Class information for:
Level 1: RIBOZYME//HAMMERHEAD RIBOZYME//CATALYTIC RNA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2916 2115 44.4 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
183 3       APTAMER//G QUADRUPLEX//RIBOZYME 56307
1185 2             RIBOZYME//RNASE P//CATALYTIC RNA 9289
2916 1                   RIBOZYME//HAMMERHEAD RIBOZYME//CATALYTIC RNA 2115

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RIBOZYME authKW 1354105 17% 26% 355
2 HAMMERHEAD RIBOZYME authKW 1143830 6% 61% 129
3 CATALYTIC RNA authKW 653861 5% 46% 98
4 HAIRPIN RIBOZYME authKW 630175 2% 89% 49
5 HAMMERHEAD authKW 460179 2% 74% 43
6 RNA CATALYSIS authKW 437305 3% 48% 63
7 HDV RIBOZYME authKW 189625 1% 77% 17
8 MAXIZYME authKW 173229 1% 100% 12
9 SELF CLEAVING RNA authKW 120295 0% 83% 10
10 RNA SELF CLEAVAGE authKW 103107 0% 71% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 12939 64% 0% 1345
2 Biotechnology & Applied Microbiology 1367 12% 0% 254
3 Medicine, Research & Experimental 1167 10% 0% 207
4 Virology 951 6% 0% 118
5 Biophysics 798 8% 0% 170
6 Genetics & Heredity 630 9% 0% 180
7 Cell Biology 386 9% 0% 188
8 Biochemical Research Methods 145 4% 0% 79
9 Chemistry, Medicinal 31 2% 0% 41
10 Chemistry, Multidisciplinary 22 5% 0% 116

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENE DISCOVERY 81210 1% 26% 22
2 SINGLE MOL ANAL GRP 74475 1% 30% 17
3 GENE FUNCT 61461 1% 15% 28
4 CANC UK NUCLE ACID STRUCT GRP 55458 1% 27% 14
5 NUCLEIC ACID STRUCT GRP 50518 0% 50% 7
6 MOL BIOL RNA 37577 1% 11% 23
7 RNA GRPGRP ARN 35358 0% 35% 7
8 MARKEY MOL GENET 33861 1% 13% 18
9 CANC UK NUCL ACID STRUCT GRP 32803 0% 45% 5
10 NUCLE ACID STRUCT GRP 32143 0% 32% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT 58954 2% 10% 39
2 RNA 22515 3% 2% 63
3 NUCLEIC ACIDS RESEARCH 16888 10% 1% 216
4 ANTISENSE RESEARCH AND DEVELOPMENT 16689 0% 13% 9
5 RNA-A PUBLICATION OF THE RNA SOCIETY 13064 2% 3% 34
6 HUMAN GENE THERAPY 8314 2% 1% 44
7 BIOCHEMISTRY 6757 8% 0% 160
8 OLIGONUCLEOTIDES 4329 0% 3% 9
9 GENE THERAPY 4207 2% 1% 34
10 JOURNAL OF MOLECULAR BIOLOGY 2680 3% 0% 67

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RIBOZYME 1354105 17% 26% 355 Search RIBOZYME Search RIBOZYME
2 HAMMERHEAD RIBOZYME 1143830 6% 61% 129 Search HAMMERHEAD+RIBOZYME Search HAMMERHEAD+RIBOZYME
3 CATALYTIC RNA 653861 5% 46% 98 Search CATALYTIC+RNA Search CATALYTIC+RNA
4 HAIRPIN RIBOZYME 630175 2% 89% 49 Search HAIRPIN+RIBOZYME Search HAIRPIN+RIBOZYME
5 HAMMERHEAD 460179 2% 74% 43 Search HAMMERHEAD Search HAMMERHEAD
6 RNA CATALYSIS 437305 3% 48% 63 Search RNA+CATALYSIS Search RNA+CATALYSIS
7 HDV RIBOZYME 189625 1% 77% 17 Search HDV+RIBOZYME Search HDV+RIBOZYME
8 MAXIZYME 173229 1% 100% 12 Search MAXIZYME Search MAXIZYME
9 SELF CLEAVING RNA 120295 0% 83% 10 Search SELF+CLEAVING+RNA Search SELF+CLEAVING+RNA
10 RNA SELF CLEAVAGE 103107 0% 71% 10 Search RNA+SELF+CLEAVAGE Search RNA+SELF+CLEAVAGE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FEDOR, MJ , (2009) COMPARATIVE ENZYMOLOGY AND STRUCTURAL BIOLOGY OF RNA SELF-CLEAVAGE.ANNUAL REVIEW OF BIOPHYSICS. VOL. 38. ISSUE . P. 271-299 148 86% 77
2 AMARZGUIOUI, M , PRYDZ, H , (1998) HAMMERHEAD RIBOZYME DESIGN AND APPLICATION.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 54. ISSUE 11. P. 1175 -1202 194 82% 40
3 FEDOR, MJ , (2000) STRUCTURE AND FUNCTION OF THE HAIRPIN RIBOZYME.JOURNAL OF MOLECULAR BIOLOGY. VOL. 297. ISSUE 2. P. 269 -291 136 81% 147
4 PUERTA-FERNANDEZ, E , ROMERO-LOPEZ, C , BARROSO-DELJESUS, A , BERZAL-HERRANZ, A , (2003) RIBOZYMES: RECENT ADVANCES IN THE DEVELOPMENT OF RNA TOOLS.FEMS MICROBIOLOGY REVIEWS. VOL. 27. ISSUE 1. P. 75-97 177 61% 64
5 VOROBJEVA, MA , DAVYDOVA, AS , VENYAMINOVA, AG , (2011) ARTIFICIAL HAMMERHEAD RIBOZYMES: ENGINEERING AND APPLICATIONS.RUSSIAN CHEMICAL REVIEWS. VOL. 80. ISSUE 2. P. 127 -143 108 82% 1
6 LEE, TS , RADAK, BK , HARRIS, ME , YORK, DM , (2016) A TWO-METAL-ION-MEDIATED CONFORMATIONAL SWITCHING PATHWAY FOR HDV RIBOZYME ACTIVATION.ACS CATALYSIS. VOL. 6. ISSUE 3. P. 1853 -1869 80 78% 2
7 BLOUNT, KE , UHLENBECK, OC , (2005) THE STRUCTURE-FUNCTION DILEMMA OF THE HAMMER HEAD RIBOZYME.ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE. VOL. 34. ISSUE . P. 415 -440 89 90% 95
8 BIRIKH, KR , HEATON, PA , ECKSTEIN, F , (1997) THE STRUCTURE, FUNCTION AND APPLICATION OF THE HAMMERHEAD RIBOZYME.EUROPEAN JOURNAL OF BIOCHEMISTRY. VOL. 245. ISSUE 1. P. 1-16 115 79% 205
9 WILSON, TJ , LILLEY, DMJ , (2013) A MECHANISTIC COMPARISON OF THE VARKUD SATELLITE AND HAIRPIN RIBOZYMES.CATALYTIC RNA. VOL. 120. ISSUE . P. 93-121 87 82% 1
10 JIMENEZ, RM , POLANCO, JA , LUPTAK, A , (2015) CHEMISTRY AND BIOLOGY OF SELF-CLEAVING RIBOZYMES.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 40. ISSUE 11. P. 648 -661 73 77% 9

Classes with closest relation at Level 1


Rank Class id link
1 11256 DEOXYRIBOZYME//DNAZYME//CATALYTIC DNA
2 4185 GROUP I INTRON//RIBOZYME//SELF SPLICING
3 29317 AOGEN//BRADYTROPHIC PHENOCOPY//CONTROL OF TRANSGENE EXPRESSION
4 23801 PHOSPHOROTHIOLATE//DIPHOSPHATE ANIONS//CELL MOL BIOL ICM
5 12082 RIBOSWITCH//CANC UK NUCLE ACID STRUCT GRP//RNA SWITCH
6 36765 PROGRAM BIOCHEM CHEM//2 SELENOURIDINE TRIPHOSPHATE//3 5 O DIACETYL 5 AMINOMETHYL 2 DEOXYURIDINE
7 10611 RNASE P//RIBONUCLEASE P//CARTILAGE HAIR HYPOPLASIA
8 13926 BIOL MACROMOL STRUCT//SHEARED G CENTER DOT A PAIR//SHEARED A CENTER DOT C PAIR
9 18145 RIBOSE AND NUCLEOBASE//ALTERNATE SITE SPECIFIC LABELING//DEUTERATED NUCLEOSIDES
10 9384 VIROID//PSTVD//POTATO SPINDLE TUBER VIROID

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