Class information for:
Level 2: KYNURENINE//NEOPTERIN//INDOLEAMINE 2 3 DIOXYGENASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2074 5255 39.5 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
631 3       KYNURENINE//NEOPTERIN//INDOLEAMINE 2 3 DIOXYGENASE 12928
2074 2             KYNURENINE//NEOPTERIN//INDOLEAMINE 2 3 DIOXYGENASE 5255
5001 1                   KYNURENIC ACID//KYNURENINE//QUINOLINIC ACID 1690
5931 1                   INDOLEAMINE 2 3 DIOXYGENASE//INDOLEAMINE 2//IDO 1557
10585 1                   NEOPTERIN//PTERIDINES//MED CHEM BIOCHEM FRITZ PREGL STR 3 1051
17202 1                   HUMAN CULTU//LIFE STYLE STUDIES//PELLAGRA 611
23440 1                   NICOTINAMIDE N METHYLTRANSFERASE//1 METHYLNICOTINAMIDE//NNMT 346

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KYNURENINE authKW 1575093 8% 64% 425
2 NEOPTERIN authKW 1556231 10% 52% 513
3 INDOLEAMINE 2 3 DIOXYGENASE authKW 1435671 7% 68% 364
4 KYNURENIC ACID authKW 1360651 7% 66% 357
5 QUINOLINIC ACID authKW 683042 5% 44% 267
6 KYNURENINE PATHWAY authKW 626526 3% 79% 137
7 IDO authKW 345709 2% 49% 122
8 PTERIDINES journal 327649 3% 37% 151
9 INDOLEAMINE 2 authKW 322777 2% 65% 85
10 KYNURENINE AMINOTRANSFERASE authKW 306358 1% 89% 59

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Neurosciences 3855 18% 0% 934
2 Immunology 3503 14% 0% 731
3 Biochemistry & Molecular Biology 3209 24% 0% 1254
4 Nutrition & Dietetics 1117 4% 0% 234
5 Pharmacology & Pharmacy 1086 11% 0% 572
6 Biophysics 1034 6% 0% 323
7 Medicine, Research & Experimental 1005 6% 0% 331
8 Medical Laboratory Technology 834 2% 0% 123
9 Oncology 296 6% 0% 321
10 Clinical Neurology 219 4% 0% 234

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HUMAN CULTU 229650 2% 46% 86
2 MED CHEM BIOCHEM FRITZ PREGL STR 3 172092 1% 74% 40
3 MED CHEM BIOCHEM 145683 4% 14% 184
4 LIFE STYLE STUDIES 123318 1% 56% 38
5 PHYSIOL ANAT NEUROSCI 105597 1% 37% 49
6 CENT BLOOD TRANSFUS IMMUNOL 91690 1% 53% 30
7 GERONTOL METAB CARE 85677 1% 51% 29
8 INFORMAT CLIN MED 63906 1% 32% 34
9 MARYLAND PSYCHIAT 62260 2% 11% 101
10 S FOOD SCI NUTR 50200 0% 79% 11

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PTERIDINES 327649 3% 37% 151
2 JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 10446 1% 3% 69
3 JOURNAL OF NEURAL TRANSMISSION 4373 1% 1% 56
4 AGRICULTURAL AND BIOLOGICAL CHEMISTRY 2334 1% 1% 54
5 CURRENT DRUG METABOLISM 2301 0% 2% 21
6 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2165 2% 0% 81
7 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 1989 1% 1% 66
8 JOURNAL OF NEUROCHEMISTRY 1649 2% 0% 80
9 PHARMACOLOGICAL REPORTS 1528 0% 1% 22
10 REDOX REPORT 1367 0% 2% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 KYNURENINE 1575093 8% 64% 425 Search KYNURENINE Search KYNURENINE
2 NEOPTERIN 1556231 10% 52% 513 Search NEOPTERIN Search NEOPTERIN
3 INDOLEAMINE 2 3 DIOXYGENASE 1435671 7% 68% 364 Search INDOLEAMINE+2+3+DIOXYGENASE Search INDOLEAMINE+2+3+DIOXYGENASE
4 KYNURENIC ACID 1360651 7% 66% 357 Search KYNURENIC+ACID Search KYNURENIC+ACID
5 QUINOLINIC ACID 683042 5% 44% 267 Search QUINOLINIC+ACID Search QUINOLINIC+ACID
6 KYNURENINE PATHWAY 626526 3% 79% 137 Search KYNURENINE+PATHWAY Search KYNURENINE+PATHWAY
7 IDO 345709 2% 49% 122 Search IDO Search IDO
8 INDOLEAMINE 2 322777 2% 65% 85 Search INDOLEAMINE+2 Search INDOLEAMINE+2
9 KYNURENINE AMINOTRANSFERASE 306358 1% 89% 59 Search KYNURENINE+AMINOTRANSFERASE Search KYNURENINE+AMINOTRANSFERASE
10 3 HYDROXYKYNURENINE 278021 1% 73% 66 Search 3+HYDROXYKYNURENINE Search 3+HYDROXYKYNURENINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 YEUNG, AWS , TERENTIS, AC , KING, NJC , THOMAS, SR , (2015) ROLE OF INDOLEAMINE 2,3-DIOXYGENASE IN HEALTH AND DISEASE.CLINICAL SCIENCE. VOL. 129. ISSUE 7. P. 601 -672 414 74% 13
2 LOVELACE, MD , VARNEY, B , SUNDARAM, G , LENNON, MJ , LIM, CK , JACOBS, K , GUILLEMIN, GJ , BREW, BJ , (2017) RECENT EVIDENCE FOR AN EXPANDED ROLE OF THE KYNURENINE PATHWAY OF TRYPTOPHAN METABOLISM IN NEUROLOGICAL DISEASES.NEUROPHARMACOLOGY. VOL. 112. ISSUE . P. 373 -388 130 80% 4
3 SCHWARCZ, R , BRUNO, JP , MUCHOWSKI, PJ , WU, HQ , (2012) KYNURENINES IN THE MAMMALIAN BRAIN: WHEN PHYSIOLOGY MEETS PATHOLOGY.NATURE REVIEWS NEUROSCIENCE. VOL. 13. ISSUE 7. P. 465 -477 163 84% 261
4 VECSEI, L , SZALARDY, L , FULOP, F , TOLDI, J , (2013) KYNURENINES IN THE CNS: RECENT ADVANCES AND NEW QUESTIONS.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 1. P. 64 -82 172 80% 107
5 FUJIGAKI, H , YAMAMOTO, Y , SAITO, K , (2017) L-TRYPTOPHAN-KYNURENINE PATHWAY ENZYMES ARE THERAPEUTIC TARGET FOR NEUROPSYCHIATRIC DISEASES: FOCUS ON CELL TYPE DIFFERENCES.NEUROPHARMACOLOGY. VOL. 112. ISSUE . P. 264 -274 131 81% 1
6 WANG, QX , LIU, DX , SONG, P , ZOU, MH , (2015) TRYPTOPHAN-KYNURENINE PATHWAY IS DYSREGULATED IN INFLAMMATION, AND IMMUNE ACTIVATION.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 20. ISSUE . P. 1116 -1143 159 82% 13
7 OCAMPO, JR , HUITRON, RL , GONZALEZ-ESQUIVEL, D , UGALDE-MUNIZ, P , JIMENEZ-ANGUIANO, A , PINEDA, B , PEDRAZA-CHAVERRI, J , RIOS, C , DE LA CRUZ, VP , (2014) KYNURENINES WITH NEUROACTIVE AND REDOX PROPERTIES: RELEVANCE TO AGING AND BRAIN DISEASES.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. VOL. . ISSUE . P. - 161 75% 6
8 STRASSER, B , BECKER, K , FUCHS, D , GOSTNER, JM , (2017) KYNURENINE PATHWAY METABOLISM AND IMMUNE ACTIVATION: PERIPHERAL MEASUREMENTS IN PSYCHIATRIC AND CO-MORBID CONDITIONS.NEUROPHARMACOLOGY. VOL. 112. ISSUE . P. 286 -296 90 80% 1
9 O'FARRELL, K , HARKIN, A , (2017) STRESS-RELATED REGULATION OF THE KYNURENINE PATHWAY: RELEVANCE TO NEUROPSYCHIATRIC AND DEGENERATIVE DISORDERS.NEUROPHARMACOLOGY. VOL. 112. ISSUE . P. 307 -323 121 58% 1
10 ZADORI, D , VERES, G , SZALARDY, L , KLIVENYI, P , FULOP, F , TOLDI, J , VECSEI, L , (2016) INHIBITORS OF THE KYNURENINE PATHWAY AS NEUROTHERAPEUTICS: A PATENT REVIEW (2012-2015).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 26. ISSUE 7. P. 815 -832 121 91% 0

Classes with closest relation at Level 2


Rank Class id link
1 1818 DYSTONIA//TETRAHYDROBIOPTERIN//WRITERS CRAMP
2 903 MICROGLIA//BRAIN BEHAVIOR AND IMMUNITY//CYTOKINES
3 1645 HUNTINGTONS DISEASE//HUNTINGTIN//POLYGLUTAMINE
4 488 SIGMA RECEPTOR//NMDA RECEPTOR//PHENCYCLIDINE
5 1475 THIAMINE//THIAMINE DEFICIENCY//WERNICKES ENCEPHALOPATHY
6 919 PD L1//PD 1//FOXP3
7 1367 DENDRITIC CELLS//DC SIGN//LANGERHANS CELLS
8 1832 HLA G//AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY//JOURNAL OF REPRODUCTIVE IMMUNOLOGY
9 2762 CYCLIC ADP RIBOSE//ADP RIBOSYL CYCLASE//NAADP
10 3829 MURINE AIDS//MAIDS//LP BM5

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