BB2520 Bioprocess Design 15.0 credits


Please note

The information on this page is based on a course syllabus that is not yet valid.

  • Education cycle

    Second cycle
  • Main field of study

    Chemical Science and Engineering
  • Grading scale

    A, B, C, D, E, FX, F

Course offerings

Autumn 19 for programme students

  • Periods

    Autumn 19 P2 (15.0 credits)

  • Application code


  • Start date


  • End date


  • Language of instruction


  • Campus


  • Tutoring time


  • Form of study


  • Number of places *

    Min. 7

    *) The Course date may be cancelled if number of admitted are less than minimum of places.

  • Planned timeslots

    P2: A1, B1, C1, D1, E1, F1, G1, H1, I1, J1, A2, B2, C2, D2, E2, F2, G2, H2, I2, J2, K, L, M, N, O. more info

  • Course responsible

    Antonius Van Maris <>

  • Target group

    Open for all students

  • Part of programme

Autumn 18 for programme students

Intended learning outcomes

The course has the goal to give both practical and theoretical understanding of the elements of taking a bioproduct from the discovery stage to successful pilot scale production according to a desired output with respect to product quantity, quality and process documentation. The goal is further to perform the project in close relationship to actual industrial working methodology i.e. the project is managed and operated in a project group format and theoretical lectures are only used to give the background to a selected range of techniques.

Course main content

Cultivation technology (continuous and fedbtach cultivation, medium design, scale-up of bioprocesses, process rheology), downstream processing, project management , industrial management and organisation, Matlab modelling and simulation (cultivation), factorial design for process development, small and pilot scale production, process documentation.


  • Matlab modeling and simulation of a fedbatch process
  • Deriving of modeling constants through use of continuous cultivation
  • Use of a Matlab model for continuous cultivation start-up
  • Product optimisation using software for factorial design (parameters: feed profile, pH, temp and point of induction)
  • Medium design
  • Scale up of bioprocesses
  • Process rheology impact on production
  • Small and pilot scale bioreactor set-up and operation
  • Economy overview calculation
  • Process documentation methodology (industrial concept)
  • Project planning management; theory and practice
  • Design of the down stream operations


At least 150 credits from grades 1, 2 and 3 of which at least 100 credits from years 1 and 2, and a degree project, first level, must be completed. 

The 150 credits should include a minimum of 20 credits within the fields of Mathematics, Numerical Analysis and Computer Sciences, 5 of these must be within the fields of Numerical Analysis and Computer Sciences, 20 credits of Chemistry, possibly including courses in Chemical Measuring Techniques and 20 credits of Biotechnology or Molecular Biology.

Recommended prerequisites

BSc courses in mathematics, chemistry and biotechnology comparative to the KTH:Biotechnology programme. BB1120 Cultivation technology. Knowledge of Matlab.


Compendium, selected articles.


  • PRO1 - Project Planning part 1, 2.0, grading scale: P, F
  • PRO2 - Project Planning part 2, 4.0, grading scale: P, F
  • REP1 - Final Report, 9.0, grading scale: A, B, C, D, E, FX, F

Part 1 (project plan 1). Individual. Mandatory. P/F. 2 credits.

Part 2 (project plan 2). Individual. Mandatory. P/F. 4 credits.

Report: Process documentation. Individual. Mandatory.  A-F. 9 credits.

Offered by

CBH/Industrial Biotechnology


Antonius Van Maris <>

Supplementary information

Students are required to sign up at least two weeks in advance for examination.

The course is given provided at least seven students are admitted.


Course syllabus valid from: Autumn 2019.
Examination information valid from: Spring 2019.