Class information for:
Level 2: PYRUVATE DEHYDROGENASE COMPLEX//NONKETOTIC HYPERGLYCINEMIA//DIHYDROLIPOAMIDE DEHYDROGENASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2868 2878 32.0 59%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
389 3       PEROXISOME//CARNITINE//JOURNAL OF INHERITED METABOLIC DISEASE 30841
2868 2             PYRUVATE DEHYDROGENASE COMPLEX//NONKETOTIC HYPERGLYCINEMIA//DIHYDROLIPOAMIDE DEHYDROGENASE 2878
4028 1                   PYRUVATE DEHYDROGENASE COMPLEX//DIHYDROLIPOAMIDE DEHYDROGENASE//LIPOYL DOMAIN 1860
19538 1                   REYES SYNDROME//JOSEPH KENNEDY MENTAL RETARDAT//HLTH SCI MED COMPARAT MED 500
21684 1                   NONKETOTIC HYPERGLYCINEMIA//GLYCINE CLEAVAGE SYSTEM//NKH 409
34588 1                   GLYCINE N ACYLTRANSFERASE//MEDIUM CHAIN ACYL COA SYNTHETASE//GLYCINE CONJUGATION 109

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PYRUVATE DEHYDROGENASE COMPLEX authKW 698465 5% 48% 137
2 NONKETOTIC HYPERGLYCINEMIA authKW 448172 2% 81% 52
3 DIHYDROLIPOAMIDE DEHYDROGENASE authKW 406890 2% 63% 61
4 LIPOYL DOMAIN authKW 329170 1% 97% 32
5 PYRUVATE DEHYDROGENASE KINASE authKW 302678 2% 52% 55
6 PYRUVATE DEHYDROGENASE authKW 281753 4% 23% 114
7 REYES SYNDROME authKW 281498 2% 52% 51
8 GLYCINE CLEAVAGE SYSTEM authKW 193497 1% 79% 23
9 PYRUVATE DEHYDROGENASE DEFICIENCY authKW 184153 1% 69% 25
10 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY authKW 166494 1% 83% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 9185 47% 0% 1366
2 Biophysics 1790 10% 0% 287
3 Pediatrics 1753 9% 0% 270
4 Genetics & Heredity 1167 10% 0% 278
5 Medicine, Research & Experimental 858 8% 0% 217
6 Endocrinology & Metabolism 723 7% 0% 210
7 Clinical Neurology 451 7% 0% 201
8 Cell Biology 256 7% 0% 199
9 Microbiology 129 4% 0% 124
10 Biochemical Research Methods 69 3% 0% 76

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FUNDAMENTAL MED PHARMACEUT SCI 34712 0% 55% 6
2 CHEM BIOL INTER E TRAINING PROGRAM 33944 0% 80% 4
3 GEN DEV MED 31812 0% 33% 9
4 PROT CHEM ENGN 25151 0% 22% 11
5 METAB PROGRAMME 24236 0% 29% 8
6 INHERITED DISORDERS ENERGY METAB 24104 0% 45% 5
7 CAMBRIDGE MOL RECOGNIT 23640 1% 9% 24
8 DMPK BIOTRANSFORMAT 21216 0% 100% 2
9 JOSEPH KENNEDY MENTAL RETARDAT 21216 0% 100% 2
10 EXTREMOPHILE 16558 0% 16% 10

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF INHERITED METABOLIC DISEASE 23316 3% 2% 100
2 BIOCHEMICAL JOURNAL 8218 5% 1% 152
3 EUROPEAN JOURNAL OF BIOCHEMISTRY 5229 3% 1% 100
4 MOLECULAR GENETICS AND METABOLISM 3426 1% 1% 32
5 JOURNAL OF BIOLOGICAL CHEMISTRY 2014 6% 0% 180
6 PEDIATRIC NEUROLOGY 1649 1% 1% 26
7 BIOCHEMISTRY INTERNATIONAL 1406 1% 1% 21
8 FEBS LETTERS 1387 3% 0% 76
9 PEDIATRIC RESEARCH 1364 1% 0% 35
10 BIOCHEMICAL ARCHIVES 1306 0% 1% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRUVATE DEHYDROGENASE COMPLEX 698465 5% 48% 137 Search PYRUVATE+DEHYDROGENASE+COMPLEX Search PYRUVATE+DEHYDROGENASE+COMPLEX
2 NONKETOTIC HYPERGLYCINEMIA 448172 2% 81% 52 Search NONKETOTIC+HYPERGLYCINEMIA Search NONKETOTIC+HYPERGLYCINEMIA
3 DIHYDROLIPOAMIDE DEHYDROGENASE 406890 2% 63% 61 Search DIHYDROLIPOAMIDE+DEHYDROGENASE Search DIHYDROLIPOAMIDE+DEHYDROGENASE
4 LIPOYL DOMAIN 329170 1% 97% 32 Search LIPOYL+DOMAIN Search LIPOYL+DOMAIN
5 PYRUVATE DEHYDROGENASE KINASE 302678 2% 52% 55 Search PYRUVATE+DEHYDROGENASE+KINASE Search PYRUVATE+DEHYDROGENASE+KINASE
6 PYRUVATE DEHYDROGENASE 281753 4% 23% 114 Search PYRUVATE+DEHYDROGENASE Search PYRUVATE+DEHYDROGENASE
7 REYES SYNDROME 281498 2% 52% 51 Search REYES+SYNDROME Search REYES+SYNDROME
8 GLYCINE CLEAVAGE SYSTEM 193497 1% 79% 23 Search GLYCINE+CLEAVAGE+SYSTEM Search GLYCINE+CLEAVAGE+SYSTEM
9 PYRUVATE DEHYDROGENASE DEFICIENCY 184153 1% 69% 25 Search PYRUVATE+DEHYDROGENASE+DEFICIENCY Search PYRUVATE+DEHYDROGENASE+DEFICIENCY
10 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY 166494 1% 83% 19 Search PYRUVATE+DEHYDROGENASE+COMPLEX+DEFICIENCY Search PYRUVATE+DEHYDROGENASE+COMPLEX+DEFICIENCY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PATEL, KP , O'BRIEN, TW , SUBRAMONY, SH , SHUSTER, J , STACPOOLE, PW , (2012) THE SPECTRUM OF PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY: CLINICAL, BIOCHEMICAL AND GENETIC FEATURES IN 371 PATIENTS.MOLECULAR GENETICS AND METABOLISM. VOL. 105. ISSUE 1. P. 34-43 137 88% 19
2 BERG, A , DEKOK, A , (1997) 2-OXO ACID DEHYDROGENASE MULTIENZYME COMPLEXES. THE CENTRAL ROLE OF THE LIPOYL DOMAIN.BIOLOGICAL CHEMISTRY. VOL. 378. ISSUE 7. P. 617-634 138 91% 66
3 ROCHE, TE , BAKER, JC , YAN, YH , HIROMASA, Y , GONG, XM , PENG, T , DONG, JC , TURKAN, A , KASTEN, SA , (2001) DISTINCT REGULATORY PROPERTIES OF PYRUVATE DEHYDROGENASE KINASE AND PHOSPHATASE ISOFORMS.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 70. VOL. 70. ISSUE . P. 33 -75 108 75% 112
4 CRONAN, JE , (2016) ASSEMBLY OF LIPOIC ACID ON ITS COGNATE ENZYMES: AN EXTRAORDINARY AND ESSENTIAL BIOSYNTHETIC PATHWAY.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 80. ISSUE 2. P. 429 -450 78 57% 4
5 HENGEVELD, AF , DE KOK, A , (2002) STRUCTURAL BASIS OF THE DYSFUNCTIONING OF HUMAN 2-OXO ACID DEHYDROGENASE COMPLEXES.CURRENT MEDICINAL CHEMISTRY. VOL. 9. ISSUE 4. P. 499 -520 107 71% 10
6 PERHAM, RN , (2000) SWINGING ARMS AND SWINGING DOMAINS IN MULTIFUNCTIONAL ENZYMES: CATALYTIC MACHINES FOR MULTISTEP REACTIONS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 69. ISSUE . P. 961 -1004 115 50% 292
7 DE KOK, A , HENGEVELD, AF , MARTIN, A , WESTPHAL, AH , (1998) THE PYRUVATE DEHYDROGENASE MULTI-ENZYME COMPLEX FROM GRAM-NEGATIVE BACTERIA.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. VOL. 1385. ISSUE 2. P. 353 -366 77 91% 98
8 PERHAM, RN , (1991) DOMAINS, MOTIFS, AND LINKERS IN 2-OXO ACID DEHYDROGENASE MULTIENZYME COMPLEXES - A PARADIGM IN THE DESIGN OF A MULTIFUNCTIONAL PROTEIN.BIOCHEMISTRY. VOL. 30. ISSUE 35. P. 8501-8512 77 93% 297
9 PATEL, MS , NEMERIA, NS , FUREY, W , JORDAN, F , (2014) THE PYRUVATE DEHYDROGENASE COMPLEXES: STRUCTURE-BASED FUNCTION AND REGULATION.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 289. ISSUE 24. P. 16615-16623 59 66% 32
10 ROCHE, TE , HIROMASA, Y , (2007) PYRUVATE DEHYDROGENASE KINASE REGULATORY MECHANISMS AND INHIBITION IN TREATING DIABETES, HEART ISCHEMIA, AND CANCER.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 64. ISSUE 7-8. P. 830-849 84 56% 114

Classes with closest relation at Level 2


Rank Class id link
1 2391 RARE SUGAR//TRANSKETOLASE//L ARABINOSE ISOMERASE
2 2144 JOURNAL OF INHERITED METABOLIC DISEASE//NEWBORN SCREENING//METHYLMALONIC ACIDEMIA
3 2805 BIOTIN//BIOTINIDASE DEFICIENCY//BIOTINIDASE
4 1056 GLUTAMINE//MAPLE SYRUP URINE DISEASE//LEUCINE
5 2612 WARBURG EFFECT//PKM2//PYRUVATE KINASE
6 381 MITOCHONDRIA//MELAS//MITOCHONDRIAL DISEASE
7 1504 CARNITINE//L CARNITINE//TRIMETAZIDINE
8 3076 PEPTIDE DEFORMYLASE//ENOYL ACP REDUCTASE//ACYL CARRIER PROTEIN
9 981 C 4 PHOTOSYNTHESIS//ALTERNATIVE OXIDASE//CO2 CONCENTRATING MECHANISM
10 1445 HEPATIC ENCEPHALOPATHY//HYPERAMMONEMIA//MINIMAL HEPATIC ENCEPHALOPATHY

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