Class information for:
Level 1: LRRK2//LEUCINE RICH REPEAT KINASE 2//LEUCINE RICH REPEAT KINASE 2 LRRK2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6773 1445 45.5 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
124 3       PARKINSONS DISEASE//MOVEMENT DISORDERS//DEEP BRAIN STIMULATION 67777
332 2             PARKINSONS DISEASE//ALPHA SYNUCLEIN//PARKIN 18089
6773 1                   LRRK2//LEUCINE RICH REPEAT KINASE 2//LEUCINE RICH REPEAT KINASE 2 LRRK2 1445

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LRRK2 authKW 6227851 25% 81% 365
2 LEUCINE RICH REPEAT KINASE 2 authKW 1198062 4% 90% 63
3 LEUCINE RICH REPEAT KINASE 2 LRRK2 authKW 827972 3% 85% 46
4 PARK8 authKW 826034 3% 95% 41
5 G2019S authKW 676781 2% 97% 33
6 DARDARIN authKW 455382 2% 86% 25
7 ATP13A2 authKW 368111 2% 62% 28
8 PARKINSONS DISEASE authKW 349320 49% 2% 704
9 G2019S MUTATION authKW 253561 1% 100% 12
10 KUFOR RAKEB SYNDROME authKW 223181 1% 81% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Clinical Neurology 8033 33% 0% 476
2 Neurosciences 5799 38% 0% 543
3 Genetics & Heredity 2363 18% 0% 257
4 Biochemistry & Molecular Biology 1058 26% 0% 370
5 Geriatrics & Gerontology 872 4% 0% 64
6 Cell Biology 194 8% 0% 115
7 Chemistry, Medicinal 43 2% 0% 35
8 Biophysics 30 3% 0% 41
9 Medicine, Research & Experimental 26 3% 0% 41
10 Cell & Tissue Engineering 11 0% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL BIOL GENE EXP S UNIT 185032 1% 52% 17
2 CELL BIOL GENE EXP S SECT 132245 1% 48% 13
3 PL NEUROGENET 127521 1% 46% 13
4 NEUROGENET 126868 10% 4% 148
5 WANGJIANG HOSP 124286 1% 59% 10
6 NEUROBIOL GENE THER Y 115806 2% 22% 25
7 BOOTH GARDNER PARKINSONS CARE 108655 1% 43% 12
8 NEURODEGENERAT EXPT THER EUT 106462 2% 20% 25
9 NEUROREGENERAT PROGRAM 105299 1% 28% 18
10 RD CELL DESIGN 88040 0% 83% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PARKINSONISM & RELATED DISORDERS 52313 5% 3% 77
2 MOVEMENT DISORDERS 37769 7% 2% 108
3 NEUROBIOLOGY OF AGING 11456 4% 1% 56
4 HUMAN MOLECULAR GENETICS 10543 5% 1% 70
5 NEUROGENETICS 10077 1% 3% 17
6 MOLECULAR NEURODEGENERATION 6374 1% 2% 13
7 PARKINSONS DISEASE 6110 1% 3% 11
8 FRONTIERS IN MOLECULAR NEUROSCIENCE 4371 1% 2% 11
9 NEURODEGENERATIVE DISEASES 3052 1% 1% 10
10 JOURNAL OF PARKINSONS DISEASE 2725 0% 2% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LRRK2 6227851 25% 81% 365 Search LRRK2 Search LRRK2
2 LEUCINE RICH REPEAT KINASE 2 1198062 4% 90% 63 Search LEUCINE+RICH+REPEAT+KINASE+2 Search LEUCINE+RICH+REPEAT+KINASE+2
3 LEUCINE RICH REPEAT KINASE 2 LRRK2 827972 3% 85% 46 Search LEUCINE+RICH+REPEAT+KINASE+2+LRRK2 Search LEUCINE+RICH+REPEAT+KINASE+2+LRRK2
4 PARK8 826034 3% 95% 41 Search PARK8 Search PARK8
5 G2019S 676781 2% 97% 33 Search G2019S Search G2019S
6 DARDARIN 455382 2% 86% 25 Search DARDARIN Search DARDARIN
7 ATP13A2 368111 2% 62% 28 Search ATP13A2 Search ATP13A2
8 PARKINSONS DISEASE 349320 49% 2% 704 Search PARKINSONS+DISEASE Search PARKINSONS+DISEASE
9 G2019S MUTATION 253561 1% 100% 12 Search G2019S+MUTATION Search G2019S+MUTATION
10 KUFOR RAKEB SYNDROME 223181 1% 81% 13 Search KUFOR+RAKEB+SYNDROME Search KUFOR+RAKEB+SYNDROME

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RUDENKO, I , COOKSON, M , (2014) HETEROGENEITY OF LEUCINE-RICH REPEAT KINASE 2 MUTATIONS: GENETICS, MECHANISMS AND THERAPEUTIC IMPLICATIONS.NEUROTHERAPEUTICS. VOL. 11. ISSUE 4. P. 738 -750 155 95% 8
2 WALLINGS, R , MANZONI, C , BANDOPADHYAY, R , (2015) CELLULAR PROCESSES ASSOCIATED WITH LRRK2 FUNCTION AND DYSFUNCTION.FEBS JOURNAL. VOL. 282. ISSUE 15. P. 2806 -2826 146 87% 8
3 PAISAN-RUIZ, C , LEWIS, PA , SINGLETON, AB , (2013) LRRK2: CAUSE, RISK, AND MECHANISM.JOURNAL OF PARKINSONS DISEASE. VOL. 3. ISSUE 2. P. 85 -103 150 91% 14
4 ESTEVES, AR , SWERDLOW, RH , CARDOSO, SM , (2014) LRRK2, A PUZZLING PROTEIN: INSIGHTS INTO PARKINSON'S DISEASE PATHOGENESIS.EXPERIMENTAL NEUROLOGY. VOL. 261. ISSUE . P. 206 -216 135 91% 18
5 LANGSTON, RG , RUDENKO, IN , COOKSON, MR , (2016) THE FUNCTION OF ORTHOLOGUES OF THE HUMAN PARKINSON'S DISEASE GENE LRRK2 ACROSS SPECIES: IMPLICATIONS FOR DISEASE MODELLING IN PRECLINICAL RESEARCH.BIOCHEMICAL JOURNAL. VOL. 473. ISSUE . P. 221 -232 118 86% 0
6 TAYMANS, JM , GREGGIO, E , (2016) LRRK2 KINASE INHIBITION AS A THERAPEUTIC STRATEGY FOR PARKINSON'S DISEASE, WHERE DO WE STAND?.CURRENT NEUROPHARMACOLOGY. VOL. 14. ISSUE 3. P. 214 -225 93 99% 1
7 MARTIN, I , KIM, JW , DAWSON, VL , DAWSON, TM , (2014) LRRK2 PATHOBIOLOGY IN PARKINSON'S DISEASE.JOURNAL OF NEUROCHEMISTRY. VOL. 131. ISSUE 5. P. 554 -565 90 91% 18
8 RIDEOUT, HJ , STEFANIS, L , (2014) THE NEUROBIOLOGY OF LRRK2 AND ITS ROLE IN THE PATHOGENESIS OF PARKINSON'S DISEASE.NEUROCHEMICAL RESEARCH. VOL. 39. ISSUE 3. P. 576-592 103 79% 15
9 YUE, M , HINKLE, KM , DAVIES, P , TRUSHINA, E , FIESEL, FC , CHRISTENSON, TA , SCHROEDER, AS , ZHANG, L , BOWLES, E , BEHROUZ, B , ET AL (2015) PROGRESSIVE DOPAMINERGIC ALTERATIONS AND MITOCHONDRIAL ABNORMALITIES IN LRRK2 G2019S KNOCK-IN MICE.NEUROBIOLOGY OF DISEASE. VOL. 78. ISSUE . P. 172 -195 87 81% 16
10 GOMEZ-SUAGA, P , FDEZ, E , FERNANDEZ, B , MARTINEZ-SALVADOR, M , RAMIREZ, MB , MADERO-PEREZ, J , RIVERO-RIOS, P , FUENTES, JM , HILFIKER, S , (2014) NOVEL INSIGHTS INTO THE NEUROBIOLOGY UNDERLYING LRRK2-LINKED PARKINSON'S DISEASE.NEUROPHARMACOLOGY. VOL. 85. ISSUE . P. 45 -56 101 74% 12

Classes with closest relation at Level 1


Rank Class id link
1 4709 PARKIN//PINK1//PARK2
2 4921 PARKINSONS DISEASE//MANEB//MOL CELLULAR TOXICOL HUMAN PLICAT
3 29898 3 4 DIHYDROXYPHENYLACETALDEHYDE//3 4 DIHYDROXYPHENYLGLYCOLALDEHYDE//DOPAL
4 477 ALPHA SYNUCLEIN//SYNUCLEIN//LEWY BODY
5 31685 AGING NEUROEPIDEMIOL GRP//1 3 BIS 2 CHLOROETHYL 1 NITROSOUREA//AMYOTROPHIC LATERAL SCLEROSIS MORTALITY
6 17247 DJ 1//PARK7//DJ 1 SUPERFAMILY
7 17837 RETROMER//SORTING NEXIN//VPS35
8 8954 NEUROPHARMACOL SECT//MICROGLIA//PARKINSONS DISEASE
9 18617 PKAN//NBIA//HALLERVORDEN SPATZ SYNDROME
10 24756 TRANSCRANIAL SONOGRAPHY//SUBSTANTIA NIGRA HYPERECHOGENICITY//TRANSCRANIAL ULTRASOUND

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