DD2398 Quantitative Systems Biology 7.5 credits

The basic circuitry in transcription regulation,
and other biological networks, including examples.
The principle of robustness in biological systems
of control.Kinetic proofreading and other
error-correcting mechanisms in biological
information-processing. Principles of kinetic
equations in gene regulatory modelling. Motifs
in biological and other networks.

After the course the student should be able to

* formulate mathematical models of gene regulatory networks on the level of kinetic equations

* simulate such systems and compare to experimental
  data

* discuss network properties in genomic data

* compute simple graph theoretical properties of such data

so that they will be able to

* independently construct computer programs that
  model melecular mechanisms of gene regulation

* in professional life identify biological problems
  that a sufficiently well describe that mathematical
  modeling and simulation could be of added value

Single course students: 90 university credits including 45 university credits in Mathematics or Information Technology. English B, or equivalent.

The courses in the basic block on mathematics, computer science and numerical analysis on the D-, E- or F-programme.
The course SK2530 Introduction to Biomedicine
or equivalent.

Uri Alon, 2007
An Introduction to Systems Biology: Design Principles of Biological Circuits
Chapman & Hall/CRC Mathematical and Computational Biology Series
ISBN-10: 1-58488-642-0
ISBN-13: 978-158488-642-6

If the course is discontinued, students may request to be examined during the following two academic years.

• LAB1 - Laboratory Work, 2.5 credits, grading scale: P, F
• TEN1 - Examination, 5.0 credits, grading scale: A, B, C, D, E, FX, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

Students will have one opportunity to correct every iuncorrectly executed homework assignment until the individual examination on the course start, no longer however than until three weeks after the last lecture in the course. Other possibilities and modalities to be examined on the course to be discussed with the examiner in each case.

In this course all the regulations of the code of honor at the School of Computer science and Communication apply, see: http://www.kth.se/csc/student/hederskodex/1.17237?l=en_UK.

Four homework assignments give one grade point per
correctly executed assignments. For the highest grade, four correctly executed assignments and an individual examination are required.

The individual examination is conducted by the examiner with one assistant under at least 30 minutes and at most 60 minutes per student.

Erik Aurell

• All members of a group are responsible for the group's work.
• In any assessment, every student shall honestly disclose any help received and sources used.
• In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.

Courses in KTHs International Master's Program in
Computational and Systems Biology, in particular
Omic data systems biology (Jens Lagergren examiner,
course code missing), 2D1450 Algorithmic Bioinformatics,  SK2520 Experimental Methods in Molecular Biophysics, HL1008 Cellular and Molecular Biology, and DD2447 Statistical Methods in Applied Computer Science.