Class information for:
Level 1: CYP2C8//COCKTAIL//MECHANISM BASED INHIBITION

Basic class information
Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 ONCOLOGY//CELL BIOLOGY//BIOCHEMISTRY & MOLECULAR BIOLOGY 2934640
273 3       P GLYCOPROTEIN//MULTIDRUG RESISTANCE//DRUG METABOLISM AND DISPOSITION 43782
444 2             CYTOCHROME P450//EPOXYEICOSATRIENOIC ACIDS//CYP2D6 16462
9019 1                   CYP2C8//COCKTAIL//MECHANISM BASED INHIBITION 1225

Terms with highest relevance score


rank Category termType chi_square shrOfCwithTerm shrOfTermInClass termInClass
1 CYP2C8 authKW 534145 5% 36% 58
2 COCKTAIL authKW 478856 4% 42% 44
3 MECHANISM BASED INHIBITION authKW 271641 3% 34% 31
4 DRUG METABOLISM AND DISPOSITION journal 220814 21% 3% 255
5 TIME DEPENDENT INHIBITION authKW 166814 2% 31% 21
6 CYP INHIBITION authKW 165950 2% 32% 20
7 DRUG DRUG INTERACTIONS authKW 152671 6% 8% 70
8 COCKTAIL APPROACH authKW 138915 1% 60% 9
9 DRUG DRUG INTERACTION authKW 134801 6% 7% 73
10 MECHANISM BASED INACTIVATION authKW 116061 2% 24% 19

Web of Science journal categories


chi_square_rank Category chi_square shrOfCwithTerm shrOfTermInClass termInClass
1 Pharmacology & Pharmacy 25423 82% 0% 1001
2 Toxicology 3019 15% 0% 188
3 Biochemical Research Methods 292 6% 0% 74
4 Chemistry, Analytical 229 7% 0% 90
5 Chemistry, Medicinal 187 4% 0% 54
6 Medical Laboratory Technology 49 1% 0% 16
7 Integrative & Complementary Medicine 28 1% 0% 9
8 Biochemistry & Molecular Biology 13 8% 0% 96
9 Spectroscopy 12 2% 0% 19
10 Chemistry, Multidisciplinary 2 4% 0% 53

Address terms


chi_square_rank term chi_square shrOfCwithTerm shrOfTermInClass termInClass
1 POST MKT PROD DEV 77179 0% 100% 3
2 METAB CHEM 71236 0% 46% 6
3 COMP ASSISTED THER EUT 51453 0% 100% 2
4 CORNING GENTEST CONTRACT SERV 51453 0% 100% 2
5 POSTMARKETING DEV 51453 0% 100% 2
6 DRUG METAB PHARMACOKINET 51099 6% 3% 78
7 BIOPHARMACEUT PHARMACOKINET S 43399 1% 19% 9
8 DRUG METAB 41155 4% 3% 51
9 BLADES ENTERPRISE 40970 1% 11% 14
10 PHYS METAB SCI 40940 1% 14% 11

Journals


chi_square_rank term chi_square shrOfCwithTerm shrOfTermInClass termInClass
1 DRUG METABOLISM AND DISPOSITION 220814 21% 3% 255
2 XENOBIOTICA 61232 8% 2% 97
3 CURRENT DRUG METABOLISM 30877 3% 3% 37
4 DRUG METABOLISM AND PHARMACOKINETICS 21333 2% 3% 25
5 CLINICAL PHARMACOLOGY & THERAPEUTICS 17194 5% 1% 63
6 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 8067 4% 1% 51
7 EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 5690 1% 1% 17
8 JOURNAL OF CLINICAL PHARMACOLOGY 5342 3% 1% 34
9 CLINICAL PHARMACOKINETICS 4209 2% 1% 20
10 BIOPHARMACEUTICS & DRUG DISPOSITION 3797 1% 1% 17

Author Key Words


chi_square_rank term chi_square shrOfCwithTerm shrOfTermInClass termInClass LCSH search Wikipedia search
1 CYP2C8 534145 5% 36% 58 Search CYP2C8 Search CYP2C8
2 COCKTAIL 478856 4% 42% 44 Search COCKTAIL Search COCKTAIL
3 MECHANISM BASED INHIBITION 271641 3% 34% 31 Search MECHANISM+BASED+INHIBITION Search MECHANISM+BASED+INHIBITION
4 TIME DEPENDENT INHIBITION 166814 2% 31% 21 Search TIME+DEPENDENT+INHIBITION Search TIME+DEPENDENT+INHIBITION
5 CYP INHIBITION 165950 2% 32% 20 Search CYP+INHIBITION Search CYP+INHIBITION
6 DRUG DRUG INTERACTIONS 152671 6% 8% 70 Search DRUG+DRUG+INTERACTIONS Search DRUG+DRUG+INTERACTIONS
7 COCKTAIL APPROACH 138915 1% 60% 9 Search COCKTAIL+APPROACH Search COCKTAIL+APPROACH
8 DRUG DRUG INTERACTION 134801 6% 7% 73 Search DRUG+DRUG+INTERACTION Search DRUG+DRUG+INTERACTION
9 MECHANISM BASED INACTIVATION 116061 2% 24% 19 Search MECHANISM+BASED+INACTIVATION Search MECHANISM+BASED+INACTIVATION
10 CYP3A4 113368 6% 6% 72 Search CYP3A4 Search CYP3A4

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.

Classes with closest relation at Level 1


rank cluster_id2 link
1 10591 INTERSPECIES SCALING//CLEARANCE PREDICTION//WELL STIRRED MODEL
2 22860 BISOPROLOL EFFICACY//FLURITHROMYCIN ETHYLSUCCINATE//INTRAVESICAL BCG INSTILLATION
3 19382 PHARMACOKINET BIOANAL//MICROMINIPIG//MINIPIG
4 1802 CYTOCHROME P450//SITE OF METABOLISM//CYTOCHROME P450CAM
5 16654 GRAPEFRUIT JUICE//BERGAMOTTIN//FURANOCOUMARINS
6 1473 CYP2D6//DEBRISOQUINE//CYP2C19
7 4536 OATP1B1//SLCO1B1//PITAVASTATIN
8 3381 CYP3A5//TACROLIMUS//6 BETA HYDROXYCORTISOL
9 11078 HERB DRUG INTERACTION//ST JOHNS WORT//DRUG HERB INTERACTION
10 12673 REACTIVE METABOLITES//PHARMACOKINET DYNAM METAB//BIOACTIVATION

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