Class information for:
Level 2: PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1486 7631 41.6 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
328 3       PHOSPHOLIPASE D//STIM1//REGUCALCIN 38118
1486 2             PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1 7631
1767 1                   PROTEIN KINASE C//PKC DELTA//CELLULAR CARCINOGENESIS TUMOR PROMOT 2494
3210 1                   PROTEIN KINASE C//PHORBOL ESTER//COW MAMMARY GLAND 2038
15482 1                   BCL10//PKC THETA//CARMA3 710
17826 1                   BRYOSTATIN//BRYOSTATIN 1//APLYSIATOXIN 580
19822 1                   PAR 4//ATYPICAL PROTEIN KINASE C//PROTEIN KINASE C IOTA 488
21004 1                   TELEOCIDIN//TUMOR PROMOTER//PENDOLMYCIN 437
22205 1                   RACK1//EIF6//RECEPTOR FOR ACTIVATED C KINASE 1 RACK1 390
25613 1                   UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251 276
32191 1                   ENZASTAURIN//LY317615//INTRATUMORAL VESSELS 142
36666 1                   KHIRURGIYA//AGING RELATED PROTEINS//INTESTINAL NEUROENDOCRINE CELLS 76

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN KINASE C authKW 346177 12% 10% 899
2 BRYOSTATIN authKW 268619 1% 73% 92
3 BRYOSTATIN 1 authKW 260927 1% 75% 87
4 RACK1 authKW 208878 1% 50% 104
5 PAR 4 authKW 164011 1% 63% 65
6 ENZASTAURIN authKW 131530 1% 66% 50
7 BCL10 authKW 113793 1% 55% 52
8 PKC THETA authKW 105969 1% 49% 54
9 PHORBOL ESTER authKW 95685 3% 12% 205
10 PKC DELTA authKW 93325 1% 28% 84

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 16580 40% 0% 3062
2 Cell Biology 9520 19% 0% 1485
3 Oncology 9060 19% 0% 1477
4 Biophysics 5125 10% 0% 787
5 Pharmacology & Pharmacy 669 8% 0% 621
6 Chemistry, Medicinal 657 4% 0% 269
7 Immunology 534 6% 0% 452
8 Hematology 262 3% 0% 201
9 Chemistry, Organic 182 4% 0% 304
10 Neurosciences 180 6% 0% 430

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR CARCINOGENESIS TUMOR PROMOT 64681 1% 23% 72
2 PROT PHOSPHORYLAT 38343 0% 27% 36
3 UNIT CELLULAR SIGNAL INTEGRAT 29377 0% 57% 13
4 ONCOL PROD DEV 23997 0% 100% 6
5 BIOQUIM BIOL MOL A 19644 1% 11% 43
6 BIOSIGNAL 18155 1% 9% 50
7 LP MARKEY CANC 15990 0% 50% 8
8 CHEM SYST BIOL 14312 1% 8% 44
9 MOL MECH TUMOR PROMOT SECT 13463 0% 42% 8
10 MOL TOXICOL PHARMACOL 13044 0% 23% 14

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL GROWTH & DIFFERENTIATION 9789 1% 4% 59
2 JOURNAL OF BIOLOGICAL CHEMISTRY 9262 8% 0% 617
3 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 7009 5% 1% 356
4 KHIRURGIYA 6560 1% 4% 46
5 CELLULAR SIGNALLING 6493 1% 2% 85
6 CANCER RESEARCH 6333 3% 1% 256
7 FEBS LETTERS 3358 3% 0% 193
8 CARCINOGENESIS 2459 1% 1% 87
9 BIOCHEMICAL JOURNAL 1963 2% 0% 126
10 EXPERIMENTAL CELL RESEARCH 1776 1% 1% 78

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEIN KINASE C 346177 12% 10% 899 Search PROTEIN+KINASE+C Search PROTEIN+KINASE+C
2 BRYOSTATIN 268619 1% 73% 92 Search BRYOSTATIN Search BRYOSTATIN
3 BRYOSTATIN 1 260927 1% 75% 87 Search BRYOSTATIN+1 Search BRYOSTATIN+1
4 RACK1 208878 1% 50% 104 Search RACK1 Search RACK1
5 PAR 4 164011 1% 63% 65 Search PAR+4 Search PAR+4
6 ENZASTAURIN 131530 1% 66% 50 Search ENZASTAURIN Search ENZASTAURIN
7 BCL10 113793 1% 55% 52 Search BCL10 Search BCL10
8 PKC THETA 105969 1% 49% 54 Search PKC+THETA Search PKC+THETA
9 PHORBOL ESTER 95685 3% 12% 205 Search PHORBOL+ESTER Search PHORBOL+ESTER
10 PKC DELTA 93325 1% 28% 84 Search PKC+DELTA Search PKC+DELTA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GARG, R , BENEDETTI, LG , ABERA, MB , WANG, H , ABBA, M , KAZANIETZ, MG , (2014) PROTEIN KINASE C AND CANCER: WHAT WE KNOW AND WHAT WE DO NOT.ONCOGENE. VOL. 33. ISSUE 45. P. 5225 -5237 173 75% 20
2 STEINBERG, SF , (2008) STRUCTURAL BASIS OF PROTEIN KINASE C ISOFORM FUNCTION.PHYSIOLOGICAL REVIEWS. VOL. 88. ISSUE 4. P. 1341-1378 146 63% 346
3 GRINER, EM , KAZANIETZ, MG , (2007) PROTEIN KINASE C AND OTHER DIACYLGLYCEROL EFFECTORS IN CANCER.NATURE REVIEWS CANCER. VOL. 7. ISSUE 4. P. 281-294 126 68% 497
4 REYLAND, ME , (2009) PROTEIN KINASE C ISOFORMS: MULTI-FUNCTIONAL REGULATORS OF CELL LIFE AND DEATH.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 14. ISSUE . P. 2386 -2399 117 87% 148
5 HUG, H , SARRE, TF , (1993) PROTEIN-KINASE-C ISOENZYMES - DIVERGENCE IN SIGNAL TRANSDUCTION.BIOCHEMICAL JOURNAL. VOL. 291. ISSUE . P. 329 -343 143 67% 1238
6 CORBALAN-GARCIA, S , GOMEZ-FERNANDEZ, JC , (2006) PROTEIN KINASE C REGULATORY DOMAINS: THE ART OF DECODING MANY DIFFERENT SIGNALS IN MEMBRANES.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1761. ISSUE 7. P. 633-654 175 71% 66
7 DAS, J , RAHMAN, GM , (2014) C1 DOMAINS: STRUCTURE AND LIGAND-BINDING PROPERTIES.CHEMICAL REVIEWS. VOL. 114. ISSUE 24. P. 12108 -12131 153 67% 10
8 HAGE-SLEIMAN, R , HAMZE, AB , RESLAN, L , KOBEISSY, H , DBAIBO, G , (2015) THE NOVEL PKC THETA FROM BENCHTOP TO CLINIC.JOURNAL OF IMMUNOLOGY RESEARCH. VOL. . ISSUE . P. - 135 67% 5
9 HOFMANN, J , (2004) PROTEIN KINASE C ISOZYMES AS POTENTIAL TARGETS FOR ANTICANCER THERAPY.CURRENT CANCER DRUG TARGETS. VOL. 4. ISSUE 2. P. 125 -146 170 64% 136
10 IRIE, K , YANAGITA, RC , (2014) SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SIMPLIFIED ANALOGS OF THE NATURAL PKC LIGANDS, BRYOSTATIN-1 AND APLYSIATOXIN.CHEMICAL RECORD. VOL. 14. ISSUE 2. P. 251-267 115 82% 6

Classes with closest relation at Level 2


Rank Class id link
1 2254 PHOSPHOLIPASE D//DIACYLGLYCEROL KINASE//PHOSPHATIDIC ACID
2 2528 CARCINOGENESIS//CELL TRANSFORMATION ASSAY//BHAS 42 CELLS
3 2803 GAP 43//PALMITOYLATION//MARCKS
4 2713 METHYLSULFONYLMETHANE//SEROFENDIC ACID//N ACETYL S N METHYLCARBAMOYLCYSTEINE
5 2158 NF KAPPA B//I KAPPA B//IKK
6 2896 CALPAIN//CALPASTATIN//CALPAIN INHIBITOR
7 1301 CHRONIC GRANULOMATOUS DISEASE//FORMYL PEPTIDE RECEPTOR//NADPH OXIDASE
8 3218 SECT CELLULAR SIGNALING//GH3 CELLS//THERMOSTABLE ALKALINE PHOSPHATASE
9 3564 14 3 3 PROTEIN//14 3 3//14 3 3 SIGMA
10 1195 JNK//ERK5//MAP KINASE

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