 75999 0% 100% 4
9 MAUERBERGER CHAIR NEUROPHARMACOL address 61548 1% 36% 9
10 PHOSPHATIDYLINOSITOL CASCADE authKW 60798 0% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 8717 43% 0% 697
2 Neurosciences 7766 41% 0% 658
3 Biochemistry & Molecular Biology 584 20% 0% 316
4 Anesthesiology 316 3% 0% 48
5 Medicine, Research & Experimental 241 6% 0% 92
6 Behavioral Sciences 122 2% 0% 39
7 Cell Biology 72 6% 0% 90
8 Physiology 27 2% 0% 40
9 Substance Abuse 26 1% 0% 13
10 Psychiatry 23 3% 0% 41

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MAUERBERGER CHAIR NEUROPHARMACOL 61548 1% 36% 9
2 PSYCHIAT CELLULAR MOL PHARMACOL 60798 0% 80% 4
3 PHARMACOL MOL TOLERANCE OPIACES 56999 0% 100% 3
4 UP EA 4650 38000 0% 100% 2
5 CELLULAR SIGNALING MOL PHARMACOL 37996 0% 50% 4
6 SHANGHAI CELL BIOL 37101 1% 12% 16
7 BASIC MOL CELL BIOL DRUG ADDICT 34197 0% 60% 3
8 UP EA 3919 33922 0% 36% 5
9 BIOL CELLULAIRE MOL SIGNALISAT 25332 0% 67% 2
10 STEFAN HATOS NEUROPHARMACOL 25332 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR PHARMACOLOGY 27981 7% 1% 120
2 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 13556 8% 1% 123
3 JOURNAL OF NEUROCHEMISTRY 7792 6% 0% 93
4 MOLECULAR BRAIN RESEARCH 5716 2% 1% 37
5 EUROPEAN JOURNAL OF PHARMACOLOGY 5620 6% 0% 92
6 LIFE SCIENCES 4659 4% 0% 71
7 BRAIN RESEARCH 4645 7% 0% 109
8 BRITISH JOURNAL OF PHARMACOLOGY 3283 3% 0% 56
9 REGULATORY PEPTIDES 3112 2% 1% 28
10 NEUROPHARMACOLOGY 2027 2% 0% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MU OPIOID RECEPTOR 299072 9% 11% 143 Search MU+OPIOID+RECEPTOR Search MU+OPIOID+RECEPTOR
2 OPIOID RECEPTORS 230526 10% 8% 153 Search OPIOID+RECEPTORS Search OPIOID+RECEPTORS
3 OPIOID TOLERANCE 154363 2% 25% 32 Search OPIOID+TOLERANCE Search OPIOID+TOLERANCE
4 DELTA OPIOID RECEPTOR 134549 4% 11% 63 Search DELTA+OPIOID+RECEPTOR Search DELTA+OPIOID+RECEPTOR
5 MORPHINE 109111 13% 3% 203 Search MORPHINE Search MORPHINE
6 ULTRA LOW DOSE NALTREXONE 97711 0% 86% 6 Search ULTRA+LOW+DOSE+NALTREXONE Search ULTRA+LOW+DOSE+NALTREXONE
7 ETORPHINE 84649 1% 23% 19 Search ETORPHINE Search ETORPHINE
8 ACTION POTENTIAL SHORTENING VS PROLONGATION 75999 0% 100% 4 Search ACTION+POTENTIAL+SHORTENING+VS+PROLONGATION Search ACTION+POTENTIAL+SHORTENING+VS+PROLONGATION
9 PHOSPHATIDYLINOSITOL CASCADE 60798 0% 80% 4 Search PHOSPHATIDYLINOSITOL+CASCADE Search PHOSPHATIDYLINOSITOL+CASCADE
10 MORPHINE TOLERANCE 57293 2% 12% 26 Search MORPHINE+TOLERANCE Search MORPHINE+TOLERANCE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WILLIAMS, JT , INGRAM, SL , HENDERSON, G , CHAVKIN, C , VON ZASTROW, M , SCHULZ, S , KOCH, T , EVANS, CJ , CHRISTIE, MJ , (2013) REGULATION OF MU-OPIOID RECEPTORS: DESENSITIZATION, PHOSPHORYLATION, INTERNALIZATION, AND TOLERANCE.PHARMACOLOGICAL REVIEWS. VOL. 65. ISSUE 1. P. 223-254 162 59% 126
2 ALLOUCHE, S , NOBLE, F , MARIE, N , (2014) OPIOID RECEPTOR DESENSITIZATION: MECHANISMS AND ITS LINK TO TOLERANCE.FRONTIERS IN PHARMACOLOGY. VOL. 5. ISSUE . P. - 122 64% 14
3 KOCH, T , HOLLT, V , (2008) ROLE OF RECEPTOR INTERNALIZATION IN OPIOID TOLERANCE AND DEPENDENCE.PHARMACOLOGY & THERAPEUTICS. VOL. 117. ISSUE 2. P. 199-206 89 83% 101
4 DANG, VC , CHRISTIE, MJ , (2012) MECHANISMS OF RAPID OPIOID RECEPTOR DESENSITIZATION, RESENSITIZATION AND TOLERANCE IN BRAIN NEURONS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 165. ISSUE 6. P. 1704-1716 83 81% 47
5 RAEHAL, KM , SCHMID, CL , GROER, CE , BOHN, LM , (2011) FUNCTIONAL SELECTIVITY AT THE MU-OPIOID RECEPTOR: IMPLICATIONS FOR UNDERSTANDING OPIOID ANALGESIA AND TOLERANCE.PHARMACOLOGICAL REVIEWS. VOL. 63. ISSUE 4. P. 1001 -1019 99 66% 71
6 MARIE, N , AGUILA, B , ALLOUCHE, S , (2006) TRACKING THE OPIOID RECEPTORS ON THE WAY OF DESENSITIZATION.CELLULAR SIGNALLING. VOL. 18. ISSUE 11. P. 1815-1833 121 71% 35
7 LIU, JG , ANAND, KJS , (2001) PROTEIN KINASES MODULATE THE CELLULAR ADAPTATIONS ASSOCIATED WITH OPIOID TOLERANCE AND DEPENDENCE.BRAIN RESEARCH REVIEWS. VOL. 38. ISSUE 1-2. P. 1 -19 144 60% 142
8 LAW, PY , WONG, YH , LOH, HH , (2000) MOLECULAR MECHANISMS AND REGULATION OF OPIOID RECEPTOR SIGNALING.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 40. ISSUE . P. 389 -430 114 45% 390
9 JOHNSON, EE , CHRISTIE, MJ , CONNOR, M , (2005) THE ROLE OF OPIOID RECEPTOR PHOSPHORYLATION AND TRAFFICKING IN ADAPTATIONS TO PERSISTENT OPIOID TREATMENT.NEUROSIGNALS. VOL. 14. ISSUE 6. P. 290-302 68 78% 25
10 ZHANG, Y , XIONG, W , LIN, XJ , MA, X , YU, LC , (2009) RECEPTOR TRAFFICKING INDUCED BY MU-OPIOID-RECEPTOR PHOSPHORYLATION.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. VOL. 33. ISSUE 8. P. 1192-1197 52 90% 7

Classes with closest relation at Level 1


Rank Class id link
1 1629 ENDOMORPHIN//DELTA OPIOID RECEPTOR//ENDOMORPHIN 2
2 12725 OPIOID INDUCED HYPERALGESIA//MORPHINE TOLERANCE//MORPHINE
3 8851 MORPHINE WITHDRAWAL//ACUTE DEPENDENCE//MORPHINE DEPENDENCE
4 17824 H 3ETORPHINE//H 3DIPRENORPHINE//SNPYS GROUP
5 22871 DUODENAL DISTENSION//KATEDRA FIZJOL BIOCHEM FARMAKOL TOKSYKOL//EXPT CLIN PHYSIOPHARMACOL
6 2285 G PROTEIN COUPLED RECEPTOR KINASE//ARRESTIN//BETA ARRESTIN
7 36873 STRAUB TAIL REACTION//BEIGE J MICE//MU2 OPIOID RECEPTOR
8 3821 DYNORPHIN//DYNORPHIN A//KAPPA OPIOID RECEPTOR
9 12347 OPIOID GROWTH FACTOR//OPIOID GROWTH FACTOR RECEPTOR//PRENATAL MORPHINE
10 26800 DADLE//HIBERNATION INDUCTION TRIGGER//DELTA OPIOID RECEPTOR

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