BB2170 Drug Development 6.0 credits

Läkemedelsutveckling

  • Education cycle

    Second cycle
  • Main field of study

    Biotechnology
  • Grading scale

    A, B, C, D, E, FX, F

Course offerings

Autumn 18 for programme students

Autumn 18 Doktorand for single courses students

  • Periods

    Autumn 18 P1 (6.0 credits)

  • Application code

    10173

  • Start date

    27/08/2018

  • End date

    26/10/2018

  • Language of instruction

    English

  • Campus

    AlbaNova

  • Tutoring time

    Daytime

  • Form of study

    Normal

  • Number of places *

    Max. 1

    *) If there are more applicants than number of places selection will be made.

  • Course responsible

    Veronique Chotteau <chotteau@kth.se>

  • Target group

    For doctoral students at KTH

Intended learning outcomes

After the course you should be able to describe and discuss the different steps in the process of drug development.

After passing the course, the student should be able to:

  • define important concepts within drug discovery and drug development, state which types of studies are used in the process of drug development, and describe which methods are employed in the different steps
  • explain what effects administration, absorption, distribution and elimination have on the dosing of drugs and their equilibrium concentrations, as well as drawing dose-response curves for different types of ligands
  • state which are the commercially important therapeutic areas, describe which classes of drug targets are common, and make an analysis of why these are the dominating classes
  • describe and compare classic strategies for the generation of drug substances to the use of combinatorial libraries and screening; identify advantages and disadvantages
  • identify important differences between different classes of drug substances (proteins, peptides and small, organic molecules) with respect to pharmacokinetics, production, safety and therapeutic areas           
  • prioritize between different candidate drugs for further development from of their chemical and preclinical properties

Course main content

The lectures will cover a range of aspects of drug development and give recent examples from the pharmaceutical industry. Topics that will be discussed include pharmacology, target identification and validation, methods for generation of active substances, different classes of substances and their pharmacological properties, safety requirements and documentation in industrial production, entrepreneurship and development of young research companies, and patent law in the context of biotechnology and drug development.

Eligibility

Admission requirements for programme students at KTH:
At least 150 credits from grades 1, 2 and 3 of which at least 100 credits from years 1 and 2, and degree project, first level, must be completed. 

The 150 credits should include a minimum of 20 credits within the fields of Mathematics, Numerical Analysis and Computer Sciences, 5 of these must be within the fields of Numerical Analysis and Computer Sciences, 20 credits of Chemistry, possibly including courses in Chemical Measuring Techniques and 20 credits of Biotechnology or Molecular Biology

Admission requirements for independent students:

20 ECTS in biochemistry, microbiology and gene technology/molecular biology; 20 ECTS in chemistry; 20 ECTS in mathematics/numerical analysis/computer science

Recommended prerequisites

BB1010 Introduction to Biotechnology, BB1020 Cell Biology with Immunology, KD1090 Organic Chemistry I and BB1090 Biochemistry, Theory, or equivalent.

Literature

Utdelade kompendier.

Kurslitteratur finns tillgänglig då kursen ges och består av utdelade artiklar

Examination

  • LIT1 - Literature Task, 2.0, grading scale: P, F
  • TEN1 - Examination, 4.0, grading scale: A, B, C, D, E, FX, F

Requirements for final grade

Examination (TEN1; 4,0 credits, grading scale A - F) Litterature task (LIT1; 2,0 credits, grading scale Pass/Fail).

Offered by

CBH/Industrial Biotechnology

Examiner

Amelie Eriksson Karlström <ameliek@kth.se>

Supplementary information

Students are required to sign up at least two weeks in advance for examination.

The course is given provided at least seven students are admitted.

Version

Course syllabus valid from: Autumn 2017.
Examination information valid from: Spring 2019.